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Items: 1 to 50 of 81

1.

Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes.

Rey G, Milev NB, Valekunja UK, Ch R, Ray S, Silva Dos Santos M, Nagy AD, Antrobus R, MacRae JI, Reddy AB.

Mol Syst Biol. 2018 Aug 2;14(8):e8376. doi: 10.15252/msb.20188376.

2.

Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.

Wang ECY, Pjechova M, Nightingale K, Vlahava VM, Patel M, Ruckova E, Forbes SK, Nobre L, Antrobus R, Roberts D, Fielding CA, Seirafian S, Davies J, Murrell I, Lau B, Wilkie GS, Suárez NM, Stanton RJ, Vojtesek B, Davison A, Lehner PJ, Weekes MP, Wilkinson GWG, Tomasec P.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):4998-5003. doi: 10.1073/pnas.1720950115. Epub 2018 Apr 24.

PMID:
29691324
3.

The WDR11 complex facilitates the tethering of AP-1-derived vesicles.

Navarro Negredo P, Edgar JR, Manna PT, Antrobus R, Robinson MS.

Nat Commun. 2018 Feb 9;9(1):596. doi: 10.1038/s41467-018-02919-4.

4.

Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development.

Nahorski MS, Borner GHH, Shaikh SS, Davies AK, Al-Gazali L, Antrobus R, Woods CG.

Sci Rep. 2018 Feb 5;8(1):2340. doi: 10.1038/s41598-018-19980-0.

5.

Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval.

Hirst J, Itzhak DN, Antrobus R, Borner GHH, Robinson MS.

PLoS Biol. 2018 Jan 30;16(1):e2004411. doi: 10.1371/journal.pbio.2004411. eCollection 2018 Jan.

6.

A Mass Spectrometry-Based Approach for Mapping Protein Subcellular Localization Reveals the Spatial Proteome of Mouse Primary Neurons.

Itzhak DN, Davies C, Tyanova S, Mishra A, Williamson J, Antrobus R, Cox J, Weekes MP, Borner GHH.

Cell Rep. 2017 Sep 12;20(11):2706-2718. doi: 10.1016/j.celrep.2017.08.063.

7.

Role of clathrin in dense core vesicle biogenesis.

Sahu BS, Manna PT, Edgar JR, Antrobus R, Mahata SK, Bartolomucci A, Borner GHH, Robinson MS.

Mol Biol Cell. 2017 Oct 1;28(20):2676-2685. doi: 10.1091/mbc.E16-10-0742. Epub 2017 Aug 16.

8.

Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL, Rimmington D, Ayuso E, Polex-Wolf J, Lam BYH, Dias C, Logan DW, Virtue S, Bosch F, Yeo GSH, Saudek V, O'Rahilly S, Coll AP.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9421-9426. doi: 10.1073/pnas.1707310114. Epub 2017 Aug 15.

9.

NBEAL2 is required for neutrophil and NK cell function and pathogen defense.

Sowerby JM, Thomas DC, Clare S, Espéli M, Guerrero JA, Hoenderdos K, Harcourt K, Marsden M, Abdul-Karim J, Clement M, Antrobus R, Umrania Y, Barton PR, Flint SM, Juss JK, Condliffe AM, Lyons PA, Humphreys IR, Chilvers ER, Ouwehand WH, Dougan G, Smith KG.

J Clin Invest. 2017 Sep 1;127(9):3521-3526. doi: 10.1172/JCI91684. Epub 2017 Aug 7.

10.

Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting.

Navarro Negredo P, Edgar JR, Wrobel AG, Zaccai NR, Antrobus R, Owen DJ, Robinson MS.

J Cell Biol. 2017 Sep 4;216(9):2927-2943. doi: 10.1083/jcb.201602058. Epub 2017 Jul 25.

11.

Development of an objective gene expression panel as an alternative to self-reported symptom scores in human influenza challenge trials.

Muller J, Parizotto E, Antrobus R, Francis J, Bunce C, Stranks A, Nichols M, McClain M, Hill AVS, Ramasamy A, Gilbert SC.

J Transl Med. 2017 Jun 8;15(1):134. doi: 10.1186/s12967-017-1235-3.

12.

TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway.

Neerincx A, Hermann C, Antrobus R, van Hateren A, Cao H, Trautwein N, Stevanović S, Elliott T, Deane JE, Boyle LH.

Elife. 2017 Apr 20;6. pii: e23049. doi: 10.7554/eLife.23049.

13.

VAMP3/Syb and YKT6 are required for the fusion of constitutive secretory carriers with the plasma membrane.

Gordon DE, Chia J, Jayawardena K, Antrobus R, Bard F, Peden AA.

PLoS Genet. 2017 Apr 12;13(4):e1006698. doi: 10.1371/journal.pgen.1006698. eCollection 2017 Apr.

14.

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espéli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G, Smith KG.

J Exp Med. 2017 Apr 3;214(4):1111-1128. doi: 10.1084/jem.20161382. Epub 2017 Mar 28.

15.

Mutations in mitochondrial DNA causing tubulointerstitial kidney disease.

Connor TM, Hoer S, Mallett A, Gale DP, Gomez-Duran A, Posse V, Antrobus R, Moreno P, Sciacovelli M, Frezza C, Duff J, Sheerin NS, Sayer JA, Ashcroft M, Wiesener MS, Hudson G, Gustafsson CM, Chinnery PF, Maxwell PH.

PLoS Genet. 2017 Mar 7;13(3):e1006620. doi: 10.1371/journal.pgen.1006620. eCollection 2017 Mar.

16.

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.

Fielding CA, Weekes MP, Nobre LV, Ruckova E, Wilkie GS, Paulo JA, Chang C, Suárez NM, Davies JA, Antrobus R, Stanton RJ, Aicheler RJ, Nichols H, Vojtesek B, Trowsdale J, Davison AJ, Gygi SP, Tomasec P, Lehner PJ, Wilkinson GW.

Elife. 2017 Feb 10;6. pii: e22206. doi: 10.7554/eLife.22206.

17.

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants.

Greenwood EJ, Matheson NJ, Wals K, van den Boomen DJ, Antrobus R, Williamson JC, Lehner PJ.

Elife. 2016 Sep 30;5. pii: e18296. doi: 10.7554/eLife.18296.

18.

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G, Lehner PJ.

Cell Rep. 2016 Oct 11;17(3):653-659. doi: 10.1016/j.celrep.2016.09.050.

19.

NOTCH1 mediates a switch between two distinct secretomes during senescence.

Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L, Narita M.

Nat Cell Biol. 2016 Sep;18(9):979-92. doi: 10.1038/ncb3397. Epub 2016 Aug 15.

20.

Plasma Membrane Profiling Reveals Upregulation of ABCA1 by Infected Macrophages Leading to Restriction of Mycobacterial Growth.

Long J, Basu Roy R, Zhang YJ, Antrobus R, Du Y, Smith DL, Weekes MP, Javid B.

Front Microbiol. 2016 Jul 12;7:1086. doi: 10.3389/fmicb.2016.01086. eCollection 2016.

21.

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI.

Autophagy. 2016 Oct 2;12(10):1917-1930. Epub 2016 Jul 8.

22.

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

Timms RT, Menzies SA, Tchasovnikarova IA, Christensen LC, Williamson JC, Antrobus R, Dougan G, Ellgaard L, Lehner PJ.

Nat Commun. 2016 Jun 10;7:11786. doi: 10.1038/ncomms11786.

23.

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries.

Karniely S, Weekes MP, Antrobus R, Rorbach J, van Haute L, Umrania Y, Smith DL, Stanton RJ, Minczuk M, Lehner PJ, Sinclair JH.

MBio. 2016 Mar 29;7(2):e00029. doi: 10.1128/mBio.00029-16.

24.

Mycetoma Caused by Acremonium Species in a Patient with Chronic Granulomatous Disease.

Antrobus R, Wong G, Jones J, Huissoon A.

Case Reports Immunol. 2016;2016:3209493. doi: 10.1155/2016/3209493. Epub 2016 Feb 28.

25.

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum.

Preissler S, Rato C, Chen R, Antrobus R, Ding S, Fearnley IM, Ron D.

Elife. 2015 Dec 17;4:e12621. doi: 10.7554/eLife.12621.

26.

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.

Matheson NJ, Sumner J, Wals K, Rapiteanu R, Weekes MP, Vigan R, Weinelt J, Schindler M, Antrobus R, Costa AS, Frezza C, Clish CB, Neil SJ, Lehner PJ.

Cell Host Microbe. 2015 Oct 14;18(4):409-23. doi: 10.1016/j.chom.2015.09.003. Epub 2015 Oct 1.

27.

Antagonism of aminoacid transport in primary CD4 T cells by HIV-1 Vpu.

Matheson N, Wals K, Weekes M, Rapiteanu R, Vigan R, Antrobus R, Smith D, Neil S, Lehner P.

Lancet. 2015 Feb 26;385 Suppl 1:S66. doi: 10.1016/S0140-6736(15)60381-6.

PMID:
26312888
28.

The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains.

Grice GL, Lobb IT, Weekes MP, Gygi SP, Antrobus R, Nathan JA.

Cell Rep. 2015 Jul 28;12(4):545-53. doi: 10.1016/j.celrep.2015.06.061. Epub 2015 Jul 16.

29.

Contributions of epsinR and gadkin to clathrin-mediated intracellular trafficking.

Hirst J, Edgar JR, Borner GH, Li S, Sahlender DA, Antrobus R, Robinson MS.

Mol Biol Cell. 2015 Sep 1;26(17):3085-103. doi: 10.1091/mbc.E15-04-0245. Epub 2015 Jul 15.

30.

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R, Göttgens B, Dougan G, Dawson MA, Lehner PJ.

Science. 2015 Jun 26;348(6242):1481-1485. doi: 10.1126/science.aaa7227. Epub 2015 May 28.

31.

Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.

Hsu JL, van den Boomen DJ, Tomasec P, Weekes MP, Antrobus R, Stanton RJ, Ruckova E, Sugrue D, Wilkie GS, Davison AJ, Wilkinson GW, Lehner PJ.

PLoS Pathog. 2015 Apr 14;11(4):e1004811. doi: 10.1371/journal.ppat.1004811. eCollection 2015 Apr.

32.

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory.

Swadling L, Capone S, Antrobus RD, Brown A, Richardson R, Newell EW, Halliday J, Kelly C, Bowen D, Fergusson J, Kurioka A, Ammendola V, Del Sorbo M, Grazioli F, Esposito ML, Siani L, Traboni C, Hill A, Colloca S, Davis M, Nicosia A, Cortese R, Folgori A, Klenerman P, Barnes E.

Sci Transl Med. 2014 Nov 5;6(261):261ra153. doi: 10.1126/scitranslmed.3009185.

33.

Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus.

Hepburn L, Prajsnar TK, Klapholz C, Moreno P, Loynes CA, Ogryzko NV, Brown K, Schiebler M, Hegyi K, Antrobus R, Hammond KL, Connolly J, Ochoa B, Bryant C, Otto M, Surewaard B, Seneviratne SL, Grogono DM, Cachat J, Ny T, Kaser A, Török ME, Peacock SJ, Holden M, Blundell T, Wang L, Ligoxygakis P, Minichiello L, Woods CG, Foster SJ, Renshaw SA, Floto RA.

Science. 2014 Oct 31;346(6209):641-646. doi: 10.1126/science.1258705.

34.

Transcriptomic profiling facilitates classification of response to influenza challenge.

Davenport EE, Antrobus RD, Lillie PJ, Gilbert S, Knight JC.

J Mol Med (Berl). 2015 Jan;93(1):105-14. doi: 10.1007/s00109-014-1212-8. Epub 2014 Oct 28.

35.

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm.

Gulati P, Avezov E, Ma M, Antrobus R, Lehner P, O'Rahilly S, Yeo GS.

Biosci Rep. 2014 Oct 22;34(5). pii: e00144. doi: 10.1042/BSR20140111.

36.

Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial.

Satti I, Meyer J, Harris SA, Manjaly Thomas ZR, Griffiths K, Antrobus RD, Rowland R, Ramon RL, Smith M, Sheehan S, Bettinson H, McShane H.

Lancet Infect Dis. 2014 Oct;14(10):939-46. doi: 10.1016/S1473-3099(14)70845-X. Epub 2014 Aug 20.

37.

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells.

Stanton RJ, Prod'homme V, Purbhoo MA, Moore M, Aicheler RJ, Heinzmann M, Bailer SM, Haas J, Antrobus R, Weekes MP, Lehner PJ, Vojtesek B, Miners KL, Man S, Wilkie GS, Davison AJ, Wang ECY, Tomasec P, Wilkinson GWG.

Cell Host Microbe. 2014 Aug 13;16(2):201-214. doi: 10.1016/j.chom.2014.07.005.

38.

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.

Boname JM, Bloor S, Wandel MP, Nathan JA, Antrobus R, Dingwell KS, Thurston TL, Smith DL, Smith JC, Randow F, Lehner PJ.

J Cell Biol. 2014 Jun 23;205(6):847-62. doi: 10.1083/jcb.201312009.

39.

Characterization of TSET, an ancient and widespread membrane trafficking complex.

Hirst J, Schlacht A, Norcott JP, Traynor D, Bloomfield G, Antrobus R, Kay RR, Dacks JB, Robinson MS.

Elife. 2014 May 27;3:e02866. doi: 10.7554/eLife.02866.

40.

Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens.

Antrobus RD, Coughlan L, Berthoud TK, Dicks MD, Hill AV, Lambe T, Gilbert SC.

Mol Ther. 2014 Mar;22(3):668-674. doi: 10.1038/mt.2013.284. Epub 2013 Dec 30.

41.

Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.

Timms RT, Duncan LM, Tchasovnikarova IA, Antrobus R, Smith DL, Dougan G, Weekes MP, Lehner PJ.

PLoS Pathog. 2013;9(11):e1003772. doi: 10.1371/journal.ppat.1003772. Epub 2013 Nov 21.

42.

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation.

Burr ML, van den Boomen DJ, Bye H, Antrobus R, Wiertz EJ, Lehner PJ.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14290-5. doi: 10.1073/pnas.1303380110. Epub 2013 Aug 8.

43.

Coadministration of seasonal influenza vaccine and MVA-NP+M1 simultaneously achieves potent humoral and cell-mediated responses.

Antrobus RD, Berthoud TK, Mullarkey CE, Hoschler K, Coughlan L, Zambon M, Hill AV, Gilbert SC.

Mol Ther. 2014 Jan;22(1):233-8. doi: 10.1038/mt.2013.162. Epub 2013 Jul 8.

44.

Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.

Hirst J, Borner GH, Edgar J, Hein MY, Mann M, Buchholz F, Antrobus R, Robinson MS.

Mol Biol Cell. 2013 Aug;24(16):2558-69. doi: 10.1091/mbc.E13-03-0170. Epub 2013 Jul 3.

45.

Testing for hypersensitivity to seminal fluid-free spermatozoa.

Carroll M, Horne G, Antrobus R, Fitzgerald C, Brison D, Helbert M.

Hum Fertil (Camb). 2013 Jun;16(2):128-31. doi: 10.3109/14647273.2013.800238. Epub 2013 Jun 10.

PMID:
23751111
46.

Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection.

Weekes MP, Tan SY, Poole E, Talbot S, Antrobus R, Smith DL, Montag C, Gygi SP, Sinclair JH, Lehner PJ.

Science. 2013 Apr 12;340(6129):199-202. doi: 10.1126/science.1235047.

47.

Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. doi: 10.1073/pnas.1222796110. Epub 2013 Jan 28.

48.

A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years.

Antrobus RD, Lillie PJ, Berthoud TK, Spencer AJ, McLaren JE, Ladell K, Lambe T, Milicic A, Price DA, Hill AV, Gilbert SC.

PLoS One. 2012;7(10):e48322. doi: 10.1371/journal.pone.0048322. Epub 2012 Oct 31.

49.

ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans.

Sheehy SH, Duncan CJ, Elias SC, Choudhary P, Biswas S, Halstead FD, Collins KA, Edwards NJ, Douglas AD, Anagnostou NA, Ewer KJ, Havelock T, Mahungu T, Bliss CM, Miura K, Poulton ID, Lillie PJ, Antrobus RD, Berrie E, Moyle S, Gantlett K, Colloca S, Cortese R, Long CA, Sinden RE, Gilbert SC, Lawrie AM, Doherty T, Faust SN, Nicosia A, Hill AV, Draper SJ.

Mol Ther. 2012 Dec;20(12):2355-68. doi: 10.1038/mt.2012.223. Epub 2012 Oct 23.

50.

Distinct and overlapping roles for AP-1 and GGAs revealed by the "knocksideways" system.

Hirst J, Borner GH, Antrobus R, Peden AA, Hodson NA, Sahlender DA, Robinson MS.

Curr Biol. 2012 Sep 25;22(18):1711-6. doi: 10.1016/j.cub.2012.07.012. Epub 2012 Aug 16.

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