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Light-dependent growth kinetics enable scale-up of well-mixed phototrophic bioprocesses in different types of photobioreactors.

Pfaffinger CE, Severin TS, Apel AC, Göbel J, Sauter J, Weuster-Botz D.

J Biotechnol. 2019 May 20;297:41-48. doi: 10.1016/j.jbiotec.2019.03.003. Epub 2019 Mar 18.


Enhancing Drug Residence Time by Shielding of Intra-Protein Hydrogen Bonds: A Case Study on CCR2 Antagonists.

Magarkar A, Schnapp G, Apel AK, Seeliger D, Tautermann CS.

ACS Med Chem Lett. 2019 Feb 7;10(3):324-328. doi: 10.1021/acsmedchemlett.8b00590. eCollection 2019 Mar 14.


Trends in contact lens microbial keratitis 1999 to 2015: a retrospective clinical review.

Green M, Sara S, Hughes I, Apel A, Stapleton F.

Clin Exp Ophthalmol. 2019 Feb 22. doi: 10.1111/ceo.13484. [Epub ahead of print]


Calcification of hydrophilic acrylic intraocular lenses following secondary surgical procedures in the anterior and posterior segments.

Darcy K, Apel A, Donaldson M, McDonald R, Males J, Coote M, Werner L, Chan E.

Br J Ophthalmol. 2019 Feb 23. pii: bjophthalmol-2018-313385. doi: 10.1136/bjophthalmol-2018-313385. [Epub ahead of print]


Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease.

Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, Rossor MN, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TLS, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M; Dominantly Inherited Alzheimer Network.

Nat Med. 2019 Feb;25(2):277-283. doi: 10.1038/s41591-018-0304-3. Epub 2019 Jan 21.


Serum Inflammatory Profile for the Discrimination of Clinical Subtypes in Parkinson's Disease.

Yilmaz R, Strafella AP, Bernard A, Schulte C, van den Heuvel L, Schneiderhan-Marra N, Knorpp T, Joos TO, Leypoldt F, Geritz J, Hansen C, Heinzel S, Apel A, Gasser T, Lang AE, Berg D, Maetzler W, Marras C.

Front Neurol. 2018 Dec 21;9:1123. doi: 10.3389/fneur.2018.01123. eCollection 2018.


Queensland Microbial Keratitis Database: 2005-2015.

Green M, Carnt N, Apel A, Stapleton F.

Br J Ophthalmol. 2019 Jan 5. pii: bjophthalmol-2018-312881. doi: 10.1136/bjophthalmol-2018-312881. [Epub ahead of print]


Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.

Apel AK, Cheng RKY, Tautermann CS, Brauchle M, Huang CY, Pautsch A, Hennig M, Nar H, Schnapp G.

Structure. 2019 Mar 5;27(3):427-438.e5. doi: 10.1016/j.str.2018.10.027. Epub 2018 Dec 20.


Outcomes of toric supplementary intraocular lenses for residual astigmatic refractive error in pseudophakic eyes.

McLintock CA, McKelvie J, Gatzioufas Z, Wilson JJ, Stephensen DC, Apel AJG.

Int Ophthalmol. 2018 Oct 29. doi: 10.1007/s10792-018-1027-7. [Epub ahead of print]


High-Dose Steroid Treatment of Bacterial Keratitis.

Green M, Hughes I, Hogden J, Sara S, Apel A, Stapleton F.

Cornea. 2019 Feb;38(2):135-140. doi: 10.1097/ICO.0000000000001794.


Trichophyton erinacei Transmitted to a Pregnant Woman From Her Pet Hedgehogs.

Kromer C, Nenoff P, Uhrlaß S, Apel A, Schön MP, Lippert U.

JAMA Dermatol. 2018 Aug 1;154(8):967-968. doi: 10.1001/jamadermatol.2018.1124. No abstract available.


Splice variants of the endonucleases XPF and XPG contain residual DNA repair capabilities and could be a valuable tool for personalized medicine.

Lehmann J, Schubert S, Seebode C, Apel A, Ohlenbusch A, Emmert S.

Oncotarget. 2017 Dec 8;9(1):1012-1027. doi: 10.18632/oncotarget.23105. eCollection 2018 Jan 2.


SNPs in Aβ clearance proteins: Lower CSF Aβ1-42 levels and earlier onset of dementia in PD.

Brockmann K, Lerche S, Dilger SS, Stirnkorb JG, Apel A, Hauser AK, Liepelt-Scarfone I, Berg D, Gasser T, Schulte C, Maetzler W.

Neurology. 2017 Dec 5;89(23):2335-2340. doi: 10.1212/WNL.0000000000004705. Epub 2017 Nov 8.


DCOne as an Allogeneic Cell-based Vaccine for Multiple Myeloma.

Leaf RK, Stroopinsky D, Pyzer AR, Kruisbeek AM, van Wetering S, Washington A, Ephraim A, Cole L, Morin A, Jain S, Nahas MR, Apel A, Arnason J, Hamdan A, Rosenblatt J, Avigan D.

J Immunother. 2017 Nov/Dec;40(9):315-322. doi: 10.1097/CJI.0000000000000185.


Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma.

Jain S, Washington A, Leaf RK, Bhargava P, Clark RA, Kupper TS, Stroopinsky D, Pyzer A, Cole L, Nahas M, Apel A, Rosenblatt J, Arnason J, Kufe D, Avigan D.

Mol Cancer Ther. 2017 Oct;16(10):2304-2314. doi: 10.1158/1535-7163.MCT-17-0060. Epub 2017 Jul 20.


Syp1 regulates the clathrin-mediated and clathrin-independent endocytosis of multiple cargo proteins through a novel sorting motif.

Apel AR, Hoban K, Chuartzman S, Tonikian R, Sidhu S, Schuldiner M, Wendland B, Prosser D.

Mol Biol Cell. 2017 Sep 1;28(18):2434-2448. doi: 10.1091/mbc.E15-10-0731. Epub 2017 Jul 12.


dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptome.

Bauer JS, Fillinger S, Förstner K, Herbig A, Jones AC, Flinspach K, Sharma C, Gross H, Nieselt K, Apel AK.

RNA Biol. 2017 Nov 2;14(11):1617-1626. doi: 10.1080/15476286.2017.1341020. Epub 2017 Jul 31.


Missing HLA C group 1 ligand in patients with AML and MDS is associated with reduced risk of relapse and better survival after allogeneic stem cell transplantation with fludarabine and treosulfan reduced toxicity conditioning.

Shimoni A, Vago L, Bernardi M, Yerushalmi R, Peccatori J, Greco R, Shem-Tov N, Lo Russo A, Danylesko I, Apel A, Bonini C, Lupo Stanghellini MT, Nagler A, Ciceri F.

Am J Hematol. 2017 Oct;92(10):1011-1019. doi: 10.1002/ajh.24827. Epub 2017 Jul 19.


Flux-Enabled Exploration of the Role of Sip1 in Galactose Yeast Metabolism.

Shymansky CM, Wang G, Baidoo EEK, Gin J, Apel AR, Mukhopadhyay A, García Martín H, Keasling JD.

Front Bioeng Biotechnol. 2017 May 24;5:31. doi: 10.3389/fbioe.2017.00031. eCollection 2017.


Committing to socially responsible seafood.

Kittinger JN, Teh LCL, Allison EH, Bennett NJ, Crowder LB, Finkbeiner EM, Hicks C, Scarton CG, Nakamura K, Ota Y, Young J, Alifano A, Apel A, Arbib A, Bishop L, Boyle M, Cisneros-Montemayor AM, Hunter P, Le Cornu E, Levine M, Jones RS, Koehn JZ, Marschke M, Mason JG, Micheli F, McClenachan L, Opal C, Peacey J, Peckham SH, Schemmel E, Solis-Rivera V, Swartz W, Wilhelm T'.

Science. 2017 Jun 2;356(6341):912-913. doi: 10.1126/science.aam9969. No abstract available.


MUC1 inhibition leads to decrease in PD-L1 levels via upregulation of miRNAs.

Pyzer AR, Stroopinsky D, Rosenblatt J, Anastasiadou E, Rajabi H, Washington A, Tagde A, Chu JH, Coll M, Jiao AL, Tsai LT, Tenen DE, Cole L, Palmer K, Ephraim A, Leaf RK, Nahas M, Apel A, Bar-Natan M, Jain S, McMasters M, Mendez L, Arnason J, Raby BA, Slack F, Kufe D, Avigan D.

Leukemia. 2017 Dec;31(12):2780-2790. doi: 10.1038/leu.2017.163. Epub 2017 May 30.


AGOS: A Plug-and-Play Method for the Assembly of Artificial Gene Operons into Functional Biosynthetic Gene Clusters.

Basitta P, Westrich L, Rösch M, Kulik A, Gust B, Apel AK.

ACS Synth Biol. 2017 May 19;6(5):817-825. doi: 10.1021/acssynbio.6b00319. Epub 2017 Feb 20.


MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia.

Pyzer AR, Stroopinsky D, Rajabi H, Washington A, Tagde A, Coll M, Fung J, Bryant MP, Cole L, Palmer K, Somaiya P, Karp Leaf R, Nahas M, Apel A, Jain S, McMasters M, Mendez L, Levine J, Joyce R, Arnason J, Pandolfi PP, Kufe D, Rosenblatt J, Avigan D.

Blood. 2017 Mar 30;129(13):1791-1801. doi: 10.1182/blood-2016-07-730614. Epub 2017 Jan 26.


Bone marrow stroma protects myeloma cells from cytotoxic damage via induction of the oncoprotein MUC1.

Bar-Natan M, Stroopinsky D, Luptakova K, Coll MD, Apel A, Rajabi H, Pyzer AR, Palmer K, Reagan MR, Nahas MR, Karp Leaf R, Jain S, Arnason J, Ghobrial IM, Anderson KC, Kufe D, Rosenblatt J, Avigan D.

Br J Haematol. 2017 Mar;176(6):929-938. doi: 10.1111/bjh.14493. Epub 2017 Jan 20.


Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.

Brockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Bernard A, Gasser T, Marras C, Schüle B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Berg D, Maetzler W.

Eur J Neurol. 2017 Feb;24(2):427-e6. doi: 10.1111/ene.13223.


Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek DR, Neumann U, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M.

Neuron. 2016 Jul 20;91(2):494-496. doi: 10.1016/j.neuron.2016.07.007. Epub 2016 Jul 20. No abstract available.


Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek DR, Neumann U, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M.

Neuron. 2016 Jul 6;91(1):56-66. doi: 10.1016/j.neuron.2016.05.018. Epub 2016 Jun 9. Erratum in: Neuron. 2016 Jul 20;91(2):494-496.


Challenges in the Heterologous Production of Antibiotics in Streptomyces.

Bekiesch P, Basitta P, Apel AK.

Arch Pharm (Weinheim). 2016 Aug;349(8):594-601. doi: 10.1002/ardp.201600058. Epub 2016 Jun 3. Review.


Inflammatory profile in LRRK2-associated prodromal and clinical PD.

Brockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Gasser T, Schüle B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler W.

J Neuroinflammation. 2016 May 24;13(1):122. doi: 10.1186/s12974-016-0588-5.


Neurofilament light chain in FTD is elevated not only in cerebrospinal fluid, but also in serum.

Wilke C, Preische O, Deuschle C, Roeben B, Apel A, Barro C, Maia L, Maetzler W, Kuhle J, Synofzik M.

J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):1270-1272. doi: 10.1136/jnnp-2015-312972. Epub 2016 May 17. No abstract available.


Characterization of DNA Binding Sites of RokB, a ROK-Family Regulator from Streptomyces coelicolor Reveals the RokB Regulon.

Bekiesch P, Forchhammer K, Apel AK.

PLoS One. 2016 May 4;11(5):e0153249. doi: 10.1371/journal.pone.0153249. eCollection 2016.


Insulin-Like Growth Factor 1 (IGF-1) in Parkinson's Disease: Potential as Trait-, Progression- and Prediction Marker and Confounding Factors.

Bernhard FP, Heinzel S, Binder G, Weber K, Apel A, Roeben B, Deuschle C, Maechtel M, Heger T, Nussbaum S, Gasser T, Maetzler W, Berg D.

PLoS One. 2016 Mar 11;11(3):e0150552. doi: 10.1371/journal.pone.0150552. eCollection 2016.


GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia.

Maetzler W, Deleersnijder W, Hanssens V, Bernard A, Brockmann K, Marquetand J, Wurster I, Rattay TW, Roncoroni L, Schaeffer E, Lerche S, Apel A, Deuschle C, Berg D.

PLoS One. 2016 Mar 3;11(3):e0149349. doi: 10.1371/journal.pone.0149349. eCollection 2016.


DNA affinity capturing identifies new regulators of the heterologously expressed novobiocin gene cluster in Streptomyces coelicolor M512.

Bekiesch P, Franz-Wachtel M, Kulik A, Brocker M, Forchhammer K, Gust B, Apel AK.

Appl Microbiol Biotechnol. 2016 May;100(10):4495-509. doi: 10.1007/s00253-016-7306-1. Epub 2016 Jan 21.


Two transcription factors, CabA and CabR, are independently involved in multilevel regulation of the biosynthetic gene cluster encoding the novel aminocoumarin, cacibiocin.

Wolański M, Łebkowski T, Kois-Ostrowska A, Zettler J, Apel AK, Jakimowicz D, Zakrzewska-Czerwińska J.

Appl Microbiol Biotechnol. 2016 Apr;100(7):3147-64. doi: 10.1007/s00253-015-7196-7. Epub 2015 Dec 5.


High-Risk, Advanced-Stage Hodgkin Lymphoma: The Impact of Combined Escalated BEACOPP and ABVD Treatment in Patients Who Rapidly Achieve Metabolic Complete Remission on Interim FDG-PET/CT Scan.

Kedmi M, Apel A, Davidson T, Levi I, Dann EJ, Polliack A, Ben-Bassat I, Nagler A, Avigdor A.

Acta Haematol. 2016;135(3):156-61. doi: 10.1159/000441962. Epub 2015 Nov 21.


Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.


Calcification of hydrophilic acrylic intraocular lenses associated with intracameral air injection following DMEK.

MacLean KD, Apel A, Wilson J, Werner L.

J Cataract Refract Surg. 2015 Jun;41(6):1310-4. doi: 10.1016/j.jcrs.2015.05.006. Epub 2015 Jun 19.


Engineering solutions for open microalgae mass cultivation and realistic indoor simulation of outdoor environments.

Apel AC, Weuster-Botz D.

Bioprocess Biosyst Eng. 2015 Jun;38(6):995-1008. doi: 10.1007/s00449-015-1363-1. Epub 2015 Jan 28. Review.


In vivo markers of Parkinson's disease and dementia with Lewy bodies: current value of the 5G4 α-synuclein antibody.

Maetzler W, Pilotto A, Apel A, Deuschle C, Kuebart G, Heinzel S, Liepelt-Scarfone I, Schulte C, Reusch D, Schleicher E, Rothfuss O, Schneider A, Dodel R, Gasser T, Berg D.

Acta Neuropathol. 2014 Dec;128(6):893-5. doi: 10.1007/s00401-014-1364-1. Epub 2014 Nov 7. No abstract available.


Salvage therapy with ARA-C and gemtuzumab ozogamicin in AML patients relapsing after stem cell transplantation.

Koren-Michowitz M, Maayan H, Apel A, Shem-Tov N, Yerushalmi R, Volchek Y, Avigdor A, Shimoni A, Nagler A.

Ann Hematol. 2015 Mar;94(3):375-8. doi: 10.1007/s00277-014-2229-3. Epub 2014 Oct 14.


Rare case of Langerhans cell histiocytosis of the conjunctiva.

Moloney TP, Ghaznawi M, Cheng S, Apel A.

Clin Exp Ophthalmol. 2015 Mar;43(2):191-2. doi: 10.1111/ceo.12385. Epub 2014 Aug 28. No abstract available.


Outcome differences in patients with precursor B cell acute lymphocytic leukemia over time: a retrospective analysis.

Apel A, Kedmi M, Levi E, Berkowicz M, Davidovitz Y, Kneller A, Ribakovsky E, Shimoni A, Nagler A, Avigdor A.

Isr Med Assoc J. 2014 Apr;16(4):224-8.


An unusual mutation in the XPG gene leads to an internal in-frame deletion and a XP/CS complex phenotype.

Lehmann J, Schubert S, Schäfer A, Apel A, Laspe P, Schiller S, Ohlenbusch A, Gratchev A, Emmert S.

Br J Dermatol. 2014 Oct;171(4):903-5. doi: 10.1111/bjd.13035. Epub 2014 Jul 26. No abstract available.


Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.

Flinspach K, Kapitzke C, Tocchetti A, Sosio M, Apel AK.

PLoS One. 2014 Mar 5;9(3):e90499. doi: 10.1371/journal.pone.0090499. eCollection 2014.


Comparable autoantibody serum levels against amyloid- and inflammation-associated proteins in Parkinson's disease patients and controls.

Maetzler W, Apel A, Langkamp M, Deuschle C, Dilger SS, Stirnkorb JG, Schulte C, Schleicher E, Gasser T, Berg D.

PLoS One. 2014 Feb 21;9(2):e88604. doi: 10.1371/journal.pone.0088604. eCollection 2014.


New aminocoumarins from the rare actinomycete Catenulispora acidiphila DSM 44928: identification, structure elucidation, and heterologous production.

Zettler J, Xia H, Burkard N, Kulik A, Grond S, Heide L, Apel AK.

Chembiochem. 2014 Mar 3;15(4):612-21. doi: 10.1002/cbic.201300712. Epub 2014 Feb 19.


Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.

Rückert C, Kalinowski J, Heide L, Apel AK.

Genome Announc. 2014 Jan 9;2(1). pii: e01147-13. doi: 10.1128/genomeA.01147-13.


Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the Aminocoumarin Antibiotic Novobiocin.

Flinspach K, Rückert C, Kalinowski J, Heide L, Apel AK.

Genome Announc. 2014 Jan 9;2(1). pii: e01146-13. doi: 10.1128/genomeA.01146-13.


Axial myopic progression following phakic intraocular lens implantation.

Apel W, Apel A, Stephensen D, Versace P.

J Cataract Refract Surg. 2013 Sep;39(9):1435-8. doi: 10.1016/j.jcrs.2013.06.012. Epub 2013 Jul 18.


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