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Items: 1 to 50 of 131

1.

Preventive effects of Salvia officinalis leaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone.

Ben Khedher MR, Hammami M, Arch JRS, Hislop DC, Eze D, Wargent ET, Kępczyńska MA, Zaibi MS.

PeerJ. 2018 Jan 9;6:e4166. doi: 10.7717/peerj.4166. eCollection 2018.

2.

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H.

Cell Metab. 2016 May 10;23(5):821-36. doi: 10.1016/j.cmet.2016.04.003. Epub 2016 Apr 28.

3.

Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model.

Harzallah A, Hammami M, Kępczyńska MA, Hislop DC, Arch JR, Cawthorne MA, Zaibi MS.

Arch Physiol Biochem. 2016;122(2):75-87. doi: 10.3109/13813455.2016.1148053. Epub 2016 Feb 26.

PMID:
26822470
4.

5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.

Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D'Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE.

Dis Model Mech. 2016 Apr;9(4):401-12. doi: 10.1242/dmm.023903. Epub 2016 Jan 14.

5.

New Physiological Aspects of Brown Adipose Tissue.

Trayhurn P, Arch JR.

Curr Obes Rep. 2014 Dec;3(4):414-21. doi: 10.1007/s13679-014-0125-8.

PMID:
26626918
6.

Horizons in the Pharmacotherapy of Obesity.

Arch JR.

Curr Obes Rep. 2015 Dec;4(4):451-9. doi: 10.1007/s13679-015-0177-4. Review.

PMID:
26346394
7.

Evidence from studies in rodents and in isolated adipocytes that agonists of the chemerin receptor CMKLR1 may be beneficial in the treatment of type 2 diabetes.

Wargent ET, Zaibi MS, O'Dowd JF, Cawthorne MA, Wang SJ, Arch JR, Stocker CJ.

PeerJ. 2015 Feb 5;3:e753. doi: 10.7717/peerj.753. eCollection 2015.

8.

The effects of sarcolipin over-expression in mouse skeletal muscle on metabolic activity.

Butler J, Smyth N, Broadbridge R, Council CE, Lee AG, Stocker CJ, Hislop DC, Arch JR, Cawthorne MA, Malcolm East J.

Arch Biochem Biophys. 2015 Mar 1;569:26-31. doi: 10.1016/j.abb.2015.01.027. Epub 2015 Feb 7.

9.

Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3.

Ngala RA, Zaibi MS, Langlands K, Stocker CJ, Arch JR, Cawthorne MA.

PeerJ. 2014 Oct 7;2:e614. doi: 10.7717/peerj.614. eCollection 2014.

10.

Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes.

Rumberger JM, Arch JR, Green A.

PeerJ. 2014 Oct 7;2:e611. doi: 10.7717/peerj.611. eCollection 2014.

11.

Circulating levels of the cytokines IL10, IFNγ and resistin in an obese mouse model of developmental programming.

Kępczyńska MA, Wargent ET, Cawthorne MA, Arch JR, O'Dowd JF, Stocker CJ.

J Dev Orig Health Dis. 2013 Dec;4(6):491-8. doi: 10.1017/S2040174413000263.

PMID:
24924228
12.

A novel automated image analysis method for accurate adipocyte quantification.

Osman OS, Selway JL, Kępczyńska MA, Stocker CJ, O'Dowd JF, Cawthorne MA, Arch JR, Jassim S, Langlands K.

Adipocyte. 2013 Jul 1;2(3):160-4. doi: 10.4161/adip.24652. Epub 2013 Apr 16.

13.

Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification.

Arch JR, Trayhurn P.

Front Physiol. 2013 Apr 8;4:64. doi: 10.3389/fphys.2013.00064. eCollection 2013.

14.

β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling.

Ngala RA, O'Dowd JF, Stocker CJ, Cawthorne MA, Arch JR.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Sep;386(9):761-73. doi: 10.1007/s00210-013-0860-5. Epub 2013 Apr 6.

PMID:
23564017
15.

Contrasts between the effects of zinc-α2-glycoprotein, a putative β3/2-adrenoceptor agonist and the β3/2-adrenoceptor agonist BRL35135 in C57Bl/6 (ob/ob) mice.

Wargent ET, O'Dowd JF, Zaibi MS, Gao D, Bing C, Trayhurn P, Cawthorne MA, Arch JR, Stocker CJ.

J Endocrinol. 2013 Jan 18;216(2):157-68. doi: 10.1530/JOE-12-0402. Print 2013 Feb.

PMID:
23151357
16.

Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.

Bellahcene M, O'Dowd JF, Wargent ET, Zaibi MS, Hislop DC, Ngala RA, Smith DM, Cawthorne MA, Stocker CJ, Arch JR.

Br J Nutr. 2013 May 28;109(10):1755-64. doi: 10.1017/S0007114512003923. Epub 2012 Oct 31.

PMID:
23110765
17.

A guide to analysis of mouse energy metabolism.

Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV Jr, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E.

Nat Methods. 2011 Dec 28;9(1):57-63. doi: 10.1038/nmeth.1806.

18.

Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist and decreased sensitivity to neuropeptide Y.

Stocker CJ, Wargent ET, Martin-Gronert MS, Cripps RL, O'Dowd JF, Zaibi MS, Cottrell EC, Mercer JG, Duncan JS, Cawthorne MA, Ozanne SE, Arch JR.

Int J Obes (Lond). 2012 Aug;36(8):1040-6. doi: 10.1038/ijo.2011.226. Epub 2011 Nov 29.

19.

Targeting thermogenesis and related pathways in anti-obesity drug discovery.

Clapham JC, Arch JR.

Pharmacol Ther. 2011 Sep;131(3):295-308. doi: 10.1016/j.pharmthera.2011.04.004. Epub 2011 Apr 13. Review.

PMID:
21514319
20.

Thermogenesis and related metabolic targets in anti-diabetic therapy.

Arch JR.

Handb Exp Pharmacol. 2011;(203):201-55. doi: 10.1007/978-3-642-17214-4_10. Review.

PMID:
21484574
21.

Challenges in β(3)-Adrenoceptor Agonist Drug Development.

Arch JR.

Ther Adv Endocrinol Metab. 2011 Apr;2(2):59-64. doi: 10.1177/2042018811398517. No abstract available.

22.

A new, highly selective murine peroxisome proliferator-activated receptor δ agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice.

Ngala RA, Stocker CJ, Roy AG, Hislop D, Wargent E, Bell R, Hassall DG, Harling JD, Billin AN, Willson TM, Arch JR, Cawthorne MA.

Diabetes Obes Metab. 2011 May;13(5):455-64. doi: 10.1111/j.1463-1326.2011.01371.x. Epub 2011 Jan 27.

PMID:
21272187
23.

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.

Zaibi MS, Stocker CJ, O'Dowd J, Davies A, Bellahcene M, Cawthorne MA, Brown AJ, Smith DM, Arch JR.

FEBS Lett. 2010 Jun 3;584(11):2381-6. doi: 10.1016/j.febslet.2010.04.027. Epub 2010 Apr 20.

24.

Procolipase gene: no association with early-onset obesity or fat intake.

Wermter AK, Scherag A, Holter K, Reichwald K, Lichtner P, Siegfried W, Blundell J, Lawton C, Whybrow S, Stubbs J, Arch JR, Meitinger T, Platzer M, Hinney A, Hebebrand J.

Obes Facts. 2009;2(1):40-4. doi: 10.1159/000196379. Epub 2009 Feb 9.

25.

Beta2-adrenoceptors and non-beta-adrenoceptors mediate effects of BRL37344 and clenbuterol on glucose uptake in soleus muscle: studies using knockout mice.

Ngala RA, O'Dowd J, Wang SJ, Stocker C, Cawthorne MA, Arch JR.

Br J Pharmacol. 2009 Dec;158(7):1676-82. doi: 10.1111/j.1476-5381.2009.00472.x.

26.

Identification of a novel agonist of peroxisome proliferator-activated receptors alpha and gamma that may contribute to the anti-diabetic activity of guggulipid in Lep(ob)/Lep(ob) mice.

Cornick CL, Strongitharm BH, Sassano G, Rawlins C, Mayes AE, Joseph AN, O'Dowd J, Stocker C, Wargent E, Cawthorne MA, Brown AL, Arch JR.

J Nutr Biochem. 2009 Oct;20(10):806-15. doi: 10.1016/j.jnutbio.2008.07.010. Epub 2008 Oct 15.

PMID:
18926687
27.

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists.

Arch JR.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Aug;378(2):225-40. doi: 10.1007/s00210-008-0271-1. Epub 2008 Jul 9. Review.

PMID:
18612674
28.

Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and beta2-adrenoceptor mechanisms.

Ngala RA, O'Dowd J, Wang SJ, Agarwal A, Stocker C, Cawthorne MA, Arch JR.

Br J Pharmacol. 2008 Oct;155(3):395-406. doi: 10.1038/bjp.2008.244. Epub 2008 Jun 16.

29.

Thermogenic and metabolic antiobesity drugs: rationale and opportunities.

Clapham JC, Arch JR.

Diabetes Obes Metab. 2007 May;9(3):259-75. Review.

PMID:
17391151
30.

Improved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet.

Wang SJ, Cornick C, O'Dowd J, Cawthorne MA, Arch JR.

Lipids Health Dis. 2007 Jan 19;6:2.

31.

Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers.

Stocker CJ, Wargent E, O'Dowd J, Cornick C, Speakman JR, Arch JR, Cawthorne MA.

Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1810-8. Epub 2007 Jan 18.

32.

Some mathematical and technical issues in the measurement and interpretation of open-circuit indirect calorimetry in small animals.

Arch JR, Hislop D, Wang SJ, Speakman JR.

Int J Obes (Lond). 2006 Sep;30(9):1322-31. Epub 2006 Jun 27. Review.

PMID:
16801931
33.

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese mice.

Wang SJ, Birtles S, de Schoolmeester J, Swales J, Moody G, Hislop D, O'Dowd J, Smith DM, Turnbull AV, Arch JR.

Diabetologia. 2006 Jun;49(6):1333-7. Epub 2006 Apr 13.

PMID:
16612591
34.

Fetal origins of insulin resistance and obesity.

Stocker CJ, Arch JR, Cawthorne MA.

Proc Nutr Soc. 2005 May;64(2):143-51. Review.

PMID:
15960859
35.

Central regulation of energy balance: inputs, outputs and leptin resistance.

Arch JR.

Proc Nutr Soc. 2005 Feb;64(1):39-46. Review.

PMID:
15877921
36.

Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone.

Wargent E, Stocker C, Augstein P, Heinke P, Meyer A, Hoffmann T, Subramanian A, Sennitt MV, Demuth HU, Arch JR, Cawthorne MA.

Diabetes Obes Metab. 2005 Mar;7(2):170-81.

PMID:
15715890
37.

Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation.

Wargent E, Sennitt MV, Stocker C, Mayes AE, Brown L, O'Dowd J, Wang S, Einerhand AW, Mohede I, Arch JR, Cawthorne MA.

Lipids Health Dis. 2005 Jan 10;4:3.

38.
39.

Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.

Pearce NJ, Arch JR, Clapham JC, Coghlan MP, Corcoran SL, Lister CA, Llano A, Moore GB, Murphy GJ, Smith SA, Taylor CM, Yates JW, Morrison AD, Harper AJ, Roxbee-Cox L, Abuin A, Wargent E, Holder JC.

Metabolism. 2004 Oct;53(10):1322-30.

PMID:
15375789
40.

Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation.

Stocker C, O'Dowd J, Morton NM, Wargent E, Sennitt MV, Hislop D, Glund S, Seckl JR, Arch JR, Cawthorne MA.

Int J Obes Relat Metab Disord. 2004 Jan;28(1):129-36.

PMID:
14557827
41.

Lessons in obesity from transgenic animals.

Arch JR.

J Endocrinol Invest. 2002 Nov;25(10):867-75. Review.

PMID:
12508949
42.

Immunohistochemical identification of the beta(3)-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine.

De Matteis R, Arch JR, Petroni ML, Ferrari D, Cinti S, Stock MJ.

Int J Obes Relat Metab Disord. 2002 Nov;26(11):1442-50.

PMID:
12439645
43.

Orexins and the treatment of obesity.

Smart D, Haynes AC, Williams G, Arch JR.

Eur J Pharmacol. 2002 Apr 12;440(2-3):199-212. Review.

PMID:
12007536
44.

beta(3)-Adrenoceptor agonists: potential, pitfalls and progress.

Arch JR.

Eur J Pharmacol. 2002 Apr 12;440(2-3):99-107. Review.

PMID:
12007528
45.

Effects of chronic murine and human leptin infusion on plasma leptin and corticosterone levels and energy balance in lean Zucker rats.

Al-Barazanji KA, Buckingham RE, Arch JR, Briscoe C, Jenkins O, Tadayyon M.

Diabetes Obes Metab. 2001 Dec;3(6):435-42.

PMID:
11903416
46.

Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice.

Haynes AC, Chapman H, Taylor C, Moore GB, Cawthorne MA, Tadayyon M, Clapham JC, Arch JR.

Regul Pept. 2002 Mar 15;104(1-3):153-9.

PMID:
11830290
47.

Orexins and feeding: special occasions or everyday occurrence?

Cai XJ, Liu XH, Evans M, Clapham JC, Wilson S, Arch JR, Morris R, Williams G.

Regul Pept. 2002 Mar 15;104(1-3):1-9. Review.

PMID:
11830270
48.

The beta 3-adrenergic system and beta 3-adrenergic agonists.

Arch JR.

Rev Endocr Metab Disord. 2001 Oct;2(4):385-93. Review. No abstract available.

PMID:
11725725
49.

C-terminal fragments of ACTH stimulate feeding in fasted rats.

Al-Barazanji KA, Miller JE, Rice SQ, Arch JR, Chambers JK.

Horm Metab Res. 2001 Aug;33(8):480-5.

PMID:
11544562
50.

Leptin receptor long-form signalling in a human liver cell line.

Briscoe CP, Hanif S, Arch JR, Tadayyon M.

Cytokine. 2001 May 21;14(4):225-9.

PMID:
11448122

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