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Items: 1 to 50 of 54

1.

Triggering of Toll-like Receptors in Old Individuals. Relevance for Vaccination.

Zareian N, Aprile S, Cristaldi L, Ligotti ME, Vasto S, Farzaneh F.

Curr Pharm Des. 2019 Nov 11. doi: 10.2174/1381612825666191111155800. [Epub ahead of print]

PMID:
31713478
2.

Soft drugs for dermatological applications: recent trends.

Aprile S, Serafini M, Pirali T.

Drug Discov Today. 2019 Sep 5. pii: S1359-6446(19)30335-6. doi: 10.1016/j.drudis.2019.08.007. [Epub ahead of print] Review.

PMID:
31494188
3.

Novel "Matrix-Corrected Calibration" study for the detection of polyunsaturated fatty acids (PUFAs) in plasma and erythrocytes by means of a gas chromatography-mass spectrometry approach optimized to follow up long-term parental patients.

Manca A, Alladio E, Casalini V, Puccinelli MP, Massarenti P, Pazzi M, Aprile S, De Francesco A, Mengozzi G, D'Avolio A.

J Pharm Biomed Anal. 2019 Nov 30;176:112764. doi: 10.1016/j.jpba.2019.07.012. Epub 2019 Jul 24.

PMID:
31401460
4.

Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group.

Travelli C, Aprile S, Mattoteia D, Colombo G, Clemente N, Scanziani E, Terrazzino S, Alisi MA, Polenzani L, Grosa G, Genazzani AA, Tron GC, Galli U.

Eur J Med Chem. 2019 Nov 1;181:111576. doi: 10.1016/j.ejmech.2019.111576. Epub 2019 Aug 1.

PMID:
31400709
5.

Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors.

Serafini M, Torre E, Aprile S, Massarotti A, Fallarini S, Pirali T.

Molecules. 2019 May 15;24(10). pii: E1874. doi: 10.3390/molecules24101874.

6.

Genotypic and Phenotypic Aspects of Longevity: Results from a Sicilian Survey and Implication for the Prevention and Treatment of Age-related Diseases.

Accardi G, Aprile S, Candore G, Caruso C, Cusimano R, Cristaldi L, Di Bona D, Duro G, Galimberti D, Gambino CM, Ligotti ME, Mazzucco W, Vasto S, Aiello A.

Curr Pharm Des. 2019;25(3):228-235. doi: 10.2174/1381612825666190313115233.

PMID:
30864497
7.

The signature of longevity in Sicily.

4° JOINT MEETING OF PATHOLOGY AND LABORATORY MEDICINE SIPMET–SIPMEL - SECOND JOINT MEETING IN COLLABORATION WITH ASIP–AMP–UEMS–WASPALM - 4° SIPMEL NATIONAL CONGRESS - 34° SIPMET NATIONAL CONGRESS - 4° CONGRESS OF PATHOLOGY AND LABORATORY MEDICINE, Accardi G, Scola L, Aiello A, Aprile S, Bulati M, Candore G, Caruso C, Cristaldi L, Duro G, Gambino CM, Ligotti ME, Vasto S.

J Biol Regul Homeost Agents. 2018 Jul-Aug;32(4 Suppl. 1):9-13. No abstract available.

PMID:
30761861
8.

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.

Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E.

Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6.

9.

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis.

Riva B, Griglio A, Serafini M, Cordero-Sanchez C, Aprile S, Di Paola R, Gugliandolo E, Alansary D, Biocotino I, Lim D, Grosa G, Galli U, Niemeyer B, Sorba G, Canonico PL, Cuzzocrea S, Genazzani AA, Pirali T.

J Med Chem. 2018 Nov 8;61(21):9756-9783. doi: 10.1021/acs.jmedchem.8b01512. Epub 2018 Oct 30.

PMID:
30347159
10.

Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders.

Serafini M, Griglio A, Aprile S, Seiti F, Travelli C, Pattarino F, Grosa G, Sorba G, Genazzani AA, Gonzalez-Rodriguez S, Butron L, Devesa I, Fernandez-Carvajal A, Pirali T, Ferrer-Montiel A.

J Med Chem. 2018 May 24;61(10):4436-4455. doi: 10.1021/acs.jmedchem.8b00109. Epub 2018 May 15.

PMID:
29722529
11.

Sicilian centenarian offspring are more resistant to immune ageing.

Rubino G, Bulati M, Aiello A, Aprile S, Gambino CM, Gervasi F, Caruso C, Accardi G.

Aging Clin Exp Res. 2019 Jan;31(1):125-133. doi: 10.1007/s40520-018-0936-7. Epub 2018 Mar 28.

PMID:
29594822
12.

Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects.

Bianchi M, Canavesi R, Aprile S, Grosa G, Del Grosso E.

J Pharm Biomed Anal. 2018 Feb 20;150:248-257. doi: 10.1016/j.jpba.2017.12.018. Epub 2017 Dec 9.

PMID:
29258044
13.

Biological effects of combined resveratrol and vitamin D3 on ovarian tissue.

Uberti F, Morsanuto V, Aprile S, Ghirlanda S, Stoppa I, Cochis A, Grosa G, Rimondini L, Molinari C.

J Ovarian Res. 2017 Sep 15;10(1):61. doi: 10.1186/s13048-017-0357-9.

14.

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC.

ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31.

15.

An aryne-based three-component access to α-aroylamino amides.

Serafini M, Griglio A, Viarengo S, Aprile S, Pirali T.

Org Biomol Chem. 2017 Aug 9;15(31):6604-6612. doi: 10.1039/c7ob01715d.

PMID:
28752162
16.

New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone.

Aprile S, Canavesi R, Matucci R, Bellucci C, Del Grosso E, Grosa G.

Xenobiotica. 2018 May;48(5):478-487. doi: 10.1080/00498254.2017.1342288. Epub 2017 Jul 6.

PMID:
28608746
17.

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

Travelli C, Aprile S, Rahimian R, Grolla AA, Rogati F, Bertolotti M, Malagnino F, di Paola R, Impellizzeri D, Fusco R, Mercalli V, Massarotti A, Stortini G, Terrazzino S, Del Grosso E, Fakhfouri G, Troiani MP, Alisi MA, Grosa G, Sorba G, Canonico PL, Orsomando G, Cuzzocrea S, Genazzani AA, Galli U, Tron GC.

J Med Chem. 2017 Mar 9;60(5):1768-1792. doi: 10.1021/acs.jmedchem.6b01392. Epub 2017 Feb 22.

PMID:
28165742
18.

Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products.

Aprile S, Canavesi R, Bianchi M, Grosa G, Del Grosso E.

J Pharm Biomed Anal. 2017 Jan 5;132:66-71. doi: 10.1016/j.jpba.2016.09.037. Epub 2016 Sep 26.

PMID:
27697571
19.

Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α'-Disubstituted α-Isocyanoacetamides.

Gesù A, Pozzoli C, Torre E, Aprile S, Pirali T.

Org Lett. 2016 May 6;18(9):1992-5. doi: 10.1021/acs.orglett.6b00580. Epub 2016 Apr 8.

PMID:
27057924
20.

New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement.

Canavesi R, Aprile S, Giovenzana GB, Di Sotto A, Di Giacomo S, Del Grosso E, Grosa G.

Eur J Pharm Sci. 2016 Mar 10;84:123-31. doi: 10.1016/j.ejps.2016.01.015. Epub 2016 Jan 18.

PMID:
26796144
21.

High adherence to malaria treatment: promising results of an adherence study in South Kivu, Democratic Republic of the Congo.

Gerstl S, Namagana A, Palacios L, Mweshi F, Aprile S, Lima A.

Malar J. 2015 Oct 19;14:414. doi: 10.1186/s12936-015-0933-7.

22.

Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents.

Galli U, Travelli C, Aprile S, Arrigoni E, Torretta S, Grosa G, Massarotti A, Sorba G, Canonico PL, Genazzani AA, Tron GC.

J Med Chem. 2015 Feb 12;58(3):1345-57. doi: 10.1021/jm5016389. Epub 2015 Jan 27.

PMID:
25584687
23.

Are 1,4- and 1,5-disubstituted 1,2,3-triazoles good pharmacophoric groups?

Massarotti A, Aprile S, Mercalli V, Del Grosso E, Grosa G, Sorba G, Tron GC.

ChemMedChem. 2014 Nov;9(11):2497-508. doi: 10.1002/cmdc.201402233. Epub 2014 Jul 30.

PMID:
25079879
24.

Development and validation of a stability-indicating LC-UV method for the determination of pantethine and its degradation product based on a forced degradation study.

Canavesi R, Aprile S, Varese E, Grosa G.

J Pharm Biomed Anal. 2014 Aug;97:141-50. doi: 10.1016/j.jpba.2014.04.025. Epub 2014 May 2.

PMID:
24863372
25.

Type D personality in never depressed patients at their first acute coronary syndrome.

Marchesi C, Ossola P, Scagnelli F, Paglia F, Aprile S, Monici A, Tonna M, Conte G, Masini F, De Panfilis C, Ardissino D.

Psychother Psychosom. 2014;83(3):190-1. doi: 10.1159/000358525. Epub 2014 Apr 17. No abstract available.

PMID:
24752175
26.

Type D personality in never-depressed patients and the development of major and minor depression after acute coronary syndrome.

Marchesi C, Ossola P, Scagnelli F, Paglia F, Aprile S, Monici A, Tonna M, Conte G, Masini F, De Panfilis C, Ardissino D.

J Affect Disord. 2014 Feb;155:194-9. doi: 10.1016/j.jad.2013.10.052. Epub 2013 Nov 7.

PMID:
24274964
27.

Poly-L-lactide acid-modified scaffolds for osteoinduction and osteoconduction.

Bosetti M, Fusaro L, Nicolì E, Borrone A, Aprile S, Cannas M.

J Biomed Mater Res A. 2014 Oct;102(10):3531-9. doi: 10.1002/jbm.a.35016. Epub 2013 Nov 16.

PMID:
24178410
28.

Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites.

Aprile S, Zaninetti R, Del Grosso E, Genazzani AA, Grosa G.

J Pharm Biomed Anal. 2013 May 5;78-79:233-42. doi: 10.1016/j.jpba.2013.02.030. Epub 2013 Feb 27.

PMID:
23501444
29.

A concise synthesis of pyrazole analogues of combretastatin A1 as potent anti-tubulin agents.

Zaninetti R, Cortese SV, Aprile S, Massarotti A, Canonico PL, Sorba G, Grosa G, Genazzani AA, Pirali T.

ChemMedChem. 2013 Apr;8(4):633-43. doi: 10.1002/cmdc.201200561. Epub 2013 Feb 21.

PMID:
23436706
30.

In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry.

Aprile S, Del Grosso E, Grosa G.

J Mass Spectrom. 2012 Jun;47(6):737-50. doi: 10.1002/jms.3011.

PMID:
22707166
31.

Clinical characteristics of Becker's nevus in children: report of 118 cases from Italy.

Patrizi A, Medri M, Raone B, Bianchi F, Aprile S, Neri I.

Pediatr Dermatol. 2012 Sep-Oct;29(5):571-4. doi: 10.1111/j.1525-1470.2012.01734.x. Epub 2012 Apr 4.

PMID:
22471889
32.

Management of chronic heart failure: Role of home echocardiography in monitoring care programs.

Soreca S, Aprile S, Cardone A, Carella G, Fimiani B, Guarnaccia F, Santoro G, Apuzzi V, Bosso G, Valvano A, Zito G, Oliviero U.

World J Cardiol. 2012 Mar 26;4(3):72-6. doi: 10.4330/wjc.v4.i3.72.

33.

The metabolic fate of isocombretastatin A-4 in human liver microsomes: identification, synthesis and biological evaluation of metabolites.

Soussi MA, Aprile S, Messaoudi S, Provot O, Del Grosso E, Bignon J, Dubois J, Brion JD, Grosa G, Alami M.

ChemMedChem. 2011 Oct 4;6(10):1781-8. doi: 10.1002/cmdc.201100193. Epub 2011 Jul 11. No abstract available.

PMID:
21748852
34.

Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.

Theeramunkong S, Caldarelli A, Massarotti A, Aprile S, Caprioglio D, Zaninetti R, Teruggi A, Pirali T, Grosa G, Tron GC, Genazzani AA.

J Med Chem. 2011 Jul 28;54(14):4977-86. doi: 10.1021/jm200555r. Epub 2011 Jun 30.

PMID:
21696175
35.

In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite.

Aprile S, Del Grosso E, Grosa G.

Xenobiotica. 2011 Mar;41(3):212-25. doi: 10.3109/00498254.2010.532887. Epub 2010 Nov 18.

PMID:
21087117
36.

Defense mechanisms and symptom severity in panic disorder.

Fario M, Aprile S, Cabrino C, Maggini C, Marchesi C.

Acta Biomed. 2010 Dec;81(1):30-4.

PMID:
20857850
37.

Defense style in panic disorder before and after pharmacological treatment.

Marchesi C, Parenti P, Aprile S, Cabrino C, De Panfilis C.

Psychiatry Res. 2011 May 30;187(3):382-6. doi: 10.1016/j.psychres.2010.07.001. Epub 2010 Aug 9.

PMID:
20692044
38.

Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4.

Aprile S, Del Grosso E, Grosa G.

Drug Metab Dispos. 2010 Jul;38(7):1141-6. doi: 10.1124/dmd.109.031435. Epub 2010 Apr 7.

PMID:
20375181
39.

Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products.

Tamaro I, Aprile S, Giovenzana GB, Grosa G.

J Pharm Biomed Anal. 2010 Apr 6;51(5):1024-31. doi: 10.1016/j.jpba.2009.10.026. Epub 2009 Nov 6.

PMID:
19962264
40.

Usefulness of dermatoscopy for the early diagnosis of sebaceous naevus and differentiation from aplasia cutis congenita.

Neri I, Savoia F, Giacomini F, Raone B, Aprile S, Patrizi A.

Clin Exp Dermatol. 2009 Jul;34(5):e50-2. doi: 10.1111/j.1365-2230.2008.03189.x. Epub 2009 May 5.

PMID:
19438569
41.

In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite.

Aprile S, Del Grosso E, Grosa G.

Xenobiotica. 2009 Feb;39(2):148-61. doi: 10.1080/00498250802566976.

PMID:
19255941
42.

Personality and attrition from behavioral weight-loss treatment for obesity.

De Panfilis C, Torre M, Cero S, Salvatore P, Dall'Aglio E, Marchesi C, Cabrino C, Aprile S, Maggini C.

Gen Hosp Psychiatry. 2008 Nov-Dec;30(6):515-20. doi: 10.1016/j.genhosppsych.2008.06.003. Epub 2008 Aug 3.

PMID:
19061677
43.

In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes.

Aprile S, Del Grosso E, Tron GC, Grosa G.

Drug Metab Dispos. 2007 Dec;35(12):2252-61. Epub 2007 Sep 21.

PMID:
17890446
44.

[2-dimensional echocardiography in infarct of the right ventricle: correlation with clinical, hemodynamic and scintigraphic findings].

Barretta G, Aprile S, Greco R, Severino S, Siciliano S, Mininni N, Gentile F.

G Ital Cardiol. 1987 May;17(5):426-36. Italian.

PMID:
3653601
45.
46.

[Report of the activities of the Centro Sperimentale di Assistenza Integrale Antitubercolare di Napoli from September, 1950, to June 30, 1959].

APRILE S.

Arch Tisiol Mal Appar Respir. 1960 Apr;15:295-9. Italian. No abstract available.

PMID:
13683914
47.

[Clinical statistics and results of mass photofluorographic studies performed at the Experimental Center in 5 years].

APRILE S, MARRA A, DELLI VENERI F.

Arch Tisiol Mal Appar Respir. 1956 Nov;11(11):828-44. Italian. No abstract available.

PMID:
13412374
48.

[An experiment with mass screening in a large urban center].

APRILE S, DELLI VENERI F, MARRA A.

Arch Tisiol Mal Appar Respir. 1956 Apr;11(4):276-83. Italian. No abstract available.

PMID:
13355579
49.

[Exogenous reinfection based on data from a section of the city of Naples].

APRILE S, MARRA A, DELLI VENERI F.

Arch Tisiol Mal Appar Respir. 1956 Jan;11(1):77-84. Italian. No abstract available.

PMID:
13341493
50.

[Antituberculosis sanatorial assistance at the Prince of Piemont Institute and at Tuberculosis Clinic of the University of Napoli].

MONALDI V, MARCONI P, APRILE S, DELLI VENERI F.

Lotta Tuberc. 1953 Dec;23(12):993-1007. Undetermined Language. No abstract available.

PMID:
13153287

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