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Items: 5


A thiocyanopalladation/carbocyclization transformation identified through enzymatic screening: stereocontrolled tandem C-SCN and C-C bond formation.

Malik G, Swyka RA, Tiwari VK, Fei X, Applegate GA, Berkowitz DB.

Chem Sci. 2017 Dec 1;8(12):8050-8060. doi: 10.1039/c7sc04083k. Epub 2017 Oct 3.


Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.

Nelson DL, Applegate GA, Beio ML, Graham DL, Berkowitz DB.

J Biol Chem. 2017 Aug 25;292(34):13986-14002. doi: 10.1074/jbc.M117.777904. Epub 2017 Jul 10.


Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis.

Applegate GA, Berkowitz DB.

Adv Synth Catal. 2015 May 26;357(8):1619-1632. Epub 2015 May 12.


A new dehydrogenase from Clostridium acetobutylicum for asymmetric synthesis: dynamic reductive kinetic resolution entry into the Taxotère side chain.

Applegate GA, Cheloha RW, Nelson DL, Berkowitz DB.

Chem Commun (Camb). 2011 Feb 28;47(8):2420-2. doi: 10.1039/c0cc04585c. Epub 2010 Dec 20.

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