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Items: 34


The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response.

Zhu Z, Shukla A, Ramezani-Rad P, Apgar JR, Rickert RC.

Life Sci Alliance. 2019 Nov 25;2(6). pii: e201900506. doi: 10.26508/lsa.201900506. Print 2019 Dec.


Self-reactive B cells in the GALT are actively curtailed to prevent gut inflammation.

Shukla A, Chen C, Jellusova J, Leung CR, Kao E, Bhat N, Lin WW, Apgar JR, Rickert RC.

JCI Insight. 2019 Jul 23;5. pii: 130621. doi: 10.1172/jci.insight.130621.


New Methods To Analyze B Cell Immune Responses to Thymus-Dependent Antigen Sheep Red Blood Cells.

McAllister EJ, Apgar JR, Leung CR, Rickert RC, Jellusova J.

J Immunol. 2017 Oct 15;199(8):2998-3003. doi: 10.4049/jimmunol.1700454. Epub 2017 Sep 15.


Gsk3 is a metabolic checkpoint regulator in B cells.

Jellusova J, Cato MH, Apgar JR, Ramezani-Rad P, Leung CR, Chen C, Richardson AD, Conner EM, Benschop RJ, Woodgett JR, Rickert RC.

Nat Immunol. 2017 Mar;18(3):303-312. doi: 10.1038/ni.3664. Epub 2017 Jan 23.


Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.

Apgar JR, Mader M, Agostinelli R, Benard S, Bialek P, Johnson M, Gao Y, Krebs M, Owens J, Parris K, St Andre M, Svenson K, Morris C, Tchistiakova L.

MAbs. 2016 Oct;8(7):1302-1318. Epub 2016 Sep 13.


Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.

Root AR, Cao W, Li B, LaPan P, Meade C, Sanford J, Jin M, O'Sullivan C, Cummins E, Lambert M, Sheehan AD, Ma W, Gatto S, Kerns K, Lam K, D'Antona AM, Zhu L, Brady WA, Benard S, King A, He T, Racie L, Arai M, Barrett D, Stochaj W, LaVallie ER, Apgar JR, Svenson K, Mosyak L, Yang Y, Chichili GR, Liu L, Li H, Burke S, Johnson S, Alderson R, Finlay WJJ, Lin L, Olland S, Somers W, Bonvini E, Gerber HP, May C, Moore PA, Tchistiakova L, Bloom L.

Antibodies (Basel). 2016 Mar 4;5(1). pii: E6. doi: 10.3390/antib5010006.


Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.

Townsend S, Fennell BJ, Apgar JR, Lambert M, McDonnell B, Grant J, Wade J, Franklin E, Foy N, Ní Shúilleabháin D, Fields C, Darmanin-Sheehan A, King A, Paulsen JE, Hickling TP, Tchistiakova L, Cunningham O, Finlay WJ.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15354-9. doi: 10.1073/pnas.1510944112. Epub 2015 Nov 30.


AB-Bind: Antibody binding mutational database for computational affinity predictions.

Sirin S, Apgar JR, Bennett EM, Keating AE.

Protein Sci. 2016 Feb;25(2):393-409. doi: 10.1002/pro.2829. Epub 2015 Nov 6.


Cluster expansion models for flexible-backbone protein energetics.

Apgar JR, Hahn S, Grigoryan G, Keating AE.

J Comput Chem. 2009 Nov 30;30(15):2402-13. doi: 10.1002/jcc.21249.


Predicting helix orientation for coiled-coil dimers.

Apgar JR, Gutwin KN, Keating AE.

Proteins. 2008 Aug 15;72(3):1048-65. doi: 10.1002/prot.22118.


Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL.

Fu X, Apgar JR, Keating AE.

J Mol Biol. 2007 Aug 24;371(4):1099-117. Epub 2007 May 5.


Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma.

Zuberi RI, Hsu DK, Kalayci O, Chen HY, Sheldon HK, Yu L, Apgar JR, Kawakami T, Lilly CM, Liu FT.

Am J Pathol. 2004 Dec;165(6):2045-53.


Critical role of galectin-3 in phagocytosis by macrophages.

Sano H, Hsu DK, Apgar JR, Yu L, Sharma BB, Kuwabara I, Izui S, Liu FT.

J Clin Invest. 2003 Aug;112(3):389-97.


Mast cells. Receptors, secretagogues, and signaling.

Sharma BB, Apgar JR, Liu FT.

Clin Rev Allergy Immunol. 2002 Apr;22(2):119-48. Review. No abstract available.


Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.

Field KA, Apgar JR, Hong-Geller E, Siraganian RP, Baird B, Holowka D.

Mol Biol Cell. 2000 Oct;11(10):3661-73.


Human galectin-3 is a novel chemoattractant for monocytes and macrophages.

Sano H, Hsu DK, Yu L, Apgar JR, Kuwabara I, Yamanaka T, Hirashima M, Liu FT.

J Immunol. 2000 Aug 15;165(4):2156-64.


Pleckstrin homology domains interact with filamentous actin.

Yao L, Janmey P, Frigeri LG, Han W, Fujita J, Kawakami Y, Apgar JR, Kawakami T.

J Biol Chem. 1999 Jul 9;274(28):19752-61.


Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

Ucker DS, Obermiller PS, Eckhart W, Apgar JR, Berger NA, Meyers J.

Mol Cell Biol. 1992 Jul;12(7):3060-9.


Cytoskeletal function in CD8- and T cell receptor-mediated interaction of cytotoxic T lymphocytes with class I protein.

O'Rourke AM, Apgar JR, Kane KP, Martz E, Mescher MF.

J Exp Med. 1991 Jan 1;173(1):241-9.


Triton X-100 extraction of P815 tumor cells: evidence for a plasma membrane skeleton structure.

Apgar JR, Herrmann SH, Robinson JM, Mescher MF.

J Cell Biol. 1985 May;100(5):1369-78.


The plasma membrane 'skeleton' of tumor and lymphoid cells: a role in cell lysis?

Mescher MF, Apgar JR.

Adv Exp Med Biol. 1985;184:387-400. Review. No abstract available.


Expression of cell surface lectins on activated human lymphoid cells.

Apgar JR, Cresswell P.

Eur J Immunol. 1982 Jul;12(7):570-6.


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