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Items: 9


Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing.

Leung DC, Dong KB, Maksakova IA, Goyal P, Appanah R, Lee S, Tachibana M, Shinkai Y, Lehnertz B, Mager DL, Rossi F, Lorincz MC.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5718-23. doi: 10.1073/pnas.1014660108. Epub 2011 Mar 22.


Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells.

Casanova M, Preissner T, Cerase A, Poot R, Yamada D, Li X, Appanah R, Bezstarosti K, Demmers J, Koseki H, Brockdorff N.

Development. 2011 Apr;138(8):1471-82. doi: 10.1242/dev.053652. Epub 2011 Mar 2.


Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation.

Rush M, Appanah R, Lee S, Lam LL, Goyal P, Lorincz MC.

Epigenetics. 2009 Aug 16;4(6):404-14. Epub 2009 Aug 29.


DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity.

Dong KB, Maksakova IA, Mohn F, Leung D, Appanah R, Lee S, Yang HW, Lam LL, Mager DL, Schübeler D, Tachibana M, Shinkai Y, Lorincz MC.

EMBO J. 2008 Oct 22;27(20):2691-701. doi: 10.1038/emboj.2008.193. Epub 2008 Sep 25.


An unmethylated 3' promoter-proximal region is required for efficient transcription initiation.

Appanah R, Dickerson DR, Goyal P, Groudine M, Lorincz MC.

PLoS Genet. 2007 Feb 16;3(2):e27. Epub 2007 Jan 2.


Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.

de Napoles M, Mermoud JE, Wakao R, Tang YA, Endoh M, Appanah R, Nesterova TB, Silva J, Otte AP, Vidal M, Koseki H, Brockdorff N.

Dev Cell. 2004 Nov;7(5):663-76.


Reactivation of the paternal X chromosome in early mouse embryos.

Mak W, Nesterova TB, de Napoles M, Appanah R, Yamanaka S, Otte AP, Brockdorff N.

Science. 2004 Jan 30;303(5658):666-9.


Skewing X chromosome choice by modulating sense transcription across the Xist locus.

Nesterova TB, Johnston CM, Appanah R, Newall AE, Godwin J, Alexiou M, Brockdorff N.

Genes Dev. 2003 Sep 1;17(17):2177-90.


Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.

Silva J, Mak W, Zvetkova I, Appanah R, Nesterova TB, Webster Z, Peters AH, Jenuwein T, Otte AP, Brockdorff N.

Dev Cell. 2003 Apr;4(4):481-95.

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