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Comparison of liver regeneration after partial hepatectomy and acetaminophen-induced acute liver failure: A global picture based on transcriptome analysis.

Bhushan B, Gunewardena S, Edwards G, Apte U.

Food Chem Toxicol. 2020 Feb 8:111186. doi: 10.1016/j.fct.2020.111186. [Epub ahead of print]


Mechanisms and biomarkers of liver regeneration after drug-induced liver injury.

Clemens MM, McGill MR, Apte U.

Adv Pharmacol. 2019;85:241-262. doi: 10.1016/bs.apha.2019.03.001. Epub 2019 Mar 21. Review.


Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets.

Tang Q, Villar MT, Artigues A, Thyfault JP, Apte U, Zhu H, Peterson KR, Fenton AW.

Sci Rep. 2019 Jun 21;9(1):9031. doi: 10.1038/s41598-019-45202-2.


Leukocyte cell derived chemotaxin-2 (Lect2) as a predictor of survival in adult acute liver failure.

Slowik V, Borude P, Jaeschke H, Woolbright BL, Lee WM, Apte U; Acute Liver Failure Study Group.

Transl Gastroenterol Hepatol. 2019 Mar 20;4:17. doi: 10.21037/tgh.2019.03.03. eCollection 2019.


The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.

Clemens MM, Kennon-McGill S, Apte U, James LP, Finck BN, McGill MR.

Food Chem Toxicol. 2019 Mar;125:279-288. doi: 10.1016/j.fct.2019.01.014. Epub 2019 Jan 14.


Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities.

Bhushan B, Apte U.

Am J Pathol. 2019 Apr;189(4):719-729. doi: 10.1016/j.ajpath.2018.12.006. Epub 2019 Jan 14. Review.


Hepatocyte Nuclear Factor 4 Alpha Activation Is Essential for Termination of Liver Regeneration in Mice.

Huck I, Gunewardena S, Espanol-Suner R, Willenbring H, Apte U.

Hepatology. 2019 Aug;70(2):666-681. doi: 10.1002/hep.30405. Epub 2019 Mar 10.


Paradoxical Protective Effect of Perfluorooctanesulfonic Acid Against High-Fat Diet-Induced Hepatic Steatosis in Mice.

Huck I, Beggs K, Apte U.

Int J Toxicol. 2018 Sep/Oct;37(5):383-392. doi: 10.1177/1091581818790934. Epub 2018 Aug 22.


TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaan1230. doi: 10.1126/scitranslmed.aan1230.


Inhibition of Mast Cell Degranulation With Cromolyn Sodium Exhibits Organ-Specific Effects in Polycystic Kidney (PCK) Rats.

Jiang L, Fang P, Septer S, Apte U, Pritchard MT.

Int J Toxicol. 2018 Jul/Aug;37(4):308-326. doi: 10.1177/1091581818777754. Epub 2018 Jun 3.


Deciphering the Cell-Specific Role of Wnts in the Liver: New Tools for a Difficult Task.

Apte U.

Hepatology. 2018 Aug;68(2):412-414. doi: 10.1002/hep.30038. No abstract available.


Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose.

Borude P, Bhushan B, Gunewardena S, Akakpo J, Jaeschke H, Apte U.

Am J Pathol. 2018 Jun;188(6):1406-1418. doi: 10.1016/j.ajpath.2018.03.006. Epub 2018 Apr 11.


DNA Damage Response Regulates Initiation of Liver Regeneration Following Acetaminophen Overdose.

Borude P, Bhushan B, Apte U.

Gene Expr. 2018 May 18;18(2):115-123. doi: 10.3727/105221618X15205260749346. Epub 2018 Mar 14.


Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.

McGreal SR, Bhushan B, Walesky C, McGill MR, Lebofsky M, Kandel SE, Winefield RD, Jaeschke H, Zachara NE, Zhang Z, Tan EP, Slawson C, Apte U.

Toxicol Sci. 2018 Apr 1;162(2):599-610. doi: 10.1093/toxsci/kfy002.


Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis.

Pradhan-Sundd T, Zhou L, Vats R, Jiang A, Molina L, Singh S, Poddar M, Russell J, Stolz DB, Oertel M, Apte U, Watkins S, Ranganathan S, Nejak-Bowen KN, Sundd P, Monga SP.

Hepatology. 2018 Jun;67(6):2320-2337. doi: 10.1002/hep.29585. Epub 2018 Apr 19.


Increased YAP Activation Is Associated With Hepatic Cyst Epithelial Cell Proliferation in ARPKD/CHF.

Jiang L, Sun L, Edwards G, Manley M Jr, Wallace DP, Septer S, Manohar C, Pritchard MT, Apte U.

Gene Expr. 2017 Nov 27;17(4):313-326. doi: 10.3727/105221617X15034976037343. Epub 2017 Sep 15.


Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.

Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ.

Cell Metab. 2017 Sep 5;26(3):509-522.e6. doi: 10.1016/j.cmet.2017.08.006.


Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism.

Tan EP, McGreal SR, Graw S, Tessman R, Koppel SJ, Dhakal P, Zhang Z, Machacek M, Zachara NE, Koestler DC, Peterson KR, Thyfault JP, Swerdlow RH, Krishnamurthy P, DiTacchio L, Apte U, Slawson C.

J Biol Chem. 2017 Sep 8;292(36):14940-14962. doi: 10.1074/jbc.M117.797944. Epub 2017 Jul 24.


Heparan sulfate promotes recovery from acute liver injury: Inhibition of progressive cell death or enhanced regeneration?

Apte U, Kaplowitz N.

Hepatology. 2017 Nov;66(5):1381-1383. doi: 10.1002/hep.29381. Epub 2017 Sep 29. No abstract available.


Disruption of Estrogen Receptor Alpha in Rats Results in Faster Initiation of Compensatory Regeneration Despite Higher Liver Injury After Carbon Tetrachloride Treatment.

McGreal SR, Rumi K, Soares MJ, Woolbright BL, Jaeschke H, Apte U.

Int J Toxicol. 2017 May/Jun;36(3):199-206. doi: 10.1177/1091581817706067. Epub 2017 May 8.


Leukocyte Cell-Derived Chemotaxin-2: It's Role in Pathophysiology and Future in Clinical Medicine.

Slowik V, Apte U.

Clin Transl Sci. 2017 Jul;10(4):249-259. doi: 10.1111/cts.12469. Epub 2017 May 23. Review. No abstract available.


Wnt/β-Catenin Signaling Drives Thioacetamide-Mediated Heteroprotection Against Acetaminophen-Induced Lethal Liver Injury.

Dadhania VP, Bhushan B, Apte U, Mehendale HM.

Dose Response. 2017 Jan 30;15(1):1559325817690287. doi: 10.1177/1559325817690287. eCollection 2017 Jan-Mar.


A Brief Report of Immunohistochemical Markers to Identify Aggressive Hepatoblastoma.

Singh V, Manalang M, Singh M, Apte U.

Appl Immunohistochem Mol Morphol. 2018 Oct;26(9):654-657. doi: 10.1097/PAI.0000000000000492.


Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.

Bhushan B, Chavan H, Borude P, Xie Y, Du K, McGill MR, Lebofsky M, Jaeschke H, Krishnamurthy P, Apte U.

Toxicol Sci. 2017 Feb;155(2):363-378. doi: 10.1093/toxsci/kfw213. Epub 2016 Oct 23.


Inhibition of Glycogen Synthase Kinase 3 Accelerated Liver Regeneration after Acetaminophen-Induced Hepatotoxicity in Mice.

Bhushan B, Poudel S, Manley MW Jr, Roy N, Apte U.

Am J Pathol. 2017 Mar;187(3):543-552. doi: 10.1016/j.ajpath.2016.11.014. Epub 2017 Jan 6.


Evidence for a "Pathogenic Triumvirate" in Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease.

Jiang L, Fang P, Weemhoff JL, Apte U, Pritchard MT.

Biomed Res Int. 2016;2016:4918798. Epub 2016 Nov 7. Review.


The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction.

Beggs KM, McGreal SR, McCarthy A, Gunewardena S, Lampe JN, Lau C, Apte U.

Toxicol Appl Pharmacol. 2016 Aug 1;304:18-29. doi: 10.1016/j.taap.2016.05.001. Epub 2016 May 3.


Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling.

Sun L, Beggs K, Borude P, Edwards G, Bhushan B, Walesky C, Roy N, Manley MW Jr, Gunewardena S, O'Neil M, Li H, Apte U.

Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G91-G104. doi: 10.1152/ajpgi.00027.2015. Epub 2016 May 5.


Liver-Specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration After Acetaminophen Overdose.

Bhushan B, Edwards G, Desai A, Michalopoulos GK, Apte U.

Gene Expr. 2016;17(1):35-45. doi: 10.3727/105221616X691578. Epub 2016 Apr 27.


Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.

Saha SK, Parachoniak CA, Ghanta KS, Fitamant J, Ross KN, Najem MS, Gurumurthy S, Akbay EA, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J, Popovici-Muller J, Gliser C, Ferrone CR, Apte U, Llovet JM, Wong KK, Ramaswamy S, Bardeesy N.

Nature. 2015 Dec 3;528(7580):152. doi: 10.1038/nature16136. Epub 2015 Nov 18. No abstract available.


Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer.

Li T, Apte U.

Adv Pharmacol. 2015;74:263-302. doi: 10.1016/bs.apha.2015.04.003. Epub 2015 May 27. Review.


Role of hepatocyte nuclear factor 4α (HNF4α) in cell proliferation and cancer.

Walesky C, Apte U.

Gene Expr. 2015;16(3):101-8. doi: 10.3727/105221615X14181438356292. Review.


Mg2+/Mn2+-dependent phosphatase 1A is involved in regulating pregnane X receptor-mediated cytochrome p450 3A4 gene expression.

Pondugula SR, Flannery PC, Apte U, Babu JR, Geetha T, Rege SD, Chen T, Abbott KL.

Drug Metab Dispos. 2015 Mar;43(3):385-91. doi: 10.1124/dmd.114.062083. Epub 2015 Jan 5.


Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.

Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, Gallazzini M, Olson EN, Lam H, Henske EP, Dong Z, Apte U, Pallet N, Johnson RL, Terzi F, Kwiatkowski DJ, Scoazec JY, Martignoni G, Pende M.

J Exp Med. 2014 Oct 20;211(11):2249-63. doi: 10.1084/jem.20140341. Epub 2014 Oct 6.


Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model.

Bhushan B, Walesky C, Manley M, Gallagher T, Borude P, Edwards G, Monga SP, Apte U.

Am J Pathol. 2014 Nov;184(11):3013-25. doi: 10.1016/j.ajpath.2014.07.019. Epub 2014 Sep 2.


Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.

Saha SK, Parachoniak CA, Ghanta KS, Fitamant J, Ross KN, Najem MS, Gurumurthy S, Akbay EA, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J, Popovici-Muller J, Gliser C, Ferrone CR, Apte U, Llovet JM, Wong KK, Ramaswamy S, Bardeesy N.

Nature. 2014 Sep 4;513(7516):110-4. doi: 10.1038/nature13441. Epub 2014 Jul 2. Erratum in: Nature. 2015 Dec 3;528(7580):152.


Fibroblast growth factor 15 deficiency impairs liver regeneration in mice.

Kong B, Huang J, Zhu Y, Li G, Williams J, Shen S, Aleksunes LM, Richardson JR, Apte U, Rudnick DA, Guo GL.

Am J Physiol Gastrointest Liver Physiol. 2014 May 15;306(10):G893-902. doi: 10.1152/ajpgi.00337.2013. Epub 2014 Apr 3.


Suppression of autophagic flux by bile acids in hepatocytes.

Manley S, Ni HM, Kong B, Apte U, Guo G, Ding WX.

Toxicol Sci. 2014 Feb;137(2):478-90. doi: 10.1093/toxsci/kft246. Epub 2013 Nov 4.


Role of bile acids in liver injury and regeneration following acetaminophen overdose.

Bhushan B, Borude P, Edwards G, Walesky C, Cleveland J, Li F, Ma X, Apte U.

Am J Pathol. 2013 Nov;183(5):1518-1526. doi: 10.1016/j.ajpath.2013.07.012. Epub 2013 Sep 3.


Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents.

Walesky C, Edwards G, Borude P, Gunewardena S, O'Neil M, Yoo B, Apte U.

Hepatology. 2013 Jun;57(6):2480-90. doi: 10.1002/hep.26251.


Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation.

Walesky C, Gunewardena S, Terwilliger EF, Edwards G, Borude P, Apte U.

Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G26-37. doi: 10.1152/ajpgi.00064.2012. Epub 2012 Oct 25.


Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice.

Borude P, Edwards G, Walesky C, Li F, Ma X, Kong B, Guo GL, Apte U.

Hepatology. 2012 Dec;56(6):2344-52. doi: 10.1002/hep.25918.


Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.

Ni HM, Boggess N, McGill MR, Lebofsky M, Borude P, Apte U, Jaeschke H, Ding WX.

Toxicol Sci. 2012 Jun;127(2):438-50. doi: 10.1093/toxsci/kfs133. Epub 2012 Apr 5.


Yes-associated protein is involved in proliferation and differentiation during postnatal liver development.

Septer S, Edwards G, Gunewardena S, Wolfe A, Li H, Daniel J, Apte U.

Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G493-503. doi: 10.1152/ajpgi.00056.2011. Epub 2011 Dec 22.


Deregulation of Hippo kinase signalling in human hepatic malignancies.

Li H, Wolfe A, Septer S, Edwards G, Zhong X, Abdulkarim AB, Ranganathan S, Apte U.

Liver Int. 2012 Jan;32(1):38-47. doi: 10.1111/j.1478-3231.2011.02646.x. Epub 2011 Oct 20.


Increased activation of the Wnt/β-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice.

Wolfe A, Thomas A, Edwards G, Jaseja R, Guo GL, Apte U.

J Pharmacol Exp Ther. 2011 Jul;338(1):12-21. doi: 10.1124/jpet.111.179390. Epub 2011 Mar 23.


Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration.

Weaver BP, Zhang Y, Hiscox S, Guo GL, Apte U, Taylor KM, Sheline CT, Wang L, Andrews GK.

PLoS One. 2010 Oct 4;5(10). pii: e13158. doi: 10.1371/journal.pone.0013158.

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