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FlbA-Regulated Gene rpnR Is Involved in Stress Resistance and Impacts Protein Secretion when Aspergillus niger Is Grown on Xylose.

Aerts D, van den Bergh SG, Post H, Altelaar MAF, Arentshorst M, Ram AFJ, Ohm RA, Wösten HAB.

Appl Environ Microbiol. 2019 Jan 9;85(2). pii: e02282-18. doi: 10.1128/AEM.02282-18. Print 2019 Jan 15.


W361R mutation in GaaR, the regulator of D-galacturonic acid-responsive genes, leads to constitutive production of pectinases in Aspergillus niger.

Alazi E, Niu J, Otto SB, Arentshorst M, Pham TTM, Tsang A, Ram AFJ.

Microbiologyopen. 2018 Oct 8:e732. doi: 10.1002/mbo3.732. [Epub ahead of print]


Parasexual Crossings for Bulk Segregant Analysis in Aspergillus niger to Facilitate Mutant Identification Via Whole Genome Sequencing.

Arentshorst M, Ram AFJ.

Methods Mol Biol. 2018;1775:277-287. doi: 10.1007/978-1-4939-7804-5_22.


Inducer-independent production of pectinases in Aspergillus niger by overexpression of the D-galacturonic acid-responsive transcription factor gaaR.

Alazi E, Knetsch T, Di Falco M, Reid ID, Arentshorst M, Visser J, Tsang A, Ram AFJ.

Appl Microbiol Biotechnol. 2018 Mar;102(6):2723-2736. doi: 10.1007/s00253-018-8753-7. Epub 2018 Jan 24.


The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production.

Aerts D, Hauer EE, Ohm RA, Arentshorst M, Teertstra WR, Phippen C, Ram AFJ, Frisvad JC, Wösten HAB.

Antonie Van Leeuwenhoek. 2018 Mar;111(3):311-322. doi: 10.1007/s10482-017-0952-1. Epub 2017 Sep 30.


The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger.

Alazi E, Khosravi C, Homan TG, du Pré S, Arentshorst M, Di Falco M, Pham TTM, Peng M, Aguilar-Pontes MV, Visser J, Tsang A, de Vries RP, Ram AFJ.

FEBS Lett. 2017 May;591(10):1408-1418. doi: 10.1002/1873-3468.12654. Epub 2017 May 6.


An Evolutionarily Conserved Transcriptional Activator-Repressor Module Controls Expression of Genes for D-Galacturonic Acid Utilization in Aspergillus niger.

Niu J, Alazi E, Reid ID, Arentshorst M, Punt PJ, Visser J, Tsang A, Ram AF.

Genetics. 2017 Jan;205(1):169-183. doi: 10.1534/genetics.116.194050. Epub 2016 Nov 9.


Exploring Responsible Neuroimaging Innovation: Visions From a Societal Actor Perspective.

Arentshorst ME, de Cock Buning T, Broerse JEW.

Bull Sci Technol Soc. 2016 Dec;36(4):229-240. doi: 10.1177/0270467617727457. Epub 2017 Aug 31.


Highly active promoters and native secretion signals for protein production during extremely low growth rates in Aspergillus niger.

Wanka F, Arentshorst M, Cairns TC, Jørgensen T, Ram AF, Meyer V.

Microb Cell Fact. 2016 Aug 20;15(1):145. doi: 10.1186/s12934-016-0543-2.


Aspergillus fumigatus MADS-Box Transcription Factor rlmA Is Required for Regulation of the Cell Wall Integrity and Virulence.

Rocha MC, Fabri JH, Franco de Godoy K, Alves de Castro P, Hori JI, Ferreira da Cunha A, Arentshorst M, Ram AF, van den Hondel CA, Goldman GH, Malavazi I.

G3 (Bethesda). 2016 Sep 8;6(9):2983-3002. doi: 10.1534/g3.116.031112.


Transcriptomic and molecular genetic analysis of the cell wall salvage response of Aspergillus niger to the absence of galactofuranose synthesis.

Park J, Hulsman M, Arentshorst M, Breeman M, Alazi E, Lagendijk EL, Rocha MC, Malavazi I, Nitsche BM, van den Hondel CA, Meyer V, Ram AF.

Cell Microbiol. 2016 Sep;18(9):1268-84. doi: 10.1111/cmi.12624. Epub 2016 Jul 29.


A set of isogenic auxotrophic strains for constructing multiple gene deletion mutants and parasexual crossings in Aspergillus niger.

Niu J, Arentshorst M, Seelinger F, Ram AF, Ouedraogo JP.

Arch Microbiol. 2016 Nov;198(9):861-8. doi: 10.1007/s00203-016-1240-6. Epub 2016 Jun 1.


Improving cellulase production by Aspergillus niger using adaptive evolution.

Patyshakuliyeva A, Arentshorst M, Allijn IE, Ram AF, de Vries RP, Gelber IB.

Biotechnol Lett. 2016 Jun;38(6):969-74. doi: 10.1007/s10529-016-2060-0. Epub 2016 Feb 15.


I-SceI enzyme mediated integration (SEMI) for fast and efficient gene targeting in Trichoderma reesei.

Ouedraogo JP, Arentshorst M, Nikolaev I, Barends S, Ram AF.

J Biotechnol. 2016 Mar 20;222:25-8. doi: 10.1016/j.jbiotec.2016.02.012. Epub 2016 Feb 6.


Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites.

Niu J, Arentshorst M, Nair PD, Dai Z, Baker SE, Frisvad JC, Nielsen KF, Punt PJ, Ram AF.

G3 (Bethesda). 2015 Nov 13;6(1):193-204. doi: 10.1534/g3.115.024067.


I-SceI-mediated double-strand DNA breaks stimulate efficient gene targeting in the industrial fungus Trichoderma reesei.

Ouedraogo JP, Arentshorst M, Nikolaev I, Barends S, Ram AF.

Appl Microbiol Biotechnol. 2015 Dec;99(23):10083-95. doi: 10.1007/s00253-015-6829-1. Epub 2015 Aug 15.


Responsible Reporting: Neuroimaging News in the Age of Responsible Research and Innovation.

de Jong IM, Kupper F, Arentshorst M, Broerse J.

Sci Eng Ethics. 2016 Aug;22(4):1107-1130. doi: 10.1007/s11948-015-9684-7. Epub 2015 Jul 25.


The interaction of induction and repression mechanisms in the regulation of galacturonic acid-induced genes in Aspergillus niger.

Niu J, Homan TG, Arentshorst M, de Vries RP, Visser J, Ram AF.

Fungal Genet Biol. 2015 Sep;82:32-42. doi: 10.1016/j.fgb.2015.06.006. Epub 2015 Jun 27.


A new vector for efficient gene targeting to the pyrG locus in Aspergillus niger.

Arentshorst M, Lagendijk EL, Ram AF.

Fungal Biol Biotechnol. 2015 Mar 14;2:2. doi: 10.1186/s40694-015-0012-4. eCollection 2015.


Identification of the UDP-glucose-4-epimerase required for galactofuranose biosynthesis and galactose metabolism in A. niger.

Park J, Tefsen B, Arentshorst M, Lagendijk E, van den Hondel CA, van Die I, Ram AF.

Fungal Biol Biotechnol. 2014 Oct 14;1:6. doi: 10.1186/s40694-014-0006-7. eCollection 2014.


Molecular genetic analysis of vesicular transport in Aspergillus niger reveals partial conservation of the molecular mechanism of exocytosis in fungi.

Kwon MJ, Arentshorst M, Fiedler M, de Groen FL, Punt PJ, Meyer V, Ram AF.

Microbiology. 2014 Feb;160(Pt 2):316-29. doi: 10.1099/mic.0.074252-0. Epub 2013 Dec 2.


The transcriptional repressor TupA in Aspergillus niger is involved in controlling gene expression related to cell wall biosynthesis, development, and nitrogen source availability.

Schachtschabel D, Arentshorst M, Nitsche BM, Morris S, Nielsen KF, van den Hondel CA, Klis FM, Ram AF.

PLoS One. 2013 Oct 29;8(10):e78102. doi: 10.1371/journal.pone.0078102. eCollection 2013.


The transcriptomic signature of RacA activation and inactivation provides new insights into the morphogenetic network of Aspergillus niger.

Kwon MJ, Nitsche BM, Arentshorst M, Jørgensen TR, Ram AF, Meyer V.

PLoS One. 2013 Jul 24;8(7):e68946. doi: 10.1371/journal.pone.0068946. Print 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/ffb09608-0f66-4985-97a9-3da9d498b3bf.


Characterization of the T-cell-mediated immune response against the Aspergillus fumigatus proteins Crf1 and catalase 1 in healthy individuals.

Jolink H, Meijssen IC, Hagedoorn RS, Arentshorst M, Drijfhout JW, Mulder A, Claas FH, van Dissel JT, Falkenburg JH, Heemskerk MH.

J Infect Dis. 2013 Sep 1;208(5):847-56. doi: 10.1093/infdis/jit237. Epub 2013 May 22.


Heterogeneity in liquid shaken cultures of Aspergillus niger inoculated with melanised conidia or conidia of pigmentation mutants.

van Veluw GJ, Teertstra WR, de Bekker C, Vinck A, van Beek N, Muller WH, Arentshorst M, van der Mei HC, Ram AF, Dijksterhuis J, Wösten HA.

Stud Mycol. 2013 Mar 15;74(1):47-57. doi: 10.3114/sim0008. Epub 2012 Sep 14.


The transcriptomic fingerprint of glucoamylase over-expression in Aspergillus niger.

Kwon MJ, Jørgensen TR, Nitsche BM, Arentshorst M, Park J, Ram AF, Meyer V.

BMC Genomics. 2012 Dec 13;13:701. doi: 10.1186/1471-2164-13-701.


Genome-wide expression analysis upon constitutive activation of the HacA bZIP transcription factor in Aspergillus niger reveals a coordinated cellular response to counteract ER stress.

Carvalho ND, Jørgensen TR, Arentshorst M, Nitsche BM, van den Hondel CA, Archer DB, Ram AF.

BMC Genomics. 2012 Jul 30;13:350. doi: 10.1186/1471-2164-13-350.


Vacuolar H(+)-ATPase plays a key role in cell wall biosynthesis of Aspergillus niger.

Schachtschabel D, Arentshorst M, Lagendijk EL, Ram AF.

Fungal Genet Biol. 2012 Apr;49(4):284-93. doi: 10.1016/j.fgb.2011.12.008. Epub 2011 Dec 29.


Using non-homologous end-joining-deficient strains for functional gene analyses in filamentous fungi.

Arentshorst M, Ram AF, Meyer V.

Methods Mol Biol. 2012;835:133-50. doi: 10.1007/978-1-61779-501-5_9.


Submerged conidiation and product formation by Aspergillus niger at low specific growth rates are affected in aerial developmental mutants.

Jørgensen TR, Nielsen KF, Arentshorst M, Park J, van den Hondel CA, Frisvad JC, Ram AF.

Appl Environ Microbiol. 2011 Aug;77(15):5270-7. doi: 10.1128/AEM.00118-11. Epub 2011 Jun 7.


Fungal gene expression on demand: an inducible, tunable, and metabolism-independent expression system for Aspergillus niger.

Meyer V, Wanka F, van Gent J, Arentshorst M, van den Hondel CA, Ram AF.

Appl Environ Microbiol. 2011 May;77(9):2975-83. doi: 10.1128/AEM.02740-10. Epub 2011 Mar 4.


Functional YFP-tagging of the essential GDP-mannose transporter reveals an important role for the secretion related small GTPase SrgC protein in maintenance of Golgi bodies in Aspergillus niger.

Carvalho ND, Arentshorst M, Weenink XO, Punt PJ, van den Hondel CA, Ram AF.

Fungal Biol. 2011 Mar;115(3):253-64. doi: 10.1016/j.funbio.2010.12.010. Epub 2010 Dec 29.


The molecular and genetic basis of conidial pigmentation in Aspergillus niger.

Jørgensen TR, Park J, Arentshorst M, van Welzen AM, Lamers G, Vankuyk PA, Damveld RA, van den Hondel CA, Nielsen KF, Frisvad JC, Ram AF.

Fungal Genet Biol. 2011 May;48(5):544-53. doi: 10.1016/j.fgb.2011.01.005. Epub 2011 Jan 26.


Functional characterization of Rho GTPases in Aspergillus niger uncovers conserved and diverged roles of Rho proteins within filamentous fungi.

Kwon MJ, Arentshorst M, Roos ED, van den Hondel CA, Meyer V, Ram AF.

Mol Microbiol. 2011 Mar;79(5):1151-67. doi: 10.1111/j.1365-2958.2010.07524.x. Epub 2011 Jan 18.


Effects of a defective ERAD pathway on growth and heterologous protein production in Aspergillus niger.

Carvalho ND, Arentshorst M, Kooistra R, Stam H, Sagt CM, van den Hondel CA, Ram AF.

Appl Microbiol Biotechnol. 2011 Jan;89(2):357-73. doi: 10.1007/s00253-010-2916-5. Epub 2010 Oct 5.


Transcriptomic insights into the physiology of Aspergillus niger approaching a specific growth rate of zero.

Jørgensen TR, Nitsche BM, Lamers GE, Arentshorst M, van den Hondel CA, Ram AF.

Appl Environ Microbiol. 2010 Aug;76(16):5344-55. doi: 10.1128/AEM.00450-10. Epub 2010 Jun 18.


Expanding the ku70 toolbox for filamentous fungi: establishment of complementation vectors and recipient strains for advanced gene analyses.

Carvalho ND, Arentshorst M, Jin Kwon M, Meyer V, Ram AF.

Appl Microbiol Biotechnol. 2010 Jul;87(4):1463-73. doi: 10.1007/s00253-010-2588-1. Epub 2010 Apr 27.


Reconstruction of signaling networks regulating fungal morphogenesis by transcriptomics.

Meyer V, Arentshorst M, Flitter SJ, Nitsche BM, Kwon MJ, Reynaga-Peña CG, Bartnicki-Garcia S, van den Hondel CA, Ram AF.

Eukaryot Cell. 2009 Nov;8(11):1677-91. doi: 10.1128/EC.00050-09. Epub 2009 Sep 11.


A novel screening method for cell wall mutants in Aspergillus niger identifies UDP-galactopyranose mutase as an important protein in fungal cell wall biosynthesis.

Damveld RA, Franken A, Arentshorst M, Punt PJ, Klis FM, van den Hondel CA, Ram AF.

Genetics. 2008 Feb;178(2):873-81. doi: 10.1534/genetics.107.073148. Epub 2008 Feb 3.


Evolution of CDC42, a putative virulence factor triggering meristematic growth in black yeasts.

Deng S, van den Ende AH, Ram AF, Arentshorst M, Gräser Y, Hu H, de Hoog GS.

Stud Mycol. 2008;61:121-9. doi: 10.3114/sim.2008.61.12.


The polarisome component SpaA localises to hyphal tips of Aspergillus niger and is important for polar growth.

Meyer V, Arentshorst M, van den Hondel CA, Ram AF.

Fungal Genet Biol. 2008 Feb;45(2):152-64. Epub 2007 Aug 3.


Survival in the presence of antifungals: genome-wide expression profiling of Aspergillus niger in response to sublethal concentrations of caspofungin and fenpropimorph.

Meyer V, Damveld RA, Arentshorst M, Stahl U, van den Hondel CA, Ram AF.

J Biol Chem. 2007 Nov 9;282(45):32935-48. Epub 2007 Sep 5.


The effect of oxybutynin on structural changes of the obstructed guinea pig bladder.

Scheepe JR, de Jong BW, Wolffenbuttel KP, Arentshorst ME, Lodder P, Kok DJ.

J Urol. 2007 Oct;178(4 Pt 2):1807-12. Epub 2007 Aug 17.


Detrusor glycogen reflects the functional history of bladders with partial outlet obstruction.

de Jong BW, Wolffenbuttel KP, Arentshorst ME, Lodder P, Kok DJ.

BJU Int. 2007 Oct;100(4):846-52. Epub 2007 Jul 23.


Highly efficient gene targeting in the Aspergillus niger kusA mutant.

Meyer V, Arentshorst M, El-Ghezal A, Drews AC, Kooistra R, van den Hondel CA, Ram AF.

J Biotechnol. 2007 Mar 10;128(4):770-5. Epub 2007 Jan 10.


Activity of quinones from teak (Tectona grandis) on fungal cell wall stress.

Sumthong P, Damveld RA, Choi YH, Arentshorst M, Ram AF, van den Hondel CA, Verpoorte R.

Planta Med. 2006 Aug;72(10):943-4.


The Aspergillus niger MADS-box transcription factor RlmA is required for cell wall reinforcement in response to cell wall stress.

Damveld RA, Arentshorst M, Franken A, vanKuyk PA, Klis FM, van den Hondel CA, Ram AF.

Mol Microbiol. 2005 Oct;58(1):305-19.


Characterisation of CwpA, a putative glycosylphosphatidylinositol-anchored cell wall mannoprotein in the filamentous fungus Aspergillus niger.

Damveld RA, Arentshorst M, VanKuyk PA, Klis FM, van den Hondel CA, Ram AF.

Fungal Genet Biol. 2005 Oct;42(10):873-85.


Expression of agsA, one of five 1,3-alpha-D-glucan synthase-encoding genes in Aspergillus niger, is induced in response to cell wall stress.

Damveld RA, vanKuyk PA, Arentshorst M, Klis FM, van den Hondel CA, Ram AF.

Fungal Genet Biol. 2005 Feb;42(2):165-77. Epub 2004 Dec 31.


Agrobacterium-mediated transformation leads to improved gene replacement efficiency in Aspergillus awamori.

Michielse CB, Arentshorst M, Ram AF, van den Hondel CA.

Fungal Genet Biol. 2005 Jan;42(1):9-19.


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