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Clustering of IRE1α depends on sensing ER stress but not on its RNase activity.

Ricci D, Marrocco I, Blumenthal D, Dibos M, Eletto D, Vargas J, Boyle S, Iwamoto Y, Chomistek S, Paton JC, Paton AW, Argon Y.

FASEB J. 2019 Sep;33(9):9811-9827. doi: 10.1096/fj.201801240RR. Epub 2019 Jun 14.


Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response.

Gómez-Fernández P, Urtasun A, Paton AW, Paton JC, Borrego F, Dersh D, Argon Y, Alloza I, Vandenbroeck K.

Front Immunol. 2018 Dec 14;9:2934. doi: 10.3389/fimmu.2018.02934. eCollection 2018.


Quality Control across Compartments-Connecting ERAD with Ribosomal Quality Control.

Argon Y, Gidalevitz T.

J Mol Biol. 2019 Jan 18;431(2):142-144. doi: 10.1016/j.jmb.2018.11.023. Epub 2018 Nov 30. No abstract available.


CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum.

Bagashev A, Sotillo E, Tang CH, Black KL, Perazzelli J, Seeholzer SH, Argon Y, Barrett DM, Grupp SA, Hu CC, Thomas-Tikhonenko A.

Mol Cell Biol. 2018 Oct 15;38(21). pii: e00383-18. doi: 10.1128/MCB.00383-18. Print 2018 Nov 1.


Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling.

Biswas C, Rao S, Slade K, Hyman D, Dersh D, Mantegazza AR, Zoltick PW, Marks MS, Argon Y, Behrens EM.

PLoS One. 2018 Jul 19;13(7):e0200913. doi: 10.1371/journal.pone.0200913. eCollection 2018.


Correlation of Insulin-Like Growth Factor-I and -II Concentrations at Birth Measured by Mass Spectrometry and Growth from Birth to Two Months.

Hawkes CP, Murray DM, Kenny LC, Kiely M, O'B Hourihane J, Irvine AD, Wu Z, Argon Y, Reitz RE, McPhaul MJ, Grimberg A.

Horm Res Paediatr. 2018;89(2):122-131. doi: 10.1159/000486035. Epub 2018 Jan 18.


Mitochondrial function requires NGLY1.

Kong J, Peng M, Ostrovsky J, Kwon YJ, Oretsky O, McCormick EM, He M, Argon Y, Falk MJ.

Mitochondrion. 2018 Jan;38:6-16. doi: 10.1016/j.mito.2017.07.008. Epub 2017 Jul 25.


Tay-Sachs disease mutations in HEXA target the α chain of hexosaminidase A to endoplasmic reticulum-associated degradation.

Dersh D, Iwamoto Y, Argon Y.

Mol Biol Cell. 2016 Dec 1;27(24):3813-3827. Epub 2016 Sep 28.


A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production.

Marzec M, Hawkes CP, Eletto D, Boyle S, Rosenfeld R, Hwa V, Wit JM, van Duyvenvoorde HA, Oostdijk W, Losekoot M, Pedersen O, Yeap BB, Flicker L, Barzilai N, Atzmon G, Grimberg A, Argon Y.

Endocrinology. 2016 May;157(5):1914-28. doi: 10.1210/en.2015-2058. Epub 2016 Mar 16.


PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1.

Eletto D, Eletto D, Boyle S, Argon Y.

FASEB J. 2016 Feb;30(2):653-65. doi: 10.1096/fj.15-275883. Epub 2015 Oct 20.


Stressed-Out Endoplasmic Reticulum Inflames the Mitochondria.

Shin S, Argon Y.

Immunity. 2015 Sep 15;43(3):409-11. doi: 10.1016/j.immuni.2015.08.027.


Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.

Zhai J, Zhang L, Mojsilovic-Petrovic J, Jian X, Thomas J, Homma K, Schmitz A, Famulok M, Ichijo H, Argon Y, Randazzo PA, Kalb RG.

J Neurosci. 2015 Jun 17;35(24):9088-105. doi: 10.1523/JNEUROSCI.5032-13.2015.


Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease.

Peng M, Ostrovsky J, Kwon YJ, Polyak E, Licata J, Tsukikawa M, Marty E, Thomas J, Felix CA, Xiao R, Zhang Z, Gasser DL, Argon Y, Falk MJ.

Hum Mol Genet. 2015 Sep 1;24(17):4829-47. doi: 10.1093/hmg/ddv207. Epub 2015 Jun 3.


Candidate genes that affect aging through protein homeostasis.

Argon Y, Gidalevitz T.

Adv Exp Med Biol. 2015;847:45-72. doi: 10.1007/978-1-4939-2404-2_2. Review.


Redox controls UPR to control redox.

Eletto D, Chevet E, Argon Y, Appenzeller-Herzog C.

J Cell Sci. 2014 Sep 1;127(Pt 17):3649-58. doi: 10.1242/jcs.153643. Epub 2014 Aug 8. Review.


OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation.

Dersh D, Jones SM, Eletto D, Christianson JC, Argon Y.

Mol Biol Cell. 2014 Aug 1;25(15):2220-34. doi: 10.1091/mbc.E14-03-0805. Epub 2014 Jun 4.


Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association.

Eletto D, Eletto D, Dersh D, Gidalevitz T, Argon Y.

Mol Cell. 2014 Feb 20;53(4):562-576. doi: 10.1016/j.molcel.2014.01.004. Epub 2014 Feb 6.


Orchestration of secretory protein folding by ER chaperones.

Gidalevitz T, Stevens F, Argon Y.

Biochim Biophys Acta. 2013 Nov;1833(11):2410-24. doi: 10.1016/j.bbamcr.2013.03.007. Epub 2013 Mar 15. Review.


Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response.

Eletto D, Maganty A, Eletto D, Dersh D, Makarewich C, Biswas C, Paton JC, Paton AW, Doroudgar S, Glembotski CC, Argon Y.

J Cell Sci. 2012 Oct 15;125(Pt 20):4865-75. doi: 10.1242/jcs.108928. Epub 2012 Aug 1.


Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production.

Barton ER, Park S, James JK, Makarewich CA, Philippou A, Eletto D, Lei H, Brisson B, Ostrovsky O, Li Z, Argon Y.

FASEB J. 2012 Sep;26(9):3691-702. doi: 10.1096/fj.11-203026. Epub 2012 May 30.


Development of a Grp94 inhibitor.

Duerfeldt AS, Peterson LB, Maynard JC, Ng CL, Eletto D, Ostrovsky O, Shinogle HE, Moore DS, Argon Y, Nicchitta CV, Blagg BS.

J Am Chem Soc. 2012 Jun 13;134(23):9796-804. doi: 10.1021/ja303477g. Epub 2012 May 29.


GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum.

Marzec M, Eletto D, Argon Y.

Biochim Biophys Acta. 2012 Mar;1823(3):774-87. doi: 10.1016/j.bbamcr.2011.10.013. Epub 2011 Nov 3. Review.


The actin regulatory protein HS1 is required for antigen uptake and presentation by dendritic cells.

Huang Y, Biswas C, Klos Dehring DA, Sriram U, Williamson EK, Li S, Clarke F, Gallucci S, Argon Y, Burkhardt JK.

J Immunol. 2011 Dec 1;187(11):5952-63. doi: 10.4049/jimmunol.1100870. Epub 2011 Oct 26.


Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells.

Dehring DA, Clarke F, Ricart BG, Huang Y, Gomez TS, Williamson EK, Hammer DA, Billadeau DD, Argon Y, Burkhardt JK.

J Immunol. 2011 Apr 15;186(8):4805-18. doi: 10.4049/jimmunol.1003102. Epub 2011 Mar 11.


GRP94 in ER quality control and stress responses.

Eletto D, Dersh D, Argon Y.

Semin Cell Dev Biol. 2010 Jul;21(5):479-85. doi: 10.1016/j.semcdb.2010.03.004. Epub 2010 Mar 16. Review.


Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors.

Ostrovsky O, Eletto D, Makarewich C, Barton ER, Argon Y.

Biochim Biophys Acta. 2010 Feb;1803(2):333-41. doi: 10.1016/j.bbamcr.2009.11.005. Epub 2009 Nov 13.


An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells.

Ostrovsky O, Makarewich CA, Snapp EL, Argon Y.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11600-5. doi: 10.1073/pnas.0902626106. Epub 2009 Jun 24.


The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation.

Ostrovsky O, Ahmed NT, Argon Y.

Mol Biol Cell. 2009 Mar;20(6):1855-64. doi: 10.1091/mbc.E08-04-0346. Epub 2009 Jan 21.


Alternative pathways of disulfide bond formation yield secretion-competent, stable and functional immunoglobulins.

Elkabetz Y, Ofir A, Argon Y, Bar-Nun S.

Mol Immunol. 2008 Nov;46(1):97-105. doi: 10.1016/j.molimm.2008.07.005. Epub 2008 Aug 9.


IL-4 suppresses dendritic cell response to type I interferons.

Sriram U, Biswas C, Behrens EM, Dinnall JA, Shivers DK, Monestier M, Argon Y, Gallucci S.

J Immunol. 2007 Nov 15;179(10):6446-55.


GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.

Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y.

Mol Biol Cell. 2007 Oct;18(10):3764-75. Epub 2007 Jul 18.


The peptide-binding activity of GRP94 is regulated by calcium.

Biswas C, Ostrovsky O, Makarewich CA, Wanderling S, Gidalevitz T, Argon Y.

Biochem J. 2007 Jul 15;405(2):233-41.


The N-terminal fragment of GRP94 is sufficient for peptide presentation via professional antigen-presenting cells.

Biswas C, Sriram U, Ciric B, Ostrovsky O, Gallucci S, Argon Y.

Int Immunol. 2006 Jul;18(7):1147-57. Epub 2006 Jun 13.


Cysteines in CH1 underlie retention of unassembled Ig heavy chains.

Elkabetz Y, Argon Y, Bar-Nun S.

J Biol Chem. 2005 Apr 15;280(15):14402-12. Epub 2005 Feb 10.


Identification of the N-terminal peptide binding site of glucose-regulated protein 94.

Gidalevitz T, Biswas C, Ding H, Schneidman-Duhovny D, Wolfson HJ, Stevens F, Radford S, Argon Y.

J Biol Chem. 2004 Apr 16;279(16):16543-52. Epub 2004 Jan 30.


Radicicol-sensitive peptide binding to the N-terminal portion of GRP94.

Vogen S, Gidalevitz T, Biswas C, Simen BB, Stein E, Gulmen F, Argon Y.

J Biol Chem. 2002 Oct 25;277(43):40742-50. Epub 2002 Aug 19.


Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain.

Davis DP, Gallo G, Vogen SM, Dul JL, Sciarretta KL, Kumar A, Raffen R, Stevens FJ, Argon Y.

J Mol Biol. 2001 Nov 9;313(5):1021-34.


Hsp70 and antifibrillogenic peptides promote degradation and inhibit intracellular aggregation of amyloidogenic light chains.

Dul JL, Davis DP, Williamson EK, Stevens FJ, Argon Y.

J Cell Biol. 2001 Feb 19;152(4):705-16.


Inhibition of amyloid fiber assembly by both BiP and its target peptide.

Davis PD, Raffen R, Dul LJ, Vogen MS, Williamson KE, Stevens JF, Argon Y.

Immunity. 2000 Oct;13(4):433-42.


GRP94, an ER chaperone with protein and peptide binding properties.

Argon Y, Simen BB.

Semin Cell Dev Biol. 1999 Oct;10(5):495-505. Review.


Protein folding in the ER.

Stevens FJ, Argon Y.

Semin Cell Dev Biol. 1999 Oct;10(5):443-54. Review.


Pathogenic light chains and the B-cell repertoire.

Stevens FJ, Argon Y.

Immunol Today. 1999 Oct;20(10):451-7. Review.


Mapping the major interaction between binding protein and Ig light chains to sites within the variable domain.

Davis DP, Khurana R, Meredith S, Stevens FJ, Argon Y.

J Immunol. 1999 Oct 1;163(7):3842-50.


Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.

Schulte TW, Akinaga S, Murakata T, Agatsuma T, Sugimoto S, Nakano H, Lee YS, Simen BB, Argon Y, Felts S, Toft DO, Neckers LM, Sharma SV.

Mol Endocrinol. 1999 Sep;13(9):1435-48.


Partial block in B lymphocyte development at the transition into the pre-B cell receptor stage in Vpre-B1-deficient mice.

Mårtensson A, Argon Y, Melchers F, Dul JL, Mårtensson IL.

Int Immunol. 1999 Mar;11(3):453-60.


Phosphotransferases associated with the regulation of kinesin motor activity.

Lindesmith L, McIlvain JM Jr, Argon Y, Sheetz MP.

J Biol Chem. 1997 Sep 5;272(36):22929-33.


Ig light chains are secreted predominantly as monomers.

Dul JL, Aviel S, Melnick J, Argon Y.

J Immunol. 1996 Oct 1;157(7):2969-75.


Inhibition of immunoglobulin folding and secretion by dominant negative BiP ATPase mutants.

Hendershot L, Wei J, Gaut J, Melnick J, Aviel S, Argon Y.

Proc Natl Acad Sci U S A. 1996 May 28;93(11):5269-74.

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