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Items: 1 to 50 of 65

1.

Author Correction: GABAA receptor signalling mechanisms revealed by structural pharmacology.

Masiulis S, Desai R, Uchański T, Martin IS, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Feb;566(7744):E8. doi: 10.1038/s41586-019-0929-5.

PMID:
30733619
2.

GABAA receptor signalling mechanisms revealed by structural pharmacology.

Masiulis S, Desai R, Uchański T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Jan;565(7740):454-459. doi: 10.1038/s41586-018-0832-5. Epub 2019 Jan 2. Erratum in: Nature. 2019 Feb 7;:.

PMID:
30602790
3.

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer.

Laverty D, Desai R, Uchański T, Masiulis S, Stec WJ, Malinauskas T, Zivanov J, Pardon E, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Jan;565(7740):516-520. doi: 10.1038/s41586-018-0833-4. Epub 2019 Jan 2.

PMID:
30602789
4.

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.

Elegheert J, Behiels E, Bishop B, Scott S, Woolley RE, Griffiths SC, Byrne EFX, Chang VT, Stuart DI, Jones EY, Siebold C, Aricescu AR.

Nat Protoc. 2018 Dec;13(12):2991-3017. doi: 10.1038/s41596-018-0075-9.

PMID:
30455477
5.

Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships.

Zhang P, Lu H, Peixoto RT, Pines MK, Ge Y, Oku S, Siddiqui TJ, Xie Y, Wu W, Archer-Hartmann S, Yoshida K, Tanaka KF, Aricescu AR, Azadi P, Gordon MD, Sabatini BL, Wong ROL, Craig AM.

Cell. 2018 Sep 6;174(6):1450-1464.e23. doi: 10.1016/j.cell.2018.07.002. Epub 2018 Aug 9.

6.

Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome.

Berridge G, Menassa DA, Moloney T, Waters PJ, Welding I, Thomsen S, Zuberi S, Fischer R, Aricescu AR, Pike M, Dale RC, Kessler B, Vincent A, Lim M, Irani SR, Lang B.

Neurology. 2018 Aug 21;91(8):e714-e723. doi: 10.1212/WNL.0000000000006035. Epub 2018 Jul 25.

7.

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.

Altemose N, Noor N, Bitoun E, Tumian A, Imbeault M, Chapman JR, Aricescu AR, Myers SR.

Elife. 2017 Oct 26;6. pii: e28383. doi: 10.7554/eLife.28383.

8.

nandb-number and brightness in R with a novel automatic detrending algorithm.

Nolan R, Alvarez LAJ, Elegheert J, Iliopoulou M, Jakobsdottir GM, Rodriguez-Muñoz M, Aricescu AR, Padilla-Parra S.

Bioinformatics. 2017 Nov 1;33(21):3508-3510. doi: 10.1093/bioinformatics/btx434.

9.

Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.

Farhy-Tselnicker I, van Casteren ACM, Lee A, Chang VT, Aricescu AR, Allen NJ.

Neuron. 2017 Oct 11;96(2):428-445.e13. doi: 10.1016/j.neuron.2017.09.053.

10.

A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.

Davies B, Brown LA, Cais O, Watson J, Clayton AJ, Chang VT, Biggs D, Preece C, Hernandez-Pliego P, Krohn J, Bhomra A, Twigg SRF, Rimmer A, Kanapin A; WGS500 Consortium, Sen A, Zaiwalla Z, McVean G, Foster R, Donnelly P, Taylor JC, Blair E, Nutt D, Aricescu AR, Greger IH, Peirson SN, Flint J, Martin HC.

Hum Mol Genet. 2017 Oct 15;26(20):3869-3882. doi: 10.1093/hmg/ddx270.

11.

Structural basis for GABAA receptor potentiation by neurosteroids.

Miller PS, Scott S, Masiulis S, De Colibus L, Pardon E, Steyaert J, Aricescu AR.

Nat Struct Mol Biol. 2017 Nov;24(11):986-992. doi: 10.1038/nsmb.3484. Epub 2017 Oct 9.

12.

Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.

Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, de Wit J, Begbie J, Craig AM, Aricescu AR.

Neuron. 2017 Sep 27;96(1):242-244. doi: 10.1016/j.neuron.2017.09.011. No abstract available.

13.

Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.

Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, de Wit J, Begbie J, Craig AM, Aricescu AR.

Neuron. 2017 Aug 16;95(4):896-913.e10. doi: 10.1016/j.neuron.2017.07.040.

14.

A GluD Coming-Of-Age Story.

Yuzaki M, Aricescu AR.

Trends Neurosci. 2017 Mar;40(3):138-150. doi: 10.1016/j.tins.2016.12.004. Epub 2017 Jan 19. Review.

15.

Structural basis for integration of GluD receptors within synaptic organizer complexes.

Elegheert J, Kakegawa W, Clay JE, Shanks NF, Behiels E, Matsuda K, Kohda K, Miura E, Rossmann M, Mitakidis N, Motohashi J, Chang VT, Siebold C, Greger IH, Nakagawa T, Yuzaki M, Aricescu AR.

Science. 2016 Jul 15;353(6296):295-9. doi: 10.1126/science.aae0104.

16.

Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins.

Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa W, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M.

Neuron. 2016 May 18;90(4):752-67. doi: 10.1016/j.neuron.2016.04.001. Epub 2016 Apr 28.

17.

Initiation of T cell signaling by CD45 segregation at 'close contacts'.

Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJC, Klenerman D, Aricescu AR, Davis SJ.

Nat Immunol. 2016 May;17(5):574-582. doi: 10.1038/ni.3392. Epub 2016 Mar 21.

18.

A Computational Model for the AMPA Receptor Phosphorylation Master Switch Regulating Cerebellar Long-Term Depression.

Gallimore AR, Aricescu AR, Yuzaki M, Calinescu R.

PLoS Comput Biol. 2016 Jan 25;12(1):e1004664. doi: 10.1371/journal.pcbi.1004664. eCollection 2016 Jan.

19.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.

Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N.

Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

20.

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Taylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G.

Nat Genet. 2015 Jul;47(7):717-726. doi: 10.1038/ng.3304. Epub 2015 May 18.

21.

Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum.

Kakegawa W, Mitakidis N, Miura E, Abe M, Matsuda K, Takeo YH, Kohda K, Motohashi J, Takahashi A, Nagao S, Muramatsu S, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M.

Neuron. 2015 Jan 21;85(2):316-29. doi: 10.1016/j.neuron.2014.12.020.

22.

Production of cell surface and secreted glycoproteins in mammalian cells.

Seiradake E, Zhao Y, Lu W, Aricescu AR, Jones EY.

Methods Mol Biol. 2015;1261:115-27. doi: 10.1007/978-1-4939-2230-7_6.

PMID:
25502196
23.

Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.

Coles CH, Mitakidis N, Zhang P, Elegheert J, Lu W, Stoker AW, Nakagawa T, Craig AM, Jones EY, Aricescu AR.

Nat Commun. 2014 Nov 11;5:5209. doi: 10.1038/ncomms6209.

24.

Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.

Coles CH, Jones EY, Aricescu AR.

Semin Cell Dev Biol. 2015 Jan;37:98-107. doi: 10.1016/j.semcdb.2014.09.007. Epub 2014 Sep 16. Review.

25.

Crystal structure of a human GABAA receptor.

Miller PS, Aricescu AR.

Nature. 2014 Aug 21;512(7514):270-5. doi: 10.1038/nature13293. Epub 2014 Jun 8.

26.

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses.

Seiradake E, Schaupp A, del Toro Ruiz D, Kaufmann R, Mitakidis N, Harlos K, Aricescu AR, Klein R, Jones EY.

Nat Struct Mol Biol. 2013 Aug;20(8):958-64. doi: 10.1038/nsmb.2617. Epub 2013 Jun 30.

27.

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.

Bell CH, Healey E, van Erp S, Bishop B, Tang C, Gilbert RJC, Aricescu AR, Pasterkamp RJ, Siebold C.

Science. 2013 Jul 5;341(6141):77-80. doi: 10.1126/science.1232322. Epub 2013 Jun 6.

28.

Expression of recombinant glycoproteins in mammalian cells: towards an integrative approach to structural biology.

Aricescu AR, Owens RJ.

Curr Opin Struct Biol. 2013 Jun;23(3):345-56. doi: 10.1016/j.sbi.2013.04.003. Epub 2013 Apr 25. Review.

29.

Atomic-resolution monitoring of protein maturation in live human cells by NMR.

Banci L, Barbieri L, Bertini I, Luchinat E, Secci E, Zhao Y, Aricescu AR.

Nat Chem Biol. 2013 May;9(5):297-9. doi: 10.1038/nchembio.1202. Epub 2013 Mar 3.

30.

Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis.

Bowden TA, Baruah K, Coles CH, Harvey DJ, Yu X, Song BD, Stuart DI, Aricescu AR, Scanlan CN, Jones EY, Crispin M.

J Am Chem Soc. 2012 Oct 24;134(42):17554-63. doi: 10.1021/ja306068g. Epub 2012 Oct 15.

31.

Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling.

Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY.

Dev Cell. 2011 Nov 15;21(5):848-61. doi: 10.1016/j.devcel.2011.09.007. Epub 2011 Oct 13.

32.

Structural basis for cell surface patterning through NetrinG-NGL interactions.

Seiradake E, Coles CH, Perestenko PV, Harlos K, McIlhinney RA, Aricescu AR, Jones EY.

EMBO J. 2011 Sep 23;30(21):4479-88. doi: 10.1038/emboj.2011.346.

33.

A dual binding mode for RhoGTPases in plexin signalling.

Bell CH, Aricescu AR, Jones EY, Siebold C.

PLoS Biol. 2011 Aug;9(8):e1001134. doi: 10.1371/journal.pbio.1001134. Epub 2011 Aug 30.

34.

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.

Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY.

Nat Struct Mol Biol. 2011 Jul 10;18(8):886-93. doi: 10.1038/nsmb.2081.

35.

Automation of large scale transient protein expression in mammalian cells.

Zhao Y, Bishop B, Clay JE, Lu W, Jones M, Daenke S, Siebold C, Stuart DI, Jones EY, Aricescu AR.

J Struct Biol. 2011 Aug;175(2):209-15. doi: 10.1016/j.jsb.2011.04.017. Epub 2011 May 6.

36.

Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.

Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR.

Science. 2011 Apr 22;332(6028):484-8. doi: 10.1126/science.1200840. Epub 2011 Mar 31.

37.

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly.

Seiradake E, Harlos K, Sutton G, Aricescu AR, Jones EY.

Nat Struct Mol Biol. 2010 Apr;17(4):398-402. doi: 10.1038/nsmb.1782. Epub 2010 Mar 14.

38.

Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signaling.

Bowden TA, Aricescu AR, Nettleship JE, Siebold C, Rahman-Huq N, Owens RJ, Stuart DI, Jones EY.

Structure. 2009 Dec 9;17(12):1679. doi: 10.1016/j.str.2009.11.004. Epub 2009 Dec 8. No abstract available.

39.

Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling.

Bowden TA, Aricescu AR, Nettleship JE, Siebold C, Rahman-Huq N, Owens RJ, Stuart DI, Jones EY.

Structure. 2009 Oct 14;17(10):1386-97. doi: 10.1016/j.str.2009.07.018.

40.

Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors.

Clayton A, Siebold C, Gilbert RJ, Sutton GC, Harlos K, McIlhinney RA, Jones EY, Aricescu AR.

J Mol Biol. 2009 Oct 9;392(5):1125-32. doi: 10.1016/j.jmb.2009.07.082. Epub 2009 Aug 3.

PMID:
19651138
41.

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, Siebold C.

Nat Struct Mol Biol. 2009 Jul;16(7):698-703. doi: 10.1038/nsmb.1607. Epub 2009 Jun 28.

42.

Preparation of recombinant fibronectin fragments for functional and structural studies.

Staunton D, Millard CJ, Aricescu AR, Campbell ID.

Methods Mol Biol. 2009;522:73-99. doi: 10.1007/978-1-59745-413-1_5.

PMID:
19247602
43.

Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions.

Crispin M, Bowden TA, Coles CH, Harlos K, Aricescu AR, Harvey DJ, Stuart DI, Jones EY.

J Mol Biol. 2009 Apr 17;387(5):1061-6. doi: 10.1016/j.jmb.2009.02.033. Epub 2009 Feb 21.

PMID:
19236877
44.

Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design.

Bowden TA, Crispin M, Harvey DJ, Aricescu AR, Grimes JM, Jones EY, Stuart DI.

J Virol. 2008 Dec;82(23):11628-36. doi: 10.1128/JVI.01344-08. Epub 2008 Sep 24.

45.

Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2.

Bowden TA, Aricescu AR, Gilbert RJ, Grimes JM, Jones EY, Stuart DI.

Nat Struct Mol Biol. 2008 Jun;15(6):567-72. doi: 10.1038/nsmb.1435. Epub 2008 May 18.

PMID:
18488039
46.

Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.

Maretto S, Müller PS, Aricescu AR, Cho KW, Bikoff EK, Robertson EJ.

Dev Biol. 2008 Jun 1;318(1):184-93. doi: 10.1016/j.ydbio.2008.03.021. Epub 2008 Mar 26.

47.

Receptor protein tyrosine phosphatase micro: measuring where to stick.

Aricescu AR, Siebold C, Jones EY.

Biochem Soc Trans. 2008 Apr;36(Pt 2):167-72. doi: 10.1042/BST0360167. Review.

PMID:
18363557
48.

Protein tyrosine phosphatases: structure-function relationships.

Tabernero L, Aricescu AR, Jones EY, Szedlacsek SE.

FEBS J. 2008 Mar;275(5):867-82. doi: 10.1111/j.1742-4658.2008.06251.x. Review.

49.

Immunoglobulin superfamily cell adhesion molecules: zippers and signals.

Aricescu AR, Jones EY.

Curr Opin Cell Biol. 2007 Oct;19(5):543-50. Epub 2007 Oct 23. Review.

PMID:
17935964
50.

Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism.

Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ, van der Merwe PA, Jones EY.

Science. 2007 Aug 31;317(5842):1217-20.

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