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ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency.

Vázquez-Fonseca L, Schaefer J, Navas-Enamorado I, Santos-Ocaña C, Hernández-Camacho JD, Guerra I, Cascajo MV, Sánchez-Cuesta A, Horvath Z, Siendones E, Jou C, Casado M, Gutiérrez P, Brea-Calvo G, López-Lluch G, Fernández-Ayala DJM, Cortés-Rodríguez AB, Rodríguez-Aguilera JC, Matté C, Ribes A, Prieto-Soler SY, Dominguez-Del-Toro E, Francesco AD, Aon MA, Bernier M, Salviati L, Artuch R, Cabo R, Jackson S, Navas P.

J Clin Med. 2019 Sep 2;8(9). pii: E1374. doi: 10.3390/jcm8091374.


Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans.

Stekovic S, Hofer SJ, Tripolt N, Aon MA, Royer P, Pein L, Stadler JT, Pendl T, Prietl B, Url J, Schroeder S, Tadic J, Eisenberg T, Magnes C, Stumpe M, Zuegner E, Bordag N, Riedl R, Schmidt A, Kolesnik E, Verheyen N, Springer A, Madl T, Sinner F, de Cabo R, Kroemer G, Obermayer-Pietsch B, Dengjel J, Sourij H, Pieber TR, Madeo F.

Cell Metab. 2019 Sep 3;30(3):462-476.e5. doi: 10.1016/j.cmet.2019.07.016. Epub 2019 Aug 27.


Control and Regulation of Substrate Selection in Cytoplasmic and Mitochondrial Catabolic Networks. A Systems Biology Analysis.

Cortassa S, Aon MA, Sollott SJ.

Front Physiol. 2019 Mar 8;10:201. doi: 10.3389/fphys.2019.00201. eCollection 2019.


Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator.

Lloyd D, Murray DB, Aon MA, Cortassa S, Roussel MR, Beckmann M, Poole RK.

J Biomed Opt. 2018 Dec;24(5):1-17. doi: 10.1117/1.JBO.24.5.051404.


Metabolic remodelling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice.

Cortassa S, Caceres V, Tocchetti CG, Bernier M, de Cabo R, Paolocci N, Sollott SJ, Aon MA.

J Physiol. 2018 Nov 21. doi: 10.1113/JP276824. [Epub ahead of print]


Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability.

Kembro JM, Cortassa S, Lloyd D, Sollott SJ, Aon MA.

Sci Rep. 2018 Oct 18;8(1):15422. doi: 10.1038/s41598-018-33582-w.


Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories.

Mitchell SJ, Bernier M, Mattison JA, Aon MA, Kaiser TA, Anson RM, Ikeno Y, Anderson RM, Ingram DK, de Cabo R.

Cell Metab. 2019 Jan 8;29(1):221-228.e3. doi: 10.1016/j.cmet.2018.08.011. Epub 2018 Sep 6.


Plasma proteomic signature of age in healthy humans.

Tanaka T, Biancotto A, Moaddel R, Moore AZ, Gonzalez-Freire M, Aon MA, Candia J, Zhang P, Cheung F, Fantoni G; CHI consortium, Semba RD, Ferrucci L.

Aging Cell. 2018 Oct;17(5):e12799. doi: 10.1111/acel.12799. Epub 2018 Jul 11.


Assessing Spatiotemporal and Functional Organization of Mitochondrial Networks.

Kurz FT, Aon MA, O'Rourke B, Armoundas AA.

Methods Mol Biol. 2018;1782:383-402. doi: 10.1007/978-1-4939-7831-1_23.


Computational Modeling of Mitochondrial Function from a Systems Biology Perspective.

Cortassa S, Sollott SJ, Aon MA.

Methods Mol Biol. 2018;1782:249-265. doi: 10.1007/978-1-4939-7831-1_14.


Overexpression of CYB5R3 and NQO1, two NAD+ -producing enzymes, mimics aspects of caloric restriction.

Diaz-Ruiz A, Lanasa M, Garcia J, Mora H, Fan F, Martin-Montalvo A, Di Francesco A, Calvo-Rubio M, Salvador-Pascual A, Aon MA, Fishbein KW, Pearson KJ, Villalba JM, Navas P, Bernier M, de Cabo R.

Aging Cell. 2018 Aug;17(4):e12767. doi: 10.1111/acel.12767. Epub 2018 Apr 28.


Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models.

Vakrou S, Fukunaga R, Foster DB, Sorensen L, Liu Y, Guan Y, Woldemichael K, Pineda-Reyes R, Liu T, Tardiff JC, Leinwand LA, Tocchetti CG, Abraham TP, O'Rourke B, Aon MA, Abraham MR.

JCI Insight. 2018 Mar 22;3(6). pii: 94493. doi: 10.1172/jci.insight.94493.


Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status.

Afzal J, Chan A, Karakas MF, Woldemichael K, Vakrou S, Guan Y, Rathmell J, Wahl R, Pomper M, Foster DB, Aon MA, Tsui B, O'Rourke B, Abraham MR.

JACC Basic Transl Sci. 2017 Oct;2(5):543-560. doi: 10.1016/j.jacbts.2017.03.016. Epub 2017 Oct 30.


Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.

Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001.


Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation.

Marosi K, Moehl K, Navas-Enamorado I, Mitchell SJ, Zhang Y, Lehrmann E, Aon MA, Cortassa S, Becker KG, Mattson MP.

FASEB J. 2018 Jul;32(7):3844-3858. doi: 10.1096/fj.201701378RR. Epub 2018 Feb 27.


Mitochondrial respiration and ROS emission during β-oxidation in the heart: An experimental-computational study.

Cortassa S, Sollott SJ, Aon MA.

PLoS Comput Biol. 2017 Jun 9;13(6):e1005588. doi: 10.1371/journal.pcbi.1005588. eCollection 2017 Jun.


Functional Implications of Cardiac Mitochondria Clustering.

Kurz FT, Aon MA, O'Rourke B, Armoundas AA.

Adv Exp Med Biol. 2017;982:1-24. doi: 10.1007/978-3-319-55330-6_1. Review.


The fractal organization of ultradian rhythms in avian behavior.

Guzmán DA, Flesia AG, Aon MA, Pellegrini S, Marin RH, Kembro JM.

Sci Rep. 2017 Apr 6;7(1):684. doi: 10.1038/s41598-017-00743-2.


Network dynamics: quantitative analysis of complex behavior in metabolism, organelles, and cells, from experiments to models and back.

Kurz FT, Kembro JM, Flesia AG, Armoundas AA, Cortassa S, Aon MA, Lloyd D.

Wiley Interdiscip Rev Syst Biol Med. 2017 Jan;9(1). doi: 10.1002/wsbm.1352. Epub 2016 Sep 7. Review.


Mitochondrial health, the epigenome and healthspan.

Aon MA, Cortassa S, Juhaszova M, Sollott SJ.

Clin Sci (Lond). 2016 Aug 1;130(15):1285-305. doi: 10.1042/CS20160002. Review.


High resolution, week-long, locomotion time series from Japanese quail in a home-box environment.

Guzmán DA, Pellegrini S, Flesia AG, Aon MA, Marin RH, Kembro JM.

Sci Data. 2016 Jun 7;3:160036. doi: 10.1038/sdata.2016.36.


Mitochondrial redox and pH signaling occurs in axonal and synaptic organelle clusters.

Breckwoldt MO, Armoundas AA, Aon MA, Bendszus M, O'Rourke B, Schwarzländer M, Dick TP, Kurz FT.

Sci Rep. 2016 Mar 22;6:23251. doi: 10.1038/srep23251.


ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity.

Belmonte F, Das S, Sysa-Shah P, Sivakumaran V, Stanley B, Guo X, Paolocci N, Aon MA, Nagane M, Kuppusamy P, Steenbergen C, Gabrielson K.

Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1271-80. doi: 10.1152/ajpheart.00517.2014. Epub 2015 Aug 7.


Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes.

Tocchetti CG, Stanley BA, Sivakumaran V, Bedja D, O'Rourke B, Paolocci N, Cortassa S, Aon MA.

Clin Sci (Lond). 2015 Oct;129(7):561-74. doi: 10.1042/CS20150204. Epub 2015 Jun 11.


Mitochondrial networks in cardiac myocytes reveal dynamic coupling behavior.

Kurz FT, Derungs T, Aon MA, O'Rourke B, Armoundas AA.

Biophys J. 2015 Apr 21;108(8):1922-33. doi: 10.1016/j.bpj.2015.01.040.


Mitochondria: hubs of cellular signaling, energetics and redox balance. A rich, vibrant, and diverse landscape of mitochondrial research.

Aon MA, Camara AK.

Front Physiol. 2015 Mar 26;6:94. doi: 10.3389/fphys.2015.00094. eCollection 2015. No abstract available.


Diabetic cardiomyopathy and the role of mitochondrial dysfunction: novel insights, mechanisms, and therapeutic strategies.

Aon MA, Foster DB.

Antioxid Redox Signal. 2015 Jun 10;22(17):1499-501. doi: 10.1089/ars.2015.6349. Epub 2015 Apr 29.


Exercise heart rates in patients with hypertrophic cardiomyopathy.

Luo HC, Dimaano VL, Kembro JM, Hilser A, Hurtado-de-Mendoza D, Pozios I, Tomas MS, Yalcin H, Dolores-Cerna K, Mormontoy W, Aon MA, Cameron D, Bluemke DA, Stewart KJ, Russell SD, Cordova JG, Abraham TP, Abraham MR.

Am J Cardiol. 2015 Apr 15;115(8):1144-1150. doi: 10.1016/j.amjcard.2015.01.548. Epub 2015 Feb 4.


Protective mechanisms of mitochondria and heart function in diabetes.

Aon MA, Tocchetti CG, Bhatt N, Paolocci N, Cortassa S.

Antioxid Redox Signal. 2015 Jun 10;22(17):1563-86. doi: 10.1089/ars.2014.6123. Epub 2015 Mar 31. Review.


Function of metabolic and organelle networks in crowded and organized media.

Aon MA, Cortassa S.

Front Physiol. 2015 Jan 21;5:523. doi: 10.3389/fphys.2014.00523. eCollection 2014. Review.


From metabolomics to fluxomics: a computational procedure to translate metabolite profiles into metabolic fluxes.

Cortassa S, Caceres V, Bell LN, O'Rourke B, Paolocci N, Aon MA.

Biophys J. 2015 Jan 6;108(1):163-72. doi: 10.1016/j.bpj.2014.11.1857.


Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose.

Bhatt NM, Aon MA, Tocchetti CG, Shen X, Dey S, Ramirez-Correa G, O'Rourke B, Gao WD, Cortassa S.

Am J Physiol Heart Circ Physiol. 2015 Feb 15;308(4):H291-302. doi: 10.1152/ajpheart.00378.2014. Epub 2014 Dec 5.


Cardiac mitochondria exhibit dynamic functional clustering.

Kurz FT, Aon MA, O'Rourke B, Armoundas AA.

Front Physiol. 2014 Sep 2;5:329. doi: 10.3389/fphys.2014.00329. eCollection 2014.


Mitochondrial and cellular mechanisms for managing lipid excess.

Aon MA, Bhatt N, Cortassa SC.

Front Physiol. 2014 Jul 31;5:282. doi: 10.3389/fphys.2014.00282. eCollection 2014. Review.


Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol.

Williams CF, Yarlett N, Aon MA, Lloyd D.

Mol Biochem Parasitol. 2014 Aug;196(1):45-52. doi: 10.1016/j.molbiopara.2014.07.010. Epub 2014 Aug 4.


Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function.

Kembro JM, Cortassa S, Aon MA.

Front Physiol. 2014 Jul 8;5:257. doi: 10.3389/fphys.2014.00257. eCollection 2014.


Effect of isoflurane on myocardial energetic and oxidative stress in cardiac muscle from Zucker diabetic fatty rat.

Shen X, Bhatt N, Xu J, Meng T, Aon MA, O'Rourke B, Berkowitz DE, Cortassa S, Gao WD.

J Pharmacol Exp Ther. 2014 Apr;349(1):21-8. doi: 10.1124/jpet.113.211144. Epub 2014 Jan 15.


Redox-optimized ROS balance and the relationship between mitochondrial respiration and ROS.

Cortassa S, O'Rourke B, Aon MA.

Biochim Biophys Acta. 2014 Feb;1837(2):287-95. doi: 10.1016/j.bbabio.2013.11.007. Epub 2013 Nov 20.


Mitochondrial dysfunction, alternans, and arrhythmias.

Aon MA.

Front Physiol. 2013 Apr 19;4:83. doi: 10.3389/fphys.2013.00083. eCollection 2013. No abstract available.


Integrating mitochondrial energetics, redox and ROS metabolic networks: a two-compartment model.

Kembro JM, Aon MA, Winslow RL, O'Rourke B, Cortassa S.

Biophys J. 2013 Jan 22;104(2):332-43. doi: 10.1016/j.bpj.2012.11.3808.


Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs.

Xie C, Biary N, Tocchetti CG, Aon MA, Paolocci N, Kauffman J, Akar FG.

Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H916-26. doi: 10.1152/ajpheart.00026.2012. Epub 2013 Feb 1.


Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes.

Kurdi M, Sivakumaran V, Duhé RJ, Aon MA, Paolocci N, Booz GW.

Int J Biochem Cell Biol. 2012 Dec;44(12):2106-15. doi: 10.1016/j.biocel.2012.08.016. Epub 2012 Aug 22.


Mitochondrial network energetics in the heart.

Aon MA, Cortassa S.

Wiley Interdiscip Rev Syst Biol Med. 2012 Nov-Dec;4(6):599-613. doi: 10.1002/wsbm.1188. Epub 2012 Aug 15. Review.


GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.

Tocchetti CG, Caceres V, Stanley BA, Xie C, Shi S, Watson WH, O'Rourke B, Spadari-Bratfisch RC, Cortassa S, Akar FG, Paolocci N, Aon MA.

Diabetes. 2012 Dec;61(12):3094-105. doi: 10.2337/db12-0072. Epub 2012 Jul 17.


Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: an experimental-computational study.

Aon MA, Stanley BA, Sivakumaran V, Kembro JM, O'Rourke B, Paolocci N, Cortassa S.

J Gen Physiol. 2012 Jun;139(6):479-91. doi: 10.1085/jgp.201210772. Epub 2012 May 14.


Metabolic control analysis applied to mitochondrial networks.

Cortassa S, Aon MA, O'Rourke B, Winslow RL.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4673-6. doi: 10.1109/IEMBS.2011.6091157.


What yeast and cardiomyocytes share: ultradian oscillatory redox mechanisms of cellular coherence and survival.

Lloyd D, Cortassa S, O'Rourke B, Aon MA.

Integr Biol (Camb). 2012 Jan;4(1):65-74. doi: 10.1039/c1ib00124h. Epub 2011 Dec 5. Review.


Computational modeling of mitochondrial function.

Cortassa S, Aon MA.

Methods Mol Biol. 2012;810:311-26. doi: 10.1007/978-1-61779-382-0_19.


Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.

Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM.

J Cell Biol. 2011 Oct 17;195(2):263-76. doi: 10.1083/jcb.201108059. Epub 2011 Oct 10.


Thioredoxin reductase-2 is essential for keeping low levels of H(2)O(2) emission from isolated heart mitochondria.

Stanley BA, Sivakumaran V, Shi S, McDonald I, Lloyd D, Watson WH, Aon MA, Paolocci N.

J Biol Chem. 2011 Sep 23;286(38):33669-77. doi: 10.1074/jbc.M111.284612. Epub 2011 Aug 5.

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