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Items: 1 to 50 of 71

1.

[Euglycemic Diabetic Ketoacidosis Caused by a Sodium-glucose Co-transporter (SGLT) 2 Inhibitor after Coronary Artery Bypass Grafting].

Kameda Y, Kato M, Inoue B, Yamazaki S, Sahara N, Aoki T, Nagashima Y, Nemoto N, Anzai H, Araki W, Kobayashi N.

Kyobu Geka. 2019 May;72(5):354-357. Japanese.

PMID:
31268032
2.

Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer's Disease Model Mice.

Taniguchi K, Yamamoto F, Arai T, Yang J, Sakai Y, Itoh M, Mamada N, Sekiguchi M, Yamada D, Saitoh A, Kametani F, Tamaoka A, Araki YM, Wada K, Mizusawa H, Araki W.

J Alzheimers Dis. 2019;70(3):937-952. doi: 10.3233/JAD-190098.

PMID:
31227651
3.

TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons.

Yamamoto F, Taniguchi K, Mamada N, Tamaoka A, Kametani F, Lakshmana MK, Araki W.

Neuroscience. 2019 Mar 15;402:11-22. doi: 10.1016/j.neuroscience.2019.01.010. Epub 2019 Jan 21.

PMID:
30677488
4.

Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders.

Araki W, Hattori K, Kanemaru K, Yokoi Y, Omachi Y, Takano H, Sakata M, Yoshida S, Tsukamoto T, Murata M, Saito Y, Kunugi H, Goto YI, Nagaoka U, Nagao M, Komori T, Arima K, Ishii K, Murayama S, Matsuda H, Tachimori H, Araki YM, Mizusawa H.

Biomark Res. 2017 Sep 22;5:28. doi: 10.1186/s40364-017-0108-5. eCollection 2017.

5.

Reversibility of Aβ oligomer neurotoxicity.

Araki W.

Oncotarget. 2017 Jul 7;8(31):50335-50336. doi: 10.18632/oncotarget.19083. eCollection 2017 Aug 1. No abstract available.

6.

Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.

Mamada N, Tanokashira D, Ishii K, Tamaoka A, Araki W.

Biochem Biophys Res Commun. 2017 Apr 29;486(2):321-328. doi: 10.1016/j.bbrc.2017.03.035. Epub 2017 Mar 14.

PMID:
28302486
7.

The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model.

Tanokashira D, Mamada N, Yamamoto F, Taniguchi K, Tamaoka A, Lakshmana MK, Araki W.

Mol Brain. 2017 Jan 31;10(1):4. doi: 10.1186/s13041-016-0284-5.

8.

Post-translational regulation of the β-secretase BACE1.

Araki W.

Brain Res Bull. 2016 Sep;126(Pt 2):170-177. doi: 10.1016/j.brainresbull.2016.04.009. Epub 2016 Apr 13. Review.

PMID:
27086128
9.

Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons.

Mamada N, Tanokashira D, Hosaka A, Kametani F, Tamaoka A, Araki W.

Mol Brain. 2015 Nov 9;8(1):73. doi: 10.1186/s13041-015-0163-5.

10.

LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking

Tanokashira D, Motoki K, Minegishi S, Hosaka A, Mamada N, Tamaoka A, Okada T, Lakshmana MK, Araki W.

eNeuro. 2015 Apr 22;2(2). pii: ENEURO.0006-15.2015. doi: 10.1523/ENEURO.0006-15.2015. eCollection 2015 Mar-Apr.

11.

Amyloid beta-protein and lipid rafts: focused on biogenesis and catabolism.

Araki W, Tamaoka A.

Front Biosci (Landmark Ed). 2015 Jan 1;20:314-24. Review.

PMID:
25553453
12.

Use of ultrasonic back-reflection intensity for predicting the onset of crack growth due to low-cycle fatigue in stainless steel under block loading.

Islam MN, Arai Y, Araki W.

Ultrasonics. 2015 Feb;56:354-60. doi: 10.1016/j.ultras.2014.09.001. Epub 2014 Sep 17.

PMID:
25287974
13.

Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway.

Araki W, Minegishi S, Motoki K, Kume H, Hohjoh H, Araki YM, Tamaoka A.

Mol Neurobiol. 2014 Dec;50(3):1049-58. doi: 10.1007/s12035-014-8644-6. Epub 2014 Jan 30.

PMID:
24477737
14.

Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model.

Ohno M, Hiraoka Y, Lichtenthaler SF, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T, Nishi E.

Neurobiol Aging. 2014 Jan;35(1):213-22. doi: 10.1016/j.neurobiolaging.2013.07.014. Epub 2013 Aug 15.

15.

Potential repurposing of oncology drugs for the treatment of Alzheimer's disease.

Araki W.

BMC Med. 2013 Mar 26;11:82. doi: 10.1186/1741-7015-11-82.

16.

Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons.

Hosaka A, Araki W, Oda A, Tomidokoro Y, Tamaoka A.

Neurochem Res. 2013 Mar;38(3):589-600. doi: 10.1007/s11064-012-0956-1. Epub 2012 Dec 28.

PMID:
23269484
17.

Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice.

Hayes CD, Dey D, Palavicini JP, Wang H, Araki W, Lakshmana MK.

PLoS One. 2012;7(10):e45841. doi: 10.1371/journal.pone.0045841. Epub 2012 Oct 3.

18.

Reduction of β-amyloid accumulation by reticulon 3 in transgenic mice.

Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin RW, Tamaoka A, Ogino K.

Curr Alzheimer Res. 2013 Feb;10(2):135-42.

PMID:
22742855
19.

Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant.

Motoki K, Kume H, Oda A, Tamaoka A, Hosaka A, Kametani F, Araki W.

Brain Behav. 2012 May;2(3):270-82. doi: 10.1002/brb3.52.

20.

Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis.

Mutoh T, Kawamura N, Hirabayashi Y, Shima S, Miyashita T, Ito S, Asakura K, Araki W, Cazzaniga E, Muto E, Masserini M.

FASEB J. 2012 Jul;26(7):3065-74. doi: 10.1096/fj.11-198630. Epub 2012 Apr 16.

PMID:
22508690
21.

Autoreactive-Aβ antibodies promote APP β-secretase processing.

Deng J, Hou H, Giunta B, Mori T, Wang YJ, Fernandez F, Weggen S, Araki W, Obregon D, Tan J.

J Neurochem. 2012 Mar;120(5):732-40. doi: 10.1111/j.1471-4159.2011.07629.x. Epub 2012 Jan 23.

22.

ER-stress-inducible Herp, facilitates the degradation of immature nicastrin.

Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H.

Biochim Biophys Acta. 2011 Aug;1810(8):790-8. doi: 10.1016/j.bbagen.2011.04.017. Epub 2011 May 12.

PMID:
21600962
23.

Mechanism of photoluminescence quenching of InGaAs/GaAs quantum dots resulting from nanoprobe indentation.

Xu L, Arai Y, Ozasa K, Kakoi H, Liang YH, Araki W.

J Nanosci Nanotechnol. 2011 Jan;11(1):106-14.

PMID:
21446413
24.

MEK inhibitors suppress beta-amyloid production by altering the level of a beta-C-terminal fragment of amyloid precursor protein in neuronal cells.

Araki W, Kametani F, Oda A, Tamaoka A.

FEBS Lett. 2010 Aug 4;584(15):3410-4. doi: 10.1016/j.febslet.2010.06.038. Epub 2010 Jun 30.

25.

Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.

Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.

J Biol Chem. 2010 May 14;285(20):14920-31. doi: 10.1074/jbc.M109.038760. Epub 2010 Mar 18.

26.

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.

Oda A, Tamaoka A, Araki W.

J Neurosci Res. 2010 Apr;88(5):1137-45. doi: 10.1002/jnr.22271.

PMID:
19885829
27.

An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein.

Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H.

FEBS J. 2009 Oct;276(20):5832-40. doi: 10.1111/j.1742-4658.2009.07264.x. Epub 2009 Sep 2.

28.

Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.

Hoshino T, Namba T, Takehara M, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T.

J Biol Chem. 2009 Jul 3;284(27):18493-502. doi: 10.1074/jbc.M109.003269. Epub 2009 Apr 30.

29.

The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1.

Kume H, Murayama KS, Araki W.

J Neurosci Res. 2009 Oct;87(13):2963-72. doi: 10.1002/jnr.22112.

PMID:
19405102
30.

Expression of reticulon 3 in Alzheimer's disease brain.

Kume H, Konishi Y, Murayama KS, Kametani F, Araki W.

Neuropathol Appl Neurobiol. 2009 Apr;35(2):178-88. doi: 10.1111/j.1365-2990.2008.00974.x.

31.

IGF-1 promotes beta-amyloid production by a secretase-independent mechanism.

Araki W, Kume H, Oda A, Tamaoka A, Kametani F.

Biochem Biophys Res Commun. 2009 Feb 27;380(1):111-4. doi: 10.1016/j.bbrc.2009.01.044. Epub 2009 Jan 22.

PMID:
19167357
32.

A family of membrane proteins associated with presenilin expression and gamma-secretase function.

Araki W, Takahashi-Sasaki N, Chui DH, Saito S, Takeda K, Shirotani K, Takahashi K, Murayama KS, Kametani F, Shiraishi H, Komano H, Tabira T.

FASEB J. 2008 Mar;22(3):819-27. Epub 2007 Oct 10.

PMID:
17928364
33.

Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo.

Hoshino T, Nakaya T, Homan T, Tanaka K, Sugimoto Y, Araki W, Narita M, Narumiya S, Suzuki T, Mizushima T.

J Biol Chem. 2007 Nov 9;282(45):32676-88. Epub 2007 Sep 2.

34.

A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein.

Murayama KS, Kametani F, Tabira T, Araki W.

J Neurosci Methods. 2007 Apr 15;161(2):244-9. Epub 2007 Jan 4.

PMID:
17207535
35.

Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides.

Hoshino T, Nakaya T, Araki W, Suzuki K, Suzuki T, Mizushima T.

Biochem J. 2007 Mar 15;402(3):581-9.

36.

Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.

Murayama KS, Kametani F, Saito S, Kume H, Akiyama H, Araki W.

Eur J Neurosci. 2006 Sep;24(5):1237-44. Epub 2006 Sep 8.

PMID:
16965550
37.

Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif.

Araki W, Saito S, Takahashi-Sasaki N, Shiraishi H, Komano H, Murayama KS.

J Mol Neurosci. 2006;29(1):35-43.

PMID:
16757808
38.

Altered localization of amyloid precursor protein under endoplasmic reticulum stress.

Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.

Biochem Biophys Res Commun. 2006 Jun 2;344(2):525-30. Epub 2006 Apr 5.

PMID:
16630560
39.

Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.

Shiraishi H, Marutani T, Wang HQ, Maeda Y, Kurono Y, Takashima A, Araki W, Nishimura M, Yanagisawa K, Komano H.

Genes Cells. 2006 Jan;11(1):83-93.

40.

Extracellular release of BACE1 holoproteins from human neuronal cells.

Murayama KS, Kametani F, Araki W.

Biochem Biophys Res Commun. 2005 Dec 16;338(2):800-7. Epub 2005 Oct 13.

PMID:
16243299
41.
42.

Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein.

Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H.

Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):70-6. Epub 2005 Mar 19.

PMID:
15950763
43.

Amyloid beta peptide binds a novel death-inducing protein, AB-DIP.

Lakshmana MK, Araki W, Tabira T.

FASEB J. 2005 Aug;19(10):1362-4. Epub 2005 May 27.

PMID:
15923395
44.

Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease.

Hasegawa T, Ukai W, Jo DG, Xu X, Mattson MP, Nakagawa M, Araki W, Saito T, Yamada T.

J Neurosci Res. 2005 Jun 15;80(6):869-76.

PMID:
15898106
45.

Identification and characterization of a novel human APH-1b splice variant lacking exon 4.

Saito S, Takahashi-Sasaki N, Araki W.

Biochem Biophys Res Commun. 2005 May 20;330(4):1068-72.

PMID:
15823552
46.

Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes.

Saito S, Araki W.

Biochem Biophys Res Commun. 2005 Feb 4;327(1):18-22.

PMID:
15629423
47.
48.

Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.

Watanabe N, Araki W, Chui DH, Makifuchi T, Ihara Y, Tabira T.

FASEB J. 2004 Jun;18(9):1013-5. Epub 2004 Apr 14.

PMID:
15084524
49.

Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.

Takeda K, Araki W, Tabira T.

Eur J Neurosci. 2004 Jan;19(2):258-264.

PMID:
14725619
50.

A novel mutation at position +11 in the intron following exon 10 of the tau gene in FTDP-17.

Kowalska A, Hasegawa M, Miyamoto K, Akiguchi I, Ikemoto A, Takahashi K, Araki W, Tabira T.

J Appl Genet. 2002;43(4):535-43.

PMID:
12441638

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