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Items: 1 to 50 of 263

1.

Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease.

Ranchoux B, Nadeau V, Bourgeois A, Provencher S, Tremblay E, Omura J, Côté N, Abu-Alhayja'a R, Dumais V, Nachbar RT, Tastet L, Dahou A, Breuils-Bonnet S, Marette A, Pibarot P, Dupuis J, Boucherat O, Paulin R, Archer SL, Bonnet S, Potus F.

Circ Res. 2019 Jun 3. doi: 10.1161/CIRCRESAHA.118.314555. [Epub ahead of print]

PMID:
31154939
2.

Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.

Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA, Archer SL.

Circ Res. 2019 Jun 7;124(12):1727-1746. doi: 10.1161/CIRCRESAHA.118.314284. Epub 2019 Mar 29.

PMID:
30922174
3.
4.

Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities.

Xiong PY, Tian L, Dunham-Snary KJ, Chen KH, Mewburn JD, Neuber-Hess M, Martin A, Dasgupta A, Potus F, Archer SL.

Front Cardiovasc Med. 2019 Jan 25;5:195. doi: 10.3389/fcvm.2018.00195. eCollection 2018.

5.

Clinical Determinants and Prognostic Implications of Right Ventricular Dysfunction in Pulmonary Hypertension Caused by Chronic Lung Disease.

Prins KW, Rose L, Archer SL, Pritzker M, Weir EK, Olson MD, Thenappan T.

J Am Heart Assoc. 2019 Jan 22;8(2):e011464. doi: 10.1161/JAHA.118.011464.

6.

Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again.

Prins KW, Thenappan T, Weir EK, Kalra R, Pritzker M, Archer SL.

J Am Heart Assoc. 2019 Jan 8;8(1):e011343. doi: 10.1161/JAHA.118.011343. No abstract available.

7.

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR; UK NIHR BioResource Rare Diseases Consortium; UK PAH Cohort Study Consortium; US PAH Biobank Consortium.

Lancet Respir Med. 2019 Mar;7(3):227-238. doi: 10.1016/S2213-2600(18)30409-0. Epub 2018 Dec 5.

8.

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat.

Xiong PY, Baba S, Nishioka N, Fujimoto Y, Archer SL, Minamisawa S.

J Vis Exp. 2018 Nov 18;(141). doi: 10.3791/58787.

PMID:
30507912
9.

Survival in pulmonary hypertension due to chronic lung disease: Influence of low diffusion capacity of the lungs for carbon monoxide.

Rose L, Prins KW, Archer SL, Pritzker M, Weir EK, Misialek JR, Thenappan T.

J Heart Lung Transplant. 2019 Feb;38(2):145-155. doi: 10.1016/j.healun.2018.09.011. Epub 2018 Sep 14.

PMID:
30391191
10.
11.

A Step Closer to Understanding How Riociguat Results in Remodelling of the Right Ventricle in Chronic Thromboembolic Pulmonary Hypertension.

D'Arsigny CL, Archer SL.

Can J Cardiol. 2018 Sep;34(9):1098-1101. doi: 10.1016/j.cjca.2018.07.008. Epub 2018 Jul 18. No abstract available.

PMID:
30170664
12.

Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement.

Lahm T, Douglas IS, Archer SL, Bogaard HJ, Chesler NC, Haddad F, Hemnes AR, Kawut SM, Kline JA, Kolb TM, Mathai SC, Mercier O, Michelakis ED, Naeije R, Tuder RM, Ventetuolo CE, Vieillard-Baron A, Voelkel NF, Vonk-Noordegraaf A, Hassoun PM; American Thoracic Society Assembly on Pulmonary Circulation.

Am J Respir Crit Care Med. 2018 Aug 15;198(4):e15-e43. doi: 10.1164/rccm.201806-1160ST.

PMID:
30109950
13.

Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension.

Tian L, Potus F, Wu D, Dasgupta A, Chen KH, Mewburn J, Lima P, Archer SL.

Front Physiol. 2018 Jul 10;9:828. doi: 10.3389/fphys.2018.00828. eCollection 2018.

14.

A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017.

Kuebler WM, Nicolls MR, Olschewski A, Abe K, Rabinovitch M, Stewart D, Chan SY, Morrell NW, Archer SL, Spiekerkoetter E.

Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L502-L516. doi: 10.1152/ajplung.00150.2018. Epub 2018 Jun 7.

PMID:
29877097
15.

Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research.

Provencher S, Archer SL, Ramirez FD, Hibbert B, Paulin R, Boucherat O, Lacasse Y, Bonnet S.

Circ Res. 2018 Mar 30;122(7):1021-1032. doi: 10.1161/CIRCRESAHA.117.312579. Review.

PMID:
29599278
16.

Pulmonary arterial hypertension: pathogenesis and clinical management.

Thenappan T, Ormiston ML, Ryan JJ, Archer SL.

BMJ. 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. Review.

PMID:
29540357
17.

Fourteen-month-olds' sensitivity to acoustic salience in minimal pair word learning.

Archer SL, Curtin S.

J Child Lang. 2018 Sep;45(5):1198-1211. doi: 10.1017/S0305000917000617. Epub 2018 Feb 21.

PMID:
29465335
18.

Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension: A Population-Based Cohort Study in Ontario, Canada.

Wijeratne DT, Lajkosz K, Brogly SB, Lougheed MD, Jiang L, Housin A, Barber D, Johnson A, Doliszny KM, Archer SL.

Circ Cardiovasc Qual Outcomes. 2018 Feb;11(2):e003973. doi: 10.1161/CIRCOUTCOMES.117.003973.

19.

Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.

Chen KH, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, Fu J, Mewburn J, Wu D, Dunham-Snary K, Theilmann AL, Jing ZC, Hindmarch C, Ormiston ML, Lawrie A, Archer SL.

Circulation. 2018 Jul 17;138(3):287-304. doi: 10.1161/CIRCULATIONAHA.117.031258. Epub 2018 Feb 5.

20.

Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension.

Prins KW, Rose L, Archer SL, Pritzker M, Weir EK, Kazmirczak F, Misialek JR, Thenappan T.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1496-1499. doi: 10.1164/rccm.201712-2405LE. No abstract available.

21.

Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.

Archer SL.

Circulation. 2017 Dec 19;136(25):2486-2490. doi: 10.1161/CIRCULATIONAHA.117.031655. No abstract available.

22.

Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension.

Xiong PY, Potus F, Chan W, Archer SL.

Hypertension. 2018 Jan;71(1):34-55. doi: 10.1161/HYPERTENSIONAHA.117.08824. Epub 2017 Nov 20. Review. No abstract available.

23.

Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension.

Prins KW, Archer SL, Pritzker M, Rose L, Weir EK, Sharma A, Thenappan T.

J Heart Lung Transplant. 2018 Mar;37(3):376-384. doi: 10.1016/j.healun.2017.08.011. Epub 2017 Sep 1.

24.

Resistance over compliance describes right ventricular afterload better than resistance-compliance time: a friendly amendment.

Thenappan T, Archer SL, Weir EK.

Pulm Circ. 2017 Feb 1;7(1):275. doi: 10.1177/2045893216681025. eCollection 2017 Mar. No abstract available.

25.

Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension.

Prins KW, Tian L, Wu D, Thenappan T, Metzger JM, Archer SL.

J Am Heart Assoc. 2017 May 31;6(6). pii: e006195. doi: 10.1161/JAHA.117.006195.

26.

Abnormal angiogenesis in blood outgrowth endothelial cells derived from von Willebrand disease patients.

Selvam SN, Casey LJ, Bowman ML, Hawke LG, Longmore AJ, Mewburn J, Ormiston ML, Archer SL, Maurice DH, James P.

Blood Coagul Fibrinolysis. 2017 Oct;28(7):521-533. doi: 10.1097/MBC.0000000000000635.

27.

Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.

Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL.

J Mol Med (Berl). 2017 Apr;95(4):381-393. doi: 10.1007/s00109-017-1522-8. Epub 2017 Mar 6.

28.

Pulmonary pulse wave transit time is associated with right ventricular-pulmonary artery coupling in pulmonary arterial hypertension.

Prins KW, Weir EK, Archer SL, Markowitz J, Rose L, Pritzker M, Madlon-Kay R, Thenappan T.

Pulm Circ. 2016 Dec;6(4):576-585. doi: 10.1086/688879.

29.

Trends and Outcomes of Pulmonary Arterial Hypertension-Related Hospitalizations in the United States: Analysis of the Nationwide Inpatient Sample Database From 2001 Through 2012.

Anand V, Roy SS, Archer SL, Weir EK, Garg SK, Duval S, Thenappan T.

JAMA Cardiol. 2016 Dec 1;1(9):1021-1029. doi: 10.1001/jamacardio.2016.3591.

PMID:
27851838
30.

Executive Summary of the American Heart Association and American Thoracic Society Joint Guidelines for Pediatric Pulmonary Hypertension.

Abman SH, Ivy DD, Archer SL, Wilson K; AHA/ATS Joint Guidelines for Pediatric Pulmonary Hypertension Committee.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):898-906.

31.

The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease.

Atkins K, Dasgupta A, Chen KH, Mewburn J, Archer SL.

Clin Sci (Lond). 2016 Nov 1;130(21):1861-74. doi: 10.1042/CS20160030. Review.

PMID:
27660309
32.

MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype.

Hong Z, Chen KH, DasGupta A, Potus F, Dunham-Snary K, Bonnet S, Tian L, Fu J, Breuils-Bonnet S, Provencher S, Wu D, Mewburn J, Ormiston ML, Archer SL.

Am J Respir Crit Care Med. 2017 Feb 15;195(4):515-529. doi: 10.1164/rccm.201604-0814OC.

33.

Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.

Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL.

Chest. 2017 Jan;151(1):181-192. doi: 10.1016/j.chest.2016.09.001. Epub 2016 Sep 16. Review.

34.
35.

Pulmonary hypertension begets pulmonary hypertension: mutually reinforcing roles for haemodynamics, inflammation, and cancer-like phenotypes.

Wu D, Archer SL.

Cardiovasc Res. 2016 Jul 1;111(1):1-4. doi: 10.1093/cvr/cvw110. Epub 2016 May 23. No abstract available.

36.

Nine-month-olds use frequency of onset clusters to segment novel words.

Archer SL, Curtin S.

J Exp Child Psychol. 2016 Aug;148:131-41. doi: 10.1016/j.jecp.2016.04.004. Epub 2016 May 12.

PMID:
27181298
37.

Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension.

Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED.

Am J Respir Crit Care Med. 2016 Aug 15;194(4):464-75. doi: 10.1164/rccm.201508-1678OC.

38.

Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society.

Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; and the American Thoracic Society.

Circulation. 2015 Nov 24;132(21):2037-99. doi: 10.1161/CIR.0000000000000329. Epub 2015 Nov 3. Erratum in: Circulation. 2016 Jan 26;133(4):e368.

PMID:
26534956
39.

Gone fission: an asymptomatic STAT2 mutation elongates mitochondria and causes human disease following viral infection.

Dasgupta A, Chen KH, Tian L, Archer SL.

Brain. 2015 Oct;138(Pt 10):2802-6. doi: 10.1093/brain/awv237. No abstract available.

40.

A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus.

Dunham-Snary KJ, Hong ZG, Xiong PY, Del Paggio JC, Herr JE, Johri AM, Archer SL.

Pflugers Arch. 2016 Jan;468(1):43-58. doi: 10.1007/s00424-015-1736-y. Epub 2015 Sep 23. Review.

41.
42.

Right ventricular adaptation and failure in pulmonary arterial hypertension.

Ryan JJ, Huston J, Kutty S, Hatton ND, Bowman L, Tian L, Herr JE, Johri AM, Archer SL.

Can J Cardiol. 2015 Apr;31(4):391-406. doi: 10.1016/j.cjca.2015.01.023. Epub 2015 Jan 29. Review.

43.

[Relevant issues in the pathology and pathobiology of pulmonary hypertension].

Tuder RM, Archer SL, Dorfmüller P, Erzurum SC, Guignabert C, Michelakis E, Rabinovitch M, Schermuly R, Stenmark KR, Morrell NW.

Turk Kardiyol Dern Ars. 2014 Oct;42 Suppl 1:5-16. Turkish.

44.

Mitochondrial dynamics in pulmonary arterial hypertension.

Ryan J, Dasgupta A, Huston J, Chen KH, Archer SL.

J Mol Med (Berl). 2015 Mar;93(3):229-42. doi: 10.1007/s00109-015-1263-5. Epub 2015 Feb 13. Review.

45.

Soluble guanylate cyclase: a new therapeutic target for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.

Dasgupta A, Bowman L, D'Arsigny CL, Archer SL.

Clin Pharmacol Ther. 2015 Jan;97(1):88-102. doi: 10.1002/cpt.10. Epub 2014 Nov 28. Review.

46.

Mitochondrial dynamics in cardiovascular disease: fission and fusion foretell form and function.

Sharp WW, Archer SL.

J Mol Med (Berl). 2015 Mar;93(3):225-8. doi: 10.1007/s00109-015-1258-2. Epub 2015 Feb 12. No abstract available.

47.

Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model.

Sharp WW, Beiser DG, Fang YH, Han M, Piao L, Varughese J, Archer SL.

Crit Care Med. 2015 Feb;43(2):e38-47. doi: 10.1097/CCM.0000000000000817.

48.

Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension.

Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J.

Circulation. 2015 Jan 27;131(4):401-9; discussion 409. doi: 10.1161/CIRCULATIONAHA.114.013317. Epub 2014 Oct 31.

49.
50.

Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus.

Hong Z, Cabrera JA, Mahapatra S, Kutty S, Weir EK, Archer SL.

J Mol Med (Berl). 2014 Sep;92(9):995-1007. doi: 10.1007/s00109-014-1162-1. Epub 2014 Jun 8.

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