Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 72

1.

Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats.

Prokop J, Lněničková K, Cibiček N, Kosina P, Tománková V, Jourová L, Láníčková T, Skálová L, Szotáková B, Anzenbacher P, Zapletalová I, Rácová Z, Anzenbacherová E, Ulrichová J.

Food Chem Toxicol. 2019 Jul;129:382-390. doi: 10.1016/j.fct.2019.04.051. Epub 2019 May 3.

PMID:
31059744
2.

Gut microbiota metabolizes nabumetone in vitro: Consequences for its bioavailability in vivo in the rodents with altered gut microbiome.

Jourova L, Anzenbacher P, Matuskova Z, Vecera R, Strojil J, Kolar M, Nobilis M, Hermanova P, Hudcovic T, Kozakova H, Kverka M, Anzenbacherova E.

Xenobiotica. 2019 Feb 22:1-7. doi: 10.1080/00498254.2018.1558310. [Epub ahead of print]

PMID:
30794062
3.

Isothiocyanate from Broccoli, Sulforaphane, and Its Properties.

Vanduchova A, Anzenbacher P, Anzenbacherova E.

J Med Food. 2019 Feb;22(2):121-126. doi: 10.1089/jmf.2018.0024. Epub 2018 Oct 27. Review.

PMID:
30372361
4.

In vivo evaluation of effect of anthocyanin-rich wheat on rat liver microsomal drug-metabolizing cytochromes P450 and on biochemical and antioxidant parameters in rats.

Prokop J, Anzenbacher P, Mrkvicová E, Pavlata L, Zapletalová I, Šťastník O, Martinek P, Kosina P, Anzenbacherová E.

Food Chem Toxicol. 2018 Dec;122:225-233. doi: 10.1016/j.fct.2018.10.029. Epub 2018 Oct 11.

PMID:
30316842
5.

Effects of obesity on liver cytochromes P450 in various animal models.

Tomankova V, Anzenbacher P, Anzenbacherova E.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Jun;161(2):144-151. doi: 10.5507/bp.2017.026. Epub 2017 May 25.

6.

Colonization by non-pathogenic bacteria alters mRNA expression of cytochromes P450 in originally germ-free mice.

Jourová L, Anzenbacher P, Lišková B, Matušková Z, Hermanová P, Hudcovic T, Kozáková H, Hrnčířová L, Anzenbacherová E.

Folia Microbiol (Praha). 2017 Nov;62(6):463-469. doi: 10.1007/s12223-017-0517-8. Epub 2017 Mar 23.

PMID:
28337589
7.

Influence of Sulforaphane Metabolites on Activities of Human Drug-Metabolizing Cytochrome P450 and Determination of Sulforaphane in Human Liver Cells.

Vanduchova A, Tomankova V, Anzenbacher P, Anzenbacherova E.

J Med Food. 2016 Dec;19(12):1141-1146. Epub 2016 Oct 25.

PMID:
27779894
8.

Human gut microbiota plays a role in the metabolism of drugs.

Jourova L, Anzenbacher P, Anzenbacherova E.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Sep;160(3):317-26. doi: 10.5507/bp.2016.039. Epub 2016 Aug 2. Review.

9.

Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities.

Kopečná-Zapletalová M, Krasulová K, Anzenbacher P, Hodek P, Anzenbacherová E.

Xenobiotica. 2017 Apr;47(4):324-331. doi: 10.1080/00498254.2016.1195028. Epub 2016 Jun 17.

PMID:
27312150
10.

Effect of Lactobacillus casei on the Pharmacokinetics of Amiodarone in Male Wistar Rats.

Matuskova Z, Anzenbacher P, Vecera R, Siller M, Tlaskalova-Hogenova H, Strojil J, Anzenbacherova E.

Eur J Drug Metab Pharmacokinet. 2017 Feb;42(1):29-36. doi: 10.1007/s13318-015-0315-0.

PMID:
26797809
11.

Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators.

Spicakova A, Anzenbacher P, Liskova B, Kuca K, Fusek J, Anzenbacherova E.

Food Chem Toxicol. 2016 Feb;88:100-4. doi: 10.1016/j.fct.2015.11.024. Epub 2015 Dec 31.

PMID:
26747974
12.

Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity.

Tomankova V, Liskova B, Skalova L, Bartikova H, Bousova I, Jourova L, Anzenbacher P, Ulrichova J, Anzenbacherova E.

Life Sci. 2015 Jul 15;133:15-20. doi: 10.1016/j.lfs.2015.04.014. Epub 2015 May 18.

PMID:
25998026
13.

Interaction of rocuronium with human liver cytochromes P450.

Anzenbacherova E, Spicakova A, Jourova L, Ulrichova J, Adamus M, Bachleda P, Anzenbacher P.

J Pharmacol Sci. 2015 Feb;127(2):190-5. doi: 10.1016/j.jphs.2014.12.006. Epub 2014 Dec 23.

14.

Influence of diet supplementation with green tea extract on drug-metabolizing enzymes in a mouse model of monosodium glutamate-induced obesity.

Boušová I, Matoušková P, Bártíková H, Szotáková B, Hanušová V, Tománková V, Anzenbacherová E, Lišková B, Anzenbacher P, Skálová L.

Eur J Nutr. 2016 Feb;55(1):361-71. doi: 10.1007/s00394-015-0856-7. Epub 2015 Feb 8.

PMID:
25663641
15.

Antioxidant effects of coumarins include direct radical scavenging, metal chelation and inhibition of ROS-producing enzymes.

Filipský T, Říha M, Macáková K, Anzenbacherová E, Karlíčková J, Mladěnka P.

Curr Top Med Chem. 2015;15(5):415-31. Review.

PMID:
25658804
16.

Effect of dihydromyricetin on benzo[a]pyrene activation in rats.

Hodek P, Fousova P, Brabencova E, Moserova M, Pavek P, Anzenbacherova E, Brotanek J, Hudecek J, Frei E, Stiborova M.

Neuro Endocrinol Lett. 2014;35 Suppl 2:158-68.

PMID:
25638381
17.

Pressure effects reveal that changes in the redox states of the heme iron complexes in the sensor domains of two heme-based oxygen sensor proteins, EcDOS and YddV, have profound effects on their flexibility.

Anzenbacher P, Marchal S, Palacký J, Anzenbacherová E, Domaschke T, Lange R, Shimizu T, Kitanishi K, Stranava M, Stiborová M, Martinkova M.

FEBS J. 2014 Dec;281(23):5208-19. doi: 10.1111/febs.13060. Epub 2014 Oct 13.

18.

Interaction of selected platinum(II) complexes containing roscovitine-based CDK inhibitors as ligands with human liver microsomal cytochrome P450.

Masek V, Starha P, Harvanova M, Michalova M, Milde D, Travnicek Z, Anzenbacherova E.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Sep;159(3):382-7. doi: 10.5507/bp.2014.031. Epub 2014 Jul 4.

19.

Acyclic nucleoside phosphonates: a study on cytochrome P450 gene expression.

Nekvindova J, Contreras JA, Juvan P, Fon Tacer K, Anzenbacher P, Zidek Z, Kopecna Zapletalova M, Rozman D, Anzenbacherova E.

Xenobiotica. 2014 Aug;44(8):708-15. doi: 10.3109/00498254.2014.895880. Epub 2014 Mar 5.

PMID:
24593268
20.

Administration of a probiotic can change drug pharmacokinetics: effect of E. coli Nissle 1917 on amidarone absorption in rats.

Matuskova Z, Anzenbacherova E, Vecera R, Tlaskalova-Hogenova H, Kolar M, Anzenbacher P.

PLoS One. 2014 Feb 5;9(2):e87150. doi: 10.1371/journal.pone.0087150. eCollection 2014.

21.

Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes.

Srovnalova A, Svecarova M, Zapletalova MK, Anzenbacher P, Bachleda P, Anzenbacherova E, Dvorak Z.

J Agric Food Chem. 2014 Jan 22;62(3):789-97. doi: 10.1021/jf404643w. Epub 2014 Jan 10.

PMID:
24387788
22.

Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines.

Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Zapletalova M, Anzenbacher P, Dvorak Z.

Toxicol Lett. 2013 Jul 31;221(1):1-8. doi: 10.1016/j.toxlet.2013.05.007. Epub 2013 Jun 2.

23.

Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T.

Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Anzenbacher P, Dvorak Z.

Toxicol Lett. 2013 Apr 26;218(3):253-9. doi: 10.1016/j.toxlet.2013.01.020. Epub 2013 Feb 16.

24.

The influence of rosuvastatin on liver microsomal CYP2C6 in hereditary hypertriglyceridemic rat.

Vecera R, Zacharová A, Siller M, Matuskova Z, Skottová N, Anzenbacherová E, Anzenbacher P.

Neuro Endocrinol Lett. 2012;33 Suppl 3:48-52.

PMID:
23353843
25.

Binding of quinidine radically increases the stability and decreases the flexibility of the cytochrome P450 2D6 active site.

Berka K, Anzenbacherová E, Hendrychová T, Lange R, Mašek V, Anzenbacher P, Otyepka M.

J Inorg Biochem. 2012 May;110:46-50. doi: 10.1016/j.jinorgbio.2012.02.010. Epub 2012 Feb 22.

PMID:
22459173
26.

Rosuvastatin suppresses the liver microsomal CYP2C11 and CYP2C6 expression in male Wistar rats.

Zachařová A, Siller M, Spičáková A, Anzenbacherová E, Skottová N, Anzenbacher P, Večeřa R.

Xenobiotica. 2012 Aug;42(8):731-6. doi: 10.3109/00498254.2012.661099. Epub 2012 Feb 24.

PMID:
22360448
27.

Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats.

Matuskova Z, Siller M, Tunkova A, Anzenbacherova E, Zacharova A, Tlaskalova-Hogenova H, Zidek Z, Anzenbacher P.

Neuro Endocrinol Lett. 2011;32 Suppl 1:8-14.

PMID:
22167211
28.

In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism.

Siller M, Anzenbacher P, Anzenbacherová E, Doležal K, Strnad M.

Xenobiotica. 2011 Nov;41(11):934-44. doi: 10.3109/00498254.2011.593209. Epub 2011 Jul 11.

PMID:
21745145
29.

Interaction of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates with human liver microsomal cytochromes P450: comparison with free doxorubicin.

Masek V, Anzenbacherová E, Etrych T, Strohalm J, Ulbrich K, Anzenbacher P.

Drug Metab Dispos. 2011 Sep;39(9):1704-10. doi: 10.1124/dmd.110.037986. Epub 2011 Jun 3.

PMID:
21642392
30.

Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases.

Jančová P, Siller M, Anzenbacherová E, Křen V, Anzenbacher P, Simánek V.

Xenobiotica. 2011 Sep;41(9):743-51. doi: 10.3109/00498254.2011.573017. Epub 2011 Apr 27.

PMID:
21524189
31.

Effects of probiotic Escherichia coli Nissle 1917 on expression of cytochromes P450 along the gastrointestinal tract of male rats.

Matuskova Z, Tunkova A, Anzenbacherova E, Vecera R, Siller M, Tlaskalova-Hogenova H, Zidek Z, Anzenbacher P.

Neuro Endocrinol Lett. 2010;31 Suppl 2:46-50.

PMID:
21187832
32.

Phase II drug metabolizing enzymes.

Jancova P, Anzenbacher P, Anzenbacherova E.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Jun;154(2):103-16. Review.

33.

Flexibility of human cytochrome P450 enzymes: molecular dynamics and spectroscopy reveal important function-related variations.

Hendrychová T, Anzenbacherová E, Hudeček J, Skopalík J, Lange R, Hildebrandt P, Otyepka M, Anzenbacher P.

Biochim Biophys Acta. 2011 Jan;1814(1):58-68. doi: 10.1016/j.bbapap.2010.07.017. Epub 2010 Jul 23.

PMID:
20656072
34.

Influence of probiotics on rat liver biotransformation enzymes.

Matuskova Z, Tunkova A, Anzenbacherova E, Zidek Z, Tlaskalova-Hogenova H, Anzenbacher P.

Neuro Endocrinol Lett. 2009;30 Suppl 1:41-5.

PMID:
20027143
35.

Porcine CYP2A19, CYP2E1 and CYP1A2 forms are responsible for skatole biotransformation in the reconstituted system.

Matal J, Matuskova Z, Tunkova A, Anzenbacherova E, Anzenbacher P.

Neuro Endocrinol Lett. 2009;30 Suppl 1:36-40.

PMID:
20027142
36.

Isolation of two cytochrome P450 forms, CYP2A19 and CYP1A, from pig liver microsomes.

Matal J, Tunková A, Siller M, Anzenbacherová E, Anzenbacher P.

J Vet Pharmacol Ther. 2009 Oct;32(5):470-6. doi: 10.1111/j.1365-2885.2009.01076.x.

PMID:
19754914
37.

Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro.

Veinlichova A, Jancova P, Siller M, Anzenbacher P, Kuca K, Jun D, Fusek J, Anzenbacherova E.

Chem Biol Interact. 2009 Aug 14;180(3):449-53. doi: 10.1016/j.cbi.2009.03.016. Epub 2009 Mar 31.

PMID:
19539805
38.

Interaction of antitumor platinum complexes with human liver microsomal cytochromes P450.

Masek V, Anzenbacherová E, Machová M, Brabec V, Anzenbacher P.

Anticancer Drugs. 2009 Jun;20(5):305-11.

PMID:
19378397
39.

Interactions of olomoucine II with human liver microsomal cytochromes P450.

Siller M, Anzenbacher P, Anzenbacherova E, Dolezal K, Popa I, Strnad M.

Drug Metab Dispos. 2009 Jun;37(6):1198-202. doi: 10.1124/dmd.108.025502. Epub 2009 Feb 27.

PMID:
19251823
40.

Interspecies comparison of the glucuronidation processes in the man, monkey, pig, dog and rat.

Matal J, Jancova P, Siller M, Masek V, Anzenbacherova E, Anzenbacher P.

Neuro Endocrinol Lett. 2008 Oct;29(5):738-43.

PMID:
18987594
41.

SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes.

Henklova P, Vrzal R, Papouskova B, Bednar P, Jancova P, Anzenbacherova E, Ulrichova J, Maurel P, Pavek P, Dvorak Z.

Eur J Pharmacol. 2008 Sep 28;593(1-3):16-23. doi: 10.1016/j.ejphar.2008.07.007. Epub 2008 Jul 10.

PMID:
18655782
42.

Enzyme systems of detoxication - overview of recent approaches.

Anzenbacher P, Anzenbacherová E.

Interdiscip Toxicol. 2008 Jun;1(1):6-7. doi: 10.2478/v10102-010-0022-2. No abstract available.

43.

Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.

Svecova L, Vrzal R, Burysek L, Anzenbacherova E, Cerveny L, Grim J, Trejtnar F, Kunes J, Pour M, Staud F, Anzenbacher P, Dvorak Z, Pavek P.

Drug Metab Dispos. 2008 Feb;36(2):339-48. Epub 2007 Nov 12.

PMID:
17998298
44.

JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes.

Dvorak Z, Vrzal R, Henklova P, Jancova P, Anzenbacherova E, Maurel P, Svecova L, Pavek P, Ehrmann J, Havlik R, Bednar P, Lemr K, Ulrichova J.

Biochem Pharmacol. 2008 Jan 15;75(2):580-8. Epub 2007 Sep 16.

PMID:
17959153
45.

In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450.

Anzenbacherová E, Anzenbacher P, Zídek Z, Buchar E, Kmonícková E, Potmesil P, Nekvindová J, Veinlichová A, Holý A.

Physiol Res. 2008;57(5):761-7. Epub 2007 Oct 11.

46.

Silybin is metabolized by cytochrome P450 2C8 in vitro.

Jancová P, Anzenbacherová E, Papousková B, Lemr K, Luzná P, Veinlichová A, Anzenbacher P, Simánek V.

Drug Metab Dispos. 2007 Nov;35(11):2035-9. Epub 2007 Aug 1.

PMID:
17670841
47.

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.

Drug Metab Dispos. 2007 Jul;35(7):1032-41. Epub 2007 Mar 28.

PMID:
17392393
48.

Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.

Nekvindová J, Masek V, Veinlichová A, Anzenbacherová E, Anzenbacher P, Zídek Z, Holý A.

Xenobiotica. 2006 Dec;36(12):1165-77.

PMID:
17162464
49.

Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.

Matal J, Orság J, Nekvindová J, Anzenbacherová E, Veinlichová A, Anzenbacher P, Zídek Z, Holý A.

Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:27-30.

PMID:
17159773
50.

Structural analysis of cytochromes P450 shows differences in flexibility of heme 2- and 4-vinyls.

Hudecek J, Hodek P, Anzenbacherová E, Anzenbacher P.

Biochim Biophys Acta. 2007 Mar;1770(3):413-9. Epub 2006 Oct 18.

PMID:
17123739

Supplemental Content

Loading ...
Support Center