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Items: 1 to 50 of 55

1.

Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis.

Martínez-Burgo Y, Santos-Aberturas J, Rodríguez-García A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P.

Front Microbiol. 2019 Mar 26;10:580. doi: 10.3389/fmicb.2019.00580. eCollection 2019.

2.

Phosphate effect on filipin production and morphological differentiation in Streptomyces filipinensis and the role of the PhoP transcription factor.

Barreales EG, Payero TD, de Pedro A, Aparicio JF.

PLoS One. 2018 Dec 6;13(12):e0208278. doi: 10.1371/journal.pone.0208278. eCollection 2018.

3.

Promoter Engineering Reveals the Importance of Heptameric Direct Repeats for DNA Binding by Streptomyces Antibiotic Regulatory Protein-Large ATP-Binding Regulator of the LuxR Family (SARP-LAL) Regulators in Streptomyces natalensis.

Barreales EG, Vicente CM, de Pedro A, Santos-Aberturas J, Aparicio JF.

Appl Environ Microbiol. 2018 May 1;84(10). pii: e00246-18. doi: 10.1128/AEM.00246-18. Print 2018 May 15.

4.

Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation.

Aparicio JF, Barreales EG, Payero TD, Vicente CM, de Pedro A, Santos-Aberturas J.

Appl Microbiol Biotechnol. 2016 Jan;100(1):61-78. doi: 10.1007/s00253-015-7077-0. Epub 2015 Oct 29. Review.

5.

Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives.

Payero TD, Vicente CM, Rumbero Á, Barreales EG, Santos-Aberturas J, de Pedro A, Aparicio JF.

Microb Cell Fact. 2015 Aug 7;14:114. doi: 10.1186/s12934-015-0307-4.

6.

Pathway-specific regulation revisited: cross-regulation of multiple disparate gene clusters by PAS-LuxR transcriptional regulators.

Vicente CM, Payero TD, Santos-Aberturas J, Barreales EG, de Pedro A, Aparicio JF.

Appl Microbiol Biotechnol. 2015 Jun;99(12):5123-35. doi: 10.1007/s00253-015-6472-x. Epub 2015 Feb 26.

PMID:
25715784
7.

PAS-LuxR transcriptional control of filipin biosynthesis in S. avermitilis.

Vicente CM, Santos-Aberturas J, Payero TD, Barreales EG, de Pedro A, Aparicio JF.

Appl Microbiol Biotechnol. 2014 Nov;98(22):9311-24. doi: 10.1007/s00253-014-5998-7. Epub 2014 Aug 9.

PMID:
25104037
8.

Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species.

Beites T, Rodríguez-García A, Santos-Beneit F, Moradas-Ferreira P, Aparicio JF, Mendes MV.

Appl Microbiol Biotechnol. 2014 Mar;98(5):2231-41. doi: 10.1007/s00253-013-5455-z. Epub 2014 Jan 11. Erratum in: Appl Microbiol Biotechnol. 2014 Mar;98(5):2357. Santos-Beneit, Fernando [added].

PMID:
24413916
9.

Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).

Barreiro C, Prieto C, Sola-Landa A, Solera E, Martínez-Castro M, Pérez-Redondo R, García-Estrada C, Aparicio JF, Fernández-Martínez LT, Santos-Aberturas J, Salehi-Najafabadi Z, Rodríguez-García A, Tauch A, Martín JF.

J Bacteriol. 2012 Jul;194(14):3756-7. doi: 10.1128/JB.00692-12.

10.

Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator PimM.

Santos-Aberturas J, Vicente CM, Payero TD, Martín-Sánchez L, Cañibano C, Martín JF, Aparicio JF.

PLoS One. 2012;7(6):e38536. doi: 10.1371/journal.pone.0038536. Epub 2012 Jun 5.

11.

LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor.

Guerra SM, Rodríguez-García A, Santos-Aberturas J, Vicente CM, Payero TD, Martín JF, Aparicio JF.

PLoS One. 2012;7(2):e31475. doi: 10.1371/journal.pone.0031475. Epub 2012 Feb 20.

12.

Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis.

Santos-Aberturas J, Payero TD, Vicente CM, Guerra SM, Cañibano C, Martín JF, Aparicio JF.

Metab Eng. 2011 Nov;13(6):756-67. doi: 10.1016/j.ymben.2011.09.011. Epub 2011 Oct 7.

PMID:
22001323
13.

Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes.

Santos-Aberturas J, Vicente CM, Guerra SM, Payero TD, Martín JF, Aparicio JF.

J Biol Chem. 2011 Mar 18;286(11):9150-61. doi: 10.1074/jbc.M110.182428. Epub 2010 Dec 27.

14.

Structure of cytochrome P450 PimD suggests epoxidation of the polyene macrolide pimaricin occurs via a hydroperoxoferric intermediate.

Kells PM, Ouellet H, Santos-Aberturas J, Aparicio JF, Podust LM.

Chem Biol. 2010 Aug 27;17(8):841-51. doi: 10.1016/j.chembiol.2010.05.026.

15.

PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis.

Vicente CM, Santos-Aberturas J, Guerra SM, Payero TD, Martín JF, Aparicio JF.

Microb Cell Fact. 2009 Jun 8;8:33. doi: 10.1186/1475-2859-8-33.

16.

Enzymology of the polyenes pimaricin and candicidin biosynthesis.

Martín JF, Aparicio JF.

Methods Enzymol. 2009;459:215-42. doi: 10.1016/S0076-6879(09)04610-2.

PMID:
19362642
17.

Microbial cholesterol oxidases: bioconversion enzymes or signal proteins?

Aparicio JF, Martín JF.

Mol Biosyst. 2008 Aug;4(8):804-9. doi: 10.1039/b717500k. Epub 2008 May 13.

PMID:
18633481
18.

Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents.

Caffrey P, Aparicio JF, Malpartida F, Zotchev SB.

Curr Top Med Chem. 2008;8(8):639-53. Review.

PMID:
18473889
19.

PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.

Antón N, Santos-Aberturas J, Mendes MV, Guerra SM, Martín JF, Aparicio JF.

Microbiology. 2007 Sep;153(Pt 9):3174-83.

PMID:
17768260
20.

Cholesterol oxidases act as signaling proteins for the biosynthesis of the polyene macrolide pimaricin.

Mendes MV, Recio E, Antón N, Guerra SM, Santos-Aberturas J, Martín JF, Aparicio JF.

Chem Biol. 2007 Mar;14(3):279-90.

21.

The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis.

Mendes MV, Tunca S, Antón N, Recio E, Sola-Landa A, Aparicio JF, Martín JF.

Metab Eng. 2007 Mar;9(2):217-27. Epub 2006 Oct 24.

PMID:
17142079
23.

An efficient gene transfer system for the pimaricin producer Streptomyces natalensis.

Enríquez LL, Mendes MV, Antón N, Tunca S, Guerra SM, Martín JF, Aparicio JF.

FEMS Microbiol Lett. 2006 Apr;257(2):312-8.

24.

Generating novel polyene antifungal drugs.

Aparicio JF.

Chem Biol. 2005 May;12(5):509-10.

25.

PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis.

Recio E, Colinas A, Rumbero A, Aparicio JF, Martín JF.

J Biol Chem. 2004 Oct 1;279(40):41586-93. Epub 2004 Jul 1.

26.
27.

Polyene macrolide antibiotic biosynthesis.

Aparicio JF, Mendes MV, Antón N, Recio E, Martín JF.

Curr Med Chem. 2004 Jun;11(12):1645-56. Review.

PMID:
15180569
28.
29.

Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis.

Antón N, Mendes MV, Martín JF, Aparicio JF.

J Bacteriol. 2004 May;186(9):2567-75.

30.

Characterization of the ask-asd operon in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.

Cuadrado Y, Fernández M, Recio E, Aparicio JF, Martín JF.

Appl Microbiol Biotechnol. 2004 Apr;64(2):228-36. Epub 2003 Oct 11.

PMID:
14556040
31.

Polyene antibiotic biosynthesis gene clusters.

Aparicio JF, Caffrey P, Gil JA, Zotchev SB.

Appl Microbiol Biotechnol. 2003 May;61(3):179-88. Epub 2002 Dec 18. Review.

PMID:
12698274
33.

Nitrate regulation of alpha-aminoadipate reductase formation and lysine inhibition of its activity in Penicillium chrysogenum and Acremonium chrysogenum.

Hijarrubia MJ, Aparicio JF, Martín JF.

Appl Microbiol Biotechnol. 2002 Jul;59(2-3):270-7. Epub 2002 May 8.

PMID:
12111157
34.

Characterization of the hom-thrC-thrB cluster in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.

Fernández M, Cuadrado Y, Recio E, Aparicio JF, Martín JF.

Microbiology. 2002 May;148(Pt 5):1413-20.

PMID:
11988515
35.

Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis.

Mendes MV, Recio E, Fouces R, Luiten R, Martín JF, Aparicio JF.

Chem Biol. 2001 Jul;8(7):635-44.

36.

Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional alpha-aminoadipate activating and reducing enzyme.

Hijarrubia MJ, Aparicio JF, Casqueiro J, Martín JF.

Mol Gen Genet. 2001 Feb;264(6):755-62.

PMID:
11254122
40.

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.

Aparicio JF, Molnár I, Schwecke T, König A, Haydock SF, Khaw LE, Staunton J, Leadlay PF.

Gene. 1996 Feb 22;169(1):9-16.

PMID:
8635756
41.

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.

Molnár I, Aparicio JF, Haydock SF, Khaw LE, Schwecke T, König A, Staunton J, Leadlay PF.

Gene. 1996 Feb 22;169(1):1-7.

PMID:
8635730
42.

Evidence for a double-helical structure for modular polyketide synthases.

Staunton J, Caffrey P, Aparicio JF, Roberts GA, Bethell SS, Leadlay PF.

Nat Struct Biol. 1996 Feb;3(2):188-92.

PMID:
8564546
43.

Functional analysis of pneumolysin by use of monoclonal antibodies.

de los Toyos JR, Méndez FJ, Aparicio JF, Vázquez F, Del Mar García Suárez M, Fleites A, Hardisson C, Morgan PJ, Andrew PW, Mitchell TJ.

Infect Immun. 1996 Feb;64(2):480-4.

44.

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases.

Haydock SF, Aparicio JF, Molnár I, Schwecke T, Khaw LE, König A, Marsden AF, Galloway IS, Staunton J, Leadlay PF.

FEBS Lett. 1995 Oct 30;374(2):246-8.

45.

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

Schwecke T, Aparicio JF, Molnár I, König A, Khaw LE, Haydock SF, Oliynyk M, Caffrey P, Cortés J, Lester JB, et al.

Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7839-43.

46.

A novel exocytoplasmic endonuclease from Streptomyces antibioticus.

Cal S, Aparicio JF, de los Reyes-Gavilan CG, Nicieza RG, Sanchez J.

Biochem J. 1995 Feb 15;306 ( Pt 1):93-100.

47.

Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase.

Aparicio JF, Caffrey P, Marsden AF, Staunton J, Leadlay PF.

J Biol Chem. 1994 Mar 18;269(11):8524-8.

48.

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase.

Marsden AF, Caffrey P, Aparicio JF, Loughran MS, Staunton J, Leadlay PF.

Science. 1994 Jan 21;263(5145):378-80.

PMID:
8278811
49.

The erythromycin-producing polyketide synthase.

Leadlay PF, Staunton J, Aparicio JF, Bevitt DJ, Caffrey P, Cortes J, Marsden A, Roberts GA.

Biochem Soc Trans. 1993 Feb;21(1):218-22. Review. No abstract available.

PMID:
8449298
50.

A Streptomyces glaucescens endodeoxyribonuclease which shows a strong preference for CC dinucleotide.

Aparicio JF, Freije JM, Lopez-Otin C, Cal S, Sanchez J.

Eur J Biochem. 1992 Apr 15;205(2):695-9.

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