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Items: 1 to 50 of 154

1.

Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin.

Chang L, Cui W, Yang Y, Xu S, Zhou W, Fu H, Hu S, Mak S, Hu J, Wang Q, Ma VP, Choi TC, Ma ED, Tao L, Pang Y, Rowan MJ, Anwyl R, Han Y, Wang Q.

Sci Rep. 2015 Jul 21;5:10256. doi: 10.1038/srep10256.

2.

Rosiglitazone prevents amyloid-β oligomer-induced impairment of synapse formation and plasticity via increasing dendrite and spine mitochondrial number.

Xu S, Liu G, Bao X, Wu J, Li S, Zheng B, Anwyl R, Wang Q.

J Alzheimers Dis. 2014;39(2):239-51. doi: 10.3233/JAD-130680.

PMID:
24150104
3.

Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3.

Chen X, Lin R, Chang L, Xu S, Wei X, Zhang J, Wang C, Anwyl R, Wang Q.

Neuroscience. 2013 Dec 3;253:435-43. doi: 10.1016/j.neuroscience.2013.08.054. Epub 2013 Sep 5.

PMID:
24012839
4.

Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption.

Li F, Chen X, Wang F, Xu S, Chang L, Anwyl R, Wang Q.

Neural Regen Res. 2013 Jan 5;8(1):49-55. doi: 10.3969/j.issn.1673-5374.2013.01.006.

5.

Plasticity of NMDA receptor-mediated excitatory postsynaptic currents at perforant path inputs to dendrite-targeting interneurons.

Harney SC, Anwyl R.

J Physiol. 2012 Aug 15;590(16):3771-86. doi: 10.1113/jphysiol.2012.234740. Epub 2012 May 21.

6.

Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus.

Ondrejcak T, Wang Q, Kew JN, Virley DJ, Upton N, Anwyl R, Rowan MJ.

Eur J Pharmacol. 2012 Feb 29;677(1-3):63-70. doi: 10.1016/j.ejphar.2011.12.008. Epub 2011 Dec 16.

PMID:
22200627
7.

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.

Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, Frank RF, Reif B, Günther S, Walsh DM, Wanker EE.

Nat Chem Biol. 2011 Nov 20;8(1):93-101. doi: 10.1038/nchembio.719.

PMID:
22101602
8.
9.

GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo.

Hu NW, Klyubin I, Anwyl R, Rowan MJ.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20504-9. doi: 10.1073/pnas.0908083106. Epub 2009 Nov 16. Erratum in: Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12734. Anwy, Roger [corrected to Anwyl, Roger].

10.

Metabotropic glutamate receptor-dependent long-term potentiation.

Anwyl R.

Neuropharmacology. 2009 Mar;56(4):735-40. Review.

PMID:
19705571
11.

Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine.

Klyubin I, Wang Q, Reed MN, Irving EA, Upton N, Hofmeister J, Cleary JP, Anwyl R, Rowan MJ.

Neurobiol Aging. 2011 Apr;32(4):614-23. doi: 10.1016/j.neurobiolaging.2009.04.005. Epub 2009 May 14.

PMID:
19446369
12.

Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus.

Welsby PJ, Rowan MJ, Anwyl R.

Eur J Neurosci. 2009 Jan;29(1):65-75. doi: 10.1111/j.1460-9568.2008.06562.x. Epub 2008 Dec 11.

PMID:
19077124
13.

Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs.

Harney SC, Jane DE, Anwyl R.

J Neurosci. 2008 Nov 5;28(45):11685-94. doi: 10.1523/JNEUROSCI.3035-08.2008.

14.

Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene-environment rat model of depression.

Ryan B, Musazzi L, Mallei A, Tardito D, Gruber SH, El Khoury A, Anwyl R, Racagni G, Mathé AA, Rowan MJ, Popoli M.

Int J Neuropsychopharmacol. 2009 May;12(4):553-9. doi: 10.1017/S1461145708009607. Epub 2008 Oct 31.

PMID:
18976544
15.

5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress.

Ryan BK, Anwyl R, Rowan MJ.

Neuropharmacology. 2008 Aug;55(2):175-82. doi: 10.1016/j.neuropharm.2008.05.006. Epub 2008 May 16.

PMID:
18538800
16.

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.

Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ.

J Neurosci. 2008 Apr 16;28(16):4231-7. doi: 10.1523/JNEUROSCI.5161-07.2008.

17.

Involvement of group I mGluRs in LTP induced by strong high frequency stimulation in the dentate gyrus in vitro.

Wu J, Harney S, Rowan MJ, Anwyl R.

Neurosci Lett. 2008 May 9;436(2):235-8. doi: 10.1016/j.neulet.2008.03.027. Epub 2008 Mar 15.

PMID:
18403113
18.

Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity.

Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesne S, Falinska A, Younkin LH, Younkin SG, Rowan M, Cleary J, Wallis RA, Sun GY, Cole G, Frautschy S, Anwyl R, Ashe KH.

Brain. 2008 Mar;131(Pt 3):651-64. doi: 10.1093/brain/awn008.

19.

Inhibition of LTP by beta-amyloid is prevented by activation of beta2 adrenoceptors and stimulation of the cAMP/PKA signalling pathway.

Wang QW, Rowan MJ, Anwyl R.

Neurobiol Aging. 2009 Oct;30(10):1608-13. doi: 10.1016/j.neurobiolaging.2007.12.004. Epub 2008 Feb 12.

PMID:
18272254
20.
21.

Synaptic memory mechanisms: Alzheimer's disease amyloid beta-peptide-induced dysfunction.

Rowan MJ, Klyubin I, Wang Q, Hu NW, Anwyl R.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1219-23. Review.

PMID:
17956317
22.

Performance- and task-dependent effects of the dopamine D1/D5 receptor agonist SKF 38393 on learning and memory in the rat.

Amico F, Spowart-Manning L, Anwyl R, Rowan MJ.

Eur J Pharmacol. 2007 Dec 22;577(1-3):71-7. Epub 2007 Sep 11.

PMID:
17900561
23.

Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP.

Welsby PJ, Rowan MJ, Anwyl R.

Neuropharmacology. 2007 Jul;53(1):188-95. Epub 2007 May 27.

PMID:
17610911
24.

Alpha v integrins mediate beta-amyloid induced inhibition of long-term potentiation.

Wang Q, Klyubin I, Wright S, Griswold-Prenner I, Rowan MJ, Anwyl R.

Neurobiol Aging. 2008 Oct;29(10):1485-93. Epub 2007 Apr 17.

PMID:
17442458
26.

Muscarinic acetylcholine receptor-dependent induction of persistent synaptic enhancement in rat hippocampus in vivo.

Li S, Cullen WK, Anwyl R, Rowan MJ.

Neuroscience. 2007 Jan 19;144(2):754-61. Epub 2006 Nov 13.

PMID:
17101232
27.
28.

Autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse.

Cooke SF, Wu J, Plattner F, Errington M, Rowan M, Peters M, Hirano A, Bradshaw KD, Anwyl R, Bliss TV, Giese KP.

J Physiol. 2006 Aug 1;574(Pt 3):805-18. Epub 2006 May 25.

31.

Induction and expression mechanisms of postsynaptic NMDA receptor-independent homosynaptic long-term depression.

Anwyl R.

Prog Neurobiol. 2006 Jan;78(1):17-37. Epub 2006 Jan 19. Review.

PMID:
16423442
32.

Beta-amyloid inhibition of long-term potentiation is mediated via tumor necrosis factor.

Wang Q, Wu J, Rowan MJ, Anwyl R.

Eur J Neurosci. 2005 Dec;22(11):2827-32.

PMID:
16324117
33.

Synaptic plasticity disruption by amyloid beta protein: modulation by potential Alzheimer's disease modifying therapies.

Rowan MJ, Klyubin I, Wang Q, Anwyl R.

Biochem Soc Trans. 2005 Aug;33(Pt 4):563-7. Review.

PMID:
16042545
34.

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ.

Nat Med. 2005 May;11(5):556-61. Epub 2005 Apr 17.

PMID:
15834427
35.

Mechanisms of the inhibitory effects of amyloid beta-protein on synaptic plasticity.

Rowan MJ, Klyubin I, Wang Q, Anwyl R.

Exp Gerontol. 2004 Nov-Dec;39(11-12):1661-7.

PMID:
15582282
38.

Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo.

Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ.

Eur J Neurosci. 2004 May;19(10):2839-46.

PMID:
15147317
40.
42.
43.

Synaptic plasticity in animal models of early Alzheimer's disease.

Rowan MJ, Klyubin I, Cullen WK, Anwyl R.

Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):821-8. Review.

44.

Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty.

Li S, Cullen WK, Anwyl R, Rowan MJ.

Nat Neurosci. 2003 May;6(5):526-31.

PMID:
12704392
45.
48.

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ.

Nature. 2002 Apr 4;416(6880):535-9.

PMID:
11932745
49.

Early spatial memory deficit induced by 2,5-hexanedione in the rat.

Carney R, Dardis C, Cullen WK, Felipo V, Anwyl R, Rowan MJ.

Toxicol Lett. 2002 Mar 10;128(1-3):107-15.

PMID:
11869822

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