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Items: 1 to 50 of 200

1.

ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.

Rashid M, van der Horst M, Mentzel T, Butera F, Ferreira I, Pance A, Rütten A, Luzar B, Marusic Z, de Saint Aubain N, Ko JS, Billings SD, Chen S, Abi Daoud M, Hewinson J, Louzada S, Harms PW, Cerretelli G, Robles-Espinoza CD, Patel RM, van der Weyden L, Bakal C, Hornick JL, Arends MJ, Brenn T, Adams DJ.

Nat Commun. 2019 May 17;10(1):2213. doi: 10.1038/s41467-019-09979-0.

2.

MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance.

Sale MJ, Balmanno K, Saxena J, Ozono E, Wojdyla K, McIntyre RE, Gilley R, Woroniuk A, Howarth KD, Hughes G, Dry JR, Arends MJ, Caro P, Oxley D, Ashton S, Adams DJ, Saez-Rodriguez J, Smith PD, Cook SJ.

Nat Commun. 2019 May 2;10(1):2030. doi: 10.1038/s41467-019-09438-w.

3.

The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome.

Crosbie EJ, Ryan NAJ, Arends MJ, Bosse T, Burn J, Cornes JM, Crawford R, Eccles D, Frayling IM, Ghaem-Maghami S, Hampel H, Kauff ND, Kitchener HC, Kitson SJ, Manchanda R, McMahon RFT, Monahan KJ, Menon U, Møller P, Möslein G, Rosenthal A, Sasieni P, Seif MW, Singh N, Skarrott P, Snowsill TM, Steele R, Tischkowitz M; Manchester International Consensus Group, Evans DG.

Genet Med. 2019 Mar 28. doi: 10.1038/s41436-019-0489-y. [Epub ahead of print]

4.

Survey of UK histopathology consultants' attitudes towards academic and molecular pathology.

Brockmoeller S, Young C, Lee J, Arends MJ, Wilkins BS, Thomas GJ, Oien KA, Jones L, Hunter KD.

J Clin Pathol. 2019 Jun;72(6):399-405. doi: 10.1136/jclinpath-2018-205568. Epub 2019 Mar 25.

5.

FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.

Ballesteros Reviriego C, Clare S, Arends MJ, Cambridge EL, Swiatkowska A, Caetano S, Abu-Helil B, Kane L, Harcourt K, Goulding DA, Gleeson D, Ryder E, Doe B, White JK, van der Weyden L, Dougan G, Adams DJ, Speak AO.

PLoS One. 2019 Mar 6;14(3):e0212481. doi: 10.1371/journal.pone.0212481. eCollection 2019.

6.

Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma.

Wong K, van der Weyden L, Schott CR, Foote A, Constantino-Casas F, Smith S, Dobson JM, Murchison EP, Wu H, Yeh I, Fullen DR, Joseph N, Bastian BC, Patel RM, Martincorena I, Robles-Espinoza CD, Iyer V, Kuijjer ML, Arends MJ, Brenn T, Harms PW, Wood GA, Adams DJ.

Nat Commun. 2019 Jan 21;10(1):353. doi: 10.1038/s41467-018-08081-1.

7.

Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma.

Wong K, Robles-Espinoza CD, Rodriguez D, Rudat SS, Puig S, Potrony M, Wong CC, Hewinson J, Aguilera P, Puig-Butille JA, Bressac-de Paillerets B, Zattara H, van der Weyden L, Fletcher CDM, Brenn T, Arends MJ, Quesada V, Newton-Bishop JA, Lopez-Otin C, Bishop DT, Harms PW, Johnson TM, Durham AB, Lombard DB, Adams DJ.

JAMA Dermatol. 2018 Dec 26. doi: 10.1001/jamadermatol.2018.3662. [Epub ahead of print]

PMID:
30586141
8.

DNA mismatch repair and CD133-marked cancer stem cells in colorectal carcinoma.

Cheah PL, Li J, Looi LM, Teoh KH, Ong DB, Arends MJ.

PeerJ. 2018 Sep 11;6:e5530. doi: 10.7717/peerj.5530. eCollection 2018.

9.

A novel panel of short mononucleotide repeats linked to informative polymorphisms enabling effective high volume low cost discrimination between mismatch repair deficient and proficient tumours.

Redford L, Alhilal G, Needham S, O'Brien O, Coaker J, Tyson J, Amorim LM, Middleton I, Izuogu O, Arends M, Oniscu A, Alonso ÁM, Laguna SM, Gallon R, Sheth H, Santibanez-Koref M, Jackson MS, Burn J.

PLoS One. 2018 Aug 29;13(8):e0203052. doi: 10.1371/journal.pone.0203052. eCollection 2018.

10.

Pulmonary metastatic colonisation and granulomas in NOX2-deficient mice.

van der Weyden L, Speak AO, Swiatkowska A, Clare S, Schejtman A, Santilli G, Arends MJ, Adams DJ.

J Pathol. 2018 Nov;246(3):300-310. doi: 10.1002/path.5140. Epub 2018 Sep 19.

11.

Lynch syndrome - cancer pathways, heterogeneity and immune escape.

Seth S, Ager A, Arends MJ, Frayling IM.

J Pathol. 2018 Oct;246(2):129-133. doi: 10.1002/path.5139. Epub 2018 Aug 27. Review.

PMID:
30027543
12.

Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease-Associated Colorectal Cancers.

Din S, Wong K, Mueller MF, Oniscu A, Hewinson J, Black CJ, Miller ML, Jiménez-Sánchez A, Rabbie R, Rashid M, Satsangi J, Adams DJ, Arends MJ.

Clin Cancer Res. 2018 Oct 15;24(20):5133-5142. doi: 10.1158/1078-0432.CCR-17-3713. Epub 2018 Jun 27.

13.

The murine hepatic sequelae of long-term ethanol consumption are sex-specific and exacerbated by Aldh1b1 loss.

Müller MF, Kendall TJ, Adams DJ, Zhou Y, Arends MJ.

Exp Mol Pathol. 2018 Aug;105(1):63-70. doi: 10.1016/j.yexmp.2018.05.008. Epub 2018 Jun 1.

PMID:
29859945
14.

Adaptive pathway development for Fabry disease: a clinical approach.

Schuller Y, Arends M, Körver S, Langeveld M, Hollak CEM.

Drug Discov Today. 2018 Jun;23(6):1251-1257. doi: 10.1016/j.drudis.2018.02.004. Epub 2018 Feb 15. Review.

15.

Agalsidase alfa versus agalsidase beta for the treatment of Fabry disease: an international cohort study.

Arends M, Biegstraaten M, Wanner C, Sirrs S, Mehta A, Elliott PM, Oder D, Watkinson OT, Bichet DG, Khan A, Iwanochko M, Vaz FM, van Kuilenburg ABP, West ML, Hughes DA, Hollak CEM.

J Med Genet. 2018 May;55(5):351-358. doi: 10.1136/jmedgenet-2017-104863. Epub 2018 Feb 7.

16.

Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations.

Hollis RL, Meynert AM, Churchman M, Rye T, Mackean M, Nussey F, Arends MJ, Sims AH, Semple CA, Herrington CS, Gourley C.

BMC Cancer. 2018 Jan 3;18(1):16. doi: 10.1186/s12885-017-3981-2.

17.

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis.

Smith MD, Harley ME, Kemp AJ, Wills J, Lee M, Arends M, von Kriegsheim A, Behrends C, Wilkinson S.

Dev Cell. 2018 Jan 22;44(2):217-232.e11. doi: 10.1016/j.devcel.2017.11.024. Epub 2017 Dec 28.

18.

Widespread spontaneous hyperproliferation, melanosis and melanoma in Hgf-Cdk4R24C mice.

van der Weyden L, Arends MJ, Brenn T, Tuting T, Adams DJ.

Melanoma Res. 2018 Feb;28(1):76-78. doi: 10.1097/CMR.0000000000000414. No abstract available.

19.

A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization.

Speak AO, Swiatkowska A, Karp NA, Arends MJ, Adams DJ, van der Weyden L.

Nat Protoc. 2017 Dec;12(12):2465-2477. doi: 10.1038/nprot.2017.118. Epub 2017 Nov 2.

PMID:
29095442
20.

Phenotype, disease severity and pain are major determinants of quality of life in Fabry disease: results from a large multicenter cohort study.

Arends M, Körver S, Hughes DA, Mehta A, Hollak CEM, Biegstraaten M.

J Inherit Metab Dis. 2018 Jan;41(1):141-149. doi: 10.1007/s10545-017-0095-6. Epub 2017 Oct 16.

21.

Determination of the physiological and pathological roles of E2F3 in adult tissues.

Gamper I, Burkhart DL, Bywater MJ, Garcia D, Wilson CH, Kreuzaler PA, Arends MJ, Zheng YW, Perfetto A, Littlewood TD, Evan GI.

Sci Rep. 2017 Aug 30;7(1):9932. doi: 10.1038/s41598-017-09494-6.

22.

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.

Dovey OM, Cooper JL, Mupo A, Grove CS, Lynn C, Conte N, Andrews RM, Pacharne S, Tzelepis K, Vijayabaskar MS, Green P, Rad R, Arends M, Wright P, Yusa K, Bradley A, Varela I, Vassiliou GS.

Blood. 2017 Oct 26;130(17):1911-1922. doi: 10.1182/blood-2017-01-760595. Epub 2017 Aug 23.

23.

Retrospective study of long-term outcomes of enzyme replacement therapy in Fabry disease: Analysis of prognostic factors.

Arends M, Biegstraaten M, Hughes DA, Mehta A, Elliott PM, Oder D, Watkinson OT, Vaz FM, van Kuilenburg ABP, Wanner C, Hollak CEM.

PLoS One. 2017 Aug 1;12(8):e0182379. doi: 10.1371/journal.pone.0182379. eCollection 2017.

24.

Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome.

Coan PM, Barrier M, Alfazema N, Carter RN, Marion de Procé S, Dopico XC, Garcia Diaz A, Thomson A, Jackson-Jones LH, Moyon B, Webster Z, Ross D, Moss J, Arends MJ, Morton NM, Aitman TJ.

Hypertension. 2017 Jul 24. pii: HYPERTENSIONAHA.117.09242. doi: 10.1161/HYPERTENSIONAHA.117.09242. [Epub ahead of print]

25.

Favourable effect of early versus late start of enzyme replacement therapy on plasma globotriaosylsphingosine levels in men with classical Fabry disease.

Arends M, Wijburg FA, Wanner C, Vaz FM, van Kuilenburg ABP, Hughes DA, Biegstraaten M, Mehta A, Hollak CEM, Langeveld M.

Mol Genet Metab. 2017 Jun;121(2):157-161. doi: 10.1016/j.ymgme.2017.05.001. Epub 2017 May 4.

PMID:
28495078
26.

A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS.

Bao L, Al-Assar O, Drynan LF, Arends MJ, Tyers P, Barker RA, Rabbitts TH.

Sci Rep. 2017 Mar 21;7:44899. doi: 10.1038/srep44899.

27.

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.

Gupta A, Anjomani-Virmouni S, Koundouros N, Dimitriadi M, Choo-Wing R, Valle A, Zheng Y, Chiu YH, Agnihotri S, Zadeh G, Asara JM, Anastasiou D, Arends MJ, Cantley LC, Poulogiannis G.

Mol Cell. 2017 Mar 16;65(6):999-1013.e7. doi: 10.1016/j.molcel.2017.02.019.

28.

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

van der Weyden L, Arends MJ, Campbell AD, Bald T, Wardle-Jones H, Griggs N, Velasco-Herrera MD, Tüting T, Sansom OJ, Karp NA, Clare S, Gleeson D, Ryder E, Galli A, Tuck E, Cambridge EL, Voet T, Macaulay IC, Wong K; Sanger Mouse Genetics Project, Spiegel S, Speak AO, Adams DJ.

Nature. 2017 Jan 12;541(7636):233-236. doi: 10.1038/nature20792. Epub 2017 Jan 4.

29.

Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.

Müller MF, Zhou Y, Adams DJ, Arends MJ.

J Pathol. 2017 Apr;241(5):649-660. doi: 10.1002/path.4869. Epub 2017 Mar 7.

30.

Characterization of Classical and Nonclassical Fabry Disease: A Multicenter Study.

Arends M, Wanner C, Hughes D, Mehta A, Oder D, Watkinson OT, Elliott PM, Linthorst GE, Wijburg FA, Biegstraaten M, Hollak CE.

J Am Soc Nephrol. 2017 May;28(5):1631-1641. doi: 10.1681/ASN.2016090964. Epub 2016 Dec 15.

31.

Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency.

Kuijpers TW, Tool ATJ, van der Bijl I, de Boer M, van Houdt M, de Cuyper IM, Roos D, van Alphen F, van Leeuwen K, Cambridge EL, Arends MJ, Dougan G, Clare S, Ramirez-Solis R, Pals ST, Adams DJ, Meijer AB, van den Berg TK.

J Allergy Clin Immunol. 2017 Jul;140(1):273-277.e10. doi: 10.1016/j.jaci.2016.09.061. Epub 2016 Dec 10. No abstract available.

PMID:
27965109
32.

New concepts for an old problem: the diagnosis of endometrial hyperplasia.

Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT.

Hum Reprod Update. 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. Review.

33.

Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability.

Woodward J, Taylor GC, Soares DC, Boyle S, Sie D, Read D, Chathoth K, Vukovic M, Tarrats N, Jamieson D, Campbell KJ, Blyth K, Acosta JC, Ylstra B, Arends MJ, Kranc KR, Jackson AP, Bickmore WA, Wood AJ.

Genes Dev. 2016 Oct 1;30(19):2173-2186. Epub 2016 Oct 13.

34.

The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity.

Cambridge EL, McIntyre Z, Clare S, Arends MJ, Goulding D, Isherwood C, Caetano SS, Reviriego CB, Swiatkowska A, Kane L, Harcourt K; Sanger Mouse Genetics Project, Adams DJ, White JK, Speak AO.

Exp Hematol. 2017 Jan;45:64-68.e5. doi: 10.1016/j.exphem.2016.09.006. Epub 2016 Sep 22.

35.

The NCS code of practice for the quality assurance and control for volumetric modulated arc therapy.

Mans A, Schuring D, Arends MP, Vugts CA, Wolthaus JW, Lotz HT, Admiraal M, Louwe RJ, Öllers MC, van de Kamer JB.

Phys Med Biol. 2016 Oct 7;61(19):7221-7235. Epub 2016 Sep 20.

PMID:
27649474
36.

Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B12)-Defective Mice Is Subject to Maternal Influences.

Mottram L, Speak AO, Selek RM, Cambridge EL, McIntyre Z, Kane L, Mukhopadhyay S, Grove C, Colin A, Brandt C, Duque-Correa MA, Forbester J, Nguyen TA, Hale C, Vasilliou GS, Arends MJ, Wren BW, Dougan G, Clare S.

MBio. 2016 Jun 21;7(3). pii: e00830-16. doi: 10.1128/mBio.00830-16.

37.

Molecular pathological classification of colorectal cancer.

Müller MF, Ibrahim AE, Arends MJ.

Virchows Arch. 2016 Aug;469(2):125-34. doi: 10.1007/s00428-016-1956-3. Epub 2016 Jun 20. Review.

38.

Familial Adrenocortical Carcinoma in Association With Lynch Syndrome.

Challis BG, Kandasamy N, Powlson AS, Koulouri O, Annamalai AK, Happerfield L, Marker AJ, Arends MJ, Nik-Zainal S, Gurnell M.

J Clin Endocrinol Metab. 2016 Jun;101(6):2269-72. doi: 10.1210/jc.2016-1460. Epub 2016 May 4.

39.

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.

Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D, Protheroe HJ, Ingvorsen C, Galli A, Green A, Gleeson D, Ryder E, Glover L, Vizcay-Barrena G, Karp NA, Arends MJ, Brenn T, Spiegel S, Adams DJ, Watt FM, van der Weyden L.

J Pathol. 2016 Jul;239(3):374-83. doi: 10.1002/path.4737. Epub 2016 May 30.

40.

Genes and Alcohol Consumption: Studies with Mutant Mice.

Mayfield J, Arends MA, Harris RA, Blednov YA.

Int Rev Neurobiol. 2016;126:293-355. doi: 10.1016/bs.irn.2016.02.014. Review.

41.

Multilocus Inherited Neoplasia Alleles Syndrome: A Case Series and Review.

Whitworth J, Skytte AB, Sunde L, Lim DH, Arends MJ, Happerfield L, Frayling IM, van Minkelen R, Woodward ER, Tischkowitz MD, Maher ER.

JAMA Oncol. 2016 Mar;2(3):373-9. doi: 10.1001/jamaoncol.2015.4771. Review.

PMID:
26659639
42.

Discontinuation of enzyme replacement therapy in Fabry disease in the Dutch cohort.

Arends M, Linthorst GE, Hollak CE, Biegstraaten M.

Mol Genet Metab. 2016 Feb;117(2):194-8. doi: 10.1016/j.ymgme.2015.11.014. Epub 2015 Dec 1.

PMID:
26654842
43.

Animal and cellular models of human disease.

Arends MJ, White ES, Whitelaw CB.

J Pathol. 2016 Jan;238(2):137-40. doi: 10.1002/path.4662.

PMID:
26482929
44.

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.

Pontel LB, Rosado IV, Burgos-Barragan G, Garaycoechea JI, Yu R, Arends MJ, Chandrasekaran G, Broecker V, Wei W, Liu L, Swenberg JA, Crossan GP, Patel KJ.

Mol Cell. 2015 Oct 1;60(1):177-88. doi: 10.1016/j.molcel.2015.08.020. Epub 2015 Sep 24.

45.

Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines.

Scudamore CL, Soilleux EJ, Karp NA, Smith K, Poulsom R, Herrington CS, Day MJ, Brayton CF, Bolon B, Whitelaw B, White ES, Everitt JI, Arends MJ.

J Pathol. 2016 Jan;238(2):359-67. doi: 10.1002/path.4642. Epub 2015 Nov 28. Review.

PMID:
26387837
46.

Cross-species models of human melanoma.

van der Weyden L, Patton EE, Wood GA, Foote AK, Brenn T, Arends MJ, Adams DJ.

J Pathol. 2016 Jan;238(2):152-65. doi: 10.1002/path.4632. Epub 2015 Oct 9. Review.

47.

Mouse models of colorectal cancer as preclinical models.

McIntyre RE, Buczacki SJ, Arends MJ, Adams DJ.

Bioessays. 2015 Aug;37(8):909-20. doi: 10.1002/bies.201500032. Epub 2015 Jun 26. Review.

48.

Quality of life in patients with Fabry disease: a systematic review of the literature.

Arends M, Hollak CE, Biegstraaten M.

Orphanet J Rare Dis. 2015 Jun 16;10:77. doi: 10.1186/s13023-015-0296-8. Review.

49.

Correction: Signatures of Adaptation in Human Invasive Salmonella Typhimurium ST313 Populations from Sub-Saharan Africa.

Okoro CK, Barquist L, Connor TR, Harris SR, Clare S, Stevens MP, Arends MJ, Hale C, Kane L, Pickard DJ, Hill J, Harcourt K, Parkhill J, Dougan G, Kingsley RA.

PLoS Negl Trop Dis. 2015 Jun 15;9(6):e0003848. doi: 10.1371/journal.pntd.0003848. eCollection 2015 Jun. No abstract available.

50.

Corrigendum to "Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia" [Experimental Hematology, Vol. 42, Issue 12, p1053-1058.e1].

Salsbury G, Cambridge EL, McIntyre Z, Arends MJ, Karp NA, Isherwood C, Shannon C, Hooks Y; Sanger Mouse Genetics Project, Ramirez-Solis R, Adams DJ, White JK, Speak AO.

Exp Hematol. 2015 May;43(5):424. doi: 10.1016/j.exphem.2015.03.002. Epub 2015 Apr 1. No abstract available.

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