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Items: 1 to 50 of 105

1.

TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease.

Ferreira RR, Abreu RDS, Vilar-Pereira G, Degrave W, Meuser-Batista M, Ferreira NVC, da Cruz Moreira O, da Silva Gomes NL, Mello de Souza E, Ramos IP, Bailly S, Feige JJ, Lannes-Vieira J, de Araújo-Jorge TC, Waghabi MC.

PLoS Negl Trop Dis. 2019 Jul 31;13(7):e0007602. doi: 10.1371/journal.pntd.0007602. eCollection 2019 Jul.

2.

Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex.

Miranda Mendonça AP, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF, da Silva Fragoso VM.

Neurochem Int. 2019 Jun;126:210-217. doi: 10.1016/j.neuint.2019.03.017. Epub 2019 Mar 26.

PMID:
30922923
3.

A protocol update for the Selenium Treatment and Chagasic Cardiomyopathy (STCC) trial.

Holanda MT, Mediano MFF, Hasslocher-Moreno AM, Xavier SS, Saraiva RM, Sousa AS, Maciel ER, Carneiro FM, da Silva PS, Sangenis LHC, Veloso HH, Cardoso CSA, Bonecini-Almeida MDG, Souza AL, Roma EH, Azevedo MJ, Pereira-Silva FS, Pimentel LO, Mendes MO, Garzoni LR, Gonzaga BMS, Carvalho ACC, Brasil PEAA, Sperandio da Silva GM, Araújo-Jorge TC.

Trials. 2018 Sep 19;19(1):507. doi: 10.1186/s13063-018-2889-8.

4.

TGF-β Polymorphisms Are a Risk Factor for Chagas Disease.

Ferreira RR, Madeira FDS, Alves GF, Chambela MDC, Curvo EOV, Moreira ADS, Almeida de Sá R, Mendonça-Lima L, Cabello PH, Bailly S, Feige JJ, Araujo-Jorge TC, Saraiva RM, Waghabi MC.

Dis Markers. 2018 Feb 18;2018:4579198. doi: 10.1155/2018/4579198. eCollection 2018.

5.

Proteins involved on TGF-β pathway are up-regulated during the acute phase of experimental Chagas disease.

Ferreira RR, de Souza EM, de Oliveira FL, Ferrão PM, Gomes LH, Mendonça-Lima L, Meuser-Batista M, Bailly S, Feige JJ, de Araujo-Jorge TC, Waghabi MC.

Immunobiology. 2016 May;221(5):587-94. doi: 10.1016/j.imbio.2016.01.009. Epub 2016 Jan 29.

PMID:
26852285
6.

Use of haloperidol and risperidone in highly aggressive Swiss Webster mice by applying the model of spontaneous aggression (MSA).

Fragoso VM, Hoppe LY, de Araújo-Jorge TC, de Azevedo MJ, Campos JD, Cortez CM, de Oliveira GM.

Behav Brain Res. 2016 Mar 15;301:110-8. doi: 10.1016/j.bbr.2015.12.010. Epub 2015 Dec 14.

PMID:
26698401
7.

Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion.

Ferrão PM, d'Avila-Levy CM, Araujo-Jorge TC, Degrave WM, Gonçalves Ada S, Garzoni LR, Lima AP, Feige JJ, Bailly S, Mendonça-Lima L, Waghabi MC.

PLoS One. 2015 May 4;10(5):e0124832. doi: 10.1371/journal.pone.0124832. eCollection 2015.

8.

Selenium Treatment and Chagasic Cardiopathy (STCC): study protocol for a double-blind randomized controlled trial.

Alvarenga Americano do Brasil PE, Pereira de Souza A, Hasslocher-Moreno AM, Xavier SS, Lambert Passos SR, de Fátima Ramos Moreira M, Santini de Oliveira M, Sperandio da Silva GM, Magalhães Saraiva R, Santos de Aguiar Cardoso C, de Sousa AS, Mediano MF, Bonecini de Almeida Mda G, da Cruz Moreira O, Britto C, de Araújo-Jorge TC.

Trials. 2014 Oct 6;15:388. doi: 10.1186/1745-6215-15-388.

9.

Towards a paradigm shift in the treatment of chronic Chagas disease.

Viotti R, Alarcón de Noya B, Araujo-Jorge T, Grijalva MJ, Guhl F, López MC, Ramsey JM, Ribeiro I, Schijman AG, Sosa-Estani S, Torrico F, Gascon J; Latin American Network for Chagas Disease, NHEPACHA.

Antimicrob Agents Chemother. 2014;58(2):635-9. doi: 10.1128/AAC.01662-13. Epub 2013 Nov 18.

10.

Predictive value of transforming growth factor-β1in Chagas disease: towards a biomarker surrogate of clinical outcome.

Saraiva RM, Waghabi MC, Vilela MF, Madeira FS, Sperandio da Silva GM, Xavier SS, Feige JJ, Hasslocher-Moreno AM, Araujo-Jorge TC.

Trans R Soc Trop Med Hyg. 2013 Aug;107(8):518-25. doi: 10.1093/trstmh/trt050. Epub 2013 Jun 20.

PMID:
23787193
11.

The TGF-β pathway as an emerging target for Chagas disease therapy.

Araújo-Jorge TC, Waghabi MC, Bailly S, Feige JJ.

Clin Pharmacol Ther. 2012 Nov;92(5):613-21. doi: 10.1038/clpt.2012.102. Epub 2012 Sep 19. Review.

PMID:
22990752
12.

Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease.

de Oliveira FL, Araújo-Jorge TC, de Souza EM, de Oliveira GM, Degrave WM, Feige JJ, Bailly S, Waghabi MC.

PLoS Negl Trop Dis. 2012;6(6):e1696. doi: 10.1371/journal.pntd.0001696. Epub 2012 Jun 12.

13.

A phosphoproteomic approach towards the understanding of the role of TGF-β in Trypanosoma cruzi biology.

Ferrão PM, de Oliveira FL, Degrave WM, Araujo-Jorge TC, Mendonça-Lima L, Waghabi MC.

PLoS One. 2012;7(6):e38736. doi: 10.1371/journal.pone.0038736. Epub 2012 Jun 12.

14.

[Dialogy of Laughter: a new concept introducing joy for health promotion based on dialogue, laughter, joy and the art of the clown].

Matraca MV, Wimmer G, Araújo-Jorge TC.

Cien Saude Colet. 2011 Oct;16(10):4127-38. Portuguese.

15.

Would selenium supplementation aid in therapy for Chagas disease?

Jelicks LA, de Souza AP, Araújo-Jorge TC, Tanowitz HB.

Trends Parasitol. 2011 Mar;27(3):102-5. doi: 10.1016/j.pt.2010.12.002. Epub 2011 Jan 4.

16.

The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice.

Souza AP, Jelicks LA, Tanowitz HB, Olivieri BP, Medeiros MM, Oliveira GM, Pires AR, Santos AM, Araújo-Jorge TC.

Mem Inst Oswaldo Cruz. 2010 Sep;105(6):746-51.

17.

The centennial of the discovery of Chagas disease: facing the current challenges.

Lannes-Vieira J, de Araújo-Jorge TC, Soeiro Mde N, Gadelha P, Corrêa-Oliveira R.

PLoS Negl Trop Dis. 2010 Jun 29;4(6):e645. doi: 10.1371/journal.pntd.0000645. No abstract available.

18.

Intravenous immunoglobulin increases survival time in the acute phase of experimental Chagas disease.

Olivieri BP, Vasconcellos R, Nóbrega A, Minoprio P, Kaveri SV, Araújo-Jorge TC.

Parasite Immunol. 2010 Jun;32(6):464-9. doi: 10.1111/j.1365-3024.2010.01212.x.

19.

Trypanosoma cruzi infection: do distinct populations cause intestinal motility alteration?

de Melo Medeiros M, Araújo-Jorge TC, Batista WS, da Silva TM, de Souza AP.

Parasitol Res. 2010 Jun;107(1):239-42. doi: 10.1007/s00436-010-1871-5. Epub 2010 May 8.

PMID:
20454805
20.

A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.

Olivieri BP, Molina JT, de Castro SL, Pereira MC, Calvet CM, Urbina JA, Araújo-Jorge TC.

Int J Antimicrob Agents. 2010 Jul;36(1):79-83. doi: 10.1016/j.ijantimicag.2010.03.006. Epub 2010 May 7.

PMID:
20452188
21.

Glycosylation patterns of human alpha2-macroglobulin: analysis of lectin binding by electron microscopy.

Paiva MM, Soeiro MN, Barbosa HS, Meirelles MN, Delain E, Araújo-Jorge TC.

Micron. 2010 Aug;41(6):666-73. doi: 10.1016/j.micron.2010.02.015. Epub 2010 Mar 6.

PMID:
20399104
22.

The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection.

de Souza AP, Sieberg R, Li H, Cahill HR, Zhao D, Araújo-Jorge TC, Tanowitz HB, Jelicks LA.

Parasitol Res. 2010 May;106(6):1293-8. doi: 10.1007/s00436-010-1794-1. Epub 2010 Feb 27.

23.

Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection.

Waghabi MC, Coutinho-Silva R, Feige JJ, Higuchi Mde L, Becker D, Burnstock G, Araújo-Jorge TC.

Mem Inst Oswaldo Cruz. 2009 Dec;104(8):1083-90.

24.

Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection.

Oliveira GM, Masuda MO, Rocha NN, Schor N, Hooper CS, Araújo-Jorge TC, Henriques-Pons A.

Mem Inst Oswaldo Cruz. 2009 Dec;104(8):1063-71.

25.

[The design and promotion of health in the Fiocruz research laboratories].

Grossman E, Araújo IS, Araújo-Jorge TC.

Hist Cienc Saude Manguinhos. 2009 Apr-Jun;16(2):377-92. Portuguese.

PMID:
19856750
26.

Chagas disease centennial anniversary celebration: historical overview and prospective proposals aiming to maintain vector control and improve patient prognosis--a permanent challenge.

Lannes-Vieira J, Soeiro Mde N, Corrêa-Oliveira R, Araújo-Jorge TC.

Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1:5-7. No abstract available.

27.

Pharmacological inhibition of transforming growth factor beta signaling decreases infection and prevents heart damage in acute Chagas' disease.

Waghabi MC, de Souza EM, de Oliveira GM, Keramidas M, Feige JJ, Araújo-Jorge TC, Bailly S.

Antimicrob Agents Chemother. 2009 Nov;53(11):4694-701. doi: 10.1128/AAC.00580-09. Epub 2009 Sep 8.

28.

[Reflections about health and educational objects and physical environments].

Grossman E, de Araújo-Jorge TC, de Araujo IS.

Cien Saude Colet. 2008 Dec;13 Suppl 2:2269-77. Portuguese.

29.

[The knowledge of chagasic patients about their disease: collective construction of a research instrument and test of its applicability].

Ballester-Gil LM, Stotz EN, Hasslocher-Moreno AM, de Azevedo BA, de Araújo-Jorge TC.

Cien Saude Colet. 2008 Dec;13 Suppl 2:2199-214. Portuguese.

30.

Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy.

Araújo-Jorge TC, Waghabi MC, Soeiro Mde N, Keramidas M, Bailly S, Feige JJ.

Cytokine Growth Factor Rev. 2008 Oct-Dec;19(5-6):405-13. doi: 10.1016/j.cytogfr.2008.08.002. Epub 2008 Oct 19. Review.

PMID:
18938102
31.

Regulation of extracellular matrix expression and distribution in Trypanosoma cruzi-infected cardiomyocytes.

Calvet CM, Oliveira FO Jr, Araújo-Jorge TC, Pereira MC.

Int J Med Microbiol. 2009 Apr;299(4):301-12. doi: 10.1016/j.ijmm.2008.08.005. Epub 2008 Oct 16.

PMID:
18929503
32.

Urban transmission of Chagas disease in Cochabamba, Bolivia.

Medrano-Mercado N, Ugarte-Fernandez R, Butrón V, Uber-Busek S, Guerra HL, Araújo-Jorge TC, Correa-Oliveira R.

Mem Inst Oswaldo Cruz. 2008 Aug;103(5):423-30.

33.

Applicability of the use of charcoal for the evaluation of intestinal motility in a murine model of Trypanosoma cruzi infection.

de Oliveira GM, de Melo Medeiros M, da Silva Batista W, Santana R, Araújo-Jorge TC, de Souza AP.

Parasitol Res. 2008 Mar;102(4):747-50. Epub 2007 Dec 28.

PMID:
18163190
34.

Trypanosoma cruzi: alpha-2-macroglobulin regulates host cell apoptosis induced by the parasite infection in vitro.

De Souza EM, Meuser-Batista M, Batista DG, Duarte BB, Araújo-Jorge TC, Soeiro MN.

Exp Parasitol. 2008 Mar;118(3):331-7. Epub 2007 Sep 14.

PMID:
18028912
35.

Introducing DNA concepts to Swiss high school students based on a Brazilian educational game.

da S Cardona T, Spiegel CN, Alves GG, Ducommun J, Henriques-Pons A, Araújo-Jorge TC.

Biochem Mol Biol Educ. 2007 Nov;35(6):416-21. doi: 10.1002/bmb.95.

36.

Fas ligand-dependent inflammatory regulation in acute myocarditis induced by Trypanosoma cruzi infection.

de Oliveira GM, Diniz RL, Batista W, Batista MM, Bani Correa C, de Araújo-Jorge TC, Henriques-Pons A.

Am J Pathol. 2007 Jul;171(1):79-86.

37.

SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion.

Waghabi MC, Keramidas M, Calvet CM, Meuser M, de Nazaré C Soeiro M, Mendonça-Lima L, Araújo-Jorge TC, Feige JJ, Bailly S.

Antimicrob Agents Chemother. 2007 Aug;51(8):2905-10. Epub 2007 May 25.

38.

Trypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice.

Olivieri BP, de Souza AP, Cotta-de-Almeida V, de Castro SL, Araújo-Jorge T.

Exp Parasitol. 2006 Nov;114(3):228-34. Epub 2006 Apr 18.

PMID:
16620811
39.

Antiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi.

De Souza EM, Menna-Barreto R, Araújo-Jorge TC, Kumar A, Hu Q, Boykin DW, Soeiro MN.

Parasitology. 2006 Jul;133(Pt 1):75-9. Epub 2006 Mar 27.

PMID:
16563202
40.

Uptake of host cell transforming growth factor-beta by Trypanosoma cruzi amastigotes in cardiomyocytes: potential role in parasite cycle completion.

Waghabi MC, Keramidas M, Bailly S, Degrave W, Mendonça-Lima L, Soeiro Mde N, Meirelles Mde N, Paciornik S, Araújo-Jorge TC, Feige JJ.

Am J Pathol. 2005 Oct;167(4):993-1003.

41.

Experimental infection with Trypanosoma cruzi increases the population of CD8(+), but not CD4(+), immunoglobulin G Fc receptor-positive T lymphocytes.

Henriques-Pons A, Olivieri BP, Oliveira GM, Daëron M, de Araújo-Jorge TC.

Infect Immun. 2005 Aug;73(8):5048-52.

42.

Magnetic resonance imaging in experimental Chagas disease: a brief review of the utility of the method for monitoring right ventricular chamber dilatation.

de Souza AP, Tang B, Tanowitz HB, Araújo-Jorge TC, Jelicks EL.

Parasitol Res. 2005 Sep;97(2):87-90. Epub 2005 Jun 29. Review.

PMID:
15986245
43.

Benznidazole therapy in Trypanosoma cruzi-infected mice blocks thymic involution and apoptosis of CD4+CD8+ double-positive thymocytes.

Olivieri BP, Farias-De-Oliveira DA, Araujo-Jorge TC, Cotta-de-Almeida V.

Antimicrob Agents Chemother. 2005 May;49(5):1981-7.

44.

DNA immunizations with M2 muscarinic and beta1 adrenergic receptor coding plasmids impair cardiac function in mice.

Giménez LE, Hernández CC, Mattos EC, Brandão IT, Olivieri B, Campelo RP, Araújo-Jorge T, Silva CL, Campos de Carvalho AC, Kurtenbach E.

J Mol Cell Cardiol. 2005 May;38(5):703-14.

PMID:
15850564
45.

Activation of transforming growth factor beta by Trypanosoma cruzi.

Waghabi MC, Keramidas M, Feige JJ, Araujo-Jorge TC, Bailly S.

Cell Microbiol. 2005 Apr;7(4):511-7.

PMID:
15760451
46.

In vitro measurement of enzymatic markers as a tool to detect mouse cardiomyocytes injury.

Souza EM, Henriques-Pons A, Bailly C, Lansiaux A, Araújo-Jorge TC, Soeiro Mde N.

Mem Inst Oswaldo Cruz. 2004 Nov;99(7):697-701. Epub 2005 Jan 12.

47.

Phenyl substitution of furamidine markedly potentiates its anti-parasitic activity against Trypanosoma cruzi and Leishmania amazonensis.

De Souza EM, Lansiaux A, Bailly C, Wilson WD, Hu Q, Boykin DW, Batista MM, Araújo-Jorge TC, Soeiro MN.

Biochem Pharmacol. 2004 Aug 15;68(4):593-600.

PMID:
15276066
48.

Microscopy images as interactive tools in cell modeling and cell biology education.

Araújo-Jorge TC, Cardona TS, Mendes CL, Henriques-Pons A, Meirelles RM, Coutinho CM, Aguiar LE, Meirelles Mde N, de Castro SL, Barbosa HS, Luz MR.

Cell Biol Educ. 2004 Summer;3(2):99-110.

49.

Fas and perforin are not required for thymus atrophy induced by Trypanosoma cruzi infection.

Henriques-Pons A, DeMeis J, Cotta-De-Almeida V, Savino W, Araújo-Jorge TC.

Exp Parasitol. 2004 May-Jun;107(1-2):1-4.

PMID:
15208031
50.

Extracellular ATP induces cell death in CD4+/CD8+ double-positive thymocytes in mice infected with Trypanosoma cruzi.

Mantuano-Barradas M, Henriques-Pons A, Araújo-Jorge TC, Di Virgilio F, Coutinho-Silva R, Persechini PM.

Microbes Infect. 2003 Dec;5(15):1363-71.

PMID:
14670449

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