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Items: 17

1.

The Draft Whole-Genome Sequence of the Antibiotic Producer Empedobacter haloabium ATCC 31962 Provides Indications for Its Taxonomic Reclassification.

Miess H, Arlt P, Apel AK, Weber T, Nieselt K, Hanssen F, Czemmel S, Nahnsen S, Gross H.

Microbiol Resour Announc. 2019 Nov 7;8(45). pii: e01120-19. doi: 10.1128/MRA.01120-19.

2.

Enhancing Drug Residence Time by Shielding of Intra-Protein Hydrogen Bonds: A Case Study on CCR2 Antagonists.

Magarkar A, Schnapp G, Apel AK, Seeliger D, Tautermann CS.

ACS Med Chem Lett. 2019 Feb 7;10(3):324-328. doi: 10.1021/acsmedchemlett.8b00590. eCollection 2019 Mar 14.

PMID:
30891134
3.

Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.

Apel AK, Cheng RKY, Tautermann CS, Brauchle M, Huang CY, Pautsch A, Hennig M, Nar H, Schnapp G.

Structure. 2019 Mar 5;27(3):427-438.e5. doi: 10.1016/j.str.2018.10.027. Epub 2018 Dec 20.

PMID:
30581043
4.

dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptome.

Bauer JS, Fillinger S, Förstner K, Herbig A, Jones AC, Flinspach K, Sharma C, Gross H, Nieselt K, Apel AK.

RNA Biol. 2017 Nov 2;14(11):1617-1626. doi: 10.1080/15476286.2017.1341020. Epub 2017 Jul 31.

5.

AGOS: A Plug-and-Play Method for the Assembly of Artificial Gene Operons into Functional Biosynthetic Gene Clusters.

Basitta P, Westrich L, Rösch M, Kulik A, Gust B, Apel AK.

ACS Synth Biol. 2017 May 19;6(5):817-825. doi: 10.1021/acssynbio.6b00319. Epub 2017 Feb 20.

PMID:
28182401
6.

Challenges in the Heterologous Production of Antibiotics in Streptomyces.

Bekiesch P, Basitta P, Apel AK.

Arch Pharm (Weinheim). 2016 Aug;349(8):594-601. doi: 10.1002/ardp.201600058. Epub 2016 Jun 3. Review.

PMID:
27258165
7.

Characterization of DNA Binding Sites of RokB, a ROK-Family Regulator from Streptomyces coelicolor Reveals the RokB Regulon.

Bekiesch P, Forchhammer K, Apel AK.

PLoS One. 2016 May 4;11(5):e0153249. doi: 10.1371/journal.pone.0153249. eCollection 2016.

8.

DNA affinity capturing identifies new regulators of the heterologously expressed novobiocin gene cluster in Streptomyces coelicolor M512.

Bekiesch P, Franz-Wachtel M, Kulik A, Brocker M, Forchhammer K, Gust B, Apel AK.

Appl Microbiol Biotechnol. 2016 May;100(10):4495-509. doi: 10.1007/s00253-016-7306-1. Epub 2016 Jan 21.

PMID:
26795961
9.

Two transcription factors, CabA and CabR, are independently involved in multilevel regulation of the biosynthetic gene cluster encoding the novel aminocoumarin, cacibiocin.

Wolański M, Łebkowski T, Kois-Ostrowska A, Zettler J, Apel AK, Jakimowicz D, Zakrzewska-Czerwińska J.

Appl Microbiol Biotechnol. 2016 Apr;100(7):3147-64. doi: 10.1007/s00253-015-7196-7. Epub 2015 Dec 5.

PMID:
26637421
10.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

11.

Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.

Flinspach K, Kapitzke C, Tocchetti A, Sosio M, Apel AK.

PLoS One. 2014 Mar 5;9(3):e90499. doi: 10.1371/journal.pone.0090499. eCollection 2014.

12.

New aminocoumarins from the rare actinomycete Catenulispora acidiphila DSM 44928: identification, structure elucidation, and heterologous production.

Zettler J, Xia H, Burkard N, Kulik A, Grond S, Heide L, Apel AK.

Chembiochem. 2014 Mar 3;15(4):612-21. doi: 10.1002/cbic.201300712. Epub 2014 Feb 19.

PMID:
24554531
13.

Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.

Rückert C, Kalinowski J, Heide L, Apel AK.

Genome Announc. 2014 Jan 9;2(1). pii: e01147-13. doi: 10.1128/genomeA.01147-13.

14.

Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the Aminocoumarin Antibiotic Novobiocin.

Flinspach K, Rückert C, Kalinowski J, Heide L, Apel AK.

Genome Announc. 2014 Jan 9;2(1). pii: e01146-13. doi: 10.1128/genomeA.01146-13.

15.

Phosphate and carbon source regulation of two PhoP-dependent glycerophosphodiester phosphodiesterase genes of Streptomyces coelicolor.

Santos-Beneit F, Rodríguez-García A, Apel AK, Martín JF.

Microbiology. 2009 Jun;155(Pt 6):1800-11. doi: 10.1099/mic.0.026799-0. Epub 2009 Apr 21.

PMID:
19383699
16.

Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor.

Sola-Landa A, Rodríguez-García A, Apel AK, Martín JF.

Nucleic Acids Res. 2008 Mar;36(4):1358-68. doi: 10.1093/nar/gkm1150. Epub 2008 Jan 10.

17.

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