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Items: 42


A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation.

Roos-Weil D, Decaudin C, Armand M, Della-Valle V, Diop MK, Ghamlouch H, Ropars V, Hérate C, Lara D, Durot E, Haddad R, Mylonas E, Damm F, Pflumio F, Stoilova B, Metzner M, Elemento O, Dessen P, Camara-Clayette V, Cosset FL, Verhoeyen E, Leblond V, Ribrag V, Cornillet-Lefebvre P, Rameau P, Azar N, Charlotte F, Morel P, Charbonnier JB, Vyas P, Mercher T, Aoufouchi S, Droin N, Guillouf C, Nguyen-Khac F, Bernard OA.

Cancer Discov. 2019 Apr 24. doi: 10.1158/2159-8290.CD-18-0873. [Epub ahead of print]


TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.

Dominguez PM, Ghamlouch H, Rosikiewicz W, Kumar P, Béguelin W, Fontán L, Rivas MA, Pawlikowska P, Armand M, Mouly E, Torres-Martin M, Doane AS, Calvo Fernandez MT, Durant M, Della-Valle V, Teater M, Cimmino L, Droin N, Tadros S, Motanagh S, Shih AH, Rubin MA, Tam W, Aifantis I, Levine RL, Elemento O, Inghirami G, Green MR, Figueroa ME, Bernard OA, Aoufouchi S, Li S, Shaknovich R, Melnick AM.

Cancer Discov. 2018 Dec;8(12):1632-1653. doi: 10.1158/2159-8290.CD-18-0657. Epub 2018 Oct 1.


B-cell tumor development in Tet2-deficient mice.

Mouly E, Ghamlouch H, Della-Valle V, Scourzic L, Quivoron C, Roos-Weil D, Pawlikowska P, Saada V, Diop MK, Lopez CK, Fontenay M, Dessen P, Touw IP, Mercher T, Aoufouchi S, Bernard OA.

Blood Adv. 2018 Mar 27;2(6):703-714. doi: 10.1182/bloodadvances.2017014118.


Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine.

Nebot-Bral L, Brandao D, Verlingue L, Rouleau E, Caron O, Despras E, El-Dakdouki Y, Champiat S, Aoufouchi S, Leary A, Marabelle A, Malka D, Chaput N, Kannouche PL.

Eur J Cancer. 2017 Oct;84:290-303. doi: 10.1016/j.ejca.2017.07.026. Epub 2017 Aug 29. Review.


Diagnosis of Xeroderma pigmentosum variant in a young patient with two novel mutations in the POLH gene.

De Palma A, Morren MA, Ged C, Pouvelle C, Taïeb A, Aoufouchi S, Sarasin A.

Am J Med Genet A. 2017 Sep;173(9):2511-2516. doi: 10.1002/ajmg.a.38340. Epub 2017 Jul 8.


The IGH locus relocalizes to a "recombination compartment" in the perinucleolar region of differentiating B-lymphocytes.

Pichugin A, Iarovaia OV, Gavrilov A, Sklyar I, Barinova N, Barinov A, Ivashkin E, Caron G, Aoufouchi S, Razin SV, Fest T, Lipinski M, Vassetzky YS.

Oncotarget. 2017 Jun 20;8(25):40079-40089. doi: 10.18632/oncotarget.16941.


V(D)J recombination process and the Pre-B to immature B-cells transition are altered in Fanca-/- mice.

Nguyen TV, Pawlikowska P, Firlej V, Rosselli F, Aoufouchi S.

Sci Rep. 2016 Nov 24;6:36906. doi: 10.1038/srep36906.


A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.

Fritzen R, Delbos F, De Smet A, Palancade B, Canman CE, Aoufouchi S, Weill JC, Reynaud CA, Storck S.

DNA Repair (Amst). 2016 Oct;46:37-46. doi: 10.1016/j.dnarep.2016.07.002. Epub 2016 Jul 25.


129-Derived Mouse Strains Express an Unstable but Catalytically Active DNA Polymerase Iota Variant.

Aoufouchi S, De Smet A, Delbos F, Gelot C, Guerrera IC, Weill JC, Reynaud CA.

Mol Cell Biol. 2015 Sep 1;35(17):3059-70. doi: 10.1128/MCB.00371-15. Epub 2015 Jun 29.


Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility.

Renaudin X, Guervilly JH, Aoufouchi S, Rosselli F.

J Cell Sci. 2014 Aug 15;127(Pt 16):3546-54. doi: 10.1242/jcs.150706. Epub 2014 Jul 11.


Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells.

Nguyen TV, Riou L, Aoufouchi S, Rosselli F.

J Exp Med. 2014 Jun 2;211(6):1011-8. doi: 10.1084/jem.20131637. Epub 2014 May 5.


Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.

Gineau L, Cognet C, Kara N, Lach FP, Dunne J, Veturi U, Picard C, Trouillet C, Eidenschenk C, Aoufouchi S, Alcaïs A, Smith O, Geissmann F, Feighery C, Abel L, Smogorzewska A, Stillman B, Vivier E, Casanova JL, Jouanguy E.

J Clin Invest. 2012 Mar;122(3):821-32. doi: 10.1172/JCI61014. Epub 2012 Feb 22.


AID and partners: for better and (not) for worse.

Storck S, Aoufouchi S, Weill JC, Reynaud CA.

Curr Opin Immunol. 2011 Jun;23(3):337-44. doi: 10.1016/j.coi.2011.02.002. Epub 2011 Mar 24. Review.


A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.

Faili A, Stary A, Delbos F, Weller S, Aoufouchi S, Sarasin A, Weill JC, Reynaud CA.

J Immunol. 2009 May 15;182(10):6353-9. doi: 10.4049/jimmunol.0900177.


ATM localization and gene expression in the adult mouse eye.

Leemput J, Masson C, Bigot K, Errachid A, Dansault A, Provost A, Gadin S, Aoufouchi S, Menasche M, Abitbol M.

Mol Vis. 2009;15:393-416. Epub 2009 Feb 20.


Competitive repair pathways in immunoglobulin gene hypermutation.

Reynaud CA, Delbos F, Faili A, Guéranger Q, Aoufouchi S, Weill JC.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):613-9. doi: 10.1098/rstb.2008.0206. Review.


Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line.

Gueranger Q, Stary A, Aoufouchi S, Faili A, Sarasin A, Reynaud CA, Weill JC.

DNA Repair (Amst). 2008 Sep 1;7(9):1551-62. doi: 10.1016/j.dnarep.2008.05.012. Epub 2008 Jul 21.


Proteasomal degradation restricts the nuclear lifespan of AID.

Aoufouchi S, Faili A, Zober C, D'Orlando O, Weller S, Weill JC, Reynaud CA.

J Exp Med. 2008 Jun 9;205(6):1357-68. doi: 10.1084/jem.20070950. Epub 2008 May 12.


[Immunoglobulin gene hypermutation: when error becomes a quality].

Reynaud CA, Delbos F, Aoufouchi S, Faili A, Weill JC.

Med Sci (Paris). 2007 May;23(5):470-2. French. No abstract available.


DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.

Delbos F, Aoufouchi S, Faili A, Weill JC, Reynaud CA.

J Exp Med. 2007 Jan 22;204(1):17-23. Epub 2006 Dec 26.


Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse.

Delbos F, De Smet A, Faili A, Aoufouchi S, Weill JC, Reynaud CA.

J Exp Med. 2005 Apr 18;201(8):1191-6. Epub 2005 Apr 11.


Expression of the AID protein in normal and neoplastic B cells.

Pasqualucci L, Guglielmino R, Houldsworth J, Mohr J, Aoufouchi S, Polakiewicz R, Chaganti RS, Dalla-Favera R.

Blood. 2004 Nov 15;104(10):3318-25. Epub 2004 Aug 10.


DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

Faili A, Aoufouchi S, Weller S, Vuillier F, Stary A, Sarasin A, Reynaud CA, Weill JC.

J Exp Med. 2004 Jan 19;199(2):265-70.


What role for AID: mutator, or assembler of the immunoglobulin mutasome?

Reynaud CA, Aoufouchi S, Faili A, Weill JC.

Nat Immunol. 2003 Jul;4(7):631-8. Review.


Hypermutation in human B cells in vivo and in vitro.

Weller S, Faili A, Aoufouchi S, Guéranger Q, Braun M, Reynaud CA, Weill JC.

Ann N Y Acad Sci. 2003 Apr;987:158-65. Review.


Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

Faili A, Aoufouchi S, Flatter E, Guéranger Q, Reynaud CA, Weill JC.

Nature. 2002 Oct 31;419(6910):944-7.


AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.

Faili A, Aoufouchi S, Guéranger Q, Zober C, Léon A, Bertocci B, Weill JC, Reynaud CA.

Nat Immunol. 2002 Sep;3(9):815-21. Epub 2002 Jul 29.


Ig gene hypermutation: a mechanism is due.

Weill JC, Bertocci B, Faili A, Aoufouchi S, Frey S, De Smet A, Storck S, Dahan A, Delbos F, Weller S, Flatter E, Reynaud CA.

Adv Immunol. 2002;80:183-202. Review. No abstract available.


Transcription, beta-like DNA polymerases and hypermutation.

Reynaud CA, Frey S, Aoufouchi S, Faili A, Bertocci B, Dahan A, Flatter E, Delbos F, Storck S, Zober C, Weill JC.

Philos Trans R Soc Lond B Biol Sci. 2001 Jan 29;356(1405):91-7. Review.


Two novel human and mouse DNA polymerases of the polX family.

Aoufouchi S, Flatter E, Dahan A, Faili A, Bertocci B, Storck S, Delbos F, Cocea L, Gupta N, Weill JC, Reynaud CA.

Nucleic Acids Res. 2000 Sep 15;28(18):3684-93.


Inhibition of apoptosis of a PARP(-)/(-)cell line transfected with PARP DNA-binding domain mutants.

Aoufouchi S, Yélamos J, Milstein C.

J Mol Biol. 1999 Jul 30;290(5):943-9.


Post-translational activation of non-homologous DNA end-joining in Xenopus oocyte extracts.

Aoufouchi S, Patrick T, Lindsay HD, Shall S, Ford CC.

Eur J Biochem. 1997 Jul 15;247(2):518-25.


The cloning and characterization of a cDNA encoding Xenopus laevis DNA ligase I.

Lepetit D, Thiebaud P, Aoufouchi S, Prigent C, Guesné R, Thézé N.

Gene. 1996 Jun 26;172(2):273-7.


Cyclin B/p34cdc2 triggers phosphorylation of DNA ligase I during Xenopus laevis oocyte maturation.

Aoufouchi S, Prigent C, Ford C, Thiebaud P, Philippe M, Theze N.

Eur J Biochem. 1995 Jun 1;230(2):491-7.


Inhibition of Xenopus laevis poly (ADP-ribose) polymerase in oocytes.

Aoufouchi S, Shall S.

Biochem Soc Trans. 1995 May;23(2):181S. No abstract available.


Expression of DNA ligases I and II during oogenesis and early development of Xenopus laevis.

Aoufouchi S, Prigent C, Theze N, Philippe M, Thiebaud P.

Dev Biol. 1992 Jul;152(1):199-202.


Reinvestigation of DNA ligase I in axolotl and Pleurodeles development.

Aoufouchi S, Hardy S, Prigent C, Philippe M, Thiebaud P.

Nucleic Acids Res. 1991 Aug 25;19(16):4395-8.


DNA ligase I from Xenopus laevis eggs.

Hardy S, Aoufouchi S, Thiebaud P, Prigent C.

Nucleic Acids Res. 1991 Feb 25;19(4):701-5.


Identification of DNA ligase I related polypeptides in three different human cells.

Prigent C, Aoufouchi S, Philippe M.

Biochem Biophys Res Commun. 1990 Jun 29;169(3):888-95.


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