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Items: 32


Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy.

Aroniadou-Anderjaska V, Figueiredo TH, Apland JP, Braga MF.

Neurobiol Dis. 2019 Feb 21:104406. doi: 10.1016/j.nbd.2019.02.017. [Epub ahead of print] Review.


Acute and long-term consequences of exposure to organophosphate nerve agents in humans.

Figueiredo TH, Apland JP, Braga MFM, Marini AM.

Epilepsia. 2018 Oct;59 Suppl 2:92-99. doi: 10.1111/epi.14500. Epub 2018 Aug 29. Review.


Full Protection Against Soman-Induced Seizures and Brain Damage by LY293558 and Caramiphen Combination Treatment in Adult Rats.

Apland JP, Aroniadou-Anderjaska V, Figueiredo TH, De Araujo Furtado M, Braga MFM.

Neurotox Res. 2018 Oct;34(3):511-524. doi: 10.1007/s12640-018-9907-1. Epub 2018 Apr 30.


Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population.

Apland JP, Aroniadou-Anderjaska V, Figueiredo TH, Pidoplichko VI, Rossetti K, Braga MFM.

J Pharmacol Exp Ther. 2018 May;365(2):314-326. doi: 10.1124/jpet.117.245969. Epub 2018 Feb 21.


Susceptibility to Soman Toxicity and Efficacy of LY293558 Against Soman-Induced Seizures and Neuropathology in 10-Month-Old Male Rats.

Apland JP, Aroniadou-Anderjaska V, Figueiredo TH, Prager EM, Olsen CH, Braga MFM.

Neurotox Res. 2017 Nov;32(4):694-706. doi: 10.1007/s12640-017-9789-7. Epub 2017 Aug 3.


The M1 Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala.

Miller SL, Aroniadou-Anderjaska V, Pidoplichko VI, Figueiredo TH, Apland JP, Krishnan JK, Braga MF.

J Pharmacol Exp Ther. 2017 Jan;360(1):23-32. Epub 2016 Oct 31.


Long-term neuropathological and behavioral impairments after exposure to nerve agents.

Aroniadou-Anderjaska V, Figueiredo TH, Apland JP, Prager EM, Pidoplichko VI, Miller SL, Braga MF.

Ann N Y Acad Sci. 2016 Jun;1374(1):17-28. doi: 10.1111/nyas.13028. Epub 2016 Mar 22. Review.


Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure.

Piermartiri TC, Pan H, Chen J, McDonough J, Grunberg N, Apland JP, Marini AM.

Neuromolecular Med. 2015 Sep;17(3):251-69. doi: 10.1007/s12017-015-8353-y. Epub 2015 Apr 29.


A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists.

Miller SL, Aroniadou-Anderjaska V, Figueiredo TH, Prager EM, Almeida-Suhett CP, Apland JP, Braga MF.

Toxicol Appl Pharmacol. 2015 Apr 15;284(2):204-16. doi: 10.1016/j.taap.2015.02.008. Epub 2015 Feb 15.


LY293558 prevents soman-induced pathophysiological alterations in the basolateral amygdala and the development of anxiety.

Prager EM, Figueiredo TH, Long RP 2nd, Aroniadou-Anderjaska V, Apland JP, Braga MF.

Neuropharmacology. 2015 Feb;89:11-8. doi: 10.1016/j.neuropharm.2014.08.014. Epub 2014 Sep 6.


The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.

Apland JP, Aroniadou-Anderjaska V, Figueiredo TH, Rossetti F, Miller SL, Braga MF.

J Pharmacol Exp Ther. 2014 Nov;351(2):359-72. doi: 10.1124/jpet.114.217299. Epub 2014 Aug 25.


Pathophysiological mechanisms underlying increased anxiety after soman exposure: reduced GABAergic inhibition in the basolateral amygdala.

Prager EM, Pidoplichko VI, Aroniadou-Anderjaska V, Apland JP, Braga MF.

Neurotoxicology. 2014 Sep;44:335-43. doi: 10.1016/j.neuro.2014.08.007. Epub 2014 Aug 20.


The recovery of acetylcholinesterase activity and the progression of neuropathological and pathophysiological alterations in the rat basolateral amygdala after soman-induced status epilepticus: relation to anxiety-like behavior.

Prager EM, Aroniadou-Anderjaska V, Almeida-Suhett CP, Figueiredo TH, Apland JP, Rossetti F, Olsen CH, Braga MF.

Neuropharmacology. 2014 Jun;81:64-74. doi: 10.1016/j.neuropharm.2014.01.035. Epub 2014 Jan 31.


Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure.

Prager EM, Aroniadou-Anderjaska V, Almeida-Suhett CP, Figueiredo TH, Apland JP, Braga MF.

Neurotoxicology. 2013 Sep;38:84-90. doi: 10.1016/j.neuro.2013.06.006. Epub 2013 Jun 29.


Efficacy of the GluK1/AMPA receptor antagonist LY293558 against seizures and neuropathology in a soman-exposure model without pretreatment and its pharmacokinetics after intramuscular administration.

Apland JP, Aroniadou-Anderjaska V, Figueiredo TH, Green CE, Swezey R, Yang C, Qashu F, Braga MF.

J Pharmacol Exp Ther. 2013 Jan;344(1):133-40. doi: 10.1124/jpet.112.198689. Epub 2012 Oct 5.


Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations.

Adler M, Deshpande SS, Apland JP, Murray B, Borrell A.

Neurochem Int. 2012 Nov;61(6):866-73. doi: 10.1016/j.neuint.2012.07.015. Epub 2012 Jul 25.


Neuroprotective efficacy of caramiphen against soman and mechanisms of its action.

Figueiredo TH, Aroniadou-Anderjaska V, Qashu F, Apland JP, Pidoplichko V, Stevens D, Ferrara TM, Braga MF.

Br J Pharmacol. 2011 Nov;164(5):1495-505. doi: 10.1111/j.1476-5381.2011.01427.x.


The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology.

Figueiredo TH, Qashu F, Apland JP, Aroniadou-Anderjaska V, Souza AP, Braga MF.

J Pharmacol Exp Ther. 2011 Feb;336(2):303-12. doi: 10.1124/jpet.110.171835. Epub 2010 Oct 20.


Higher susceptibility of the ventral versus the dorsal hippocampus and the posteroventral versus anterodorsal amygdala to soman-induced neuropathology.

Apland JP, Figueiredo TH, Qashu F, Aroniadou-Anderjaska V, Souza AP, Braga MF.

Neurotoxicology. 2010 Sep;31(5):485-92. doi: 10.1016/j.neuro.2010.05.014. Epub 2010 Jun 8.


Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure.

Haigh JR, Adler M, Apland JP, Deshpande SS, Barham CB, Desmond P, Koplovitz I, Lenz DE, Gordon RK.

Chem Biol Interact. 2010 Sep 6;187(1-3):416-20. doi: 10.1016/j.cbi.2010.02.003. Epub 2010 Feb 8.


Primary brain targets of nerve agents: the role of the amygdala in comparison to the hippocampus.

Aroniadou-Anderjaska V, Figueiredo TH, Apland JP, Qashu F, Braga MF.

Neurotoxicology. 2009 Sep;30(5):772-6. doi: 10.1016/j.neuro.2009.06.011. Epub 2009 Jul 8.


Soman induces ictogenesis in the amygdala and interictal activity in the hippocampus that are blocked by a GluR5 kainate receptor antagonist in vitro.

Apland JP, Aroniadou-Anderjaska V, Braga MF.

Neuroscience. 2009 Mar 3;159(1):380-9. doi: 10.1016/j.neuroscience.2008.11.053. Epub 2008 Dec 14.


Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis.

Qashu F, Figueiredo TH, Aroniadou-Anderjaska V, Apland JP, Braga MF.

Amino Acids. 2010 Jan;38(1):189-97. doi: 10.1007/s00726-008-0227-2. Epub 2009 Jan 7.


Inhibition of neurotransmitter release by peptides that mimic the N-terminal domain of SNAP-25.

Apland JP, Adler M, Oyler GA.

J Protein Chem. 2003 Feb;22(2):147-53.


Peptides that mimic the carboxy-terminal domain of SNAP-25 block acetylcholine release at an Aplysia synapse.

Apland JP, Biser JA, Adler M, Ferrer-Montiel AV, Montal M, Canaves JM, Filbert MG.

J Appl Toxicol. 1999 Dec;19 Suppl 1:S23-6. Erratum in: J Appl Toxicol 2000 Nov-Dec;20(6):499.


The 26-mer peptide released from SNAP-25 cleavage by botulinum neurotoxin E inhibits vesicle docking.

Ferrer-Montiel AV, GutiƩrrez LM, Apland JP, Canaves JM, Gil A, Viniegra S, Biser JA, Adler M, Montal M.

FEBS Lett. 1998 Sep 11;435(1):84-8.


Suppression of drug-induced epileptiform discharges by cyclic AMP in rat hippocampus.

Apland JP, Helekar SA, Lebeda FJ.

Mol Chem Neuropathol. 1997 Aug;31(3):265-78.


Anesthetic agents for use in the invertebrate sea snail, Aplysia californica.

Clark TR, Nossov PC, Apland JP, Filbert MC.

Contemp Top Lab Anim Sci. 1996 Sep;35(5):75-9. No abstract available.


Anticonvulsant effects of memantine and MK-801 in guinea pig hippocampal slices.

Apland JP, Cann FJ.

Brain Res Bull. 1995;37(3):311-6.


Brevetoxin depresses synaptic transmission in guinea pig hippocampal slices.

Apland JP, Adler M, Sheridan RE.

Brain Res Bull. 1993;31(1-2):201-7.


Paraoxon block of chloride conductance in cell R2 of Aplysia californica.

Filbert MG, Apland JP, Petrali JP, Adler M.

Brain Res Bull. 1992 Mar;28(3):473-7.


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