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Items: 42

1.

Gaining ligand selectivity in thyroid hormone receptors via entropy.

Martínez L, Nascimento AS, Nunes FM, Phillips K, Aparicio R, Dias SM, Figueira AC, Lin JH, Nguyen P, Apriletti JW, Neves FA, Baxter JD, Webb P, Skaf MS, Polikarpov I.

Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20717-22. doi: 10.1073/pnas.0911024106. Epub 2009 Nov 19.

2.

Differential effects of TR ligands on hormone dissociation rates: evidence for multiple ligand entry/exit pathways.

Cunha Lima ST, Nguyen NH, Togashi M, Apriletti JW, Nguyen P, Polikarpov I, Scanlan TS, Baxter JD, Webb P.

J Steroid Biochem Mol Biol. 2009 Nov;117(4-5):125-31. doi: 10.1016/j.jsbmb.2009.08.003. Epub 2009 Sep 1.

3.

Human thyroid receptor forms tetramers in solution, which dissociate into dimers upon ligand binding.

Figueira AC, Dias SM, Santos MA, Apriletti JW, Baxter JD, Webb P, Neves FA, Simeoni LA, Ribeiro RC, Polikarpov I.

Cell Biochem Biophys. 2006;44(3):453-62.

PMID:
16679533
4.

Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists.

Nguyen NH, Apriletti JW, Baxter JD, Scanlan TS.

J Am Chem Soc. 2005 Apr 6;127(13):4599-608.

PMID:
15796525
5.

Thyroxine-thyroid hormone receptor interactions.

Sandler B, Webb P, Apriletti JW, Huber BR, Togashi M, Cunha Lima ST, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD.

J Biol Chem. 2004 Dec 31;279(53):55801-8. Epub 2004 Oct 4.

6.

Towards selectively modulating mineralocorticoid receptor function: lessons from other systems.

Baxter JD, Funder JW, Apriletti JW, Webb P.

Mol Cell Endocrinol. 2004 Mar 31;217(1-2):151-65. Review.

PMID:
15134814
7.

Structural determinants of selective thyromimetics.

Yoshihara HA, Apriletti JW, Baxter JD, Scanlan TS.

J Med Chem. 2003 Jul 3;46(14):3152-61.

PMID:
12825953
8.

Design of thyroid hormone receptor antagonists from first principles.

Webb P, Nguyen NH, Chiellini G, Yoshihara HA, Cunha Lima ST, Apriletti JW, Ribeiro RC, Marimuthu A, West BL, Goede P, Mellstrom K, Nilsson S, Kushner PJ, Fletterick RJ, Scanlan TS, Baxter JD.

J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):59-73. Review.

PMID:
12650702
9.

Two resistance to thyroid hormone mutants with impaired hormone binding.

Huber BR, Sandler B, West BL, Cunha Lima ST, Nguyen HT, Apriletti JW, Baxter JD, Fletterick RJ.

Mol Endocrinol. 2003 Apr;17(4):643-52. Epub 2003 Jan 16.

PMID:
12554782
10.

Low resolution structures of the retinoid X receptor DNA-binding and ligand-binding domains revealed by synchrotron X-ray solution scattering.

Fischer H, Dias SM, Santos MA, Alves AC, Zanchin N, Craievich AF, Apriletti JW, Baxter JD, Webb P, Neves FA, Ribeiro RC, Polikarpov I.

J Biol Chem. 2003 May 2;278(18):16030-8. Epub 2003 Jan 17.

11.

Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.

Nguyen NH, Apriletti JW, Cunha Lima ST, Webb P, Baxter JD, Scanlan TS.

J Med Chem. 2002 Jul 18;45(15):3310-20.

PMID:
12109914
12.

Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist.

Baxter JD, Goede P, Apriletti JW, West BL, Feng W, Mellstrom K, Fletterick RJ, Wagner RL, Kushner PJ, Ribeiro RC, Webb P, Scanlan TS, Nilsson S.

Endocrinology. 2002 Feb;143(2):517-24.

PMID:
11796506
13.

Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives.

Chiellini G, Nguyen NH, Apriletti JW, Baxter JD, Scanlan TS.

Bioorg Med Chem. 2002 Feb;10(2):333-46.

PMID:
11741782
14.

A designed antagonist of the thyroid hormone receptor.

Yoshihara HA, Apriletti JW, Baxter JD, Scanlan TS.

Bioorg Med Chem Lett. 2001 Nov 5;11(21):2821-5.

PMID:
11597408
15.

Selective modulation of thyroid hormone receptor action.

Baxter JD, Dillmann WH, West BL, Huber R, Furlow JD, Fletterick RJ, Webb P, Apriletti JW, Scanlan TS.

J Steroid Biochem Mol Biol. 2001 Jan-Mar;76(1-5):31-42. Review.

PMID:
11384861
16.

Hormone selectivity in thyroid hormone receptors.

Wagner RL, Huber BR, Shiau AK, Kelly A, Cunha Lima ST, Scanlan TS, Apriletti JW, Baxter JD, West BL, Fletterick RJ.

Mol Endocrinol. 2001 Mar;15(3):398-410.

PMID:
11222741
17.

Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor.

Ribeiro RC, Feng W, Wagner RL, Costa CH, Pereira AC, Apriletti JW, Fletterick RJ, Baxter JD.

J Biol Chem. 2001 May 4;276(18):14987-95. Epub 2001 Jan 5.

18.

Molecular and structural biology of thyroid hormone receptors.

Apriletti JW, Ribeiro RC, Wagner RL, Feng W, Webb P, Kushner PJ, West BL, Nilsson S, Scanlan TS, Fletterick RJ, Baxter JD.

Clin Exp Pharmacol Physiol Suppl. 1998 Nov;25:S2-11. Review.

PMID:
9809185
19.

Structure and specificity of nuclear receptor-coactivator interactions.

Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR.

Genes Dev. 1998 Nov 1;12(21):3343-56.

20.

Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies.

Ribeiro RC, Apriletti JW, Wagner RL, West BL, Feng W, Huber R, Kushner PJ, Nilsson S, Scanlan T, Fletterick RJ, Schaufele F, Baxter JD.

Recent Prog Horm Res. 1998;53:351-92; discussion 392-4. Review.

PMID:
9769715
21.

X-ray crystallographic and functional studies of thyroid hormone receptor.

Ribeiro RC, Apriletti JW, Wagner RL, Feng W, Kushner PJ, Nilsson S, Scanlan TS, West BL, Fletterick RJ, Baxter JD.

J Steroid Biochem Mol Biol. 1998 Apr;65(1-6):133-41. Review.

PMID:
9699866
22.

A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor.

Chiellini G, Apriletti JW, Yoshihara HA, Baxter JD, Ribeiro RC, Scanlan TS.

Chem Biol. 1998 Jun;5(6):299-306.

23.

Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors.

Feng W, Ribeiro RC, Wagner RL, Nguyen H, Apriletti JW, Fletterick RJ, Baxter JD, Kushner PJ, West BL.

Science. 1998 Jun 12;280(5370):1747-9.

24.

Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.

Saatcioglu F, Lopez G, West BL, Zandi E, Feng W, Lu H, Esmaili A, Apriletti JW, Kushner PJ, Baxter JD, Karin M.

Mol Cell Biol. 1997 Aug;17(8):4687-95.

25.

A structural role for hormone in the thyroid hormone receptor.

Wagner RL, Apriletti JW, McGrath ME, West BL, Baxter JD, Fletterick RJ.

Nature. 1995 Dec 14;378(6558):690-7.

PMID:
7501015
26.

The molecular biology of thyroid hormone action.

Ribeiro RC, Apriletti JW, West BL, Wagner RL, Fletterick RJ, Schaufele F, Baxter JD.

Ann N Y Acad Sci. 1995 Jun 30;758:366-89. Review. No abstract available.

PMID:
7625705
28.

Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor.

Ribeiro RC, Apriletti JW, Yen PM, Chin WW, Baxter JD.

Endocrinology. 1994 Nov;135(5):2076-85.

PMID:
7956930
30.

Preliminary crystallographic studies of the ligand-binding domain of the thyroid hormone receptor complexed with triiodothyronine.

McGrath ME, Wagner RL, Apriletti JW, West BL, Ramalingam V, Baxter JD, Fletterick RJ.

J Mol Biol. 1994 Mar 25;237(2):236-9. Review.

PMID:
8126736
31.

Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation.

Yen PM, Brubaker JH, Apriletti JW, Baxter JD, Chin WW.

Endocrinology. 1994 Mar;134(3):1075-81.

PMID:
8119145
32.

Phosphorylation selectively increases triiodothyronine receptor homodimer binding to DNA.

Sugawara A, Yen PM, Apriletti JW, Ribeiro RC, Sacks DB, Baxter JD, Chin WW.

J Biol Chem. 1994 Jan 7;269(1):433-7.

33.

Thyroid hormone alters in vitro DNA binding of monomers and dimers of thyroid hormone receptors.

Ribeiro RC, Kushner PJ, Apriletti JW, West BL, Baxter JD.

Mol Endocrinol. 1992 Jul;6(7):1142-52.

PMID:
1508227
34.
35.

Interactions of the nuclear thyroid hormone receptor with core histones.

Apriletti JW, David-Inouye Y, Eberhardt NL, Baxter JD.

J Biol Chem. 1984 Sep 10;259(17):10941-8.

36.

Photoaffinity labelling of the rat liver nuclear thyroid hormone receptor with [125I]triiodothyronine.

David-Inouye Y, Somack R, Nordeen SK, Apriletti JW, Baxter JD, Eberhardt NL.

Endocrinology. 1982 Nov;111(5):1758-60.

PMID:
6290199
37.

Affinity chromatography of thyroid hormone receptors. Biospecific elution from support matrices, characterization of the partially purified receptor.

Apriletti JW, Eberhardt NL, Latham KR, Baxter JD.

J Biol Chem. 1981 Dec 10;256(23):12094-101. No abstract available.

38.

Development of support matrices for affinity chromatography of thyroid hormone receptors.

Latham KR, Apriletti JW, Eberhardt NL, Baxter JD.

J Biol Chem. 1981 Dec 10;256(23):12088-93.

39.

Regulation of activity of chromatin receptors for thyroid hormone: possible involvement of histone-like proteins.

Eberhardt NL, Ring JC, Johnson LK, Latham KR, Apriletti JW, Kitsis RN, Baxter JD.

Proc Natl Acad Sci U S A. 1979 Oct;76(10):5005-9.

40.

Thyroid hormone receptors and responses.

Baxter JD, Eberhardt NL, Apriletti JW, Johnson LK, Ivarie RD, Schachter BS, Morris JA, Seeburg PH, Goodman HM, Latham KR, Polansky JR, Martial JA.

Recent Prog Horm Res. 1979;35:97-153. Review. No abstract available.

PMID:
229530
41.

Cellular RNA synthesis in normal and mengovirus-infected L-929 cells.

Apriletti JW, Penhoet EE.

J Biol Chem. 1978 Jan 25;253(2):603-11.

42.

Recovery of DNA-dependent RNA polymerase activities from L cells after mengovirus infection.

Apriletti JW, Penhoet EE.

Virology. 1974 Oct;61(2):597-601. No abstract available.

PMID:
4371761

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