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Items: 32


The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.

Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A.

EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825.


Nanofibre optic force transducers with sub-piconewton resolution via near-field plasmon-dielectric interactions.

Huang Q, Lee J, Arce FT, Yoon I, Angsantikul P, Liu J, Shi Y, Villanueva J, Thamphiwatana S, Ma X, Zhang L, Chen S, Lal R, Sirbuly DJ.

Nat Photonics. 2017;11:352-355. doi: 10.1038/nphoton.2017.74. Epub 2017 May 15.


Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels.

Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R.

Methods Mol Biol. 2016;1345:251-68. doi: 10.1007/978-1-4939-2978-8_16.


Atomic force microscopy shows connexin26 hemichannel clustering in purified membrane fragments.

Meckes B, Ambrosi C, Barnard H, Arce FT, Sosinsky GE, Lal R.

Biochemistry. 2014 Dec 2;53(47):7407-14. doi: 10.1021/bi501265p. Epub 2014 Nov 17.


Insulated conducting cantilevered nanotips and two-chamber recording system for high resolution ion sensing AFM.

Meckes B, Arce FT, Connelly LS, Lal R.

Sci Rep. 2014 Mar 25;4:4454. doi: 10.1038/srep04454.


Structure and permeability of ion-channels by integrated AFM and waveguide TIRF microscopy.

Ramachandran S, Arce FT, Patel NR, Quist AP, Cohen DA, Lal R.

Sci Rep. 2014 Mar 21;4:4424. doi: 10.1038/srep04424.


Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.

Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R.

Chem Soc Rev. 2014 Oct 7;43(19):6750-64. doi: 10.1039/c3cs60459d. Review.


Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.

Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R.

J Phys Chem B. 2013 Oct 3;117(39):11518-29. doi: 10.1021/jp405389n. Epub 2013 Sep 13.


Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli.

Arce FT, Meckes B, Camp SM, Garcia JG, Dudek SM, Lal R.

Nanomedicine. 2013 Oct;9(7):875-84. doi: 10.1016/j.nano.2013.03.006. Epub 2013 Mar 20.


Alzheimer's disease: which type of amyloid-preventing drug agents to employ?

Jang H, Connelly L, Arce FT, Ramachandran S, Lal R, Kagan BL, Nussinov R.

Phys Chem Chem Phys. 2013 Jun 21;15(23):8868-77. doi: 10.1039/c3cp00017f. Epub 2013 Feb 28. Review.


Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane.

Jang H, Connelly L, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R.

J Chem Theory Comput. 2013 Jan 8;9(1):822-833. Epub 2012 Dec 5.


Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations.

Connelly L, Jang H, Arce FT, Ramachandran S, Kagan BL, Nussinov R, Lal R.

Biochemistry. 2012 Apr 10;51(14):3031-8. doi: 10.1021/bi300257e. Epub 2012 Mar 28.


Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology.

Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R.

J Phys Chem B. 2012 Feb 9;116(5):1728-35. doi: 10.1021/jp2108126. Epub 2012 Jan 25.


Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation.

Arce FT, Jang H, Ramachandran S, Landon PB, Nussinov R, Lal R.

Soft Matter. 2011 May 9;7(11):5267-5273.


Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link.

Jang H, Arce FT, Mustata M, Ramachandran S, Capone R, Nussinov R, Lal R.

Biophys J. 2011 Apr 6;100(7):1775-83. doi: 10.1016/j.bpj.2011.01.072.


Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation.

Ayala R, Zhang C, Yang D, Hwang Y, Aung A, Shroff SS, Arce FT, Lal R, Arya G, Varghese S.

Biomaterials. 2011 May;32(15):3700-11. doi: 10.1016/j.biomaterials.2011.02.004.


β-Barrel topology of Alzheimer's β-amyloid ion channels.

Jang H, Arce FT, Ramachandran S, Capone R, Lal R, Nussinov R.

J Mol Biol. 2010 Dec 17;404(5):917-34. doi: 10.1016/j.jmb.2010.10.025. Epub 2010 Oct 21.


Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.

Dudek SM, Chiang ET, Camp SM, Guo Y, Zhao J, Brown ME, Singleton PA, Wang L, Desai A, Arce FT, Lal R, Van Eyk JE, Imam SZ, Garcia JG.

Mol Biol Cell. 2010 Nov 15;21(22):4042-56. doi: 10.1091/mbc.E09-10-0876. Epub 2010 Sep 22.


Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies.

Capone R, Mustata M, Jang H, Arce FT, Nussinov R, Lal R.

Biophys J. 2010 Jun 2;98(11):2644-52. doi: 10.1016/j.bpj.2010.02.024.


Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.

Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6538-43. doi: 10.1073/pnas.0914251107. Epub 2010 Mar 22.


Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels.

Jang H, Arce FT, Capone R, Ramachandran S, Lal R, Nussinov R.

Biophys J. 2009 Dec 2;97(11):3029-37. doi: 10.1016/j.bpj.2009.09.014.


K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis.

Mustata M, Capone R, Jang H, Arce FT, Ramachandran S, Lal R, Nussinov R.

J Am Chem Soc. 2009 Oct 21;131(41):14938-45. doi: 10.1021/ja9049299.


Nanoscale structural and mechanical properties of nontypeable Haemophilus influenzae biofilms.

Arce FT, Carlson R, Monds J, Veeh R, Hu FZ, Stewart PS, Lal R, Ehrlich GD, Avci R.

J Bacteriol. 2009 Apr;191(8):2512-20. doi: 10.1128/JB.01596-08. Epub 2009 Feb 13.


Endothelial permeability is controlled by spatially defined cytoskeletal mechanics: atomic force microscopy force mapping of pulmonary endothelial monolayer.

Birukova AA, Arce FT, Moldobaeva N, Dudek SM, Garcia JG, Lal R, Birukov KG.

Nanomedicine. 2009 Mar;5(1):30-41. doi: 10.1016/j.nano.2008.07.002. Epub 2008 Sep 27.


Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.

Arce FT, Whitlock JL, Birukova AA, Birukov KG, Arnsdorf MF, Lal R, Garcia JG, Dudek SM.

Biophys J. 2008 Jul;95(2):886-94. doi: 10.1529/biophysj.107.127167. Epub 2008 Apr 11.


Analyses of soft tissue from Tyrannosaurus rex suggest the presence of protein.

Schweitzer MH, Suo Z, Avci R, Asara JM, Allen MA, Arce FT, Horner JR.

Science. 2007 Apr 13;316(5822):277-80.


Assembly of multilayer films incorporating a viral protein cage architecture.

Suci PA, Klem MT, Arce FT, Douglas T, Young M.

Langmuir. 2006 Oct 10;22(21):8891-6.


Modification of surface properties of a poly(dimethylsiloxane)-based elastomer, RTV11, upon exposure to seawater.

Arce FT, Avci R, Beech IB, Cooksey KE, Wigglesworth-Cooksey B.

Langmuir. 2006 Aug 15;22(17):7217-25.


Nanomechanics of hemichannel conformations: connexin flexibility underlying channel opening and closing.

Liu F, Arce FT, Ramachandran S, Lal R.

J Biol Chem. 2006 Aug 11;281(32):23207-17. Epub 2006 Jun 12.


Dendritic structures of poly(ethylene glycol) on silicon nitride and gold surfaces.

Suo Z, Arce FT, Avci R, Thieltges K, Spangler B.

Langmuir. 2006 Apr 11;22(8):3844-50.


Comparison of antibody--antigen interactions on collagen measured by conventional immunological techniques and atomic force microscopy.

Avci R, Schweitzer M, Boyd RD, Wittmeyer J, Steele A, Toporski J, Beech I, Arce FT, Spangler B, Cole KM, McKay DS.

Langmuir. 2004 Dec 7;20(25):11053-63.


A live bioprobe for studying diatom-surface interactions.

Arce FT, Avci R, Beech IB, Cooksey KE, Wigglesworth-Cooksey B.

Biophys J. 2004 Dec;87(6):4284-97. Epub 2004 Sep 17.

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