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Items: 1 to 50 of 118

1.

Innate IFN-γ-Producing Cells Developing in the Absence of IL-2 Receptor Common γ-Chain.

Resende M, Cardoso MS, Ribeiro AR, Flórido M, Borges M, Castro AG, Alves NL, Cooper AM, Appelberg R.

J Immunol. 2017 Aug 15;199(4):1429-1439. doi: 10.4049/jimmunol.1601701. Epub 2017 Jul 7.

2.

Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling.

Moreira-Teixeira L, Sousa J, McNab FW, Torrado E, Cardoso F, Machado H, Castro F, Cardoso V, Gaifem J, Wu X, Appelberg R, Castro AG, O'Garra A, Saraiva M.

J Immunol. 2016 Dec 15;197(12):4714-4726. Epub 2016 Nov 14.

3.

Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment.

Silva JP, Gonçalves C, Costa C, Sousa J, Silva-Gomes R, Castro AG, Pedrosa J, Appelberg R, Gama FM.

J Control Release. 2016 Aug 10;235:112-124. doi: 10.1016/j.jconrel.2016.05.064. Epub 2016 Jun 1.

PMID:
27261333
4.

Antimicrobial peptides as novel anti-tuberculosis therapeutics.

Silva JP, Appelberg R, Gama FM.

Biotechnol Adv. 2016 Sep-Oct;34(5):924-940. doi: 10.1016/j.biotechadv.2016.05.007. Epub 2016 May 24. Review.

PMID:
27235189
5.

Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection.

Marques F, Vale-Costa S, Cruz T, Marques JM, Silva T, Neves JV, Cortes S, Fernandes A, Rocha E, Appelberg R, Rodrigues P, Tomás AM, Gomes MS.

Parasit Vectors. 2015 Dec 18;8:644. doi: 10.1186/s13071-015-1259-6.

6.

IL-17A Promotes Intracellular Growth of Mycobacterium by Inhibiting Apoptosis of Infected Macrophages.

Cruz A, Ludovico P, Torrado E, Gama JB, Sousa J, Gaifem J, Appelberg R, Rodrigues F, Cooper AM, Pedrosa J, Saraiva M, Castro AG.

Front Immunol. 2015 Sep 30;6:498. doi: 10.3389/fimmu.2015.00498. eCollection 2015.

7.

Predominant role of interferon-γ in the host protective effect of CD8(+) T cells against Neospora caninum infection.

Correia A, Ferreirinha P, Botelho S, Belinha A, Leitão C, Caramalho Í, Teixeira L, González-Fernandéz Á, Appelberg R, Vilanova M.

Sci Rep. 2015 Oct 9;5:14913. doi: 10.1038/srep14913.

8.

Lack of the Transcription Factor Hypoxia-Inducible Factor 1α (HIF-1α) in Macrophages Accelerates the Necrosis of Mycobacterium avium-Induced Granulomas.

Cardoso MS, Silva TM, Resende M, Appelberg R, Borges M.

Infect Immun. 2015 Sep;83(9):3534-44. doi: 10.1128/IAI.00144-15. Epub 2015 Jun 22.

9.

Prevalence of Mycobacterium avium subsp. paratuberculosis and Escherichia coli in blood samples from patients with inflammatory bowel disease.

Nazareth N, Magro F, Machado E, Ribeiro TG, Martinho A, Rodrigues P, Alves R, Macedo GN, Gracio D, Coelho R, Abreu C, Appelberg R, Dias C, Macedo G, Bull T, Sarmento A.

Med Microbiol Immunol. 2015 Dec;204(6):681-92. doi: 10.1007/s00430-015-0420-3. Epub 2015 May 21.

PMID:
25994082
10.

The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-γ.

Appelberg R, Moreira D, Barreira-Silva P, Borges M, Silva L, Dinis-Oliveira RJ, Resende M, Correia-Neves M, Jordan MB, Ferreira NC, Abrunhosa AJ, Silvestre R.

Immunology. 2015 Aug;145(4):498-507. doi: 10.1111/imm.12464. Epub 2015 Apr 20.

11.

Increased viability but decreased culturability of Mycobacterium avium subsp. paratuberculosis in macrophages from inflammatory bowel disease patients under Infliximab treatment.

Nazareth N, Magro F, Appelberg R, Silva J, Gracio D, Coelho R, Cabral JM, Abreu C, Macedo G, Bull TJ, Sarmento A.

Med Microbiol Immunol. 2015 Dec;204(6):647-56. doi: 10.1007/s00430-015-0393-2. Epub 2015 Feb 22.

PMID:
25702170
12.

BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4⁺IL-17⁺TNF⁺IL-2⁺ T cells.

Cruz A, Torrado E, Carmona J, Fraga AG, Costa P, Rodrigues F, Appelberg R, Correia-Neves M, Cooper AM, Saraiva M, Pedrosa J, Castro AG.

Vaccine. 2015 Jan 1;33(1):85-91. doi: 10.1016/j.vaccine.2014.11.013. Epub 2014 Nov 20.

PMID:
25448107
13.

Endogenous cathelicidin production limits inflammation and protective immunity to Mycobacterium avium in mice.

Santos JC, Silva-Gomes S, Silva JP, Gama M, Rosa G, Gallo RL, Appelberg R.

Immun Inflamm Dis. 2014 Jun;2(1):1-12. doi: 10.1002/iid3.7. Epub 2013 Oct 31.

14.

Infliximab therapy increases the frequency of circulating CD16(+) monocytes and modifies macrophage cytokine response to bacterial infection.

Nazareth N, Magro F, Silva J, Duro M, Gracio D, Coelho R, Appelberg R, Macedo G, Sarmento A.

Clin Exp Immunol. 2014 Sep;177(3):703-11. doi: 10.1111/cei.12375.

15.

Iron in intracellular infection: to provide or to deprive?

Silva-Gomes S, Vale-Costa S, Appelberg R, Gomes MS.

Front Cell Infect Microbiol. 2013 Dec 9;3:96. doi: 10.3389/fcimb.2013.00096. eCollection 2013. Review.

16.

Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2.

Silva-Gomes S, Bouton C, Silva T, Santambrogio P, Rodrigues P, Appelberg R, Gomes MS.

PLoS One. 2013 Dec 9;8(12):e82874. doi: 10.1371/journal.pone.0082874. eCollection 2013.

17.

Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection.

Silva-Gomes S, Appelberg R, Larsen R, Soares MP, Gomes MS.

Infect Immun. 2013 Jul;81(7):2536-45. doi: 10.1128/IAI.00251-13. Epub 2013 Apr 29.

18.

Iron overload favors the elimination of Leishmania infantum from mouse tissues through interaction with reactive oxygen and nitrogen species.

Vale-Costa S, Gomes-Pereira S, Teixeira CM, Rosa G, Rodrigues PN, Tomás A, Appelberg R, Gomes MS.

PLoS Negl Trop Dis. 2013;7(2):e2061. doi: 10.1371/journal.pntd.0002061. Epub 2013 Feb 14.

19.

Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses.

Afonso-Barroso A, Clark SO, Williams A, Rosa GT, Nóbrega C, Silva-Gomes S, Vale-Costa S, Ummels R, Stoker N, Movahedzadeh F, van der Ley P, Sloots A, Cot M, Appelmelk BJ, Puzo G, Nigou J, Geurtsen J, Appelberg R.

Cell Microbiol. 2013 Apr;15(4):660-74. doi: 10.1111/cmi.12065. Epub 2012 Nov 21.

PMID:
23121245
20.

Molecular and cellular mechanisms of Mycobacterium avium-induced thymic atrophy.

Borges M, Barreira-Silva P, Flórido M, Jordan MB, Correia-Neves M, Appelberg R.

J Immunol. 2012 Oct 1;189(7):3600-8. Epub 2012 Aug 24.

21.

Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection.

Pearl JE, Torrado E, Tighe M, Fountain JJ, Solache A, Strutt T, Swain S, Appelberg R, Cooper AM.

Eur J Immunol. 2012 Dec;42(12):3267-79. doi: 10.1002/eji.201142158. Epub 2012 Sep 26.

22.

Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: insight into its novel chaperone activity.

Castro H, Teixeira F, Romao S, Santos M, Cruz T, Flórido M, Appelberg R, Oliveira P, Ferreira-da-Silva F, Tomás AM.

PLoS Pathog. 2011 Oct;7(10):e1002325. doi: 10.1371/journal.ppat.1002325. Epub 2011 Oct 27.

23.

Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages.

Sonawane A, Santos JC, Mishra BB, Jena P, Progida C, Sorensen OE, Gallo R, Appelberg R, Griffiths G.

Cell Microbiol. 2011 Oct;13(10):1601-17. doi: 10.1111/j.1462-5822.2011.01644.x. Epub 2011 Aug 11.

PMID:
21790937
24.

Mycobacteria-induced anaemia revisited: a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin.

Rodrigues PN, Gomes SS, Neves JV, Gomes-Pereira S, Correia-Neves M, Nunes-Alves C, Stolte J, Sanchez M, Appelberg R, Muckenthaler MU, Gomes MS.

Immunobiology. 2011 Oct;216(10):1127-34. doi: 10.1016/j.imbio.2011.04.004. Epub 2011 Apr 20.

PMID:
21601942
26.

Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses.

Carvalho NB, Oliveira FS, Durães FV, de Almeida LA, Flórido M, Prata LO, Caliari MV, Appelberg R, Oliveira SC.

Infect Immun. 2011 Apr;79(4):1638-46. doi: 10.1128/IAI.01030-10. Epub 2011 Feb 7.

27.

Macrophages from IBD patients exhibit defective tumour necrosis factor-α secretion but otherwise normal or augmented pro-inflammatory responses to infection.

Campos N, Magro F, Castro AR, Cabral J, Rodrigues P, Silva R, Appelberg R, Rodrigues S, Lopes S, Macedo G, Sarmento A.

Immunobiology. 2011 Aug;216(8):961-70. doi: 10.1016/j.imbio.2011.01.002. Epub 2011 Jan 12.

PMID:
21269730
28.

Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium.

Fernandes SS, Nunes A, Gomes AR, de Castro B, Hider RC, Rangel M, Appelberg R, Gomes MS.

Microbes Infect. 2010 Apr;12(4):287-94. doi: 10.1016/j.micinf.2010.01.003. Epub 2010 Jan 25.

PMID:
20097303
29.

Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen.

Nobrega C, Roque S, Nunes-Alves C, Coelho A, Medeiros I, Castro AG, Appelberg R, Correia-Neves M.

J Immunol. 2010 Jan 1;184(1):351-8. doi: 10.4049/jimmunol.0902152. Epub 2009 Nov 30.

30.

Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections.

Flórido M, McColl SR, Appelberg R.

Immunobiology. 2009;214(8):643-52. doi: 10.1016/j.imbio.2008.12.002. Epub 2009 Feb 27.

PMID:
19250702
31.

Constitutive expression of Bcl-2 in the haematopoietic compartment alters the metabolism of iron and increases resistance to mycobacterial infection.

Flórido M, Borges M, Rodrigues P, Vale-Costa S, Salomé Gomes M, Appelberg R.

Clin Exp Immunol. 2009 Apr;156(1):61-8. doi: 10.1111/j.1365-2249.2008.03867.x. Epub 2009 Jan 15.

32.

Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice.

Gomes-Pereira S, Rodrigues PN, Appelberg R, Gomes MS.

Infect Immun. 2008 Oct;76(10):4713-9. doi: 10.1128/IAI.00612-08. Epub 2008 Aug 11.

33.

Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity.

Gomes MS, Sousa Fernandes S, Cordeiro JV, Silva Gomes S, Vieira A, Appelberg R.

Eur J Immunol. 2008 Aug;38(8):2180-9. doi: 10.1002/eji.200737954.

34.

The thymus as a target for mycobacterial infections.

Nobrega C, Cardona PJ, Roque S, Pinto do O P, Appelberg R, Correia-Neves M.

Microbes Infect. 2007 Nov-Dec;9(14-15):1521-9. Epub 2007 Aug 31.

PMID:
18062904
36.

Virulence of Mycobacterium avium in mice does not correlate with resistance to nitric oxide.

Lousada S, Flórido M, Appelberg R.

Microb Pathog. 2007 Nov-Dec;43(5-6):243-8. Epub 2007 Jul 3.

PMID:
17683898
37.
38.

The effect of the host's iron status on tuberculosis.

Boelaert JR, Vandecasteele SJ, Appelberg R, Gordeuk VR.

J Infect Dis. 2007 Jun 15;195(12):1745-53. Epub 2007 May 4. Review.

PMID:
17492589
39.
40.

Neutrophils and intracellular pathogens: beyond phagocytosis and killing.

Appelberg R.

Trends Microbiol. 2007 Feb;15(2):87-92. Epub 2006 Dec 6. Review.

PMID:
17157505
41.

Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall.

Gobec S, Plantan I, Mravljak J, Svajger U, Wilson RA, Besra GS, Soares SL, Appelberg R, Kikelj D.

Eur J Med Chem. 2007 Jan;42(1):54-63. Epub 2006 Sep 28.

PMID:
17010479
42.

Regulation of granuloma fibrosis by nitric oxide during Mycobacterium avium experimental infection.

Lousada S, Flórido M, Appelberg R.

Int J Exp Pathol. 2006 Aug;87(4):307-15. Erratum in: Int J Exp Pathol. 2007 Jun;88(3):199.

43.

Genetic control of immune-mediated necrosis of Mycobacterium avium granulomas.

Flórido M, Appelberg R.

Immunology. 2006 May;118(1):122-30.

44.

Macrophage nutriprive antimicrobial mechanisms.

Appelberg R.

J Leukoc Biol. 2006 Jun;79(6):1117-28. Epub 2006 Apr 7. Review.

PMID:
16603587
45.

Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection.

Flórido M, Pearl JE, Solache A, Borges M, Haynes L, Cooper AM, Appelberg R.

Infect Immun. 2005 Jun;73(6):3577-86.

46.
47.

Contribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium.

Flórido M, Borges M, Yagita H, Appelberg R.

J Leukoc Biol. 2004 Nov;76(5):1039-46. Epub 2004 Aug 17.

PMID:
15316035
49.

Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium.

Gomes MS, Flórido M, Cordeiro JV, Teixeira CM, Takeuchi O, Akira S, Appelberg R.

Immunology. 2004 Feb;111(2):179-85.

50.

CD40 is required for the optimal induction of protective immunity to Mycobacterium avium.

Flórido M, Gonçalves AS, Gomes MS, Appelberg R.

Immunology. 2004 Mar;111(3):323-7.

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