Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 101


HIV mediated immune aging in young adults infected perinatally or during childhood.

Fastenackels S, Sauce D, Vigouroux C, Avettand-Fènoël V, Bastard JP, Fellahi S, Nailler L, Arezes E, Rouzioux C, Warszawski J, Viard JP, Appay V; ANRS Co19 COVERTE Study Group.

AIDS. 2019 May 29. doi: 10.1097/QAD.0000000000002275. [Epub ahead of print]


Phenotypic and Functional Differences between Human Herpesvirus 6- and Human Cytomegalovirus-Specific T Cells.

Fastenackels S, Bayard C, Larsen M, Magnier P, Bonnafous P, Seddiki N, Appay V, Gautheret-Dejean A, Sauce D.

J Virol. 2019 Jun 14;93(13). pii: e02321-18. doi: 10.1128/JVI.02321-18. Print 2019 Jul 1.


Priming of HIV-1-specific CD8+ T cells with strong functional properties from naïve T cells.

Kuse N, Sun X, Akahoshi T, Lissina A, Yamamoto T, Appay V, Takiguchi M.

EBioMedicine. 2019 Apr;42:109-119. doi: 10.1016/j.ebiom.2019.03.078. Epub 2019 Apr 5.


The STING ligand cGAMP potentiates the efficacy of vaccine-induced CD8+ T cells.

Gutjahr A, Papagno L, Nicoli F, Kanuma T, Kuse N, Cabral-Piccin MP, Rochereau N, Gostick E, Lioux T, Perouzel E, Price DA, Takiguchi M, Verrier B, Yamamoto T, Paul S, Appay V.

JCI Insight. 2019 Apr 4;4(7). pii: 125107. doi: 10.1172/jci.insight.125107. eCollection 2019 Apr 4.


New Insights into Lymphocyte Differentiation and Aging from Telomere Length and Telomerase Activity Measurements.

Fali T, Papagno L, Bayard C, Mouloud Y, Boddaert J, Sauce D, Appay V.

J Immunol. 2019 Apr 1;202(7):1962-1969. doi: 10.4049/jimmunol.1801475. Epub 2019 Feb 8.


Naïve CD8+ T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8+ T-Cells.

Nicoli F, Papagno L, Frere JJ, Cabral-Piccin MP, Clave E, Gostick E, Toubert A, Price DA, Caputo A, Appay V.

Front Immunol. 2018 Dec 21;9:2736. doi: 10.3389/fimmu.2018.02736. eCollection 2018.


Harnessing the Induction of CD8+ T-Cell Responses Through Metabolic Regulation by Pathogen-Recognition-Receptor Triggering in Antigen Presenting Cells.

Nicoli F, Paul S, Appay V.

Front Immunol. 2018 Oct 25;9:2372. doi: 10.3389/fimmu.2018.02372. eCollection 2018. Review.


Elderly human hematopoietic progenitor cells express cellular senescence markers and are more susceptible to pyroptosis.

Fali T, Fabre-Mersseman V, Yamamoto T, Bayard C, Papagno L, Fastenackels S, Zoorab R, Koup RA, Boddaert J, Sauce D, Appay V.

JCI Insight. 2018 Jul 12;3(13). pii: 95319. doi: 10.1172/jci.insight.95319.


Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.


Elevated Neopterin Levels Predict Early Death in Older Hip-fracture Patients.

Larsen M, Bayard C, Lepetitcorps H, Cohen-Bittan J, Appay V, Boddaert J, Sauce D.

EBioMedicine. 2017 Dec;26:157-164. doi: 10.1016/j.ebiom.2017.11.003. Epub 2017 Nov 6.


Immunological considerations regarding parental concerns on pediatric immunizations.

Nicoli F, Appay V.

Vaccine. 2017 May 25;35(23):3012-3019. doi: 10.1016/j.vaccine.2017.04.030. Epub 2017 Apr 29. Review.


Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses.

Gutjahr A, Papagno L, Nicoli F, Lamoureux A, Vernejoul F, Lioux T, Gostick E, Price DA, Tiraby G, Perouzel E, Appay V, Verrier B, Paul S.

J Immunol. 2017 Jun 1;198(11):4205-4209. doi: 10.4049/jimmunol.1602131. Epub 2017 Apr 21.


Triggering of TLR-3, -4, NOD2, and DC-SIGN reduces viral replication and increases T-cell activation capacity of HIV-infected human dendritic cells.

Cardinaud S, Urrutia A, Rouers A, Coulon PG, Kervevan J, Richetta C, Bet A, Maze EA, Larsen M, Iglesias MC, Appay V, Graff-Dubois S, Moris A.

Eur J Immunol. 2017 May;47(5):818-829. doi: 10.1002/eji.201646603. Epub 2017 Apr 13.


Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux.

Ahmed R, Roger L, Costa Del Amo P, Miners KL, Jones RE, Boelen L, Fali T, Elemans M, Zhang Y, Appay V, Baird DM, Asquith B, Price DA, Macallan DC, Ladell K.

Cell Rep. 2016 Dec 13;17(11):2811-2818. doi: 10.1016/j.celrep.2016.11.037.


Aging of the immune system: Focus on inflammation and vaccination.

Pinti M, Appay V, Campisi J, Frasca D, Fülöp T, Sauce D, Larbi A, Weinberger B, Cossarizza A.

Eur J Immunol. 2016 Oct;46(10):2286-2301. doi: 10.1002/eji.201546178. Review.


Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.

Angin M, Wong G, Papagno L, Versmisse P, David A, Bayard C, Charmeteau-De Muylder B, Besseghir A, Thiébaut R, Boufassa F, Pancino G, Sauce D, Lambotte O, Brun-Vézinet F, Matheron S, Rowland-Jones SL, Cheynier R, Sáez-Cirión A, Appay V; ANRS CO5 IMMUNOVIR-2 Study Group.

J Immunol. 2016 Oct 1;197(7):2787-95. doi: 10.4049/jimmunol.1600693. Epub 2016 Aug 26.


Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles.

Hamimi C, David A, Versmisse P, Weiss L, Bruel T, Zucman D, Appay V, Moris A, Ungeheuer MN, Lascoux-Combe C, Barré-Sinoussi F, Muller-Trutwin M, Boufassa F, Lambotte O, Pancino G, Sáez-Cirión A; ANRS CO21 CODEX cohort.

PLoS One. 2016 Aug 9;11(8):e0160251. doi: 10.1371/journal.pone.0160251. eCollection 2016.


Assessing immune aging in HIV-infected patients.

Appay V, Sauce D.

Virulence. 2017 Jul 4;8(5):529-538. doi: 10.1080/21505594.2016.1195536. Epub 2016 Jun 16. Review.


Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation.

Sun X, Shi Y, Akahoshi T, Fujiwara M, Gatanaga H, Schönbach C, Kuse N, Appay V, Gao GF, Oka S, Takiguchi M.

Cell Rep. 2016 Jun 7;15(10):2279-2291. doi: 10.1016/j.celrep.2016.05.017. Epub 2016 May 26.


Reduced Oxidative Burst by Primed Neutrophils in the Elderly Individuals Is Associated With Increased Levels of the CD16bright/CD62Ldim Immunosuppressive Subset.

Sauce D, Dong Y, Campillo-Gimenez L, Casulli S, Bayard C, Autran B, Boddaert J, Appay V, Elbim C.

J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):163-172. doi: 10.1093/gerona/glw062. Epub 2016 Apr 11.


Coordinated expansion of both memory T cells and NK cells in response to CMV infection in humans.

Bayard C, Lepetitcorps H, Roux A, Larsen M, Fastenackels S, Salle V, Vieillard V, Marchant A, Stern M, Boddaert J, Bajolle F, Appay V, Sauce D.

Eur J Immunol. 2016 May;46(5):1168-79. doi: 10.1002/eji.201546179. Epub 2016 Mar 11.


TCR clonotypes: molecular determinants of T-cell efficacy against HIV.

Lissina A, Chakrabarti LA, Takiguchi M, Appay V.

Curr Opin Virol. 2016 Feb;16:77-85. doi: 10.1016/j.coviro.2016.01.017. Epub 2016 Feb 12. Review.


Fine-tuning of CD8(+) T-cell effector functions by targeting the 2B4-CD48 interaction.

Lissina A, Ambrozak DR, Boswell KL, Yang W, Boritz E, Wakabayashi Y, Iglesias MC, Hashimoto M, Takiguchi M, Haddad E, Douek DC, Zhu J, Koup RA, Yamamoto T, Appay V.

Immunol Cell Biol. 2016 Jul;94(6):583-92. doi: 10.1038/icb.2016.17. Epub 2016 Feb 10.


Immune activation and immune aging in HIV infection.

Appay V, Kelleher AD.

Curr Opin HIV AIDS. 2016 Mar;11(2):242-9. doi: 10.1097/COH.0000000000000240. Review.


Priming of Qualitatively Superior Human Effector CD8+ T Cells Using TLR8 Ligand Combined with FLT3 Ligand.

Lissina A, Briceño O, Afonso G, Larsen M, Gostick E, Price DA, Mallone R, Appay V.

J Immunol. 2016 Jan 1;196(1):256-263. doi: 10.4049/jimmunol.1501140. Epub 2015 Nov 25.


Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients.

Alanio C, Nicoli F, Sultanik P, Flecken T, Perot B, Duffy D, Bianchi E, Lim A, Clave E, van Buuren MM, Schnuriger A, Johnsson K, Boussier J, Garbarg-Chenon A, Bousquet L, Mottez E, Schumacher TN, Toubert A, Appay V, Heshmati F, Thimme R, Pol S, Mallet V, Albert ML.

Elife. 2015 Nov 14;4. pii: e07916. doi: 10.7554/eLife.07916.


Reduced naïve CD8(+) T-cell priming efficacy in elderly adults.

Briceño O, Lissina A, Wanke K, Afonso G, von Braun A, Ragon K, Miquel T, Gostick E, Papagno L, Stiasny K, Price DA, Mallone R, Sauce D, Karrer U, Appay V.

Aging Cell. 2016 Feb;15(1):14-21. doi: 10.1111/acel.12384. Epub 2015 Oct 15.


Correction: Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune Protection.

Boyd A, Almeida JR, Darrah PA, Sauce D, Seder RA, Appay V, Gorochov G, Larsen M.

PLoS One. 2015 Sep 14;10(9):e0138395. doi: 10.1371/journal.pone.0138395. eCollection 2015. No abstract available.


Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune Protection.

Boyd A, Almeida JR, Darrah PA, Sauce D, Seder RA, Appay V, Gorochov G, Larsen M.

PLoS One. 2015 Jun 5;10(6):e0128714. doi: 10.1371/journal.pone.0128714. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0138395.


Increased carotid intima-media thickness is not associated with T-cell activation nor with cytomegalovirus in HIV-infected never-smoker patients.

Goulenok T, Boyd A, Larsen M, Fastenackels S, Boccara F, Meynard JL, Hadour N, Samri A, Desvarieux M, Autran B, Appay V, Girard PM, Sauce D; CHIC Study group.

AIDS. 2015 Jan 28;29(3):287-93. doi: 10.1097/QAD.0000000000000539.


Functional Exhaustion Limits CD4+ and CD8+ T-Cell Responses to Congenital Cytomegalovirus Infection.

Huygens A, Lecomte S, Tackoen M, Olislagers V, Delmarcelle Y, Burny W, Van Rysselberge M, Liesnard C, Larsen M, Appay V, Donner C, Marchant A.

J Infect Dis. 2015 Aug 1;212(3):484-94. doi: 10.1093/infdis/jiv071. Epub 2015 Feb 5.


Vitamin D supplementation is associated with reduced immune activation levels in HIV-1-infected patients on suppressive antiretroviral therapy.

Fabre-Mersseman V, Tubiana R, Papagno L, Bayard C, Briceno O, Fastenackels S, Dudoit Y, Rostane H, Salmon D, Costagliola D, Caby F, Sauce D, Viard JP, Appay V.

AIDS. 2014 Nov 28;28(18):2677-82. doi: 10.1097/QAD.0000000000000472.


Neutrophils in antiretroviral therapy-controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment.

Campillo-Gimenez L, Casulli S, Dudoit Y, Seang S, Carcelain G, Lambert-Niclot S, Appay V, Autran B, Tubiana R, Elbim C.

J Allergy Clin Immunol. 2014 Nov;134(5):1142-52.e5. doi: 10.1016/j.jaci.2014.05.040. Epub 2014 Jul 16.


Superimposed epitopes restricted by the same HLA molecule drive distinct HIV-specific CD8+ T cell repertoires.

Sun X, Fujiwara M, Shi Y, Kuse N, Gatanaga H, Appay V, Gao GF, Oka S, Takiguchi M.

J Immunol. 2014 Jul 1;193(1):77-84. doi: 10.4049/jimmunol.1400375. Epub 2014 Jun 4.


Naive T cells: the crux of cellular immune aging?

Appay V, Sauce D.

Exp Gerontol. 2014 Jun;54:90-3. doi: 10.1016/j.exger.2014.01.003. Epub 2014 Jan 15. Review.


The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate.

Lissina A, Fastenackels S, Inglesias MC, Ladell K, McLaren JE, Briceño O, Gostick E, Papagno L, Autran B, Sauce D, Price DA, Saez-Cirion A, Appay V.

AIDS. 2014 Feb 20;28(4):477-86. doi: 10.1097/QAD.0000000000000175.


[Influence of PD-1 on the immunological synapse: a facet of immune regulation ?].

Larsen M, Appay V, Sauce D.

Med Sci (Paris). 2013 Dec;29(12):1080-2. doi: 10.1051/medsci/20132912006. Epub 2013 Dec 20. French. No abstract available.


Differential impact of age and cytomegalovirus infection on the γδ T cell compartment.

Roux A, Mourin G, Larsen M, Fastenackels S, Urrutia A, Gorochov G, Autran B, Donner C, Sidi D, Sibony-Prat J, Marchant A, Stern M, Sauce D, Appay V.

J Immunol. 2013 Aug 1;191(3):1300-6. doi: 10.4049/jimmunol.1202940. Epub 2013 Jul 1.


CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation.

Roux A, Mourin G, Fastenackels S, Almeida JR, Iglesias MC, Boyd A, Gostick E, Larsen M, Price DA, Sacre K, Douek DC, Autran B, Picard C, Miranda Sd, Sauce D, Stern M, Appay V.

Clin Immunol. 2013 Jul;148(1):16-26. doi: 10.1016/j.clim.2013.03.012. Epub 2013 Mar 29.


A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells.

Ladell K, Hashimoto M, Iglesias MC, Wilmann PG, McLaren JE, Gras S, Chikata T, Kuse N, Fastenackels S, Gostick E, Bridgeman JS, Venturi V, Arkoub ZA, Agut H, van Bockel DJ, Almeida JR, Douek DC, Meyer L, Venet A, Takiguchi M, Rossjohn J, Price DA, Appay V.

Immunity. 2013 Mar 21;38(3):425-36. doi: 10.1016/j.immuni.2012.11.021.


Monitoring cellular immune markers in HIV infection: from activation to exhaustion.

Sauce D, Elbim C, Appay V.

Curr Opin HIV AIDS. 2013 Mar;8(2):125-31. doi: 10.1097/COH.0b013e32835d08a9. Review.


Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults.

Sauce D, Larsen M, Fastenackels S, Roux A, Gorochov G, Katlama C, Sidi D, Sibony-Prat J, Appay V.

J Immunol. 2012 Dec 15;189(12):5541-8. doi: 10.4049/jimmunol.1201235. Epub 2012 Nov 7.


CMV and Immunosenescence: from basics to clinics.

Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M, Bosch JA, Campos C, Cantisán S, Cicin-Sain L, Derhovanessian E, Ferrando-Martínez S, Frasca D, Fulöp T, Govind S, Grubeck-Loebenstein B, Hill A, Hurme M, Kern F, Larbi A, López-Botet M, Maier AB, McElhaney JE, Moss P, Naumova E, Nikolich-Zugich J, Pera A, Rector JL, Riddell N, Sanchez-Correa B, Sansoni P, Sauce D, van Lier R, Wang GC, Wills MR, Zieliński M, Pawelec G.

Immun Ageing. 2012 Oct 31;9(1):23. doi: 10.1186/1742-4933-9-23.


Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency.

Iglesias MC, Briceno O, Gostick E, Moris A, Meaudre C, Price DA, Ungeheuer MN, Saez-Cirion A, Mallone R, Appay V.

Immunol Lett. 2013 Jan;149(1-2):119-22. doi: 10.1016/j.imlet.2012.10.002. Epub 2012 Oct 13.


Evaluating cellular polyfunctionality with a novel polyfunctionality index.

Larsen M, Sauce D, Arnaud L, Fastenackels S, Appay V, Gorochov G.

PLoS One. 2012;7(7):e42403. doi: 10.1371/journal.pone.0042403. Epub 2012 Jul 30.


Exhausted cytotoxic control of Epstein-Barr virus in human lupus.

Larsen M, Sauce D, Deback C, Arnaud L, Mathian A, Miyara M, Boutolleau D, Parizot C, Dorgham K, Papagno L, Appay V, Amoura Z, Gorochov G.

PLoS Pathog. 2011 Oct;7(10):e1002328. doi: 10.1371/journal.ppat.1002328. Epub 2011 Oct 20.


Altered thymic activity in early life: how does it affect the immune system in young adults?

Sauce D, Appay V.

Curr Opin Immunol. 2011 Aug;23(4):543-8. doi: 10.1016/j.coi.2011.05.001. Review.


Escape from highly effective public CD8+ T-cell clonotypes by HIV.

Iglesias MC, Almeida JR, Fastenackels S, van Bockel DJ, Hashimoto M, Venturi V, Gostick E, Urrutia A, Wooldridge L, Clement M, Gras S, Wilmann PG, Autran B, Moris A, Rossjohn J, Davenport MP, Takiguchi M, Brander C, Douek DC, Kelleher AD, Price DA, Appay V.

Blood. 2011 Aug 25;118(8):2138-49. doi: 10.1182/blood-2011-01-328781. Epub 2011 Jul 6.


CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope.

Cardinaud S, Consiglieri G, Bouziat R, Urrutia A, Graff-Dubois S, Fourati S, Malet I, Guergnon J, Guihot A, Katlama C, Autran B, van Endert P, Lemonnier FA, Appay V, Schwartz O, Kloetzel PM, Moris A.

PLoS Pathog. 2011 May;7(5):e1002049. doi: 10.1371/journal.ppat.1002049. Epub 2011 May 12.


Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets.

Salaun B, Yamamoto T, Badran B, Tsunetsugu-Yokota Y, Roux A, Baitsch L, Rouas R, Fayyad-Kazan H, Baumgaertner P, Devevre E, Ramesh A, Braun M, Speiser D, Autran B, Martiat P, Appay V, Romero P.

J Transl Med. 2011 Apr 20;9:44. doi: 10.1186/1479-5876-9-44.

Supplemental Content

Support Center