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Items: 1 to 50 of 132

1.

One hits (almost) all.

Boraschi D, Apte RN, Martin MU.

Nat Immunol. 2019 Aug 19. doi: 10.1038/s41590-019-0463-5. [Epub ahead of print] No abstract available.

PMID:
31427774
2.

Pro-inflammatory macrophages promote multiple myeloma resistance to bortezomib therapy.

Beyar-Katz O, Magidey K, Reiner-Benaim A, Barak N, Avivi I, Cohen Y, Timaner M, Avraham S, Hayun M, Lavi N, Bersudsky M, Voronov E, Apte RN, Shaked Y.

Mol Cancer Res. 2019 Aug 13. pii: molcanres.0487.2019. doi: 10.1158/1541-7786.MCR-19-0487. [Epub ahead of print]

PMID:
31409628
3.

Interleukin-1α as an intracellular alarmin in cancer biology.

Voronov E, Dinarello CA, Apte RN.

Semin Immunol. 2018 Aug;38:3-14. doi: 10.1016/j.smim.2018.10.006. Epub 2018 Oct 26. Review. No abstract available.

PMID:
30554608
4.

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.

Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin GV, Shurin MR, Dinarello CA, Voronov E, Apte RN.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1361-1369. doi: 10.1073/pnas.1812266115. Epub 2018 Dec 13.

5.

Interleukin 1α-Deficient Mice Have an Altered Gut Microbiota Leading to Protection from Dextran Sodium Sulfate-Induced Colitis.

Nunberg M, Werbner N, Neuman H, Bersudsky M, Braiman A, Ben-Shoshan M, Ben Izhak M, Louzoun Y, Apte RN, Voronov E, Koren O.

mSystems. 2018 May 8;3(3). pii: e00213-17. doi: 10.1128/mSystems.00213-17. eCollection 2018 May-Jun.

6.

Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies.

Asraf K, Torika N, Apte RN, Fleisher-Berkovich S.

Front Cell Neurosci. 2018 May 1;12:116. doi: 10.3389/fncel.2018.00116. eCollection 2018.

7.

Inflammation in the pleural cavity following injection of multi-walled carbon nanotubes is dependent on their characteristics and the presence of IL-1 genes.

Arnoldussen YJ, Skaug V, Aleksandersen M, Ropstad E, Anmarkrud KH, Einarsdottir E, Chin-Lin F, Granum Bjørklund C, Kasem M, Eilertsen E, Apte RN, Zienolddiny S.

Nanotoxicology. 2018 Aug;12(6):522-538. doi: 10.1080/17435390.2018.1465139. Epub 2018 May 9.

PMID:
29742950
8.

Candesartan ameliorates brain inflammation associated with Alzheimer's disease.

Torika N, Asraf K, Apte RN, Fleisher-Berkovich S.

CNS Neurosci Ther. 2018 Mar;24(3):231-242. doi: 10.1111/cns.12802. Epub 2018 Jan 24.

9.

Targeting the Tumor Microenvironment by Intervention in Interleukin-1 Biology.

Voronov E, Apte RN.

Curr Pharm Des. 2017;23(32):4893-4905. doi: 10.2174/1381612823666170613080919. Review.

PMID:
28606052
10.

Immunotherapeutic approaches of IL-1 neutralization in the tumor microenvironment.

Apte RN, Voronov E.

J Leukoc Biol. 2017 Aug;102(2):293-306. doi: 10.1189/jlb.3MR1216-523R. Epub 2017 May 18. Review.

PMID:
28522598
11.

Alarmins: Feel the Stress.

Rider P, Voronov E, Dinarello CA, Apte RN, Cohen I.

J Immunol. 2017 Feb 15;198(4):1395-1402. doi: 10.4049/jimmunol.1601342. Review.

12.

MABp1 as a novel antibody treatment for advanced colorectal cancer: a randomised, double-blind, placebo-controlled, phase 3 study.

Hickish T, Andre T, Wyrwicz L, Saunders M, Sarosiek T, Kocsis J, Nemecek R, Rogowski W, Lesniewski-Kmak K, Petruzelka L, Apte RN, Mohanty P, Stecher M, Simard J, de Gramont A.

Lancet Oncol. 2017 Feb;18(2):192-201. doi: 10.1016/S1470-2045(17)30006-2. Epub 2017 Jan 14.

PMID:
28094194
13.

Natural Killer Receptor 1 Dampens the Development of Allergic Eosinophilic Airway Inflammation.

Elhaik Goldman S, Moshkovits I, Shemesh A, Filiba A, Tsirulsky Y, Vronov E, Shagan M, Apte RN, Benharroch DA, Karo-Atar D, Dagan R, Munitz A, Mizrachi Nebenzahl Y, Porgador A.

PLoS One. 2016 Aug 31;11(8):e0160779. doi: 10.1371/journal.pone.0160779. eCollection 2016.

14.

Telmisartan Modulates Glial Activation: In Vitro and In Vivo Studies.

Torika N, Asraf K, Danon A, Apte RN, Fleisher-Berkovich S.

PLoS One. 2016 May 17;11(5):e0155823. doi: 10.1371/journal.pone.0155823. eCollection 2016.

15.

Effects of carbon nanotubes on intercellular communication and involvement of IL-1 genes.

Arnoldussen YJ, Anmarkrud KH, Skaug V, Apte RN, Haugen A, Zienolddiny S.

J Cell Commun Signal. 2016 Jun;10(2):153-62. doi: 10.1007/s12079-016-0323-0. Epub 2016 Apr 21.

16.

Corrigendum: IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.

Cohen I, Rider P, Vornov E, Tomas M, Tudor C, Wegner M, Brondani L, Freudenberg M, Mittler G, Ferrando-May E, Dinarello CA, Apte RN, Schneider R.

Sci Rep. 2016 Jan 11;6:19100. doi: 10.1038/srep19100. No abstract available.

17.

Preface.

Voronov E, Apte RN.

Cancer Microenviron. 2015 Dec;8(3):123-4. doi: 10.1007/s12307-015-0178-6. No abstract available.

18.

IL-1 in Colon Inflammation, Colon Carcinogenesis and Invasiveness of Colon Cancer.

Voronov E, Apte RN.

Cancer Microenviron. 2015 Dec;8(3):187-200. doi: 10.1007/s12307-015-0177-7. Epub 2015 Dec 19.

19.

IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.

Cohen I, Rider P, Vornov E, Tomas M, Tudor C, Wegner M, Brondani L, Freudenberg M, Mittler G, Ferrando-May E, Dinarello CA, Apte RN, Schneider R.

Sci Rep. 2015 Oct 6;5:14756. doi: 10.1038/srep14756. Erratum in: Sci Rep. 2016;6:19100. Multiple author names corrected.

20.

Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer-drug conjugates.

Shamay Y, Raviv L, Golan M, Voronov E, Apte RN, David A.

J Control Release. 2015 Nov 10;217:102-12. doi: 10.1016/j.jconrel.2015.08.029. Epub 2015 Aug 18.

PMID:
26297207
21.

Consensus nomenclature for CD8+ T cell phenotypes in cancer.

Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, Blay JY, Bonneville M, Butterfield LH, Caignard A, Castelli C, Cavallo F, Celis E, Chen L, Colombo MP, Comin-Anduix B, Coukos G, Dhodapkar MV, Dranoff G, Frazer IH, Fridman WH, Gabrilovich DI, Gilboa E, Gnjatic S, Jäger D, Kalinski P, Kaufman HL, Kiessling R, Kirkwood J, Knuth A, Liblau R, Lotze MT, Lugli E, Marincola F, Melero I, Melief CJ, Mempel TR, Mittendorf EA, Odun K, Overwijk WW, Palucka AK, Parmiani G, Ribas A, Romero P, Schreiber RD, Schuler G, Srivastava PK, Tartour E, Valmori D, van der Burg SH, van der Bruggen P, van den Eynde BJ, Wang E, Zou W, Whiteside TL, Speiser DE, Pardoll DM, Restifo NP, Anderson AC.

Oncoimmunology. 2015 Feb 25;4(4):e998538. eCollection 2015 Apr.

22.

Blocking IL1β Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis.

Voloshin T, Alishekevitz D, Kaneti L, Miller V, Isakov E, Kaplanov I, Voronov E, Fremder E, Benhar M, Machluf M, Apte RN, Shaked Y.

Mol Cancer Ther. 2015 Jun;14(6):1385-94. doi: 10.1158/1535-7163.MCT-14-0969. Epub 2015 Apr 17.

23.

Knockdown of interleukin-1α does not attenuate LPS-induced production of interleukin-1β in mouse macrophages.

Almog T, Kandel-Kfir M, Shaish A, Dissen M, Shlomai G, Voronov E, Apte RN, Harats D, Kamari Y.

Cytokine. 2015 May;73(1):138-43. doi: 10.1016/j.cyto.2015.01.029. Epub 2015 Mar 6.

PMID:
25748836
24.

Involvement of IL-1 genes in the cellular responses to carbon nanotube exposure.

Arnoldussen YJ, Skogstad A, Skaug V, Kasem M, Haugen A, Benker N, Weinbruch S, Apte RN, Zienolddiny S.

Cytokine. 2015 May;73(1):128-37. doi: 10.1016/j.cyto.2015.01.032. Epub 2015 Mar 6.

PMID:
25748835
25.

Classification of current anticancer immunotherapies.

Galluzzi L, Vacchelli E, Bravo-San Pedro JM, Buqué A, Senovilla L, Baracco EE, Bloy N, Castoldi F, Abastado JP, Agostinis P, Apte RN, Aranda F, Ayyoub M, Beckhove P, Blay JY, Bracci L, Caignard A, Castelli C, Cavallo F, Celis E, Cerundolo V, Clayton A, Colombo MP, Coussens L, Dhodapkar MV, Eggermont AM, Fearon DT, Fridman WH, Fučíková J, Gabrilovich DI, Galon J, Garg A, Ghiringhelli F, Giaccone G, Gilboa E, Gnjatic S, Hoos A, Hosmalin A, Jäger D, Kalinski P, Kärre K, Kepp O, Kiessling R, Kirkwood JM, Klein E, Knuth A, Lewis CE, Liblau R, Lotze MT, Lugli E, Mach JP, Mattei F, Mavilio D, Melero I, Melief CJ, Mittendorf EA, Moretta L, Odunsi A, Okada H, Palucka AK, Peter ME, Pienta KJ, Porgador A, Prendergast GC, Rabinovich GA, Restifo NP, Rizvi N, Sautès-Fridman C, Schreiber H, Seliger B, Shiku H, Silva-Santos B, Smyth MJ, Speiser DE, Spisek R, Srivastava PK, Talmadge JE, Tartour E, Van Der Burg SH, Van Den Eynde BJ, Vile R, Wagner H, Weber JS, Whiteside TL, Wolchok JD, Zitvogel L, Zou W, Kroemer G.

Oncotarget. 2014 Dec 30;5(24):12472-508. Review.

26.

Modification of topoisomerases in mammospheres derived from breast cancer cell line: clinical implications for combined treatments with tyrosine kinase inhibitors.

Peleg R, Romzova M, Kogan-Zviagin I, Apte RN, Priel E.

BMC Cancer. 2014 Dec 3;14:910. doi: 10.1186/1471-2407-14-910.

27.

Multifunctional activity of a small tellurium redox immunomodulator compound, AS101, on dextran sodium sulfate-induced murine colitis.

Halpert G, Eitan T, Voronov E, Apte RN, Rath-Wolfson L, Albeck M, Kalechman Y, Sredni B.

J Biol Chem. 2014 Jun 13;289(24):17215-27. doi: 10.1074/jbc.M113.536664. Epub 2014 Apr 24.

28.

The role IL-1 in tumor-mediated angiogenesis.

Voronov E, Carmi Y, Apte RN.

Front Physiol. 2014 Mar 28;5:114. doi: 10.3389/fphys.2014.00114. eCollection 2014. Review.

29.

Lack of interleukin-1α in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice.

Olteanu S, Kandel-Kfir M, Shaish A, Almog T, Shemesh S, Barshack I, Apte RN, Harats D, Kamari Y.

Dig Liver Dis. 2014 May;46(5):433-9. doi: 10.1016/j.dld.2014.01.156. Epub 2014 Feb 26.

PMID:
24582082
30.

Critical role for IL-1β in DNA damage-induced mucositis.

Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11. doi: 10.1073/pnas.1322691111. Epub 2014 Jan 27.

31.

Cellular and molecular pathways in the tumor immunoenvironment: 3rd Cancer Immunotherapy and Immunomonitoring (CITIM) meeting, 22-25 April 2013, Krakow, Poland.

Shurin MR, Umansky V, Malyguine A, Hurwitz AA, Apte RN, Whiteside T, Jewett A, Thanavala Y, Murphy WJ.

Cancer Immunol Immunother. 2014 Jan;63(1):73-80. doi: 10.1007/s00262-013-1501-z. Epub 2013 Nov 24. No abstract available.

PMID:
24271210
32.

Interleukin-1α.

Rider P, Carmi Y, Voronov E, Apte RN.

Semin Immunol. 2013 Dec 15;25(6):430-8. doi: 10.1016/j.smim.2013.10.005. Epub 2013 Nov 1. Review.

PMID:
24183701
33.

Unique Versus Redundant Functions of IL-1α and IL-1β in the Tumor Microenvironment.

Voronov E, Dotan S, Krelin Y, Song X, Elkabets M, Carmi Y, Rider P, Idan Cohen, Romzova M, Kaplanov I, Apte RN.

Front Immunol. 2013 Jul 8;4:177. doi: 10.3389/fimmu.2013.00177. eCollection 2013.

34.

Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice.

Bersudsky M, Luski L, Fishman D, White RM, Ziv-Sokolovskaya N, Dotan S, Rider P, Kaplanov I, Aychek T, Dinarello CA, Apte RN, Voronov E.

Gut. 2014 Apr;63(4):598-609. doi: 10.1136/gutjnl-2012-303329. Epub 2013 Jun 21.

PMID:
23793223
35.

Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions.

Fejer G, Wegner MD, Györy I, Cohen I, Engelhard P, Voronov E, Manke T, Ruzsics Z, Dölken L, Prazeres da Costa O, Branzk N, Huber M, Prasse A, Schneider R, Apte RN, Galanos C, Freudenberg MA.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2191-8. doi: 10.1073/pnas.1302877110. Epub 2013 May 24.

36.

The role of IL-1β in the early tumor cell-induced angiogenic response.

Carmi Y, Dotan S, Rider P, Kaplanov I, White MR, Baron R, Abutbul S, Huszar M, Dinarello CA, Apte RN, Voronov E.

J Immunol. 2013 Apr 1;190(7):3500-9. doi: 10.4049/jimmunol.1202769. Epub 2013 Mar 8.

37.

Interleukin-1β regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability.

Nov O, Shapiro H, Ovadia H, Tarnovscki T, Dvir I, Shemesh E, Kovsan J, Shelef I, Carmi Y, Voronov E, Apte RN, Lewis E, Haim Y, Konrad D, Bashan N, Rudich A.

PLoS One. 2013;8(1):e53626. doi: 10.1371/journal.pone.0053626. Epub 2013 Jan 16.

38.

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells.

Rider P, Kaplanov I, Romzova M, Bernardis L, Braiman A, Voronov E, Apte RN.

Front Immunol. 2012 Sep 14;3:290. doi: 10.3389/fimmu.2012.00290. eCollection 2012.

39.

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.

Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S, Lapidot T.

Nat Immunol. 2012 Nov;13(11):1072-82. doi: 10.1038/ni.2408. Epub 2012 Sep 16.

PMID:
22983360
40.

Interleukin-1 receptor type-1 in non-hematopoietic cells is the target for the pro-atherogenic effects of interleukin-1 in apoE-deficient mice.

Shemesh S, Kamari Y, Shaish A, Olteanu S, Kandel-Kfir M, Almog T, Grosskopf I, Apte RN, Harats D.

Atherosclerosis. 2012 Jun;222(2):329-36. doi: 10.1016/j.atherosclerosis.2011.12.010. Epub 2011 Dec 17.

PMID:
22236482
41.

IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation.

Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN.

J Immunol. 2011 Nov 1;187(9):4835-43. doi: 10.4049/jimmunol.1102048. Epub 2011 Sep 19.

42.

The natural cytotoxicity receptor 1 contribution to early clearance of Streptococcus pneumoniae and to natural killer-macrophage cross talk.

Elhaik-Goldman S, Kafka D, Yossef R, Hadad U, Elkabets M, Vallon-Eberhard A, Hulihel L, Jung S, Ghadially H, Braiman A, Apte RN, Mandelboim O, Dagan R, Mizrachi-Nebenzahl Y, Porgador A.

PLoS One. 2011;6(8):e23472. doi: 10.1371/journal.pone.0023472. Epub 2011 Aug 22.

43.

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice.

Kamari Y, Shaish A, Vax E, Shemesh S, Kandel-Kfir M, Arbel Y, Olteanu S, Barshack I, Dotan S, Voronov E, Dinarello CA, Apte RN, Harats D.

J Hepatol. 2011 Nov;55(5):1086-94. doi: 10.1016/j.jhep.2011.01.048. Epub 2011 Feb 24.

44.

Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis.

Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, Apte RN.

J Immunol. 2011 Mar 15;186(6):3462-71. doi: 10.4049/jimmunol.1002901. Epub 2011 Feb 7.

45.

Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α.

Kamari Y, Shaish A, Shemesh S, Vax E, Grosskopf I, Dotan S, White M, Voronov E, Dinarello CA, Apte RN, Harats D.

Biochem Biophys Res Commun. 2011 Feb 11;405(2):197-203. doi: 10.1016/j.bbrc.2011.01.008. Epub 2011 Jan 8.

PMID:
21219852
46.

IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function.

Elkabets M, Ribeiro VS, Dinarello CA, Ostrand-Rosenberg S, Di Santo JP, Apte RN, Vosshenrich CA.

Eur J Immunol. 2010 Dec;40(12):3347-57. doi: 10.1002/eji.201041037.

47.

Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting.

Cohen M, Elkabets M, Perlmutter M, Porgador A, Voronov E, Apte RN, Lichtenstein RG.

J Immunol. 2010 Nov 15;185(10):5869-78. doi: 10.4049/jimmunol.1001635. Epub 2010 Oct 18.

48.

p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner.

Addadi Y, Moskovits N, Granot D, Lozano G, Carmi Y, Apte RN, Neeman M, Oren M.

Cancer Res. 2010 Dec 1;70(23):9650-8. doi: 10.1158/0008-5472.CAN-10-1146. Epub 2010 Oct 15.

49.

Targeting of polymeric nanoparticles to lung metastases by surface-attachment of YIGSR peptide from laminin.

Sarfati G, Dvir T, Elkabets M, Apte RN, Cohen S.

Biomaterials. 2011 Jan;32(1):152-61. doi: 10.1016/j.biomaterials.2010.09.014. Epub 2010 Oct 14.

PMID:
20889205
50.

IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.

Voronov E, Dotan S, Gayvoronsky L, White RM, Cohen I, Krelin Y, Benchetrit F, Elkabets M, Huszar M, El-On J, Apte RN.

Int Immunol. 2010 Apr;22(4):245-57. doi: 10.1093/intimm/dxq006. Epub 2010 Feb 24.

PMID:
20181656

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