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Items: 1 to 50 of 869

1.

Allogeneic hematopoietic cell transplantation for patients with a history of multiple relapses of acute myeloid leukemia.

Yanada M, Mori J, Aoki J, Masuko M, Harada K, Uchida N, Doki N, Fukuda T, Sakura T, Kanamori H, Sawa M, Kondo T, Katayama Y, Kanda J, Ichinohe T, Atsuta Y, Yano S.

Ann Hematol. 2019 Jun 15. doi: 10.1007/s00277-019-03736-5. [Epub ahead of print]

PMID:
31203422
2.

Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension-High-throughput Screening of 5,562 Compounds.

Kurosawa R, Satoh K, Kikuchi N, Kikuchi H, Saigusa D, Al-Mamun EA, Siddique MAH, Omura J, Satoh T, Sunamura S, Nogi M, Numano K, Miyata S, Uruno A, Kano K, Matsumoto Y, Doi T, Aoki J, Oshima Y, Yamamoto M, Shimokawa H.

Circ Res. 2019 Jun 14. doi: 10.1161/CIRCRESAHA.119.315229. [Epub ahead of print]

PMID:
31195886
3.

[A Case of Systemic Chemotherapy Combined with Molecular Drug Treatment Following Biliary Stent Implantation for Obstructive Jaundice Due to Metastases of Liver Gland Lymph Node after Colorectal Cancer Surgery].

Amemiya K, Momose H, Aoki J, Okazawa Y, Mizukoshi K, Kawano S, Munakata S, Ishiyama S, Sugimoto K, Kamiyama H, Komiyama H, Takahashi M, Kojima Y, Okuzawa J, Sakamoto K.

Gan To Kagaku Ryoho. 2019 Apr;46(4):733-735. Japanese.

PMID:
31164518
4.

Illuminating G-Protein-Coupling Selectivity of GPCRs.

Inoue A, Raimondi F, Kadji FMN, Singh G, Kishi T, Uwamizu A, Ono Y, Shinjo Y, Ishida S, Arang N, Kawakami K, Gutkind JS, Aoki J, Russell RB.

Cell. 2019 Jun 13;177(7):1933-1947.e25. doi: 10.1016/j.cell.2019.04.044. Epub 2019 May 31.

PMID:
31160049
5.

Role of alternative donor allogeneic hematopoietic stem cell transplantation in patients with intermediate- or poor-risk acute myeloid leukemia in first complete remission.

Yano S, Yokoyama H, Yanada M, Mori J, Aoki J, Ohashi K, Kanomori H, Ozawa Y, Sawa M, Nakamae H, Eto T, Ohta S, Tanaka J, Ichinohe T, Atsuta Y, Takami A.

Bone Marrow Transplant. 2019 May 31. doi: 10.1038/s41409-019-0571-8. [Epub ahead of print]

PMID:
31152148
6.

Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes.

Hisano Y, Kono M, Cartier A, Engelbrecht E, Kano K, Kawakami K, Xiong Y, Piao W, Galvani S, Yanagida K, Kuo A, Ono Y, Ishida S, Aoki J, Proia RL, Bromberg JS, Inoue A, Hla T.

J Exp Med. 2019 May 30. pii: jem.20181895. doi: 10.1084/jem.20181895. [Epub ahead of print]

PMID:
31147448
7.

Association of onset-season with characteristics and long-term outcomes in acute myocardial infarction patients: results from the Japanese registry of acute myocardial infarction diagnosed by universal definition (J-MINUET) substudy.

Okuno T, Aoki J, Tanabe K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M; J-MINUET investigators.

Heart Vessels. 2019 May 25. doi: 10.1007/s00380-019-01426-w. [Epub ahead of print]

PMID:
31129873
8.

The component changes of lysophospholipid mediators in colorectal cancer.

Kitamura C, Sonoda H, Nozawa H, Kano K, Emoto S, Murono K, Kaneko M, Hiyoshi M, Sasaki K, Nishikawa T, Shuno Y, Tanaka T, Hata K, Kawai K, Aoki J, Ishihara S.

Tumour Biol. 2019 May;41(5):1010428319848616. doi: 10.1177/1010428319848616.

PMID:
31106679
9.

Risk Stratification and Prognosticators of Acute Myeloid Leukemia with Myelodysplasia-Related Changes in Patients Undergoing Allogeneic Stem Cell Transplantation: A Retrospective Study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation.

Harada K, Konuma T, Machida S, Mori J, Aoki J, Uchida N, Ohashi K, Fukuda T, Tanaka M, Ikegame K, Ozawa Y, Iwato K, Eto T, Onizuka M, Ichinohe T, Atsuta Y, Yano S.

Biol Blood Marrow Transplant. 2019 May 2. pii: S1083-8791(19)30272-1. doi: 10.1016/j.bbmt.2019.04.025. [Epub ahead of print]

PMID:
31054982
10.

Atypical Re-Entrant Circuit of Cavo-Tricuspid Isthmus-Dependent Atrial Flutter Due to an Atrial-Septal Conduction Disturbance in a Patient With Cardiac Sarcoidosis.

Koike H, Yahagi K, Yuzawa H, Sato K, Asami M, Komiyama K, Tanaka J, Aoki J, Tanabe K, Ikeda T.

JACC Clin Electrophysiol. 2019 Apr;5(4):532-534. doi: 10.1016/j.jacep.2018.12.011. No abstract available.

PMID:
31000114
11.

GPR34 in spinal microglia exacerbates neuropathic pain in mice.

Sayo A, Konishi H, Kobayashi M, Kano K, Kobayashi H, Hibi H, Aoki J, Kiyama H.

J Neuroinflammation. 2019 Apr 11;16(1):82. doi: 10.1186/s12974-019-1458-8.

12.

Better disease control before allogeneic stem cell transplantation is crucial to improve the outcomes of transplantation for acute myeloid leukemia patients with extramedullary disease.

Yamasaki S, Aoki J, Mori J, Mizuno S, Uchida N, Ohashi K, Fukuda T, Ikegame K, Eto T, Ogawa Y, Tanaka M, Hidaka M, Iwato K, Sawa M, Ichinohe T, Kanda Y, Atsuta Y, Yanada M, Yano S; Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation.

Bone Marrow Transplant. 2019 Apr 10. doi: 10.1038/s41409-019-0527-z. [Epub ahead of print] No abstract available.

PMID:
30971777
13.

Accurate etiology diagnosis in patients with stroke and atrial fibrillation: A role for brain natriuretic peptide.

Sakamoto Y, Nito C, Nishiyama Y, Suda S, Matsumoto N, Aoki J, Shimoyama T, Kanamaru T, Suzuki K, Go Y, Mishina M, Kimura K.

J Neurol Sci. 2019 May 15;400:153-157. doi: 10.1016/j.jns.2019.03.031. Epub 2019 Mar 29.

PMID:
30953905
14.

Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression.

Fernandes JCR, Aoki JI, Maia Acuña S, Zampieri RA, Markus RP, Floeter-Winter LM, Muxel SM.

Front Cell Infect Microbiol. 2019 Mar 20;9:60. doi: 10.3389/fcimb.2019.00060. eCollection 2019.

15.

Admission Heart Rate Is a Determinant of Effectiveness of Beta-Blockers in Acute Myocardial Infarction Patients.

Okuno T, Aoki J, Tanabe K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M; J-MINUET Investigators.

Circ J. 2019 Apr 25;83(5):1054-1063. doi: 10.1253/circj.CJ-18-0995. Epub 2019 Mar 30.

16.

Evaluation of objective nutritional indexes as predictors of one-year outcomes after transcatheter aortic valve implantation.

Okuno T, Koseki K, Nakanishi T, Sato K, Ninomiya K, Tomii D, Tanaka T, Sato Y, Horiuchi Y, Koike H, Yahagi K, Komiyama K, Tanaka J, Aoki J, Yokozuka M, Miura S, Tanabe K.

J Cardiol. 2019 Jul;74(1):34-39. doi: 10.1016/j.jjcc.2019.02.017. Epub 2019 Mar 28.

PMID:
30929930
17.

Ischemic stroke during anticoagulant interruption by healthcare professionals in stroke patients with atrial fibrillation.

Sakamoto Y, Okubo S, Nito C, Nishiyama Y, Suda S, Matsumoto N, Aoki J, Shimoyama T, Kanamaru T, Muraga K, Suzuki K, Mishina M, Kimura K.

J Neurol Sci. 2019 May 15;400:113-118. doi: 10.1016/j.jns.2019.03.018. Epub 2019 Mar 20.

PMID:
30925358
18.

Increased opportunity for prolonged survival after allogeneic hematopoietic stem cell transplantation in patients aged 60-69 years with myelodysplastic syndrome.

Itonaga H, Ishiyama K, Aoki K, Aoki J, Ishikawa T, Uchida N, Ohashi K, Ueda Y, Fukuda T, Sakura T, Ohno Y, Iwato K, Okumura H, Kondo T, Ichinohe T, Takanashi M, Atsuta Y, Miyazaki Y.

Ann Hematol. 2019 Jun;98(6):1367-1381. doi: 10.1007/s00277-019-03653-7. Epub 2019 Mar 11.

PMID:
30854574
19.

An accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases.

Kawana H, Kano K, Shindou H, Inoue A, Shimizu T, Aoki J.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1053-1060. doi: 10.1016/j.bbalip.2019.02.008. Epub 2019 Mar 7.

20.

LPA1 , LPA2 , LPA4 , and LPA6 receptor expression during mouse brain development.

Suckau O, Gross I, Schrötter S, Yang F, Luo J, Wree A, Chun J, Baska D, Baumgart J, Kano K, Aoki J, Bräuer AU.

Dev Dyn. 2019 May;248(5):375-395. doi: 10.1002/dvdy.23. Epub 2019 Mar 27.

PMID:
30847983
21.

Graft-versus-MDS effect after unrelated cord blood transplantation: a retrospective analysis of 752 patients registered at the Japanese Data Center for Hematopoietic Cell Transplantation.

Ishiyama K, Aoki J, Itonaga H, Uchida N, Takahashi S, Ohno Y, Matsuhashi Y, Sakura T, Onizuka M, Miyakoshi S, Takanashi M, Fukuda T, Atsuta Y, Nakao S, Miyazaki Y.

Blood Cancer J. 2019 Mar 6;9(3):31. doi: 10.1038/s41408-019-0192-x.

22.

Identification of P2Y receptors involved in oleamide-suppressing inflammatory responses in murine microglia and human dendritic cells.

Kita M, Ano Y, Inoue A, Aoki J.

Sci Rep. 2019 Feb 28;9(1):3135. doi: 10.1038/s41598-019-40008-8.

23.

Serum autotaxin levels are associated with Graves' disease.

Nojiri T, Kurano M, Araki O, Nakawatari K, Nishikawa M, Shimamoto S, Igarashi K, Kano K, Aoki J, Kihara S, Murakami M, Yatomi Y.

Endocr J. 2019 May 28;66(5):409-422. doi: 10.1507/endocrj.EJ18-0451. Epub 2019 Mar 27.

24.

Measurement of the Spatial Distribution of S1P in Small Quantities of Tissues: Development and Application of a Highly Sensitive LC-MS/MS Method Combined with Laser Microdissection.

Wang J, Kano K, Saigusa D, Aoki J.

Mass Spectrom (Tokyo). 2019;8(1):A0072. doi: 10.5702/massspectrometry.A0072. Epub 2019 Feb 14.

25.

Molecular mechanism of lysophosphatidic acid-induced hypertensive response.

Kano K, Matsumoto H, Inoue A, Yukiura H, Kanai M, Chun J, Ishii S, Shimizu T, Aoki J.

Sci Rep. 2019 Feb 25;9(1):2662. doi: 10.1038/s41598-019-39041-4.

26.

Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells.

Yoshino O, Yamada-Nomoto K, Kano K, Ono Y, Kobayashi M, Ito M, Yoneda S, Nakashima A, Shima T, Onda T, Osuga Y, Aoki J, Saito S.

Reprod Sci. 2019 Feb 19:1933719119828112. doi: 10.1177/1933719119828112. [Epub ahead of print]

PMID:
30782093
27.

Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease.

Fernandes JCR, Acuña SM, Aoki JI, Floeter-Winter LM, Muxel SM.

Noncoding RNA. 2019 Feb 17;5(1). pii: E17. doi: 10.3390/ncrna5010017. Review.

28.

Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine.

Kimura KT, Asada H, Inoue A, Kadji FMN, Im D, Mori C, Arakawa T, Hirata K, Nomura Y, Nomura N, Aoki J, Iwata S, Shimamura T.

Nat Struct Mol Biol. 2019 Feb;26(2):121-128. doi: 10.1038/s41594-018-0180-z. Epub 2019 Feb 4.

PMID:
30723326
29.

Clinical impact of the loss of chromosome 7q on outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem cell transplantation.

Itonaga H, Ishiyama K, Aoki K, Aoki J, Ishikawa T, Ohashi K, Fukuda T, Ozawa Y, Ota S, Uchida N, Eto T, Iwato K, Ohno Y, Takanashi M, Ichinohe T, Atsuta Y, Miyazaki Y.

Bone Marrow Transplant. 2019 Feb 4. doi: 10.1038/s41409-019-0469-5. [Epub ahead of print]

PMID:
30718803
30.

GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.

Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Imai T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K.

Nature. 2019 Feb;566(7742):110-114. doi: 10.1038/s41586-019-0884-1. Epub 2019 Jan 23.

PMID:
30675063
31.

Immunoglobulin G4-Related Coronary Periarteritis With Multiple Intracoronary Images.

Koseki K, Yahagi K, Okuno T, Kikushima H, Saito A, Ninomiya K, Tomii D, Nakanishi T, Tanaka T, Sato Y, Sato K, Komiyama K, Aoki J, Tanabe K.

JACC Cardiovasc Interv. 2019 Apr 8;12(7):e59-e61. doi: 10.1016/j.jcin.2018.11.018. Epub 2019 Jan 16. No abstract available.

PMID:
30660458
32.

Identification and biochemical characterization of a second zebrafish autotaxin gene.

Kise R, Okasato R, Kano K, Inoue A, Kawahara A, Aoki J.

J Biochem. 2019 Mar 1;165(3):269-275. doi: 10.1093/jb/mvy114.

PMID:
30629186
33.

Konjac ceramide (kCer) regulates keratinocyte migration by Sema3A-like repulsion mechanism.

Usuki S, Tamura N, Tamura T, Higashiyama S, Tanji K, Mitsutake S, Inoue A, Aoki J, Mukai K, Igarashi Y.

Biochem Biophys Rep. 2019 Jan 3;17:132-138. doi: 10.1016/j.bbrep.2018.11.004. eCollection 2019 Mar.

34.

Characteristics of Acute Spontaneous Intracerebral Hemorrhage in Patients Receiving Oral Anticoagulants.

Suda S, Aoki J, Shimoyama T, Kanamaru T, Muraga K, Suzuki K, Sakamoto Y, Kutsuna A, Nishimura T, Matsumoto N, Nito C, Nishiyama Y, Mishina M, Kimura K.

J Stroke Cerebrovasc Dis. 2019 Apr;28(4):1007-1014. doi: 10.1016/j.jstrokecerebrovasdis.2018.12.013. Epub 2019 Jan 4.

PMID:
30612891
35.

Correction: Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.

Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigurdsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Röper J, Kirischuk S, Luhmann HJ, Radyushkin K, Nitsch R, Vogt J.

Mol Psychiatry. 2019 Jan 2. doi: 10.1038/s41380-018-0320-1. [Epub ahead of print]

PMID:
30602735
36.

Safety of Anticoagulant Therapy Including Direct Oral Anticoagulants in Patients With Acute Spontaneous Intracerebral Hemorrhage.

Sakamoto Y, Nito C, Nishiyama Y, Suda S, Matsumoto N, Aoki J, Shimoyama T, Kanamaru T, Suzuki K, Nishimura T, Mishina M, Kimura K.

Circ J. 2019 Jan 25;83(2):441-446. doi: 10.1253/circj.CJ-18-0938. Epub 2018 Dec 27.

37.

Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages.

Muxel SM, Acuña SM, Aoki JI, Zampieri RA, Floeter-Winter LM.

Front Immunol. 2018 Nov 29;9:2792. doi: 10.3389/fimmu.2018.02792. eCollection 2018.

38.

Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos.

Noguchi T, Suzuki M, Mutoh N, Hirata Y, Tsuchida M, Miyagawa S, Hwang GW, Aoki J, Matsuzawa A.

Cell Death Dis. 2018 Dec 13;9(12):1193. doi: 10.1038/s41419-018-1245-y.

39.

Lysophospholipids in laboratory medicine.

Yatomi Y, Kurano M, Ikeda H, Igarashi K, Kano K, Aoki J.

Proc Jpn Acad Ser B Phys Biol Sci. 2018;94(10):373-389. doi: 10.2183/pjab.94.025. Review.

40.

Autotaxin and soluble IL-2 receptor concentrations in cerebrospinal fluids are useful for the diagnosis of central nervous system invasion caused by haematological malignancies.

Shimura T, Kurano M, Morita Y, Yoshikawa N, Nishikawa M, Igarashi K, Shimamoto S, Aoki J, Yatomi Y.

Ann Clin Biochem. 2019 Mar;56(2):240-246. doi: 10.1177/0004563218818197. Epub 2019 Feb 24.

PMID:
30514094
41.

LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis.

Sumitomo A, Siriwach R, Thumkeo D, Ito K, Nakagawa R, Tanaka N, Tanabe K, Watanabe A, Kishibe M, Ishida-Yamamoto A, Honda T, Kabashima K, Aoki J, Narumiya S.

J Invest Dermatol. 2019 May;139(5):1010-1022. doi: 10.1016/j.jid.2018.10.034. Epub 2018 Nov 14.

PMID:
30447238
42.

Retrospective clinical study of 296 patients with mass lesions of the tongue.

Miyake Y, Shinozuka K, Ueki K, Teraoka J, Zama M, Ogisawa S, Shinozaki Y, Aoki J, Yanagawa K, Shimizu O, Kaneko T, Tonogi M, Ohki H.

J Oral Sci. 2018 Dec 27;60(4):574-578. doi: 10.2334/josnusd.17-0317. Epub 2018 Nov 15.

43.

Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation.

Shihoya W, Izume T, Inoue A, Yamashita K, Kadji FMN, Hirata K, Aoki J, Nishizawa T, Nureki O.

Nat Commun. 2018 Nov 9;9(1):4711. doi: 10.1038/s41467-018-07094-0.

44.

Development of specific chemiluminescent immunoassays for three subtypes of vitellogenin in grey mullet (Mugil cephalus).

Amano H, Kotake A, Hiramatsu N, Fujita T, Todo T, Aoki JY, Soyano K, Kagawa H, Hara A.

Gen Comp Endocrinol. 2019 Jan 15;271:30-38. doi: 10.1016/j.ygcen.2018.10.020. Epub 2018 Nov 5.

PMID:
30408482
45.

Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study.

Kuwajima K, Sumitani M, Kurano M, Kano K, Nishikawa M, Uranbileg B, Tsuchida R, Ogata T, Aoki J, Yatomi Y, Yamada Y.

PLoS One. 2018 Nov 8;13(11):e0207310. doi: 10.1371/journal.pone.0207310. eCollection 2018.

46.

ST-Segment Elevation Myocardial Infarction Related to Variable Calcified Lesions in Saphenous Vein Graft 33 Years After Coronary Artery Bypass Grafting.

Tanaka T, Yahagi K, Ninomiya K, Tomii D, Nakanishi T, Koseki K, Okuno T, Sato Y, Sato K, Komiyama K, Aoki J, Tanabe K.

JACC Cardiovasc Interv. 2018 Nov 26;11(22):e181-e183. doi: 10.1016/j.jcin.2018.08.011. Epub 2018 Nov 1. No abstract available.

PMID:
30391392
47.

Prior Direct Oral Anticoagulant Therapy is Related to Small Infarct Volume and No Major Artery Occlusion in Patients With Stroke and Non-Valvular Atrial Fibrillation.

Sakamoto Y, Okubo S, Sekine T, Nito C, Suda S, Matsumoto N, Nishiyama Y, Aoki J, Shimoyama T, Kanamaru T, Suzuki K, Mishina M, Kimura K.

J Am Heart Assoc. 2018 Sep 4;7(17):e009507. doi: 10.1161/JAHA.118.009507.

48.

Emergent Large Vessel Occlusion Screen Is an Ideal Prehospital Scale to Avoid Missing Endovascular Therapy in Acute Stroke.

Suzuki K, Nakajima N, Kunimoto K, Hatake S, Sakamoto Y, Hokama H, Nomura K, Hayashi T, Aoki J, Suda S, Nishiyama Y, Kimura K.

Stroke. 2018 Sep;49(9):2096-2101. doi: 10.1161/STROKEAHA.118.022107.

PMID:
30354974
49.

Diabetes mellitus inhibits complete recanalization in patients with middle cerebral artery occlusion.

Aoki J, Kimura K, Morita N, Harada M, Nagahiro S; YAMATO study investigators.

Neurol Res. 2018 Oct 15:1-8. doi: 10.1080/01616412.2018.1531201. [Epub ahead of print]

PMID:
30319049
50.

Prognostic Impact of Computed Tomography-Derived Abdominal Fat Area on Transcatheter Aortic Valve Implantation.

Okuno T, Koseki K, Nakanishi T, Ninomiya K, Tomii D, Tanaka T, Sato Y, Osanai A, Sato K, Koike H, Yahagi K, Kishi S, Komiyama K, Aoki J, Yokozuka M, Miura S, Tanabe K.

Circ J. 2018 Nov 24;82(12):3082-3089. doi: 10.1253/circj.CJ-18-0709. Epub 2018 Oct 5.

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