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Efficient Decellularization of Equine Tendon with Preserved Biomechanical Properties and Cytocompatibility for Human Tendon Surgery Indications.

Aeberhard PA, Grognuz A, Peneveyre C, McCallin S, Hirt-Burri N, Antons J, Pioletti DP, Raffoul W, Applegate LA.

Artif Organs. 2019 Oct 14. doi: 10.1111/aor.13581. [Epub ahead of print]


An injectable heparin-conjugated hyaluronan scaffold for local delivery of transforming growth factor β1 promotes successful chondrogenesis.

Levinson C, Lee M, Applegate LA, Zenobi-Wong M.

Acta Biomater. 2019 Sep 16. pii: S1742-7061(19)30629-4. doi: 10.1016/j.actbio.2019.09.017. [Epub ahead of print]


Cell therapies for skin regeneration: an overview of 40 years of experience in burn units.

Abdel-Sayed P, Michetti M, Scaletta C, Flahaut M, Hirt-Burri N, de Buys Roessingh A, Raffoul W, Applegate LA.

Swiss Med Wkly. 2019 May 19;149:w20079. doi: 10.4414/smw.2019.20079. eCollection 2019 May 6.


Gait analysis following single-shot hyaluronic acid supplementation: a pilot randomized double-blinded controlled trial.

Pereira LC, Schweizer C, Moufarrij S, Krähenbühl SM, Favre J, Gremion G, Applegate LA, Jolles BM.

Pilot Feasibility Stud. 2019 Apr 22;5:56. doi: 10.1186/s40814-019-0443-4. eCollection 2019.


Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling.

Kameda T, Zvick J, Vuk M, Sadowska A, Tam WK, Leung VY, Bölcskei K, Helyes Z, Applegate LA, Hausmann ON, Klasen J, Krupkova O, Wuertz-Kozak K.

Int J Mol Sci. 2019 Apr 10;20(7). pii: E1767. doi: 10.3390/ijms20071767.


Decellularised tissues obtained by a CO2-philic detergent and supercritical CO2.

Antons J, Marascio MG, Aeberhard P, Weissenberger G, Hirt-Burri N, Applegate LA, Bourban PE, Pioletti DP.

Eur Cell Mater. 2018 Sep 4;36:81-95. doi: 10.22203/eCM.v036a07.


Patient care for postamputation pain and the complexity of therapies: living experiences.

Flahaut M, Laurent NL, Michetti M, Hirt-Burri N, Jensen W, Lontis R, Applegate LA, Raffoul W.

Pain Manag. 2018 Nov 1;8(6):441-453. doi: 10.2217/pmt-2018-0033. Epub 2018 Sep 3.


Effect of temporal onsets of mechanical loading on bone formation inside a tissue engineering scaffold combined with cell therapy.

Hausherr TC, Nuss K, Thein E, Krähenbühl S, Applegate LA, Pioletti DP.

Bone Rep. 2018 Apr 26;8:173-179. doi: 10.1016/j.bonr.2018.04.008. eCollection 2018 Jun.


Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements.

Antons J, Marascio MGM, Nohava J, Martin R, Applegate LA, Bourban PE, Pioletti DP.

J Mater Sci Mater Med. 2018 May 4;29(5):57. doi: 10.1007/s10856-018-6066-0.


Transcriptome Analysis of Pseudomonas aeruginosa Cultured in Human Burn Wound Exudates.

Gonzalez MR, Ducret V, Leoni S, Fleuchot B, Jafari P, Raffoul W, Applegate LA, Que YA, Perron K.

Front Cell Infect Microbiol. 2018 Feb 27;8:39. doi: 10.3389/fcimb.2018.00039. eCollection 2018.


Return of the cadaver: Key role of anatomic dissection for plastic surgery resident training.

Krähenbühl SM, Čvančara P, Stieglitz T, Bonvin R, Michetti M, Flahaut M, Durand S, Deghayli L, Applegate LA, Raffoul W.

Medicine (Baltimore). 2017 Jul;96(29):e7528. doi: 10.1097/MD.0000000000007528.


Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs.

Delacrétaz A, Zdralovic A, Vandenberghe F, Saigi-Morgui N, Glatard A, Quteineh L, Gholam-Rezaee M, Raffoul W, Applegate LA, Jafari P, Gamma F, von Gunten A, Conus P, Eap CB.

Gene. 2017 Sep 10;628:8-15. doi: 10.1016/j.gene.2017.07.005. Epub 2017 Jul 8.


Development of an Effective Cell Seeding Technique: Simulation, Implementation, and Analysis of Contributing Factors.

Nasrollahzadeh N, Applegate LA, Pioletti DP.

Tissue Eng Part C Methods. 2017 Aug;23(8):485-496. doi: 10.1089/ten.TEC.2017.0108. Epub 2017 Jul 17.


First Insights into Human Fingertip Regeneration by Echo-Doppler Imaging and Wound Microenvironment Assessment.

Jafari P, Muller C, Grognuz A, Applegate LA, Raffoul W, di Summa PG, Durand S.

Int J Mol Sci. 2017 May 13;18(5). pii: E1054. doi: 10.3390/ijms18051054.


Trace element intakes should be revisited in burn nutrition protocols: A cohort study.

Jafari P, Thomas A, Haselbach D, Watfa W, Pantet O, Michetti M, Raffoul W, Applegate LA, Augsburger M, Berger MM.

Clin Nutr. 2018 Jun;37(3):958-964. doi: 10.1016/j.clnu.2017.03.028. Epub 2017 Apr 4.


Burn patient care lost in good manufacturing practices?

Dimitropoulos G, Jafari P, de Buys Roessingh A, Hirt-Burri N, Raffoul W, Applegate LA.

Ann Burns Fire Disasters. 2016 Jun 30;29(2):111-115.


Stability Enhancement Using Hyaluronic Acid Gels for Delivery of Human Fetal Progenitor Tenocytes.

Grognuz A, Scaletta C, Farron A, Pioletti DP, Raffoul W, Applegate LA.

Cell Med. 2016 Jan 14;8(3):87-97. doi: 10.3727/215517916X690486. eCollection 2016 Dec 3.


Topical Negative Pressure on Burns: An Innovative Method for Wound Exudate Collection.

Baudoin J, Jafari P, Meuli J, Applegate LA, Raffoul W.

Plast Reconstr Surg Glob Open. 2016 Nov 10;4(11):e1117. eCollection 2016 Nov.


Human Bone Progenitor Cells for Clinical Application: What Kind of Immune Reaction Does Fetal Xenograft Tissue Trigger in Immunocompetent Rats?

Hausherr TC, Nuss K, Thein E, Applegate LA, Pioletti DP.

Cell Transplant. 2017 May 9;26(5):879-890. doi: 10.3727/096368916X693789. Epub 2016 Nov 21.


Effect of Human Burn Wound Exudate on Pseudomonas aeruginosa Virulence.

Gonzalez MR, Fleuchot B, Lauciello L, Jafari P, Applegate LA, Raffoul W, Que YA, Perron K.

mSphere. 2016 Apr 27;1(2). pii: e00111-15. doi: 10.1128/mSphere.00111-15. eCollection 2016 Mar-Apr.


Corrigendum: Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages.

Abdel-Sayed P, Kaeppeli A, Siriwardena T, Darbre T, Perron K, Jafari P, Reymond JL, Pioletti DP, Applegate LA.

Sci Rep. 2016 Apr 7;6:23872. doi: 10.1038/srep23872. No abstract available.


Peptide-decorated chitosan derivatives enhance fibroblast adhesion and proliferation in wound healing.

Patrulea V, Hirt-Burri N, Jeannerat A, Applegate LA, Ostafe V, Jordan O, Borchard G.

Carbohydr Polym. 2016 May 20;142:114-23. doi: 10.1016/j.carbpol.2016.01.045. Epub 2016 Jan 22.


Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages.

Abdel-Sayed P, Kaeppeli A, Siriwardena T, Darbre T, Perron K, Jafari P, Reymond JL, Pioletti DP, Applegate LA.

Sci Rep. 2016 Feb 25;6:22020. doi: 10.1038/srep22020. Erratum in: Sci Rep. 2016;6:23872. Kaeppli, Ariane [corrected to Kaeppeli, Ariane].


How important is hydrotherapy? Effects of dynamic action of hot spring water as a rehabilitative treatment for burn patients in Switzerland.

Moufarrij S, Deghayli L, Raffoul W, Hirt-Burri N, Michetti M, de Buys Roessingh A, Norberg M, Applegate LA.

Ann Burns Fire Disasters. 2014 Dec 31;27(4):184-91.


Human Fetal Progenitor Tenocytes for Regenerative Medicine.

Grognuz A, Scaletta C, Farron A, Raffoul W, Applegate LA.

Cell Transplant. 2016;25(3):463-79. doi: 10.3727/096368915X688515. Epub 2015 Jun 24.


Sildenafil as a therapeutic option for digital ischemic ulceration: case report.

Krähenbühl SM, Depairon M, Faure M, Vietti Violi N, Applegate LA, Raffoul W.

J Hand Surg Am. 2015 May;40(5):890-3. doi: 10.1016/j.jhsa.2015.01.041. Epub 2015 Mar 25.


Optimized synthesis of O-carboxymethyl-N,N,N-trimethyl chitosan.

Patrulea V, Applegate LA, Ostafe V, Jordan O, Borchard G.

Carbohydr Polym. 2015 May 20;122:46-52. doi: 10.1016/j.carbpol.2014.12.014. Epub 2014 Dec 25.


Cell therapies for tendons: old cell choice for modern innovation.

Petrou IG, Grognuz A, Hirt-Burri N, Raffoul W, Applegate LA.

Swiss Med Wkly. 2014 Aug 7;144:w13989. doi: 10.4414/smw.2014.13989. eCollection 2014. Review.


Insurance coverage of pediatric burns: Switzerland versus USA.

Deghayli L, Moufarrij S, Norberg M, Sheridan R, Raffoul W, de Buys Roessingh A, Hirt-Burri N, Applegate LA.

Burns. 2014 Aug;40(5):814-25. doi: 10.1016/j.burns.2013.10.024. Epub 2013 Nov 26.


Development of a cost-effective method for platelet-rich plasma (PRP) preparation for topical wound healing.

Akhundov K, Pietramaggiori G, Waselle L, Darwiche S, Guerid S, Scaletta C, Hirt-Burri N, Applegate LA, Raffoul WV.

Ann Burns Fire Disasters. 2012 Dec 31;25(4):207-13.


Functionalization of microstructured open-porous bioceramic scaffolds with human fetal bone cells.

Krauss Juillerat F, Borcard F, Staedler D, Scaletta C, Applegate LA, Comas H, Gauckler LJ, Gerber-Lemaire S, Juillerat-Jeanneret L, Gonzenbach UT.

Bioconjug Chem. 2012 Nov 21;23(11):2278-90. doi: 10.1021/bc300407x. Epub 2012 Nov 12.


Biologicals and fetal cell therapy for wound and scar management.

Hirt-Burri N, Ramelet AA, Raffoul W, de Buys Roessingh A, Scaletta C, Pioletti D, Applegate LA.

ISRN Dermatol. 2011;2011:549870. doi: 10.5402/2011/549870. Epub 2011 May 18.


Epiphyseal Chondroprogenitors Provide a Stable Cell Source for Cartilage Cell Therapy.

Darwiche S, Scaletta C, Raffoul W, Pioletti DP, Applegate LA.

Cell Med. 2012 May 8;4(1):23-32. doi: 10.3727/215517912X639324. eCollection 2012 Jan.


Human fetal bone cells in delivery systems for bone engineering.

Tenorio DM, Scaletta C, Jaccoud S, Hirt-Burri N, Pioletti DP, Jaques B, Applegate LA.

J Tissue Eng Regen Med. 2011 Nov;5(10):806-14. doi: 10.1002/term.381. Epub 2011 Jan 10.


Covalent cell surface functionalization of human fetal osteoblasts for tissue engineering.

Borcard F, Godinat A, Staedler D, Blanco HC, Dumont AL, Chapuis-Bernasconi C, Scaletta C, Applegate LA, Juillerat FK, Gonzenbach UT, Gerber-Lemaire S, Juillerat-Jeanneret L.

Bioconjug Chem. 2011 Jul 20;22(7):1422-32. doi: 10.1021/bc200147m. Epub 2011 Jun 28.


Regulation of proliferation and differentiation of human fetal bone cells.

Krattinger N, Applegate LA, Biver E, Pioletti DP, Caverzasio J.

Eur Cell Mater. 2011 Jan 12;21:46-58.


Bone regeneration and stem cells.

Arvidson K, Abdallah BM, Applegate LA, Baldini N, Cenni E, Gomez-Barrena E, Granchi D, Kassem M, Konttinen YT, Mustafa K, Pioletti DP, Sillat T, Finne-Wistrand A.

J Cell Mol Med. 2011 Apr;15(4):718-46. doi: 10.1111/j.1582-4934.2010.01224.x. Review.


Plasticity of fetal cartilaginous cells.

Quintin A, Schizas C, Scaletta C, Jaccoud S, Applegate LA, Pioletti DP.

Cell Transplant. 2010;19(10):1349-57. doi: 10.3727/096368910X506854. Epub 2010 May 4.


Isolation and in vitro chondrogenic potential of human foetal spine cells.

Quintin A, Schizas C, Scaletta C, Jaccoud S, Gerber S, Osterheld MC, Juillerat L, Applegate LA, Pioletti DP.

J Cell Mol Med. 2009 Aug;13(8B):2559-69. doi: 10.1111/j.1582-4934.2008.00630.x. Epub 2008 Dec 24.


In vitro characterization of immune-related properties of human fetal bone cells for potential tissue engineering applications.

Montjovent MO, Bocelli-Tyndall C, Scaletta C, Scherberich A, Mark S, Martin I, Applegate LA, Pioletti DP.

Tissue Eng Part A. 2009 Jul;15(7):1523-32. doi: 10.1089/ten.tea.2008.0222.


Whole-cell bioprocessing of human fetal cells for tissue engineering of skin.

Applegate LA, Scaletta C, Hirt-Burri N, Raffoul W, Pioletti D.

Skin Pharmacol Physiol. 2009;22(2):63-73. doi: 10.1159/000178865. Epub 2009 Feb 4.


Chronic wound healing by fetal cell therapy may be explained by differential gene profiling observed in fetal versus old skin cells.

Ramelet AA, Hirt-Burri N, Raffoul W, Scaletta C, Pioletti DP, Offord E, Mansourian R, Applegate LA.

Exp Gerontol. 2009 Mar;44(3):208-18. doi: 10.1016/j.exger.2008.11.004. Epub 2008 Nov 20.


Laser-ultraviolet-A induced ultra weak photon emission in human skin cells: A biophotonic comparison between keratinocytes and fibroblasts.

Niggli HJ, Tudisco S, Lanzanò L, Applegate LA, Scordino A, Musumeci F.

Indian J Exp Biol. 2008 May;46(5):358-63.


Wound-healing gene family expression differences between fetal and foreskin cells used for bioengineered skin substitutes.

Hirt-Burri N, Scaletta C, Gerber S, Pioletti DP, Applegate LA.

Artif Organs. 2008 Jul;32(7):509-18. doi: 10.1111/j.1525-1594.2008.00578.x.


Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering.

Montjovent MO, Mark S, Mathieu L, Scaletta C, Scherberich A, Delabarde C, Zambelli PY, Bourban PE, Applegate LA, Pioletti DP.

Bone. 2008 Mar;42(3):554-64. doi: 10.1016/j.bone.2007.10.018. Epub 2007 Nov 7.


Consistency and safety of cell banks for research and clinical use: preliminary analysis of fetal skin banks.

Quintin A, Hirt-Burri N, Scaletta C, Schizas C, Pioletti DP, Applegate LA.

Cell Transplant. 2007;16(7):675-84.


Human muscular fetal cells: a potential cell source for muscular therapies.

Hirt-Burri N, de Buys Roessingh AS, Scaletta C, Gerber S, Pioletti DP, Applegate LA, Hohlfeld J.

Pediatr Surg Int. 2008 Jan;24(1):37-47.


Development, characterization, and use of a fetal skin cell bank for tissue engineering in wound healing.

De Buys Roessingh AS, Hohlfeld J, Scaletta C, Hirt-Burri N, Gerber S, Hohlfeld P, Gebbers JO, Applegate LA.

Cell Transplant. 2006;15(8-9):823-34.


Water-filtered infrared-A radiation (wIRA) is not implicated in cellular degeneration of human skin.

Gebbers N, Hirt-Burri N, Scaletta C, Hoffmann G, Applegate LA.

Ger Med Sci. 2007 Nov 14;5:Doc08.

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