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Detection of colonic neoplasia in vivo using near-infrared-labeled peptide targeting cMet.

Wu X, Zhou J, Wang F, Meng X, Chen J, Chang TS, Lee M, Li G, Li X, Appelman HD, Kuick R, Wang TD.

Sci Rep. 2019 Nov 29;9(1):17917. doi: 10.1038/s41598-019-54385-7.


Autoimmune Gastritis.

Hall SN, Appelman HD.

Arch Pathol Lab Med. 2019 Nov;143(11):1327-1331. doi: 10.5858/arpa.2019-0345-RA.


Sorafenib encapsulated in nanocarrier functionalized with glypican-3 specific peptide for targeted therapy of hepatocellular carcinoma.

Feng S, Zhou J, Li Z, Appelman HD, Zhao L, Zhu J, Wang TD.

Colloids Surf B Biointerfaces. 2019 Dec 1;184:110498. doi: 10.1016/j.colsurfb.2019.110498. Epub 2019 Sep 9.


Strain-Photoacoustic Imaging as a Potential Tool for Characterizing Intestinal Fibrosis.

Zhu Y, Johnson LA, Rubin JM, Appelman H, Ni L, Yuan J, Wang X, Higgins PDR, Xu G.

Gastroenterology. 2019 Nov;157(5):1196-1198. doi: 10.1053/j.gastro.2019.07.061. Epub 2019 Aug 13. No abstract available.


Correction to "Identification of Tumor Specific Peptide as EpCAM Ligand and Its Potential Diagnostic and Therapeutic Clinical Application".

Ma X, Kang X, He L, Zhou J, Zhou J, Sturm MB, Beer DG, Kuick R, Nancarrow DJ, Appelman HD, Pang Z, Li W, Zhang C, Zhang W, Zhang Y, Wang TD, Li M.

Mol Pharm. 2019 Aug 5;16(8):3726. doi: 10.1021/acs.molpharmaceut.9b00514. Epub 2019 Jul 16. No abstract available.


Identification of Tumor Specific Peptide as EpCAM Ligand and Its Potential Diagnostic and Therapeutic Clinical Application.

Ma X, Kang X, He L, Zhou J, Zhou J, Sturm MB, Beer DG, Kuick R, Nancarrow DJ, Appelman HD, Pang Z, Li W, Zhang C, Zhang W, Zhang Y, Wang TD, Li M.

Mol Pharm. 2019 May 6;16(5):2199-2213. doi: 10.1021/acs.molpharmaceut.9b00185. Epub 2019 Apr 18. Erratum in: Mol Pharm. 2019 Aug 5;16(8):3726.


Outcomes of Endoscopic Surveillance in Individuals With Genetic Predisposition to Hereditary Diffuse Gastric Cancer.

Jacobs MF, Dust H, Koeppe E, Wong S, Mulholland M, Choi EY, Appelman H, Stoffel EM.

Gastroenterology. 2019 Jul;157(1):87-96. doi: 10.1053/j.gastro.2019.03.047. Epub 2019 Mar 29.


Disrupting Inflammation-Associated CXCL8-CXCR1 Signaling Inhibits Tumorigenicity Initiated by Sporadic- and Colitis-Colon Cancer Stem Cells.

Fisher RC, Bellamkonda K, Alex Molina L, Xiang S, Liska D, Sarvestani SK, Chakrabarti S, Berg A, Jorgensen ML, Hatala D, Chen S, Aiello A, Appelman HD, Scott EW, Huang EH.

Neoplasia. 2019 Mar;21(3):269-281. doi: 10.1016/j.neo.2018.12.007. Epub 2019 Feb 7.


Approach to the Liver Biopsy in the Patient With Chronic Low-Level Aminotransferase Elevations.

Ettel MG, Appelman HD.

Arch Pathol Lab Med. 2018 Oct;142(10):1186-1190. doi: 10.5858/arpa.2018-0214-RA. Review.


Mid- and Deep-Zone Gastritis: A Histologic Pattern Associated With Autoimmune Disease but Distinct From Autoimmune Atrophic Gastritis.

Speck O, Appelman HD, Owens SR.

Am J Clin Pathol. 2018 Aug 30;150(4):364-374. doi: 10.1093/ajcp/aqy065.


Multiplexed Targeting of Barrett's Neoplasia with a Heterobivalent Ligand: Imaging Study on Mouse Xenograft in Vivo and Human Specimens ex Vivo.

Chen J, Zhou J, Gao Z, Li X, Wang F, Duan X, Li G, Joshi BP, Kuick R, Appelman HD, Wang TD.

J Med Chem. 2018 Jun 28;61(12):5323-5331. doi: 10.1021/acs.jmedchem.8b00405. Epub 2018 Jun 19.


The microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury.

Zhang X, Patil D, Odze RD, Zhao L, Lisovsky M, Guindi M, Riddell R, Bellizzi A, Yantiss RK, Nalbantoglu I, Appelman HD.

Ann N Y Acad Sci. 2018 Dec;1434(1):304-318. doi: 10.1111/nyas.13705. Epub 2018 May 15. Review.


Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab.

Yadav VN, Altshuler D, Kadiyala P, Zamler D, Comba A, Appelman H, Dunn P, Koschmann C, Castro MG, Löwenstein PR.

Neuro Oncol. 2018 Sep 3;20(10):1356-1367. doi: 10.1093/neuonc/noy055.


Identification, isolation and characterization of human LGR5-positive colon adenoma cells.

Dame MK, Attili D, McClintock SD, Dedhia PH, Ouillette P, Hardt O, Chin AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai YH, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson LC, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA.

Development. 2018 Mar 14;145(6). pii: dev153049. doi: 10.1242/dev.153049.


Use of Appropriate Surveillance for Patients With Nondysplastic Barrett's Esophagus.

Tavakkoli A, Appelman HD, Beer DG, Madiyal C, Khodadost M, Nofz K, Metko V, Elta G, Wang T, Rubenstein JH.

Clin Gastroenterol Hepatol. 2018 Jun;16(6):862-869.e3. doi: 10.1016/j.cgh.2018.01.052. Epub 2018 Feb 9.


Melanoma induced immunosuppression is mediated by hematopoietic dysregulation.

Kamran N, Li Y, Sierra M, Alghamri MS, Kadiyala P, Appelman HD, Edwards M, Lowenstein PR, Castro MG.

Oncoimmunology. 2017 Dec 14;7(3):e1408750. doi: 10.1080/2162402X.2017.1408750. eCollection 2018. Erratum in: Oncoimmunology. 2018 Feb 1;7(4):e1431073.


Identification and validation of FGFR2 peptide for detection of early Barrett's neoplasia.

Zhou J, He L, Pang Z, Appelman HD, Kuick R, Beer DG, Li M, Wang TD.

Oncotarget. 2017 Aug 1;8(50):87095-87106. doi: 10.18632/oncotarget.19764. eCollection 2017 Oct 20.


Chronic Colitis in Biopsy Samples: Is It Inflammatory Bowel Disease or Something Else?

Choi EK, Appelman HD.

Surg Pathol Clin. 2017 Dec;10(4):841-861. doi: 10.1016/j.path.2017.07.005. Epub 2017 Sep 28. Review.


In vivo near-infrared imaging of ErbB2 expressing breast tumors with dual-axes confocal endomicroscopy using a targeted peptide.

Gao Z, Li G, Li X, Zhou J, Duan X, Chen J, Joshi BP, Kuick R, Khoury B, Thomas DG, Fields T, Sabel MS, Appelman HD, Zhou Q, Li H, Kozloff K, Wang TD.

Sci Rep. 2017 Oct 31;7(1):14404. doi: 10.1038/s41598-017-13735-z.


Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene.

Graham RP, Nair AA, Davila JI, Jin L, Jen J, Sukov WR, Wu TT, Appelman HD, Torres-Mora J, Perry KD, Zhang L, Kloft-Nelson SM, Knudson RA, Greipp PT, Folpe AL.

Mod Pathol. 2017 Oct;30(10):1443-1452. doi: 10.1038/modpathol.2017.68. Epub 2017 Jul 21.


A Multicenter Study of a Fluorescence In Situ Hybridization Probe Set for Diagnosing High-Grade Dysplasia and Adenocarcinoma in Barrett's Esophagus.

Poneros JM, Faye AS, Barr Fritcher EG, Sen A, Anandasabapathy S, Bresalier RS, Marcon N, Turgeon DK, Appelman H, Normolle D, Morrison LE, Brenner DE, Halling KC.

Dig Dis Sci. 2017 May;62(5):1216-1222. doi: 10.1007/s10620-017-4517-y. Epub 2017 Mar 6.


The Use of Ancillary Stains in the Diagnosis of Barrett Esophagus and Barrett Esophagus-associated Dysplasia: Recommendations From the Rodger C. Haggitt Gastrointestinal Pathology Society.

Srivastava A, Appelman H, Goldsmith JD, Davison JM, Hart J, Krasinskas AM.

Am J Surg Pathol. 2017 May;41(5):e8-e21. doi: 10.1097/PAS.0000000000000819. Review.


Outcomes of submucosal (T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection.

Ballard DD, Choksi N, Lin J, Choi EY, Elmunzer BJ, Appelman H, Rex DK, Fatima H, Kessler W, DeWitt JM.

World J Gastrointest Endosc. 2016 Dec 16;8(20):763-769. doi: 10.4253/wjge.v8.i20.763.


Detection of Sessile Serrated Adenomas in the Proximal Colon Using Wide-Field Fluorescence Endoscopy.

Joshi BP, Dai Z, Gao Z, Lee JH, Ghimire N, Chen J, Prabhu A, Wamsteker EJ, Kwon RS, Elta GH, Stoffel EM, Pant A, Kaltenbach T, Soetikno RM, Appelman HD, Kuick R, Turgeon DK, Wang TD.

Gastroenterology. 2017 Apr;152(5):1002-1013.e9. doi: 10.1053/j.gastro.2016.12.009. Epub 2016 Dec 22.


A Curmudgeon Reflects on Half a Century of Gastrointestinal Pathology.

Appelman HD.

Gastroenterology. 2017 Jan;152(1):4-6. doi: 10.1053/j.gastro.2016.11.031. Epub 2016 Nov 23. No abstract available.


Overexpressed Claudin-1 Can Be Visualized Endoscopically in Colonic Adenomas In Vivo.

Rabinsky EF, Joshi BP, Pant A, Zhou J, Duan X, Smith A, Kuick R, Fan S, Nusrat A, Owens SR, Appelman HD, Wang TD.

Cell Mol Gastroenterol Hepatol. 2015 Dec 13;2(2):222-237. eCollection 2016 Mar.


A Historical Perspective and Exposé on Serrated Polyps of the Colorectum.

Choi EY, Appelman HD.

Arch Pathol Lab Med. 2016 Oct;140(10):1079-84. doi: 10.5858/arpa.2016-0278-RA. Review.


Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis.

Chen S, Fisher RC, Signs S, Molina LA, Shenoy AK, Lopez MC, Baker HV, Koomen JM, Chen Y, Gittleman H, Barnholtz-Sloan J, Berg A, Appelman HD, Huang EH.

Oncotarget. 2016 Jun 8;8(31):50476-50488. doi: 10.18632/oncotarget.9919. eCollection 2017 Aug 1.


Preclinical Efficacy and Safety Profile of Allometrically Scaled Doses of Doxycycline Used to Turn "On" Therapeutic Transgene Expression from High-Capacity Adenoviral Vectors in a Glioma Model.

VanderVeen N, Raja N, Yi E, Appelman H, Ng P, Palmer D, Zamler D, Dzaman M, Lowenstein PR, Castro MG.

Hum Gene Ther Methods. 2016 Jun;27(3):98-111. doi: 10.1089/hgtb.2015.168. Epub 2016 Apr 28.


Multimodal Video Colonoscope for Targeted Wide-Field Detection of Nonpolypoid Colorectal Neoplasia.

Joshi BP, Pant A, Duan X, Prabhu A, Wamsteker EJ, Kwon RS, Elta GH, Owens SR, Appelman HD, Wang TD, Turgeon DK.

Gastroenterology. 2016 May;150(5):1084-1086. doi: 10.1053/j.gastro.2016.02.075. Epub 2016 Mar 5. No abstract available.


ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma.

Koschmann C, Calinescu AA, Nunez FJ, Mackay A, Fazal-Salom J, Thomas D, Mendez F, Kamran N, Dzaman M, Mulpuri L, Krasinkiewicz J, Doherty R, Lemons R, Brosnan-Cashman JA, Li Y, Roh S, Zhao L, Appelman H, Ferguson D, Gorbunova V, Meeker A, Jones C, Lowenstein PR, Castro MG.

Sci Transl Med. 2016 Mar 2;8(328):328ra28. doi: 10.1126/scitranslmed.aac8228.


Design and Synthesis of Near-Infrared Peptide for in Vivo Molecular Imaging of HER2.

Joshi BP, Zhou J, Pant A, Duan X, Zhou Q, Kuick R, Owens SR, Appelman H, Wang TD.

Bioconjug Chem. 2016 Feb 17;27(2):481-94. doi: 10.1021/acs.bioconjchem.5b00565. Epub 2015 Dec 28.


Multimodal endoscope can quantify wide-field fluorescence detection of Barrett's neoplasia.

Joshi BP, Duan X, Kwon RS, Piraka C, Elmunzer BJ, Lu S, Rabinsky EF, Beer DG, Appelman HD, Owens SR, Kuick R, Doguchi N, Turgeon DK, Wang TD.

Endoscopy. 2016 Feb;48(2):A1-A13. doi: 10.1055/s-0034-1392803. Epub 2015 Oct 1.


Massive Jejunal Bleeding From an Unlikely Source.

Read AJ, Appelman HD, DiMagno MJ.

Clin Gastroenterol Hepatol. 2016 Feb;14(2):A25-6. doi: 10.1016/j.cgh.2015.08.028. Epub 2015 Aug 29. No abstract available.


Progression of esophageal dysplasia to cancer.

Appelman HD, Matejcic M, Parker MI, Riddell RH, Salemme M, Swanson PE, Villanacci V.

Ann N Y Acad Sci. 2014 Sep;1325:96-107. doi: 10.1111/nyas.12523.


Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors.

VanderVeen N, Paran C, Appelhans A, Krasinkiewicz J, Lemons R, Appelman H, Doherty R, Palmer D, Ng P, Lowenstein PR, Castro MG.

Mol Ther Methods Clin Dev. 2014 Feb 5;1. pii: 10.


Sporadic lymphoplasmacytic cholecystitis: a clinicopathologic entity.

Hammer ST, Appelman HD.

Am J Clin Pathol. 2014 Aug;142(2):209-12. doi: 10.1309/AJCPKO5C3MFFYLRJ.


Barrett's Esophagus Translational Research Network (BETRNet): the pivotal role of multi-institutional collaboration in esophageal adenocarcinoma research.

Abrams JA, Appelman HD, Beer DG, Berry LD, Chak A, Falk GW, Fitzgerald RC, Ginsberg GG, Grady WM, Joshi BP, Lynch JP, Markowitz S, Richmond ES, Rustgi AK, Seibel EJ, Shaheen NJ, Shyr Y, Umar A, Wang KK, Wang TC, Wang TD, Yassin R.

Gastroenterology. 2014 Jun;146(7):1586-90. doi: 10.1053/j.gastro.2014.04.014. Epub 2014 Apr 21. No abstract available.


Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapy.

Assi HH, Paran C, VanderVeen N, Savakus J, Doherty R, Petruzzella E, Hoeschele JD, Appelman H, Raptis L, Mikkelsen T, Lowenstein PR, Castro MG.

J Pharmacol Exp Ther. 2014 Jun;349(3):458-69. doi: 10.1124/jpet.114.214619. Epub 2014 Apr 2.


Epstein-Barr virus (EBV) related acute liver failure: a case series from the US Acute Liver Failure Study Group.

Mellinger JL, Rossaro L, Naugler WE, Nadig SN, Appelman H, Lee WM, Fontana RJ.

Dig Dis Sci. 2014 Jul;59(7):1630-7. doi: 10.1007/s10620-014-3029-2. Epub 2014 Jan 25. Review.


Human colonic crypts in culture: segregation of immunochemical markers in normal versus adenoma-derived.

Dame MK, Jiang Y, Appelman HD, Copley KD, McClintock SD, Aslam MN, Attili D, Elmunzer BJ, Brenner DE, Varani J, Turgeon DK.

Lab Invest. 2014 Feb;94(2):222-34. doi: 10.1038/labinvest.2013.145. Epub 2013 Dec 23.


The esophageal mucosa and submucosa: immunohistology in GERD and Barrett's esophagus.

Appelman HD, Streutker C, Vieth M, Neumann H, Neurath MF, Upton MP, Sagaert X, Wang HH, El-Zimaity H, Abraham SC, Bellizzi AM.

Ann N Y Acad Sci. 2013 Oct;1300:144-165. doi: 10.1111/nyas.12241. Review.


Immunological dysfunction during or after antiviral therapy for recurrent hepatitis C reduces graft survival.

Sharma P, Hosmer A, Appelman H, McKenna B, Jafri MS, Sullivan P, Fontana RJ, Lok AS.

Hepatol Int. 2013 Oct;7(4):990-9. doi: 10.1007/s12072-013-9436-1.


Associations of diabetes mellitus, insulin, leptin, and ghrelin with gastroesophageal reflux and Barrett's esophagus.

Rubenstein JH, Morgenstern H, McConell D, Scheiman JM, Schoenfeld P, Appelman H, McMahon LF Jr, Kao JY, Metko V, Zhang M, Inadomi JM.

Gastroenterology. 2013 Dec;145(6):1237-44.e1-5. doi: 10.1053/j.gastro.2013.08.052. Epub 2013 Aug 30.


Association between Helicobacter pylori and Barrett's esophagus, erosive esophagitis, and gastroesophageal reflux symptoms.

Rubenstein JH, Inadomi JM, Scheiman J, Schoenfeld P, Appelman H, Zhang M, Metko V, Kao JY.

Clin Gastroenterol Hepatol. 2014 Feb;12(2):239-45. doi: 10.1016/j.cgh.2013.08.029. Epub 2013 Aug 27.


In vivo molecular imaging of Barrett's esophagus with confocal laser endomicroscopy.

Sturm MB, Piraka C, Elmunzer BJ, Kwon RS, Joshi BP, Appelman HD, Turgeon DK, Wang TD.

Gastroenterology. 2013 Jul;145(1):56-58. doi: 10.1053/j.gastro.2013.05.008. Epub 2013 May 14. No abstract available.


Targeted imaging of esophageal neoplasia with a fluorescently labeled peptide: first-in-human results.

Sturm MB, Joshi BP, Lu S, Piraka C, Khondee S, Elmunzer BJ, Kwon RS, Beer DG, Appelman HD, Turgeon DK, Wang TD.

Sci Transl Med. 2013 May 8;5(184):184ra61. doi: 10.1126/scitranslmed.3004733.


Sofosbuvir and daclatasvir combination therapy in a liver transplant recipient with severe recurrent cholestatic hepatitis C.

Fontana RJ, Hughes EA, Bifano M, Appelman H, Dimitrova D, Hindes R, Symonds WT.

Am J Transplant. 2013 Jun;13(6):1601-5. doi: 10.1111/ajt.12209. Epub 2013 Apr 17.


Imaging effects of radiation therapy in the abdomen and pelvis: evaluating "innocent bystander" tissues.

Maturen KE, Feng MU, Wasnik AP, Azar SF, Appelman HD, Francis IR, Platt JF.

Radiographics. 2013 Mar-Apr;33(2):599-619. doi: 10.1148/rg.332125119.


Protective role of gluteofemoral obesity in erosive oesophagitis and Barrett's oesophagus.

Rubenstein JH, Morgenstern H, Chey WD, Murray J, Scheiman JM, Schoenfeld P, Appelman HD, McMahon L, Metko V, Kellenberg J, Kalish T, Baker J, Inadomi JM.

Gut. 2014 Feb;63(2):230-5. doi: 10.1136/gutjnl-2012-304103. Epub 2013 Mar 5.

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