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Items: 1 to 50 of 181

1.

Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment.

Kelschenbach J, He H, Kim BH, Borjabad A, Gu CJ, Chao W, Do M, Sharer LR, Zhang H, Arancio O, Potash MJ, Volsky DJ.

MBio. 2019 Jul 2;10(4). pii: e00591-19. doi: 10.1128/mBio.00591-19.

2.

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade.

Acquarone E, Argyrousi EK, van den Berg M, Gulisano W, Fà M, Staniszewski A, Calcagno E, Zuccarello E, D'Adamio L, Deng SX, Puzzo D, Arancio O, Fiorito J.

Mol Neurodegener. 2019 Jun 27;14(1):26. doi: 10.1186/s13024-019-0326-4.

3.

Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory.

Gulisano W, Melone M, Ripoli C, Tropea MR, Li Puma DD, Giunta S, Cocco S, Marcotulli D, Origlia N, Palmeri A, Arancio O, Conti F, Grassi C, Puzzo D.

J Neurosci. 2019 Jul 24;39(30):5986-6000. doi: 10.1523/JNEUROSCI.0163-19.2019. Epub 2019 May 24.

PMID:
31127002
4.

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

Roy SM, Minasov G, Arancio O, Chico LW, Van Eldik LJ, Anderson WF, Pelletier JC, Watterson DM.

J Med Chem. 2019 Jun 13;62(11):5298-5311. doi: 10.1021/acs.jmedchem.9b00058. Epub 2019 Apr 23.

5.

Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade.

Gulisano W, Maugeri D, Baltrons MA, Fà M, Amato A, Palmeri A, D'Adamio L, Grassi C, Devanand DP, Honig LS, Puzzo D, Arancio O.

J Alzheimers Dis. 2019;68(1):415. doi: 10.3233/JAD-189015. No abstract available.

PMID:
30883364
6.

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.

Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG.

Nat Med. 2019 Jan;25(1):165-175. doi: 10.1038/s41591-018-0275-4. Epub 2019 Jan 7.

7.

Correction: Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations.

Biundo F, d'Abramo C, Tambini MD, Zhang H, Del Prete D, Vitale F, Giliberto L, Arancio O, D'Adamio L.

Transl Psychiatry. 2018 Aug 31;8(1):172. doi: 10.1038/s41398-018-0188-5.

8.

Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.

Li H, Ham A, Ma TC, Kuo SH, Kanter E, Kim D, Ko HS, Quan Y, Sardi SP, Li A, Arancio O, Kang UJ, Sulzer D, Tang G.

Autophagy. 2019 Jan;15(1):113-130. doi: 10.1080/15548627.2018.1509818. Epub 2018 Oct 12.

9.

The effect of amyloid-β peptide on synaptic plasticity and memory is influenced by different isoforms, concentrations, and aggregation status.

Gulisano W, Melone M, Li Puma DD, Tropea MR, Palmeri A, Arancio O, Grassi C, Conti F, Puzzo D.

Neurobiol Aging. 2018 Nov;71:51-60. doi: 10.1016/j.neurobiolaging.2018.06.025. Epub 2018 Jul 18.

PMID:
30092511
10.

An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease.

Rutigliano G, Stazi M, Arancio O, Watterson DM, Origlia N.

Neurobiol Aging. 2018 Oct;70:86-91. doi: 10.1016/j.neurobiolaging.2018.06.006. Epub 2018 Jun 12.

11.

Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse.

Teich AF, Sharma E, Barnwell E, Zhang H, Staniszewski A, Utsuki T, Padmaraju V, Mazell C, Tzekou A, Sambamurti K, Arancio O, Maccecchini ML.

Alzheimers Dement (N Y). 2018 Jan 18;4:37-45. doi: 10.1016/j.trci.2017.12.001. eCollection 2018.

12.

Preparation of Tau Oligomers After the Protein Extraction from Bacteria and Brain Cortices.

Argyrousi EK, Staniszewski A, Nicholls RE, Arancio O.

Methods Mol Biol. 2018;1779:85-97. doi: 10.1007/978-1-4939-7816-8_7.

PMID:
29886529
13.

Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease.

Gulisano W, Tropea MR, Arancio O, Palmeri A, Puzzo D.

Neuropharmacology. 2018 Aug;138:151-159. doi: 10.1016/j.neuropharm.2018.06.002. Epub 2018 Jun 6.

PMID:
29885420
14.

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment.

Gu CJ, Borjabad A, Hadas E, Kelschenbach J, Kim BH, Chao W, Arancio O, Suh J, Polsky B, McMillan J, Edagwa B, Gendelman HE, Potash MJ, Volsky DJ.

PLoS Pathog. 2018 Jun 7;14(6):e1007061. doi: 10.1371/journal.ppat.1007061. eCollection 2018 Jun.

15.

Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade.

Gulisano W, Maugeri D, Baltrons MA, Fà M, Amato A, Palmeri A, D'Adamio L, Grassi C, Devanand DP, Honig LS, Puzzo D, Arancio O.

J Alzheimers Dis. 2018;64(s1):S611-S631. doi: 10.3233/JAD-179935. Review.

PMID:
29865055
16.

Acute vitreoretinal trauma and inflammation after traumatic brain injury in mice.

Evans LP, Newell EA, Mahajan M, Tsang SH, Ferguson PJ, Mahoney J, Hue CD, Vogel EW 3rd, Morrison B 3rd, Arancio O, Nichols R, Bassuk AG, Mahajan VB.

Ann Clin Transl Neurol. 2018 Feb 26;5(3):240-251. doi: 10.1002/acn3.523. eCollection 2018 Mar.

17.

A role for tau in learning, memory and synaptic plasticity.

Biundo F, Del Prete D, Zhang H, Arancio O, D'Adamio L.

Sci Rep. 2018 Feb 16;8(1):3184. doi: 10.1038/s41598-018-21596-3.

18.

Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides.

Yang S, Pascual-Guiral S, Ponce R, Giménez-Llort L, Baltrons MA, Arancio O, Palacio JR, Clos VM, Yuste VJ, Bayascas JR.

Front Aging Neurosci. 2018 Jan 8;9:435. doi: 10.3389/fnagi.2017.00435. eCollection 2017.

19.

RAGE mediates Aβ accumulation in a mouse model of Alzheimer's disease via modulation of β- and γ-secretase activity.

Fang F, Yu Q, Arancio O, Chen D, Gore SS, Yan SS, Yan SF.

Hum Mol Genet. 2018 Mar 15;27(6):1002-1014. doi: 10.1093/hmg/ddy017.

20.

Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.

Asam K, Staniszewski A, Zhang H, Melideo SL, Mazzeo A, Voronkov M, Huber KL, Pérez E, Stock M, Stock JB, Arancio O, Nicholls RE.

PLoS One. 2017 Dec 18;12(12):e0189413. doi: 10.1371/journal.pone.0189413. eCollection 2017.

21.

SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model.

Knock E, Matsuzaki S, Takamura H, Satoh K, Rooke G, Han K, Zhang H, Staniszewski A, Katayama T, Arancio O, Fraser PE.

Neurobiol Dis. 2018 Feb;110:154-165. doi: 10.1016/j.nbd.2017.11.015. Epub 2017 Dec 5.

PMID:
29217476
22.

Commentary: Analysis of SUMO1-conjugation at synapses.

Wilkinson KA, Martin S, Tyagarajan SK, Arancio O, Craig TJ, Guo C, Fraser PE, Goldstein SAN, Henley JM.

Front Cell Neurosci. 2017 Oct 30;11:345. doi: 10.3389/fncel.2017.00345. eCollection 2017. No abstract available.

23.

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons.

Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S.

Acta Neuropathol Commun. 2017 Oct 27;5(1):77. doi: 10.1186/s40478-017-0475-z.

24.

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease.

Fiorito J, Vendome J, Saeed F, Staniszewski A, Zhang H, Yan S, Deng SX, Arancio O, Landry DW.

J Med Chem. 2017 Nov 9;60(21):8858-8875. doi: 10.1021/acs.jmedchem.7b00979. Epub 2017 Oct 23.

PMID:
28985058
25.

Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation.

Martín-Maestro P, Gargini R, A Sproul A, García E, Antón LC, Noggle S, Arancio O, Avila J, García-Escudero V.

Front Mol Neurosci. 2017 Sep 14;10:291. doi: 10.3389/fnmol.2017.00291. eCollection 2017.

26.

Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations.

Biundo F, d'Abramo C, Tambini MD, Zhang H, Del Prete D, Vitale F, Giliberto L, Arancio O, D'Adamio L.

Transl Psychiatry. 2017 Aug 8;7(8):e1198. doi: 10.1038/tp.2017.165. Erratum in: Transl Psychiatry. 2018 Aug 31;8(1):172.

27.

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent.

Puzzo D, Piacentini R, Fá M, Gulisano W, Li Puma DD, Staniszewski A, Zhang H, Tropea MR, Cocco S, Palmeri A, Fraser P, D'Adamio L, Grassi C, Arancio O.

Elife. 2017 Jul 11;6. pii: e26991. doi: 10.7554/eLife.26991.

28.

Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice.

Manassero G, Guglielmotto M, Monteleone D, Vasciaveo V, Butenko O, Tamagno E, Arancio O, Tabaton M.

J Alzheimers Dis. 2017;59(2):743-751. doi: 10.3233/JAD-170298.

PMID:
28671129
29.

Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits.

Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, Shelanski ML, Checler F, Chami M, Marks AR.

Acta Neuropathol. 2017 Nov;134(5):749-767. doi: 10.1007/s00401-017-1733-7. Epub 2017 Jun 19.

PMID:
28631094
30.

Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory.

Palmeri A, Ricciarelli R, Gulisano W, Rivera D, Rebosio C, Calcagno E, Tropea MR, Conti S, Das U, Roy S, Pronzato MA, Arancio O, Fedele E, Puzzo D.

J Neurosci. 2017 Jul 19;37(29):6926-6937. doi: 10.1523/JNEUROSCI.3607-16.2017. Epub 2017 Jun 16.

31.

Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons.

Piacentini R, Li Puma DD, Mainardi M, Lazzarino G, Tavazzi B, Arancio O, Grassi C.

Glia. 2017 Aug;65(8):1302-1316. doi: 10.1002/glia.23163. Epub 2017 May 18.

32.

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease.

Ricciarelli R, Brullo C, Prickaerts J, Arancio O, Villa C, Rebosio C, Calcagno E, Balbi M, van Hagen BT, Argyrousi EK, Zhang H, Pronzato MA, Bruno O, Fedele E.

Sci Rep. 2017 Apr 12;7:46320. doi: 10.1038/srep46320.

33.

Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer's disease.

Koppensteiner P, Trinchese F, Fà M, Puzzo D, Gulisano W, Yan S, Poussin A, Liu S, Orozco I, Dale E, Teich AF, Palmeri A, Ninan I, Boehm S, Arancio O.

Sci Rep. 2016 Sep 1;6:32553. doi: 10.1038/srep32553.

34.

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment.

Brullo C, Ricciarelli R, Prickaerts J, Arancio O, Massa M, Rotolo C, Romussi A, Rebosio C, Marengo B, Pronzato MA, van Hagen BTJ, van Goethem NP, D'Ursi P, Orro A, Milanesi L, Guariento S, Cichero E, Fossa P, Fedele E, Bruno O.

Eur J Med Chem. 2016 Nov 29;124:82-102. doi: 10.1016/j.ejmech.2016.08.018. Epub 2016 Aug 13.

PMID:
27560284
35.

Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.

Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, Perry G, Odetti P, Arancio O, Tamagno E, Tabaton M.

Aging Cell. 2016 Oct;15(5):914-23. doi: 10.1111/acel.12500. Epub 2016 Jul 12.

36.

Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease.

Luo J, Lee SH, VandeVrede L, Qin Z, Aissa MB, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR.

Mol Neurodegener. 2016 May 18;11(1):40. No abstract available.

37.

A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease.

Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR.

Mol Neurodegener. 2016 Apr 29;11:35. doi: 10.1186/s13024-016-0103-6. Erratum in: Mol Neurodegener. 2016;11(1):40.

38.

PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease.

Teich AF, Sakurai M, Patel M, Holman C, Saeed F, Fiorito J, Arancio O.

J Alzheimers Dis. 2016;52(1):295-302. doi: 10.3233/JAD-151104.

39.

PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments.

Nicholls RE, Sontag JM, Zhang H, Staniszewski A, Yan S, Kim CY, Yim M, Woodruff CM, Arning E, Wasek B, Yin D, Bottiglieri T, Sontag E, Kandel ER, Arancio O.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3347-52. doi: 10.1073/pnas.1521018113. Epub 2016 Mar 7.

40.

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.

Fá M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, Costa JA, Lopez P, Davidowitz E, Yu WH, Haroutunian V, Brown LM, Palmeri A, Sigurdsson EM, Duff KE, Teich AF, Honig LS, Sierks M, Moe JG, D'Adamio L, Grassi C, Kanaan NM, Fraser PE, Arancio O.

Sci Rep. 2016 Jan 20;6:19393. doi: 10.1038/srep19393.

41.

Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease.

Fà M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O.

J Alzheimers Dis. 2016;49(3):707-21. doi: 10.3233/JAD-150618.

PMID:
26484927
42.

Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia.

Luo J, Lee SH, VandeVrede L, Qin Z, Piyankarage S, Tavassoli E, Asghodom RT, Ben Aissa M, Fà M, Arancio O, Yue L, Pepperberg DR, Thatcher GR.

BMC Neurosci. 2015 Oct 19;16:67. doi: 10.1186/s12868-015-0208-9.

43.

Time Course and Size of Blood-Brain Barrier Opening in a Mouse Model of Blast-Induced Traumatic Brain Injury.

Hue CD, Cho FS, Cao S, Nicholls RE, Vogel Iii EW, Sibindi C, Arancio O, Dale Bass CR, Meaney DF, Morrison Iii B.

J Neurotrauma. 2016 Jul 1;33(13):1202-11. doi: 10.1089/neu.2015.4067. Epub 2015 Nov 12.

PMID:
26414212
44.

The keystone of Alzheimer pathogenesis might be sought in Aβ physiology.

Puzzo D, Gulisano W, Arancio O, Palmeri A.

Neuroscience. 2015 Oct 29;307:26-36. doi: 10.1016/j.neuroscience.2015.08.039. Epub 2015 Aug 24. Review.

45.

Corrigendum: Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease.

Lee L, Dale E, Staniszewski A, Zhang H, Saeed F, Sakurai M, Fa' M, Orozco I, Michelassi F, Akpan N, Lehrer H, Arancio O.

Sci Rep. 2015 Jul 7;5:11782. doi: 10.1038/srep11782. No abstract available.

46.

Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model.

Fang D, Wang Y, Zhang Z, Du H, Yan S, Sun Q, Zhong C, Wu L, Vangavaragu JR, Yan S, Hu G, Guo L, Rabinowitz M, Glaser E, Arancio O, Sosunov AA, McKhann GM, Chen JX, Yan SS.

Hum Mol Genet. 2015 Sep 15;24(18):5198-210. doi: 10.1093/hmg/ddv241. Epub 2015 Jun 29.

47.

Connectivity and circuitry in a dish versus in a brain.

Chinchalongporn V, Koppensteiner P, Prè D, Thangnipon W, Bilo L, Arancio O.

Alzheimers Res Ther. 2015 Jun 4;7(1):44. doi: 10.1186/s13195-015-0129-y. eCollection 2015.

48.

SUMO1 Affects Synaptic Function, Spine Density and Memory.

Matsuzaki S, Lee L, Knock E, Srikumar T, Sakurai M, Hazrati LN, Katayama T, Staniszewski A, Raught B, Arancio O, Fraser PE.

Sci Rep. 2015 May 29;5:10730. doi: 10.1038/srep10730.

49.

Rodent models for Alzheimer's disease drug discovery.

Puzzo D, Gulisano W, Palmeri A, Arancio O.

Expert Opin Drug Discov. 2015 Jul;10(7):703-11. doi: 10.1517/17460441.2015.1041913. Epub 2015 Apr 30. Review.

50.

Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors.

Kim S, Titcombe RF, Zhang H, Khatri L, Girma HK, Hofmann F, Arancio O, Ziff EB.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3122-7. doi: 10.1073/pnas.1417498112. Epub 2015 Feb 23.

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