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Items: 14


Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle.

Hadad SM, Hardie DG, Appleyard V, Thompson AM.

Clin Transl Oncol. 2014 Aug;16(8):746-52. doi: 10.1007/s12094-013-1144-8. Epub 2013 Dec 12.


Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.

MacCallum SF, Groves MJ, James J, Murray K, Appleyard V, Prescott AR, Drbal AA, Nicolaou A, Cunningham J, Haydock S, Ganley IG, Westwood NJ, Coates PJ, Lain S, Tauro S.

Sci Rep. 2013;3:1275. doi: 10.1038/srep01275.


Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: a light-activated antitumor platinum complex that kills human cancer cells by an apoptosis-independent mechanism.

Westendorf AF, Woods JA, Korpis K, Farrer NJ, Salassa L, Robinson K, Appleyard V, Murray K, Grünert R, Thompson AM, Sadler PJ, Bednarski PJ.

Mol Cancer Ther. 2012 Sep;11(9):1894-904. doi: 10.1158/1535-7163.MCT-11-0959. Epub 2012 Jun 18.


Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma.

Watt SA, Pourreyron C, Purdie K, Hogan C, Cole CL, Foster N, Pratt N, Bourdon JC, Appleyard V, Murray K, Thompson AM, Mao X, Mein C, Bruckner-Tuderman L, Evans A, McGrath JA, Proby CM, Foerster J, Leigh IM, South AP.

Oncogene. 2011 Nov 17;30(46):4666-77. doi: 10.1038/onc.2011.180. Epub 2011 May 23.


Detection of oesophageal cancer biomarkers by plasma proteomic profiling of human cell line xenografts in response to chemotherapy.

Kelly P, Appleyard V, Murray K, Paulin F, Lamont D, Baker L, Suttie S, Exon D, Thompson A.

Br J Cancer. 2010 Jul 13;103(2):232-8. doi: 10.1038/sj.bjc.6605741. Epub 2010 Jun 15.


Does usnic acid affect microtubules in human cancer cells?

O'Neill MA, Mayer M, Murray KE, Rolim-Santos HM, Santos-Magalhães NS, Thompson AM, Appleyard VC.

Braz J Biol. 2010 Aug;70(3):659-64. Epub 2010 Apr 2.


Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen.

Staples OD, Hollick JJ, Campbell J, Higgins M, McCarthy AR, Appleyard V, Murray KE, Baker L, Thompson A, Ronseaux S, Slawin AM, Lane DP, Westwood NJ, Lain S.

Cell Cycle. 2008 Nov 1;7(21):3417-27. Epub 2008 Nov 15.


Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M, McCarthy A, Appleyard V, Murray KE, Baker L, Thompson A, Mathers J, Holland SJ, Stark MJ, Pass G, Woods J, Lane DP, Westwood NJ.

Cancer Cell. 2008 May;13(5):454-63. doi: 10.1016/j.ccr.2008.03.004.


Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.

Hadad SM, Appleyard V, Thompson AM.

Breast Cancer Res Treat. 2009 Mar;114(2):391. doi: 10.1007/s10549-008-0016-3. Epub 2008 Apr 18. No abstract available.


Thermographic assessment of tumor growth in mouse xenografts.

Song C, Appleyard V, Murray K, Frank T, Sibbett W, Cuschieri A, Thompson A.

Int J Cancer. 2007 Sep 1;121(5):1055-8.


Selective induction of apoptosis by leptomycin B in keratinocytes expressing HPV oncogenes.

Gray LJ, Bjelogrlic P, Appleyard VC, Thompson AM, Jolly CE, Lain S, Herrington CS.

Int J Cancer. 2007 Jun 1;120(11):2317-24.


Usnic acid: a non-genotoxic compound with anti-cancer properties.

Mayer M, O'Neill MA, Murray KE, Santos-Magalhães NS, Carneiro-Leão AM, Thompson AM, Appleyard VC.

Anticancer Drugs. 2005 Sep;16(8):805-9.


Activity of MDI-301, a novel synthetic retinoid, in xenografts.

Appleyard VC, O'Neill MA, Murray KE, Bray SE, Thomson G, Kernohan NM, Varani J, Zhang J, Thompson AM.

Anticancer Drugs. 2004 Nov;15(10):991-6.


Secondary metabolite production in filamentous fungi displayed.

Appleyard VC, Unkles SE, Legg M, Kinghorn JR.

Mol Gen Genet. 1995 May 10;247(3):338-42.


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