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Aging-associated impairment in metabolic compensation by subcutaneous adipose tissue promotes diet-induced fatty liver disease in mice.

Taketani H, Nishikawa T, Nakajima H, Kodo K, Sugimoto S, Aoi W, Horike SI, Meguro-Horike M, Ishiba H, Seko Y, Umemura A, Yamaguchi K, Moriguchi M, Yasui K, Itoh Y.

Diabetes Metab Syndr Obes. 2019 Aug 23;12:1473-1492. doi: 10.2147/DMSO.S214093. eCollection 2019.


Combined intake of astaxanthin, β-carotene, and resveratrol elevates protein synthesis during muscle hypertrophy in mice.

Kawamura A, Aoi W, Abe R, Kobayashi Y, Wada S, Kuwahata M, Higashi A.

Nutrition. 2020 Jan;69:110561. doi: 10.1016/j.nut.2019.110561. Epub 2019 Jul 26.


Torula yeast (Candida utilis)-derived glucosylceramide contributes to dermal elasticity in vitro.

Fukunaga S, Wada S, Yamashita M, Morita M, Aoi W, Naito Y, Higashi A.

J Food Biochem. 2019 Jul;43(7):e12847. doi: 10.1111/jfbc.12847. Epub 2019 Mar 31.


Secreted protein acidic and rich in cysteine (SPARC) improves glucose tolerance via AMP-activated protein kinase activation.

Aoi W, Hirano N, Lassiter DG, Björnholm M, Chibalin AV, Sakuma K, Tanimura Y, Mizushima K, Takagi T, Naito Y, Zierath JR, Krook A.

FASEB J. 2019 Sep;33(9):10551-10562. doi: 10.1096/fj.201900453R. Epub 2019 Jun 21.


Male Infants Born to Older Pregnant Women Are Affected by Maternal Physique at the Beginning of the Pregnancy through Birth until 18 Months of Age.

Fukuda S, Tanaka Y, Harada K, Saruwatari A, Kitaoka K, Odani K, Aoi W, Wada S, Oguni T, Asano H, Hagiwara N, Higashi A.

J Nutr Sci Vitaminol (Tokyo). 2019;65(2):123-131. doi: 10.3177/jnsv.65.123.


Combined treatment of dipeptidyl peptidase-4 inhibitor and exercise training improves lipid profile in KK/Ta mice.

Tanimura Y, Aoi W, Mizushima K, Higashimura Y, Naito Y.

Exp Physiol. 2019 Jul;104(7):1051-1060. doi: 10.1113/EP087449. Epub 2019 May 22.


Effect of dietary antioxidant-rich foods combined with aerobic training on energy metabolism in healthy young men.

Takami M, Aoi W, Terajima H, Tanimura Y, Wada S, Higashi A.

J Clin Biochem Nutr. 2019 Jan;64(1):79-85. doi: 10.3164/jcbn.18-40. Epub 2018 Aug 8.


Effect of Torula Yeast (Candida utilis)-Derived Glucosylceramide on Skin Dryness and Other Skin Conditions in Winter.

Fukunaga S, Wada S, Sato T, Hamaguchi M, Aoi W, Higashi A.

J Nutr Sci Vitaminol (Tokyo). 2018;64(4):265-270. doi: 10.3177/jnsv.64.265.


Dietary cystine is important to maintain plasma mercaptalbumin levels in rats fed low-protein diets.

Kuwahata M, Kobayashi Y, Wada Y, Aoi W, Kido Y.

Nutr Res. 2018 Aug;56:79-89. doi: 10.1016/j.nutres.2018.04.019. Epub 2018 May 12.


IL6 and LIF mRNA expression in skeletal muscle is regulated by AMPK and the transcription factors NFYC, ZBTB14, and SP1.

Nylén C, Aoi W, Abdelmoez AM, Lassiter DG, Lundell LS, Wallberg-Henriksson H, Näslund E, Pillon NJ, Krook A.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E995-E1004. doi: 10.1152/ajpendo.00398.2017. Epub 2018 Apr 24.


Effect of downhill walking on next-day muscle damage and glucose metabolism in healthy young subjects.

Nakayama A, Aoi W, Takami M, Hirano N, Ogaya Y, Wada S, Higashi A.

J Physiol Sci. 2019 Jan;69(1):31-38. doi: 10.1007/s12576-018-0614-8. Epub 2018 Apr 20.


Comparison of the effect of non-esterified and esterified astaxanthins on endurance performance in mice.

Aoi W, Maoka T, Abe R, Fujishita M, Tominaga K.

J Clin Biochem Nutr. 2018 Mar;62(2):161-166. doi: 10.3164/jcbn.17-89. Epub 2017 Dec 27.


Statuses of food-derived glutathione in intestine, blood, and liver of rat.

Yamada H, Ono S, Wada S, Aoi W, Park EY, Nakamura Y, Sato K.

NPJ Sci Food. 2018 Feb 6;2:3. doi: 10.1038/s41538-018-0011-y. eCollection 2018.


Estimation of salt intake and sodium-to-potassium ratios assessed by urinary excretion among Japanese elementary school children.

Seko C, Taguchi Y, Segawa H, Odani K, Aoi W, Wada S, Kitaoka K, Masumoto T, Higashi A.

Clin Exp Hypertens. 2018;40(5):481-486. doi: 10.1080/10641963.2017.1403620. Epub 2017 Nov 27.


Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study.

Honda Y, Kessoku T, Sumida Y, Kobayashi T, Kato T, Ogawa Y, Tomeno W, Imajo K, Fujita K, Yoneda M, Kataoka K, Taguri M, Yamanaka T, Seko Y, Tanaka S, Saito S, Ono M, Oeda S, Eguchi Y, Aoi W, Sato K, Itoh Y, Nakajima A.

BMC Gastroenterol. 2017 Aug 8;17(1):96. doi: 10.1186/s12876-017-0652-3.


Secreted protein acidic and rich in cysteine functions in colitis via IL17A regulation in mucosal CD4+ T cells.

Tanaka M, Takagi T, Naito Y, Uchiyama K, Hotta Y, Toyokawa Y, Ushiroda C, Hirai Y, Aoi W, Higashimura Y, Mizushima K, Okayama T, Katada K, Kamada K, Ishikawa T, Handa O, Itoh Y.

J Gastroenterol Hepatol. 2018 Mar;33(3):671-680. doi: 10.1111/jgh.13842.


High Maternal Age and Low Pre-Pregnancy Body Mass Index Correlate with Lower Birth Weight of Male Infants.

Fukuda S, Tanaka Y, Harada K, Saruwatari A, Kitaoka K, Odani K, Aoi W, Wada S, Nishi Y, Oguni T, Asano H, Hagiwara N, Higashi A.

Tohoku J Exp Med. 2017 Feb;241(2):117-123. doi: 10.1620/tjem.241.117.


Molecular mechanism of sarcopenia and cachexia: recent research advances.

Sakuma K, Aoi W, Yamaguchi A.

Pflugers Arch. 2017 Jun;469(5-6):573-591. doi: 10.1007/s00424-016-1933-3. Epub 2017 Jan 19. Review.


Reply to the letter from Dr. Miao et al.

Tanimura Y, Aoi W, Takanami Y, Kawai Y, Mizushima K, Naito Y, Yoshikawa T.

Physiol Rep. 2016 Sep;4(17). pii: e12964. doi: 10.14814/phy2.12964. No abstract available.


p62/SQSTM1 but not LC3 is accumulated in sarcopenic muscle of mice.

Sakuma K, Kinoshita M, Ito Y, Aizawa M, Aoi W, Yamaguchi A.

J Cachexia Sarcopenia Muscle. 2016 May;7(2):204-12. doi: 10.1002/jcsm.12045. Epub 2015 Jun 8.


Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation.

Tanimura Y, Aoi W, Takanami Y, Kawai Y, Mizushima K, Naito Y, Yoshikawa T.

Physiol Rep. 2016 Jun;4(12). pii: e12828. doi: 10.14814/phy2.12828.


Erratum to: The effect of Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon) and its derived ingredient methylthioacetic acid on energy metabolism during aerobic exercise.

Aoi W, Takeda K, Sasaki A, Hasegawa Y, Nakamura Y, Park EY, Sato K, Iwasa M, Nakayama A, Minamikawa M, Kobayashi Y, Shirota K, Suetome N.

Springerplus. 2015 Sep 21;4:530. doi: 10.1186/s40064-015-1305-z. eCollection 2015.


Maternal Body Mass Index Correlates with the Neonatal Physique of Male Infants.

Fukuda S, Tanaka Y, Harada K, Saruwatari A, Kitaoka K, Odani K, Aoi W, Wada S, Oguni T, Asano H, Hagiwara N, Higashi A.

Tohoku J Exp Med. 2015 Sep;237(1):69-75. doi: 10.1620/tjem.237.69.


Lifestyle intervention might easily improve blood pressure in hypertensive men with the C genotype of angiotensin II type 2 receptor gene.

Kitaoka K, Kitade A, Nagaoka J, Tsuzaki K, Harada K, Aoi W, Wada S, Asano H, Sakane N, Higashi A.

Nutr Res Pract. 2015 Aug;9(4):385-92. doi: 10.4162/nrp.2015.9.4.385. Epub 2015 Jun 19.


The effect of Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon) and its derived ingredient methylthioacetic acid on energy metabolism during aerobic exercise.

Aoi W, Takeda K, Sasaki A, Hasegawa Y, Nakamura Y, Park EY, Sato K, Iwasa M, Nakayama A, Minamikawa M, Kobayashi Y, Shirota K, Suetome N.

Springerplus. 2015 Jul 26;4:377. doi: 10.1186/s40064-015-1144-y. eCollection 2015. Erratum in: Springerplus. 2015;4:530.


Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study.

Fukuda T, Fukui M, Tanaka M, Senmaru T, Iwase H, Yamazaki M, Aoi W, Inui T, Nakamura N, Marunaka Y.

Biomed Rep. 2015 May;3(3):355-360. Epub 2015 Feb 25.


Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism.

Aoi W, Ogaya Y, Takami M, Konishi T, Sauchi Y, Park EY, Wada S, Sato K, Higashi A.

J Int Soc Sports Nutr. 2015 Feb 6;12:7. doi: 10.1186/s12970-015-0067-x. eCollection 2015.


Frontier impact of microRNAs in skeletal muscle research: a future perspective.

Aoi W.

Front Physiol. 2015 Jan 5;5:495. doi: 10.3389/fphys.2014.00495. eCollection 2014.


Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitric-oxide-mediated cyclooxygenase 2 activation.

Wada S, Matsushita Y, Tazawa H, Aoi W, Naito Y, Higashi A, Ohshima H, Yoshikawa T.

Free Radic Res. 2015 Mar;49(3):269-78. doi: 10.3109/10715762.2014.997230. Epub 2015 Feb 9.


Importance of pH homeostasis in metabolic health and diseases: crucial role of membrane proton transport.

Aoi W, Marunaka Y.

Biomed Res Int. 2014;2014:598986. doi: 10.1155/2014/598986. Epub 2014 Sep 11. Review.


The intriguing regulators of muscle mass in sarcopenia and muscular dystrophy.

Sakuma K, Aoi W, Yamaguchi A.

Front Aging Neurosci. 2014 Aug 29;6:230. doi: 10.3389/fnagi.2014.00230. eCollection 2014. Review.


The effects of uniquely-processed titanium on biological systems: implications for human health and performance.

Rowlands DS, Shultz SP, Ogawa T, Aoi W, Korte M.

J Funct Biomater. 2014 Jan 3;5(1):1-14. doi: 10.3390/jfb5010001.


Increase in the protein-bound form of glutathione in human blood after the oral administration of glutathione.

Park EY, Shimura N, Konishi T, Sauchi Y, Wada S, Aoi W, Nakamura Y, Sato K.

J Agric Food Chem. 2014 Jul 2;62(26):6183-9. doi: 10.1021/jf501338z. Epub 2014 Jun 11.


Intense exercise increases protein oxidation in spleen and liver of mice.

Kobayashi Y, Nakatsuji A, Aoi W, Wada S, Kuwahata M, Kido Y.

Nutr Metab Insights. 2014 Jan 13;7:1-6. doi: 10.4137/NMI.S13668. eCollection 2014.


Current understanding of sarcopenia: possible candidates modulating muscle mass.

Sakuma K, Aoi W, Yamaguchi A.

Pflugers Arch. 2015 Feb;467(2):213-29. doi: 10.1007/s00424-014-1527-x. Epub 2014 May 7. Review.


The effect of the timing of meal intake on energy metabolism during moderate exercise.

Sasaki S, Nakae S, Ebine N, Aoi W, Higashi A, Ishii K.

J Nutr Sci Vitaminol (Tokyo). 2014;60(1):28-34.


The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle.

Liu PH, Aoi W, Takami M, Terajima H, Tanimura Y, Naito Y, Itoh Y, Yoshikawa T.

J Clin Biochem Nutr. 2014 Mar;54(2):86-9. doi: 10.3164/jcbn.13-110. Epub 2014 Feb 19.


Miglitol increases energy expenditure by upregulating uncoupling protein 1 of brown adipose tissue and reduces obesity in dietary-induced obese mice.

Sugimoto S, Nakajima H, Kodo K, Mori J, Matsuo K, Kosaka K, Aoi W, Yoshimoto K, Ikegaya H, Hosoi H.

Nutr Metab (Lond). 2014 Mar 26;11(1):14. doi: 10.1186/1743-7075-11-14.


Does regulation of skeletal muscle function involve circulating microRNAs?

Aoi W, Sakuma K.

Front Physiol. 2014 Feb 17;5:39. doi: 10.3389/fphys.2014.00039. eCollection 2014. Review.


Potential role of oxidative protein modification in energy metabolism in exercise.

Aoi W, Naito Y, Yoshikawa T.

Subcell Biochem. 2014;77:175-87. doi: 10.1007/978-94-007-7920-4_15. Review.


Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats.

Marunaka Y, Yoshimoto K, Aoi W, Hosogi S, Ikegaya H.

Mol Cell Ther. 2014 Mar 1;2:6. doi: 10.1186/2052-8426-2-6. eCollection 2014.


Anthocyanin-rich Aronia melanocarpa extract improves body temperature maintenance in healthy women with a cold constitution.

Sonoda K, Aoi W, Iwata T, Li Y.

Springerplus. 2013 Nov 21;2:626. doi: 10.1186/2193-1801-2-626. eCollection 2013.


Low birth weight is associated with high waist-to-height ratio in Japanese elementary school girls.

Harada K, Saruwatari A, Kitaoka K, Aoi W, Wada S, Ohkubo T, Miura K, Watanabe Y, Kusunoki T, Higashi A.

Tohoku J Exp Med. 2013 Oct;231(2):85-91.


Role of oxidative stress in impaired insulin signaling associated with exercise-induced muscle damage.

Aoi W, Naito Y, Yoshikawa T.

Free Radic Biol Med. 2013 Dec;65:1265-1272. doi: 10.1016/j.freeradbiomed.2013.09.014. Epub 2013 Sep 27. Review.


Ingestion of low dose pyroglutamyl leucine improves dextran sulfate sodium-induced colitis and intestinal microbiota in mice.

Wada S, Sato K, Ohta R, Wada E, Bou Y, Fujiwara M, Kiyono T, Park EY, Aoi W, Takagi T, Naito Y, Yoshikawa T.

J Agric Food Chem. 2013 Sep 18;61(37):8807-13. doi: 10.1021/jf402515a. Epub 2013 Sep 5.


Fermented milk improves glucose metabolism in exercise-induced muscle damage in young healthy men.

Iwasa M, Aoi W, Mune K, Yamauchi H, Furuta K, Sasaki S, Takeda K, Harada K, Wada S, Nakamura Y, Sato K, Higashi A.

Nutr J. 2013 Jun 16;12:83. doi: 10.1186/1475-2891-12-83.


Muscle-enriched microRNA miR-486 decreases in circulation in response to exercise in young men.

Aoi W, Ichikawa H, Mune K, Tanimura Y, Mizushima K, Naito Y, Yoshikawa T.

Front Physiol. 2013 Apr 11;4:80. doi: 10.3389/fphys.2013.00080. eCollection 2013.


Improvement of insulin resistance, blood pressure and interstitial pH in early developmental stage of insulin resistance in OLETF rats by intake of propolis extracts.

Aoi W, Hosogi S, Niisato N, Yokoyama N, Hayata H, Miyazaki H, Kusuzaki K, Fukuda T, Fukui M, Nakamura N, Marunaka Y.

Biochem Biophys Res Commun. 2013 Mar 22;432(4):650-3. doi: 10.1016/j.bbrc.2013.02.029. Epub 2013 Feb 14.


Association between low birth weight and high adult waist-to-height ratio in non-obese women: a cross-sectional study in a Japanese population.

Harada K, Torii S, Saruwatari A, Tanaka Y, Kitaoka K, Takaaki J, Aoi W, Wada S, Ohkubo T, Miura K, Watanabe Y, Higashi A.

Tohoku J Exp Med. 2012 Nov;228(3):205-14.


Titanium-treated surroundings attenuate psychological stress associated with autonomic nerve regulation in office workers with daily emotional stress.

Aoi W, Kamata T, Ishiura Y, Tomaru M, Satoh Y, Hitomi Y, Uchida K, Naito Y, Yoshikawa T.

Physiol Behav. 2012 Dec 25;108:13-8. doi: 10.1016/j.physbeh.2012.09.009. Epub 2012 Sep 23.


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