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Items: 21


Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides.

Iwamoto N, Butler DCD, Svrzikapa N, Mohapatra S, Zlatev I, Sah DWY, Meena, Standley SM, Lu G, Apponi LH, Frank-Kamenetsky M, Zhang JJ, Vargeese C, Verdine GL.

Nat Biotechnol. 2017 Sep;35(9):845-851. doi: 10.1038/nbt.3948. Epub 2017 Aug 21.


Novel mouse models of oculopharyngeal muscular dystrophy (OPMD) reveal early onset mitochondrial defects and suggest loss of PABPN1 may contribute to pathology.

Vest KE, Phillips BL, Banerjee A, Apponi LH, Dammer EB, Xu W, Zheng D, Yu J, Tian B, Pavlath GK, Corbett AH.

Hum Mol Genet. 2017 Sep 1;26(17):3235-3252. doi: 10.1093/hmg/ddx206.


An Antibody to Detect Alanine-Expanded PABPN1: A New Tool to Study Oculopharyngeal Muscular Dystrophy.

Vest KE, Apponi LH, Banerjee A, Pavlath GK, Corbett AH.

J Neuromuscul Dis. 2015 Oct 20;2(4):439-446.


Creatine kinase B is necessary to limit myoblast fusion during myogenesis.

Simionescu-Bankston A, Pichavant C, Canner JP, Apponi LH, Wang Y, Steeds C, Olthoff JT, Belanto JJ, Ervasti JM, Pavlath GK.

Am J Physiol Cell Physiol. 2015 Jun 1;308(11):C919-31. doi: 10.1152/ajpcell.00029.2015. Epub 2015 Mar 25.


Control of mRNA stability contributes to low levels of nuclear poly(A) binding protein 1 (PABPN1) in skeletal muscle.

Apponi LH, Corbett AH, Pavlath GK.

Skelet Muscle. 2013 Oct 1;3(1):23. doi: 10.1186/2044-5040-3-23.


PABPN1: molecular function and muscle disease.

Banerjee A, Apponi LH, Pavlath GK, Corbett AH.

FEBS J. 2013 Sep;280(17):4230-50. doi: 10.1111/febs.12294. Epub 2013 May 24. Review.


Expression of interferon-γ, interferon-α and related genes in individuals with Down syndrome and periodontitis.

Tanaka MH, Giro EM, Cavalcante LB, Pires JR, Apponi LH, Valentini SR, Spolidório DM, Capela MV, Rossa C Jr, Scarel-Caminaga RM.

Cytokine. 2012 Dec;60(3):875-81. doi: 10.1016/j.cyto.2012.08.020. Epub 2012 Sep 18.


Expression of the interleukin-10 signaling pathway genes in individuals with Down syndrome and periodontitis.

Cavalcante LB, Tanaka MH, Pires JR, Apponi LH, Aparecida Giro EM, Valentini SR, Palomari Spolidório DM, Capela MV, Rossa C Jr, Scarel-Caminaga RM.

J Periodontol. 2012 Jul;83(7):926-35. doi: 10.1902/jop.2011.110056. Epub 2011 Nov 3.


RNA-binding proteins and gene regulation in myogenesis.

Apponi LH, Corbett AH, Pavlath GK.

Trends Pharmacol Sci. 2011 Nov;32(11):652-8. doi: 10.1016/ Epub 2011 Oct 6. Review.


Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans.

Pak C, Garshasbi M, Kahrizi K, Gross C, Apponi LH, Noto JJ, Kelly SM, Leung SW, Tzschach A, Behjati F, Abedini SS, Mohseni M, Jensen LR, Hu H, Huang B, Stahley SN, Liu G, Williams KR, Burdick S, Feng Y, Sanyal S, Bassell GJ, Ropers HH, Najmabadi H, Corbett AH, Moberg KH, Kuss AW.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12390-5. doi: 10.1073/pnas.1107103108. Epub 2011 Jul 6.


The mitogen-activated protein kinase Slt2 regulates nuclear retention of non-heat shock mRNAs during heat shock-induced stress.

Carmody SR, Tran EJ, Apponi LH, Corbett AH, Wente SR.

Mol Cell Biol. 2010 Nov;30(21):5168-79. doi: 10.1128/MCB.00735-10. Epub 2010 Sep 7.


Chemokine expression and control of muscle cell migration during myogenesis.

Griffin CA, Apponi LH, Long KK, Pavlath GK.

J Cell Sci. 2010 Sep 15;123(Pt 18):3052-60. doi: 10.1242/jcs.066241. Epub 2010 Aug 24.


Recognition of polyadenosine RNA by the zinc finger domain of nuclear poly(A) RNA-binding protein 2 (Nab2) is required for correct mRNA 3'-end formation.

Kelly SM, Leung SW, Apponi LH, Bramley AM, Tran EJ, Chekanova JA, Wente SR, Corbett AH.

J Biol Chem. 2010 Aug 20;285(34):26022-32. doi: 10.1074/jbc.M110.141127. Epub 2010 Jun 16.


Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis.

Apponi LH, Leung SW, Williams KR, Valentini SR, Corbett AH, Pavlath GK.

Hum Mol Genet. 2010 Mar 15;19(6):1058-65. doi: 10.1093/hmg/ddp569. Epub 2009 Dec 24.


Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein.

Leung SW, Apponi LH, Cornejo OE, Kitchen CM, Valentini SR, Pavlath GK, Dunham CM, Corbett AH.

Gene. 2009 Jun 15;439(1-2):71-8. doi: 10.1016/j.gene.2009.02.022. Epub 2009 Mar 18.


Expression and purification of human respiratory syncytial virus recombinant fusion protein.

Arcuri HA, Apponi LH, Valentini SR, Durigon EL, de Azevedo WF Jr, Fossey MA, Rahal P, de Souza FP.

Protein Expr Purif. 2008 Dec;62(2):146-52. doi: 10.1016/j.pep.2008.08.005. Epub 2008 Aug 26.


Synthetic lethality between eIF5A and Ypt1 reveals a connection between translation and the secretory pathway in yeast.

Frigieri MC, João Luiz MV, Apponi LH, Zanelli CF, Valentini SR.

Mol Genet Genomics. 2008 Sep;280(3):211-21. doi: 10.1007/s00438-008-0357-y. Epub 2008 Jun 21.


Structural modeling and mutational analysis of yeast eukaryotic translation initiation factor 5A reveal new critical residues and reinforce its involvement in protein synthesis.

Dias CA, Cano VS, Rangel SM, Apponi LH, Frigieri MC, Muniz JR, Garcia W, Park MH, Garratt RC, Zanelli CF, Valentini SR.

FEBS J. 2008 Apr;275(8):1874-88. doi: 10.1111/j.1742-4658.2008.06345.x. Epub 2008 Mar 13.


An interaction between two RNA binding proteins, Nab2 and Pub1, links mRNA processing/export and mRNA stability.

Apponi LH, Kelly SM, Harreman MT, Lehner AN, Corbett AH, Valentini SR.

Mol Cell Biol. 2007 Sep;27(18):6569-79. Epub 2007 Jul 16.


Actively transcribed GAL genes can be physically linked to the nuclear pore by the SAGA chromatin modifying complex.

Luthra R, Kerr SC, Harreman MT, Apponi LH, Fasken MB, Ramineni S, Chaurasia S, Valentini SR, Corbett AH.

J Biol Chem. 2007 Feb 2;282(5):3042-9. Epub 2006 Dec 6.


Expression, purification, and circular dichroism analysis of human CDK9.

Leopoldino AM, Canduri F, Cabral H, Junqueira M, de Marqui AB, Apponi LH, da Fonseca IO, Domont GB, Santos DS, Valentini S, Bonilla-Rodriguez GO, Fossey MA, de Azevedo WF Jr, Tajara EH.

Protein Expr Purif. 2006 Jun;47(2):614-20. Epub 2006 Mar 10.


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