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Items: 1 to 50 of 242


Children's views on research without prior consent in emergency situations: a UK qualitative study.

Roper L, Sherratt FC, Young B, McNamara P, Dawson A, Appleton R, Crawley E, Frith L, Gamble C, Woolfall K.

BMJ Open. 2018 Jun 9;8(6):e022894. doi: 10.1136/bmjopen-2018-022894.


Panayiotopoulos syndrome and benign partial epilepsy with centro-temporal spikes: A comparative incidence study.

Weir E, Gibbs J, Appleton R.

Seizure. 2018 Apr;57:66-69. doi: 10.1016/j.seizure.2018.03.002. Epub 2018 Mar 5.


Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.

Devinsky O, Patel AD, Thiele EA, Wong MH, Appleton R, Harden CL, Greenwood S, Morrison G, Sommerville K; GWPCARE1 Part A Study Group.

Neurology. 2018 Apr 3;90(14):e1204-e1211. doi: 10.1212/WNL.0000000000005254. Epub 2018 Mar 14.


Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children.

McTague A, Martland T, Appleton R.

Cochrane Database Syst Rev. 2018 Jan 10;1:CD001905. doi: 10.1002/14651858.CD001905.pub3. Review.


Men don't talk about their health, but will they CHAT? The potential of online holistic needs assessment in prostate cancer.

Nanton V, Appleton R, Loew J, Ahmed N, Ahmedzai S, Dale J.

BJU Int. 2018 Apr;121(4):494-496. doi: 10.1111/bju.14114. Epub 2018 Jan 22. No abstract available.


Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy.

McTague A, Nair U, Malhotra S, Meyer E, Trump N, Gazina EV, Papandreou A, Ngoh A, Ackermann S, Ambegaonkar G, Appleton R, Desurkar A, Eltze C, Kneen R, Kumar AV, Lascelles K, Montgomery T, Ramesh V, Samanta R, Scott RH, Tan J, Whitehouse W, Poduri A, Scheffer IE, Chong WKK, Cross JH, Topf M, Petrou S, Kurian MA.

Neurology. 2018 Jan 2;90(1):e55-e66. doi: 10.1212/WNL.0000000000004762. Epub 2017 Dec 1.


Seizures and Encephalitis in Myelin Oligodendrocyte Glycoprotein IgG Disease vs Aquaporin 4 IgG Disease.

Hamid SHM, Whittam D, Saviour M, Alorainy A, Mutch K, Linaker S, Solomon T, Bhojak M, Woodhall M, Waters P, Appleton R, Duddy M, Jacob A.

JAMA Neurol. 2018 Jan 1;75(1):65-71. doi: 10.1001/jamaneurol.2017.3196.


Seizures, safety and submersion: sense and sensibility.

Appleton RE.

Arch Dis Child. 2017 Oct;102(10):883-884. doi: 10.1136/archdischild-2017-313427. Epub 2017 Aug 17. No abstract available.


Integrated Care in Prostate Cancer (ICARE-P): Nonrandomized Controlled Feasibility Study of Online Holistic Needs Assessment, Linking the Patient and the Health Care Team.

Nanton V, Appleton R, Dale J, Roscoe J, Hamborg T, Ahmedzai SH, Arvanitis TN, Badger D, James N, Mendelsohn R, Khan O, Parashar D, Patel P.

JMIR Res Protoc. 2017 Jul 28;6(7):e147. doi: 10.2196/resprot.7667.


Resource implications of preparing individual participant data from a clinical trial to share with external researchers.

Tudur Smith C, Nevitt S, Appelbe D, Appleton R, Dixon P, Harrison J, Marson A, Williamson P, Tremain E.

Trials. 2017 Jul 17;18(1):319. doi: 10.1186/s13063-017-2067-4.


Emergency treatment with levetiracetam or phenytoin in status epilepticus in children-the EcLiPSE study: study protocol for a randomised controlled trial.

Lyttle MD, Gamble C, Messahel S, Hickey H, Iyer A, Woolfall K, Humphreys A, Bacon NEA, Roper L, Babl FE, Dalziel SR, Ryan M, Appleton RE; supported by Paediatric Emergency Research in the United Kingdom & Ireland (PERUKI).

Trials. 2017 Jun 19;18(1):283. doi: 10.1186/s13063-017-2010-8.


Consensus-based guidelines for Video EEG monitoring in the pre-surgical evaluation of children with epilepsy in the UK.

Pressler RM, Seri S, Kane N, Martland T, Goyal S, Iyer A, Warren E, Notghi L, Bill P, Thornton R, Appleton R, Doyle S, Rushton S, Worley A, Boyd SG; CESS Clinical Neurophysiology working group.

Seizure. 2017 Aug;50:6-11. doi: 10.1016/j.seizure.2017.05.008. Epub 2017 May 12.


Genetic regulation of gene expression in the epileptic human hippocampus.

Mirza N, Appleton R, Burn S, du Plessis D, Duncan R, Farah JO, Feenstra B, Hviid A, Josan V, Mohanraj R, Shukralla A, Sills GJ, Marson AG, Pirmohamed M.

Hum Mol Genet. 2017 May 1;26(9):1759-1769. doi: 10.1093/hmg/ddx061.


Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation.

Wadsworth I, Jaki T, Sills GJ, Appleton R, Cross JH, Marson AG, Martland T, McLellan A, Smith PE, Pellock JM, Hampson LV.

CNS Drugs. 2016 Nov;30(11):1011-1017. Review.


Improving Outcomes in Infantile Spasms: Role of Pharmacotherapy.

Iyer A, Appleton R.

Paediatr Drugs. 2016 Oct;18(5):357-66. doi: 10.1007/s40272-016-0188-y. Review.


An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters.

Mirza N, Vasieva O, Appleton R, Burn S, Carr D, Crooks D, du Plessis D, Duncan R, Farah JO, Josan V, Miyajima F, Mohanraj R, Shukralla A, Sills GJ, Marson AG, Pirmohamed M.

Epilepsia. 2016 Sep;57(9):1467-74. doi: 10.1111/epi.13473. Epub 2016 Jul 16.


Taking part in 'Understanding Your Child's Behaviour' and positive changes for parents.

Appleton R, Douglas H, Rheeston M.

Community Pract. 2016 Feb;89(2):42, 44-8.


Investigations in West Syndrome: Which, When and Why.

Appleton RE.

Pediatr Neurol Briefs. 2015 Jun;29(6):42. doi: 10.15844/pedneurbriefs-29-6-1.


Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder.

Nosadini M, Alper G, Riney CJ, Benson LA, Mohammad SS, Ramanathan S, Nolan M, Appleton R, Leventer RJ, Deiva K, Brilot F, Gorman MP, Waldman AT, Banwell B, Dale RC.

Neurol Neuroimmunol Neuroinflamm. 2016 Jan 21;3(1):e188. doi: 10.1212/NXI.0000000000000188. eCollection 2016 Feb.


Comparing paediatric intravenous phenytoin doses using physiologically based pharmacokinetic (PBPK) modelling software.

Batchelor H, Appleton R, Hawcutt DB.

Seizure. 2015 Dec;33:8-12. doi: 10.1016/j.seizure.2015.10.006. Epub 2015 Oct 17.


Deaths in children with epilepsies: a UK-wide study.

Sidebotham P, Hunter L, Appleton R, Dunkley C.

Seizure. 2015 Aug;30:113-9. doi: 10.1016/j.seizure.2015.05.003. Epub 2015 Jun 18.


Photos provide information on age, but not kinship, of Andean bear.

Van Horn RC, Zug B, Appleton RD, Velez-Liendo X, Paisley S, LaCombe C.

PeerJ. 2015 Jul 16;3:e1042. doi: 10.7717/peerj.1042. eCollection 2015.


Admissions to paediatric intensive care units (PICU) with refractory convulsive status epilepticus (RCSE): A two-year multi-centre study.

Tully I, Draper ES, Lamming CR, Mattison D, Thomas C, Martland T, Appleton R.

Seizure. 2015 Jul;29:153-61. doi: 10.1016/j.seizure.2015.04.002. Epub 2015 Apr 28.


In response to: Long-term outcome in children with infantile spasms treated with vigabatrin: A cohort of 180 patients.

Djuric M, Kravljanac R, Tadic B, Mrlješ-Popovic N, Appleton RE.

Epilepsia. 2015 May;56(5):809-10. doi: 10.1111/epi.12975. No abstract available.


Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality.

Mirza N, Appleton R, Burn S, Carr D, Crooks D, du Plessis D, Duncan R, Farah JO, Josan V, Miyajima F, Mohanraj R, Shukralla A, Sills GJ, Marson AG, Pirmohamed M.

Hum Mol Genet. 2015 Aug 1;24(15):4306-16. doi: 10.1093/hmg/ddv163. Epub 2015 May 4.


The incidence of intensive care unit-acquired weakness syndromes: A systematic review.

Appleton RT, Kinsella J, Quasim T.

J Intensive Care Soc. 2015 May;16(2):126-136. doi: 10.1177/1751143714563016. Epub 2014 Dec 18. Review.


Systemic lipopolysaccharide-mediated alteration of cortical neuromodulation involves increases in monoamine oxidase-A and acetylcholinesterase activity.

Ming Z, Wotton CA, Appleton RT, Ching JC, Loewen ME, Sawicki G, Bekar LK.

J Neuroinflammation. 2015 Feb 25;12:37. doi: 10.1186/s12974-015-0259-y.


Long-term outcome in children with infantile spasms treated with vigabatrin: a cohort of 180 patients.

Djuric M, Kravljanac R, Tadic B, Mrlješ-Popovic N, Appleton RE.

Epilepsia. 2014 Dec;55(12):1918-25. doi: 10.1111/epi.12847. Epub 2014 Nov 6.


A review of the quality of care following prolonged seizures in 1-18 year olds with epilepsies.

Hunter L, Sidebotham P, Appleton R, Dunkley C.

Seizure. 2015 Jan;24:88-92. doi: 10.1016/j.seizure.2014.09.001. Epub 2014 Sep 19. Review.


Withholding the choice of sodium valproate to young women with generalised epilepsy: Are we causing more harm than good?

Mole TB, Appleton R, Marson A.

Seizure. 2015 Jan;24:127-30. doi: 10.1016/j.seizure.2014.08.006. Epub 2014 Aug 26.


Models for transition clinics.

Carrizosa J, An I, Appleton R, Camfield P, Von Moers A.

Epilepsia. 2014 Aug;55 Suppl 3:46-51. doi: 10.1111/epi.12716. Review.


Guidelines, training, audit, and quality standards in children's epilepsy services: closing the loop.

Kirkpatrick M, Dunkley C, Ferrie C, Flower D, Waldron B, Whitehouse WP, Helen Cross J, Rodie P, Appleton R.

Seizure. 2014 Nov;23(10):864-8. doi: 10.1016/j.seizure.2014.07.009. Epub 2014 Jul 25.


Paediatric neuromyelitis optica: clinical, MRI of the brain and prognostic features.

Absoud M, Lim MJ, Appleton R, Jacob A, Kitley J, Leite MI, Pike MG, Vincent A, Wassmer E, Waters P, Woodhall M, Hemingway C, Palace J.

J Neurol Neurosurg Psychiatry. 2015 Apr;86(4):470-2. doi: 10.1136/jnnp-2014-308550. Epub 2014 Aug 4.


Outpatient anti-epileptic drug prescribing errors in a Children's Hospital: an audit and literature review.

Murphy AP, Bentur H, Dolan C, Bugembe T, Gill A, Appleton R.

Seizure. 2014 Oct;23(9):786-91. doi: 10.1016/j.seizure.2014.06.010. Epub 2014 Jun 27. Review.


Doing challenging research studies in a patient-centred way: a qualitative study to inform a randomised controlled trial in the paediatric emergency care setting.

Woolfall K, Young B, Frith L, Appleton R, Iyer A, Messahel S, Hickey H, Gamble C.

BMJ Open. 2014 May 15;4(5):e005045. doi: 10.1136/bmjopen-2014-005045.


Variations in inflammation-related genes may be associated with childhood febrile seizure susceptibility.

Emsley HC, Appleton RE, Whitmore CL, Jury F, Lamb JA, Martin JE, Ollier WE, de la Morandière KP, Southern KW, Allan SM.

Seizure. 2014 Jun;23(6):457-61. doi: 10.1016/j.seizure.2014.03.006. Epub 2014 Mar 18.


A review of the current literature and a guide to the early diagnosis of autoimmune disorders associated with neuromyelitis optica.

Iyer A, Elsone L, Appleton R, Jacob A.

Autoimmunity. 2014 May;47(3):154-61. doi: 10.3109/08916934.2014.883501. Epub 2014 Feb 10. Review.


Phenytoin dosing and serum concentrations in paediatric patients requiring 20 mg/kg intravenous loading.

Piper JD, Hawcutt DB, Verghese GK, Spinty S, Newland P, Appleton R.

Arch Dis Child. 2014 Jun;99(6):585-6. doi: 10.1136/archdischild-2013-305093. Epub 2014 Jan 15.


Role of intravenous immunoglobulin in the treatment of acute relapses of neuromyelitis optica: experience in 10 patients.

Elsone L, Panicker J, Mutch K, Boggild M, Appleton R, Jacob A.

Mult Scler. 2014 Apr;20(4):501-4. doi: 10.1177/1352458513495938. Epub 2013 Aug 28.


Management of reflex anoxic seizures in children.

Iyer A, Appleton R.

Arch Dis Child. 2013 Sep;98(9):714-7. doi: 10.1136/archdischild-2012-303133. Epub 2013 Jun 28. Review.


Migrating partial seizures of infancy: expansion of the electroclinical, radiological and pathological disease spectrum.

McTague A, Appleton R, Avula S, Cross JH, King MD, Jacques TS, Bhate S, Cronin A, Curran A, Desurkar A, Farrell MA, Hughes E, Jefferson R, Lascelles K, Livingston J, Meyer E, McLellan A, Poduri A, Scheffer IE, Spinty S, Kurian MA, Kneen R.

Brain. 2013 May;136(Pt 5):1578-91. doi: 10.1093/brain/awt073. Epub 2013 Apr 18.


Transitional services for adolescents with epilepsy in the U.K.: a survey.

Iyer A, Appleton R.

Seizure. 2013 Jul;22(6):433-7. doi: 10.1016/j.seizure.2013.02.014. Epub 2013 Mar 14.


Melatonin: helping to MEND impaired sleep.

Appleton RE, Gringras P.

Arch Dis Child. 2013 Mar;98(3):216-7. doi: 10.1136/archdischild-2012-303606. No abstract available.


New European Union regulation of clinical trials is conflicting on deferred consent in emergency situations.

Gamble C, Woolfall K, Williamson P, Appleton R, Young B.

BMJ. 2013 Feb 6;346:f667. doi: 10.1136/bmj.f667. No abstract available.


The clinical utility of an SCN1A genetic diagnosis in infantile-onset epilepsy.

Brunklaus A, Dorris L, Ellis R, Reavey E, Lee E, Forbes G, Appleton R, Cross JH, Ferrie C, Hughes I, Jollands A, King MD, Livingston J, Lynch B, Philip S, Scheffer IE, Williams R, Zuberi SM.

Dev Med Child Neurol. 2013 Feb;55(2):154-61. doi: 10.1111/dmcn.12030. Epub 2012 Nov 20.


Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial.

Gringras P, Gamble C, Jones AP, Wiggs L, Williamson PR, Sutcliffe A, Montgomery P, Whitehouse WP, Choonara I, Allport T, Edmond A, Appleton R; MENDS Study Group.

BMJ. 2012 Nov 5;345:e6664. doi: 10.1136/bmj.e6664.


The use of MElatonin in children with neurodevelopmental disorders and impaired sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS).

Appleton RE, Jones AP, Gamble C, Williamson PR, Wiggs L, Montgomery P, Sutcliffe A, Barker C, Gringras P.

Health Technol Assess. 2012;16(40):i-239. doi: 10.3310/hta16400.


Diagnosis and management of the epilepsies in children: a summary of the partial update of the 2012 NICE epilepsy guideline.

Appleton RE, Freeman A, Cross JH.

Arch Dis Child. 2012 Dec;97(12):1073-6. doi: 10.1136/archdischild-2012-302822. Epub 2012 Oct 6.


Late-onset sensorineural hearing loss due to congenital cytomegalovirus infection: could head injury be a trigger?

Iyer A, Avula S, Appleton R.

Acta Paediatr. 2013 Jan;102(1):e2-3. doi: 10.1111/apa.12044. Epub 2012 Oct 27. No abstract available.


Intravenous levetiracetam in acute repetitive seizures and status epilepticus in children: experience from a children's hospital.

McTague A, Kneen R, Kumar R, Spinty S, Appleton R.

Seizure. 2012 Sep;21(7):529-34. doi: 10.1016/j.seizure.2012.05.010. Epub 2012 Jun 19.

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