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CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis.

Somekh I, Thian M, Medgyesi D, Gülez N, Magg T, Gallón Duque A, Stauber T, Lev A, Genel F, Unal E, Simon AJ, Lee YN, Kalinichenko A, Dmytrus J, Kraakman MJ, Schiby G, Rohlfs M, Jacobson JM, Özer E, Akcal Ö, Conca R, Patiroglu T, Karakukcu M, Ozcan A, Shahin T, Appella E, Tatematsu M, Martinez-Jaramillo C, Chinn IK, Orange JS, Trujillo-Vargas CM, Franco JL, Hauck F, Somech R, Klein C, Boztug K.

Blood. 2019 Oct 31;134(18):1510-1516. doi: 10.1182/blood.2019000644.


Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.

Clausse V, Tao D, Debnath S, Fang Y, Tagad HD, Wang Y, Sun H, LeClair CA, Mazur SJ, Lane K, Shi ZD, Vasalatiy O, Eells R, Baker LK, Henderson MJ, Webb MR, Shen M, Hall MD, Appella E, Appella DH, Coussens NP.

J Biol Chem. 2019 Nov 15;294(46):17654-17668. doi: 10.1074/jbc.RA119.010201. Epub 2019 Sep 3.


Pillars Article: Purification of a Human Monocyte-Derived Neutrophil Chemotactic Factor That Has Peptide Sequence Similarity to Other Host Defense Cytokines. Proc. Natl. Acad. Sci. USA 1987. 84: 9233-9237.

Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appella E, Oppenheim JJ, Leonard EJ.

J Immunol. 2019 Jan 1;202(1):5-9. No abstract available.


Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation.

Manna A, Zhao H, Wada J, Balagopalan L, Tagad HD, Appella E, Schuck P, Samelson LE.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11914-E11923. doi: 10.1073/pnas.1817142115. Epub 2018 Dec 3.


A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity.

Debnath S, Kosek D, Tagad HD, Durell SR, Appella DH, Acevedo R, Grishaev A, Dyda F, Appella E, Mazur SJ.

J Biol Chem. 2018 May 25;293(21):7993-8008. doi: 10.1074/jbc.RA117.001213. Epub 2018 Mar 30.


Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain.

Tagad HD, Debnath S, Clausse V, Saha M, Mazur SJ, Appella E, Appella DH.

ChemMedChem. 2018 May 8;13(9):894-901. doi: 10.1002/cmdc.201700779. Epub 2018 Apr 6.


Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC.

Nat Commun. 2018 Feb 22;9(1):771. doi: 10.1038/s41467-018-03224-w.


Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome.

Giardino Torchia ML, Dutta D, Mittelstadt PR, Guha J, Gaida MM, Fish K, Barr VA, Akpan IO, Samelson LE, Tagad HD, Debnath S, Miller Jenkins LM, Appella E, Ashwell JD.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2174-2179. doi: 10.1073/pnas.1713301115. Epub 2018 Feb 12.


Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation.

Alam MS, Gaida MM, Debnath S, Tagad HD, Miller Jenkins LM, Appella E, Rahman MJ, Ashwell JD.

PLoS Biol. 2018 Jan 22;16(1):e2004111. doi: 10.1371/journal.pbio.2004111. eCollection 2018 Jan.


A novel preventive strategy against HIV-1 infection: combinatorial use of inhibitors targeting the nucleocapsid and fusion proteins.

Yang Y, Zhu J, Hassink M, Jenkins LMM, Wan Y, Appella DH, Xu J, Appella E, Zhang X.

Emerg Microbes Infect. 2017 Jun 7;6(6):e40. doi: 10.1038/emi.2017.26.


Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.

Mazur SJ, Gallagher ES, Debnath S, Durell SR, Anderson KW, Miller Jenkins LM, Appella E, Hudgens JW.

Biochemistry. 2017 May 30;56(21):2676-2689. doi: 10.1021/acs.biochem.6b01220. Epub 2017 May 12.


Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.

Veschi V, Liu Z, Voss TC, Ozbun L, Gryder B, Yan C, Hu Y, Ma A, Jin J, Mazur SJ, Lam N, Souza BK, Giannini G, Hager GL, Arrowsmith CH, Khan J, Appella E, Thiele CJ.

Cancer Cell. 2017 Jan 9;31(1):50-63. doi: 10.1016/j.ccell.2016.12.002.


Targeting cancer stem cells with p53 modulators.

Zhang Z, Liu L, Gomez-Casal R, Wang X, Hayashi R, Appella E, Kopelovich L, DeLeo AB.

Oncotarget. 2016 Jul 19;7(29):45079-45093. doi: 10.18632/oncotarget.8650.


Introduction to thematic series: protein interactions, structures, and networks.

Appella E, Jenkins LM, Guengerich FP.

J Biol Chem. 2015 Oct 30;290(44):26393-4. doi: 10.1074/jbc.R115.690370. Epub 2015 Sep 9. Review.


Cross-talk between androgen receptor/filamin A and TrkA regulates neurite outgrowth in PC12 cells.

Di Donato M, Bilancio A, D'Amato L, Claudiani P, Oliviero MA, Barone MV, Auricchio A, Appella E, Migliaccio A, Auricchio F, Castoria G.

Mol Biol Cell. 2015 Aug 1;26(15):2858-72. doi: 10.1091/mbc.E14-09-1352. Epub 2015 Jun 10.


Characterization of the p300 Taz2-p53 TAD2 complex and comparison with the p300 Taz2-p53 TAD1 complex.

Miller Jenkins LM, Feng H, Durell SR, Tagad HD, Mazur SJ, Tropea JE, Bai Y, Appella E.

Biochemistry. 2015 Mar 24;54(11):2001-10. doi: 10.1021/acs.biochem.5b00044. Epub 2015 Mar 16.


An acetyl-methyl switch drives a conformational change in p53.

Tong Q, Mazur SJ, Rincon-Arano H, Rothbart SB, Kuznetsov DM, Cui G, Liu WH, Gete Y, Klein BJ, Jenkins L, Mer G, Kutateladze AG, Strahl BD, Groudine M, Appella E, Kutateladze TG.

Structure. 2015 Feb 3;23(2):322-31. doi: 10.1016/j.str.2014.12.010.


Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1.

Tong Q, Cui G, Botuyan MV, Rothbart SB, Hayashi R, Musselman CA, Singh N, Appella E, Strahl BD, Mer G, Kutateladze TG.

Structure. 2015 Feb 3;23(2):312-21. doi: 10.1016/j.str.2014.11.013. Epub 2015 Jan 8.


SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing.

Wang RH, Lahusen TJ, Chen Q, Xu X, Jenkins LM, Leo E, Fu H, Aladjem M, Pommier Y, Appella E, Deng CX.

Int J Biol Sci. 2014 Nov 26;10(10):1193-202. doi: 10.7150/ijbs.11066. eCollection 2014.


Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells.

Castoria G, Giovannelli P, Di Donato M, Ciociola A, Hayashi R, Bernal F, Appella E, Auricchio F, Migliaccio A.

Cell Death Dis. 2014 Dec 4;5:e1548. doi: 10.1038/cddis.2014.497.


Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence.

Horikawa I, Fujita K, Jenkins LM, Hiyoshi Y, Mondal AM, Vojtesek B, Lane DP, Appella E, Harris CC.

Nat Commun. 2014 Aug 21;5:4706. doi: 10.1038/ncomms5706.


p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes.

Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC.

J Clin Invest. 2013 Dec;123(12):5247-57. doi: 10.1172/JCI70355. Epub 2013 Nov 15.


Targeting androgen receptor/Src complex impairs the aggressive phenotype of human fibrosarcoma cells.

Castoria G, Giovannelli P, Di Donato M, Hayashi R, Arra C, Appella E, Auricchio F, Migliaccio A.

PLoS One. 2013 Oct 9;8(10):e76899. doi: 10.1371/journal.pone.0076899. eCollection 2013.


Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.

Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE.

Mol Cell Biol. 2013 Nov;33(21):4140-51. doi: 10.1128/MCB.00410-13. Epub 2013 Aug 26.


Genetic variants and mutations of PPM1D control the response to DNA damage.

Dudgeon C, Shreeram S, Tanoue K, Mazur SJ, Sayadi A, Robinson RC, Appella E, Bulavin DV.

Cell Cycle. 2013 Aug 15;12(16):2656-64. doi: 10.4161/cc.25694. Epub 2013 Jul 18.


Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity.

Tanoue K, Miller Jenkins LM, Durell SR, Debnath S, Sakai H, Tagad HD, Ishida K, Appella E, Mazur SJ.

Biochemistry. 2013 Aug 27;52(34):5830-43. doi: 10.1021/bi4005649. Epub 2013 Aug 16.


The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.

Lu X, Mazur SJ, Lin T, Appella E, Xu Y.

Oncogene. 2014 May 15;33(20):2655-64. doi: 10.1038/onc.2013.209. Epub 2013 Jun 17.


Radioprobing the conformation of DNA in a p53-DNA complex.

Karamychev VN, Wang D, Mazur SJ, Appella E, Neumann RD, Zhurkin VB, Panyutin IG.

Int J Radiat Biol. 2012 Dec;88(12):1039-45. doi: 10.3109/09553002.2012.698030. Epub 2012 Jun 21.


Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio.

Goloudina AR, Mazur SJ, Appella E, Garrido C, Demidov ON.

Cell Cycle. 2012 May 15;11(10):1883-7. doi: 10.4161/cc.19901. Epub 2012 May 15.


p53 N-terminal phosphorylation: a defining layer of complex regulation.

Jenkins LM, Durell SR, Mazur SJ, Appella E.

Carcinogenesis. 2012 Aug;33(8):1441-9. doi: 10.1093/carcin/bgs145. Epub 2012 Apr 12. Review.


Polyproline and Tat transduction peptides in the study of the rapid actions of steroid receptors.

Migliaccio A, Castoria G, de Falco A, Bilancio A, Giovannelli P, Di Donato M, Marino I, Yamaguchi H, Appella E, Auricchio F.

Steroids. 2012 Aug;77(10):974-8. doi: 10.1016/j.steroids.2012.01.014. Epub 2012 Jan 28. Review.


Regulation of the Wip1 phosphatase and its effects on the stress response.

Lowe J, Cha H, Lee MO, Mazur SJ, Appella E, Fornace AJ Jr.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1480-98. Review.


Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents.

Goloudina AR, Tanoue K, Hammann A, Fourmaux E, Le Guezennec X, Bulavin DV, Mazur SJ, Appella E, Garrido C, Demidov ON.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):E68-75. doi: 10.1073/pnas.1107017108. Epub 2011 Nov 7.


Special issue: Protein structure and proteomics: introduction.

Appella E, Johansson J.

FEBS J. 2011 Oct;278(20):3795. doi: 10.1111/j.1742-4658.2011.08313.x. Epub 2011 Sep 15. No abstract available.


Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide.

Cheng-Mayer C, Huang Y, Gettie A, Tsai L, Ren W, Shakirzyanova M, Sina ST, Trunova N, Blanchard J, Jenkins LM, Lo Y, Schito ML, Appella E.

AIDS. 2011 Sep 24;25(15):1833-41. doi: 10.1097/QAD.0b013e32834a1d94.


One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.

Denton PW, Othieno F, Martinez-Torres F, Zou W, Krisko JF, Fleming E, Zein S, Powell DA, Wahl A, Kwak YT, Welch BD, Kay MS, Payne DA, Gallay P, Appella E, Estes JD, Lu M, Garcia JV.

J Virol. 2011 Aug;85(15):7582-93. doi: 10.1128/JVI.00537-11. Epub 2011 May 18.


Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).

Hayashi R, Tanoue K, Durell SR, Chatterjee DK, Jenkins LM, Appella DH, Appella E.

Biochemistry. 2011 May 31;50(21):4537-49. doi: 10.1021/bi101949t. Epub 2011 May 9.


Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites.

Ohnuma S, Chufan E, Nandigama K, Jenkins LM, Durell SR, Appella E, Sauna ZE, Ambudkar SV.

Biochemistry. 2011 May 10;50(18):3724-35. doi: 10.1021/bi200073f. Epub 2011 Apr 13.


Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

Fujita K, Horikawa I, Mondal AM, Jenkins LM, Appella E, Vojtesek B, Bourdon JC, Lane DP, Harris CC.

Nat Cell Biol. 2010 Dec;12(12):1205-12. doi: 10.1038/ncb2123. Epub 2010 Nov 7.


Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer.

Miller Jenkins LM, Ott DE, Hayashi R, Coren LV, Wang D, Xu Q, Schito ML, Inman JK, Appella DH, Appella E.

Nat Chem Biol. 2010 Dec;6(12):887-9. doi: 10.1038/nchembio.456. Epub 2010 Oct 17.


UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells.

Oh KS, Bustin M, Mazur SJ, Appella E, Kraemer KH.

DNA Repair (Amst). 2011 Jan 2;10(1):5-15. doi: 10.1016/j.dnarep.2010.09.004. Epub 2010 Oct 13.


The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.

West LE, Roy S, Lachmi-Weiner K, Hayashi R, Shi X, Appella E, Kutateladze TG, Gozani O.

J Biol Chem. 2010 Nov 26;285(48):37725-32. doi: 10.1074/jbc.M110.139527. Epub 2010 Sep 24.


Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo.

Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw AK, Banerjee B, Hande MP, Miyamoto T, Miyoshi I, Shirai T, Motoyama N, Delhase M, Appella E, Nakanishi M.

EMBO J. 2010 Oct 20;29(20):3558-70. doi: 10.1038/emboj.2010.218. Epub 2010 Sep 10.


Cooperative interactions at the SLP-76 complex are critical for actin polymerization.

Barda-Saad M, Shirasu N, Pauker MH, Hassan N, Perl O, Balbo A, Yamaguchi H, Houtman JC, Appella E, Schuck P, Samelson LE.

EMBO J. 2010 Jul 21;29(14):2315-28. doi: 10.1038/emboj.2010.133. Epub 2010 Jun 18.


Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.

Roy S, Musselman CA, Kachirskaia I, Hayashi R, Glass KC, Nix JC, Gozani O, Appella E, Kutateladze TG.

J Mol Biol. 2010 May 14;398(4):489-96. doi: 10.1016/j.jmb.2010.03.024. Epub 2010 Mar 20.


p53 binding to nucleosomal DNA depends on the rotational positioning of DNA response element.

Sahu G, Wang D, Chen CB, Zhurkin VB, Harrington RE, Appella E, Hager GL, Nagaich AK.

J Biol Chem. 2010 Jan 8;285(2):1321-32. doi: 10.1074/jbc.M109.081182. Epub 2009 Nov 3.


Dynamic interactions of proteins in complex networks.

Appella E, Anderson CW.

FEBS J. 2009 Oct;276(19):5380. doi: 10.1111/j.1742-4658.2009.07252.x. Epub 2009 Aug 27. No abstract available.


Control of p53 multimerization by Ubc13 is JNK-regulated.

Topisirovic I, Gutierrez GJ, Chen M, Appella E, Borden KL, Ronai ZA.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12676-81. doi: 10.1073/pnas.0900596106. Epub 2009 Jul 27.


Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.

Yun SM, Moulaei T, Lim D, Bang JK, Park JE, Shenoy SR, Liu F, Kang YH, Liao C, Soung NK, Lee S, Yoon DY, Lim Y, Lee DH, Otaka A, Appella E, McMahon JB, Nicklaus MC, Burke TR Jr, Yaffe MB, Wlodawer A, Lee KS.

Nat Struct Mol Biol. 2009 Aug;16(8):876-82. doi: 10.1038/nsmb.1628. Epub 2009 Jul 13. Erratum in: Nat Struct Mol Biol. 2011 Apr;18(4):516.

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