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Items: 1 to 50 of 229

1.

Non volatile constituents of the vermouth ingredient Artemisia vallesiaca.

Pollastro F, Lopatriello A, Vouillamoz JF, Appendino G, Taglialatela-Scafati O, Forino M.

Fitoterapia. 2019 Aug 13:104312. doi: 10.1016/j.fitote.2019.104312. [Epub ahead of print]

PMID:
31419464
2.

One-Pot Total Synthesis of Cannabinol via Iodine-Mediated Deconstructive Annulation.

Caprioglio D, Mattoteia D, Minassi A, Pollastro F, Lopatriello A, Muňoz E, Taglialatela-Scafati O, Appendino G.

Org Lett. 2019 Aug 2;21(15):6122-6125. doi: 10.1021/acs.orglett.9b02258. Epub 2019 Jul 24.

PMID:
31339327
3.

Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.

Rogati F, Millán E, Appendino G, Correa A, Caprioglio D, Minassi A, Muñoz E.

ACS Med Chem Lett. 2019 Jan 8;10(4):606-610. doi: 10.1021/acsmedchemlett.8b00604. eCollection 2019 Apr 11.

PMID:
30996804
4.

O-Methyl Phytocannabinoids: Semi-synthesis, Analysis in Cannabis Flowerheads, and Biological Activity.

Caprioglio D, Allegrone G, Pollastro F, Valera S, Lopatriello A, Collado JA, Munoz E, Appendino G, Taglialatela-Scafati O.

Planta Med. 2019 Aug;85(11-12):981-986. doi: 10.1055/a-0883-5383. Epub 2019 Apr 1.

PMID:
30934093
5.

Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity.

Rosa A, Caprioglio D, Isola R, Nieddu M, Appendino G, Falchi AM.

Food Funct. 2019 Mar 20;10(3):1629-1642. doi: 10.1039/c8fo02395f.

PMID:
30834410
6.

Cannabinoid derivatives acting as dual PPARγ/CB2 agonists as therapeutic agents for systemic sclerosis.

García-Martín A, Garrido-Rodríguez M, Navarrete C, Caprioglio D, Palomares B, DeMesa J, Rollland A, Appendino G, Muñoz E.

Biochem Pharmacol. 2019 May;163:321-334. doi: 10.1016/j.bcp.2019.02.029. Epub 2019 Feb 27.

PMID:
30825431
7.

Bioactive triterpenoids from the caffeine-rich plants guayusa and maté.

Chianese G, Golin-Pacheco SD, Taglialatela-Scafati O, Collado JA, Munoz E, Appendino G, Pollastro F.

Food Res Int. 2019 Jan;115:504-510. doi: 10.1016/j.foodres.2018.10.005. Epub 2018 Oct 4.

PMID:
30599971
8.

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2019 Jan 1;36(1):248-249. doi: 10.1039/c8np90041h. Epub 2018 Nov 23.

9.

VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity.

Palomares B, Ruiz-Pino F, Navarrete C, Velasco I, Sánchez-Garrido MA, Jimenez-Jimenez C, Pavicic C, Vazquez MJ, Appendino G, Bellido ML, Calzado MA, Tena-Sempere M, Muñoz E.

Sci Rep. 2018 Oct 31;8(1):16092. doi: 10.1038/s41598-018-34259-0.

10.

Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors.

Minassi A, Rogati F, Cruz C, Prados ME, Galera N, Jinénez C, Appendino G, Bellido ML, Calzado MA, Caprioglio D, Muñoz E.

J Nat Prod. 2018 Oct 26;81(10):2235-2243. doi: 10.1021/acs.jnatprod.8b00514. Epub 2018 Oct 10.

PMID:
30350996
11.

The endocannabinoid system of the skin. A potential approach for the treatment of skin disorders.

Río CD, Millán E, García V, Appendino G, DeMesa J, Muñoz E.

Biochem Pharmacol. 2018 Nov;157:122-133. doi: 10.1016/j.bcp.2018.08.022. Epub 2018 Aug 20. Review.

PMID:
30138623
12.

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space.

Lopatriello A, Caprioglio D, Minassi A, Schiano Moriello A, Formisano C, De Petrocellis L, Appendino G, Taglialatela-Scafati O.

Bioorg Med Chem. 2018 Aug 15;26(15):4532-4536. doi: 10.1016/j.bmc.2018.07.044. Epub 2018 Jul 27.

PMID:
30077611
13.

EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis.

García-Martín A, Garrido-Rodríguez M, Navarrete C, Del Río C, Bellido ML, Appendino G, Calzado MA, Muñoz E.

Biochem Pharmacol. 2018 Nov;157:304-313. doi: 10.1016/j.bcp.2018.07.047. Epub 2018 Aug 2.

PMID:
30076848
14.

VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways.

Del Rio C, Cantarero I, Palomares B, Gómez-Cañas M, Fernández-Ruiz J, Pavicic C, García-Martín A, Luz Bellido M, Ortega-Castro R, Pérez-Sánchez C, López-Pedrera C, Appendino G, Calzado MA, Muñoz E.

Br J Pharmacol. 2018 Oct;175(19):3813-3831. doi: 10.1111/bph.14450. Epub 2018 Aug 23.

PMID:
30033591
15.

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2019 Jan 1;36(1):35-107. doi: 10.1039/c7np00064b. Epub 2018 Jul 13. Review. Erratum in: Nat Prod Rep. 2018 Nov 23;:.

16.

Combined use of isotopic fingerprint and metabolomics analysis for the authentication of saw palmetto (Serenoa repens) extracts.

Perini M, Paolini M, Camin F, Appendino G, Vitulo F, De Combarieu E, Sardone N, Martinelli EM, Pace R.

Fitoterapia. 2018 Jun;127:15-19. doi: 10.1016/j.fitote.2018.04.011. Epub 2018 Apr 22.

PMID:
29689331
17.

Reprint of: Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

Pollastro F, De Petrocellis L, Schiano-Moriello A, Chianese G, Heyman H, Appendino G, Taglialatela-Scafati O.

Fitoterapia. 2018 Apr;126:35-39. doi: 10.1016/j.fitote.2018.04.002. Epub 2018 Apr 11. No abstract available.

PMID:
29655820
18.

Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy.

Navarrete C, Carrillo-Salinas F, Palomares B, Mecha M, Jiménez-Jiménez C, Mestre L, Feliú A, Bellido ML, Fiebich BL, Appendino G, Calzado MA, Guaza C, Muñoz E.

J Neuroinflammation. 2018 Mar 1;15(1):64. doi: 10.1186/s12974-018-1103-y.

19.

Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.

Pollastro F, Caprioglio D, Marotta P, Moriello AS, De Petrocellis L, Taglialatela-Scafati O, Appendino G.

J Nat Prod. 2018 Mar 23;81(3):630-633. doi: 10.1021/acs.jnatprod.7b00946. Epub 2017 Dec 14.

PMID:
29240420
20.

A Single Oxidosqualene Cyclase Produces the Seco-Triterpenoid α-Onocerin.

Almeida A, Dong L, Khakimov B, Bassard JE, Moses T, Lota F, Goossens A, Appendino G, Bak S.

Plant Physiol. 2018 Feb;176(2):1469-1484. doi: 10.1104/pp.17.01369. Epub 2017 Dec 4.

21.

Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

Pollastro F, De Petrocellis L, Schiano-Moriello A, Chianese G, Heyman H, Appendino G, Taglialatela-Scafati O.

Fitoterapia. 2017 Nov;123:13-17. doi: 10.1016/j.fitote.2017.09.010. Epub 2017 Sep 20. No abstract available. Corrected and republished in: Fitoterapia. 2018 Apr;126:35-39.

PMID:
28941742
22.

Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.

Nadal X, Del Río C, Casano S, Palomares B, Ferreiro-Vera C, Navarrete C, Sánchez-Carnerero C, Cantarero I, Bellido ML, Meyer S, Morello G, Appendino G, Muñoz E.

Br J Pharmacol. 2017 Dec;174(23):4263-4276. doi: 10.1111/bph.14019. Epub 2017 Nov 2.

23.

An improved preparation of phorbol from croton oil.

Pagani A, Gaeta S, Savchenko AI, Williams CM, Appendino G.

Beilstein J Org Chem. 2017 Jul 11;13:1361-1367. doi: 10.3762/bjoc.13.133. eCollection 2017.

24.

Electrophilic Triterpenoid Enones: A Comparative Thiol-Trapping and Bioactivity Study.

Del Prete D, Taglialatela-Scafati O, Minassi A, Sirignano C, Cruz C, Bellido ML, Muñoz E, Appendino G.

J Nat Prod. 2017 Aug 25;80(8):2276-2283. doi: 10.1021/acs.jnatprod.7b00271. Epub 2017 Jul 28.

PMID:
28753294
25.

The reaction of cinnamaldehyde and cinnam(o)yl derivatives with thiols.

Autelitano A, Minassi A, Pagani A, Taglialatela-Scafati O, Appendino G.

Acta Pharm Sin B. 2017 Jul;7(4):523-526. doi: 10.1016/j.apsb.2017.06.005. Epub 2017 Jul 8.

26.

The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.

Benemei S, De Logu F, Li Puma S, Marone IM, Coppi E, Ugolini F, Liedtke W, Pollastro F, Appendino G, Geppetti P, Materazzi S, Nassini R.

Br J Pharmacol. 2017 Sep;174(17):2897-2911. doi: 10.1111/bph.13917. Epub 2017 Jul 20.

27.

Carbonyl Activation in Electrophilic Polyene Cyclizations: A Toolbox for the Design of Isoprenoid Libraries.

Minassi A, Pollastro F, Chianese G, Caprioglio D, Taglialatela-Scafati O, Appendino G.

Angew Chem Int Ed Engl. 2017 Jun 26;56(27):7935-7938. doi: 10.1002/anie.201703455. Epub 2017 Jun 5.

PMID:
28488372
28.

Olfaction, taste and chemoreception: scientific evidence replaces "Essays in biopoetry".

Appendino G, Brönstrup M, Kubanek JM.

Nat Prod Rep. 2017 May 10;34(5):469-471. doi: 10.1039/c7np90016c. No abstract available.

PMID:
28485741
29.

New insights into the antioxidant activity and cytotoxicity of arzanol and effect of methylation on its biological properties.

Rosa A, Atzeri A, Nieddu M, Appendino G.

Chem Phys Lipids. 2017 Jun;205:55-64. doi: 10.1016/j.chemphyslip.2017.05.001. Epub 2017 May 3.

PMID:
28476462
30.

The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains.

Allegrone G, Pollastro F, Magagnini G, Taglialatela-Scafati O, Seegers J, Koeberle A, Werz O, Appendino G.

J Nat Prod. 2017 Mar 24;80(3):731-734. doi: 10.1021/acs.jnatprod.6b01126. Epub 2017 Feb 6.

PMID:
28165233
31.

Herbal Products in Italy: The Thin Line between Phytotherapy, Nutrition and Parapharmaceuticals; A Normative Overview of the Fastest Growing Market in Europe.

Biagi M, Pecorari R, Appendino G, Miraldi E, Magnano AR, Governa P, Cettolin G, Giachetti D.

Pharmaceuticals (Basel). 2016 Oct 29;9(4). pii: E65. Review.

32.

A single-dose, randomized, cross-over, two-way, open-label study for comparing the absorption of boswellic acids and its lecithin formulation.

Riva A, Morazzoni P, Artaria C, Allegrini P, Meins J, Savio D, Appendino G, Schubert-Zsilavecz M, Abdel-Tawab M.

Phytomedicine. 2016 Nov 15;23(12):1375-1382. doi: 10.1016/j.phymed.2016.07.009. Epub 2016 Jul 27.

33.

Phytocannabinoids: a unified critical inventory.

Hanuš LO, Meyer SM, Muñoz E, Taglialatela-Scafati O, Appendino G.

Nat Prod Rep. 2016 Nov 23;33(12):1357-1392. Review.

PMID:
27722705
34.

VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease.

Díaz-Alonso J, Paraíso-Luna J, Navarrete C, Del Río C, Cantarero I, Palomares B, Aguareles J, Fernández-Ruiz J, Bellido ML, Pollastro F, Appendino G, Calzado MA, Galve-Roperh I, Muñoz E.

Sci Rep. 2016 Jul 19;6:29789. doi: 10.1038/srep29789.

35.

Ingenane Diterpenoids.

Appendino G.

Prog Chem Org Nat Prod. 2016;102:1-90. doi: 10.1007/978-3-319-33172-0_1. Review.

PMID:
27380406
36.

Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study.

Pollastro F, Golin S, Chianese G, Putra MY, Schiano Moriello A, De Petrocellis L, García V, Munoz E, Taglialatela-Scafati O, Appendino G.

J Nat Prod. 2016 Jul 22;79(7):1762-8. doi: 10.1021/acs.jnatprod.6b00141. Epub 2016 Jun 28.

PMID:
27352042
37.

The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways.

del Río C, Navarrete C, Collado JA, Bellido ML, Gómez-Cañas M, Pazos MR, Fernández-Ruiz J, Pollastro F, Appendino G, Calzado MA, Cantarero I, Muñoz E.

Sci Rep. 2016 Feb 18;6:21703. doi: 10.1038/srep21703.

38.

Turmeric Sesquiterpenoids: Expeditious Resolution, Comparative Bioactivity, and a New Bicyclic Turmeronoid.

Del Prete D, Millán E, Pollastro F, Chianese G, Luciano P, Collado JA, Munoz E, Appendino G, Taglialatela-Scafati O.

J Nat Prod. 2016 Feb 26;79(2):267-73. doi: 10.1021/acs.jnatprod.5b00637. Epub 2016 Jan 20.

PMID:
26788588
39.

The génépi Artemisia species. Ethnopharmacology, cultivation, phytochemistry, and bioactivity.

Vouillamoz JF, Carlen C, Taglialatela-Scafati O, Pollastro F, Appendino G.

Fitoterapia. 2015 Oct;106:231-41. doi: 10.1016/j.fitote.2015.09.007. Epub 2015 Sep 8. Review.

PMID:
26358481
40.

Poly-Electrophilic Sesquiterpene Lactones from Vernonia amygdalina: New Members and Differences in Their Mechanism of Thiol Trapping and in Bioactivity.

Sinisi A, Millán E, Abay SM, Habluetzel A, Appendino G, Muñoz E, Taglialatela-Scafati O.

J Nat Prod. 2015 Jul 24;78(7):1618-23. doi: 10.1021/acs.jnatprod.5b00179. Epub 2015 Jun 26.

PMID:
26115003
41.

Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.

Del Prete D, Caprioglio D, Appendino G, Minassi A, Schiano-Moriello A, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):1009-11. doi: 10.1016/j.bmcl.2015.01.039. Epub 2015 Jan 28.

PMID:
25666822
42.

Omne Ignotum pro Magnifico: characterization of commercial Bilberry extracts to fight adulteration.

Giacomelli L, Appendino G, Franceschi F, Togni S, Pace R.

Eur Rev Med Pharmacol Sci. 2014;18(24):3948-53. Review.

43.

Dietary acetylenic oxylipin falcarinol differentially modulates GABAA receptors.

Czyzewska MM, Chrobok L, Kania A, Jatczak M, Pollastro F, Appendino G, Mozrzymas JW.

J Nat Prod. 2014 Dec 26;77(12):2671-7. doi: 10.1021/np500615j. Epub 2014 Dec 4.

PMID:
25474700
44.

Jatrophanes from Euphorbia squamosa as potent inhibitors of Candida albicans multidrug transporters.

Rawal MK, Shokoohinia Y, Chianese G, Zolfaghari B, Appendino G, Taglialatela-Scafati O, Prasad R, Di Pietro A.

J Nat Prod. 2014 Dec 26;77(12):2700-6. doi: 10.1021/np500756z. Epub 2014 Dec 1.

PMID:
25437914
45.

Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial.

Drobnic F, Riera J, Appendino G, Togni S, Franceschi F, Valle X, Pons A, Tur J.

J Int Soc Sports Nutr. 2014 Jun 18;11:31. doi: 10.1186/1550-2783-11-31. eCollection 2014.

46.

SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.

Koeberle A, Muñoz E, Appendino GB, Minassi A, Pace S, Rossi A, Weinigel C, Barz D, Sautebin L, Caprioglio D, Collado JA, Werz O.

J Med Chem. 2014 Jul 10;57(13):5638-48. doi: 10.1021/jm500308c. Epub 2014 Jun 24.

PMID:
24920381
47.

Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system.

Chicca A, Caprioglio D, Minassi A, Petrucci V, Appendino G, Taglialatela-Scafati O, Gertsch J.

ACS Chem Biol. 2014 Jul 18;9(7):1499-507. doi: 10.1021/cb500177c. Epub 2014 May 15.

PMID:
24831513
48.

Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs.

Appendino G, Minassi A, Taglialatela-Scafati O.

Nat Prod Rep. 2014 Jul;31(7):880-904. doi: 10.1039/c4np00010b. Epub 2014 May 14. Review.

PMID:
24823967
49.

Omnia praeclara rara. The quest for ingenol heats up.

Appendino G.

Angew Chem Int Ed Engl. 2014 Jan 20;53(4):927-9. No abstract available.

PMID:
24588025
50.

Some like it pungent and vile. TRPA1 as a molecular target for the malodorous vinyl disulfides from asafoetida.

Shokoohinia Y, Chianese G, Appendino G, Di Marzo V, De Petrocellis L, Ghannadi A, Taghvayi R, Fattahian K, Soltani R, Taglialatela-Scafati O.

Fitoterapia. 2013 Oct;90:247-51. doi: 10.1016/j.fitote.2013.08.001. Epub 2013 Aug 13.

PMID:
23954176

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