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Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo-electron microscopy.

Gopalasingam CC, Johnson RM, Chiduza GN, Tosha T, Yamamoto M, Shiro Y, Antonyuk SV, Muench SP, Hasnain SS.

Sci Adv. 2019 Aug 28;5(8):eaax1803. doi: 10.1126/sciadv.aax1803. eCollection 2019 Aug.


Catalytically important damage-free structures of a copper nitrite reductase obtained by femtosecond X-ray laser and room-temperature neutron crystallography.

Halsted TP, Yamashita K, Gopalasingam CC, Shenoy RT, Hirata K, Ago H, Ueno G, Blakeley MP, Eady RR, Antonyuk SV, Yamamoto M, Hasnain SS.

IUCrJ. 2019 Jun 23;6(Pt 4):761-772. doi: 10.1107/S2052252519008285. eCollection 2019 Jul 1.


Crystal Structure of the Japanese Encephalitis Virus Capsid Protein.

Poonsiri T, Wright GSA, Solomon T, Antonyuk SV.

Viruses. 2019 Jul 6;11(7). pii: E623. doi: 10.3390/v11070623.


LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM.

Chiduza GN, Johnson RM, Wright GSA, Antonyuk SV, Muench SP, Hasnain SS.

Acta Crystallogr D Struct Biol. 2019 Jul 1;75(Pt 7):660-669. doi: 10.1107/S2059798319009094. Epub 2019 Jun 28.


The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM.

Muench SP, Antonyuk SV, Hasnain SS.

IUCrJ. 2019 Mar 1;6(Pt 2):167-177. doi: 10.1107/S2052252519002422. eCollection 2019 Mar 1. Review.


Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone-based compounds.

Panmanee J, Bradley-Clarke J, Mato JM, O'Neill PM, Antonyuk SV, Hasnain SS.

FEBS J. 2019 Jun;286(11):2135-2154. doi: 10.1111/febs.14790. Epub 2019 Mar 4.


Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS.

Sala FA, Wright GSA, Antonyuk SV, Garratt RC, Hasnain SS.

PLoS Biol. 2019 Feb 8;17(2):e3000141. doi: 10.1371/journal.pbio.3000141. eCollection 2019 Feb.


Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts.

Lam WH, Sze KH, Ke Y, Tse MK, Zhang H, Woo PCY, Lau SKP, Lau CCY, Xu S, Lai PM, Zhou T, Antonyuk SV, Kao RYT, Yuen KY, Hao Q.

Infect Immun. 2019 Mar 25;87(4). pii: e00679-18. doi: 10.1128/IAI.00679-18. Print 2019 Apr.


Identification of a tyrosine switch in copper-haem nitrite reductases.

Dong J, Sasaki D, Eady RR, Antonyuk SV, Hasnain SS.

IUCrJ. 2018 Jun 25;5(Pt 4):510-518. doi: 10.1107/S2052252518008242. eCollection 2018 Jul 1.


X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery.

Amporndanai K, Johnson RM, O'Neill PM, Fishwick CWG, Jamson AH, Rawson S, Muench SP, Hasnain SS, Antonyuk SV.

IUCrJ. 2018 Feb 20;5(Pt 2):200-210. doi: 10.1107/S2052252518001616. eCollection 2018 Mar 1.


Enzyme catalysis captured using multiple structures from one crystal at varying temperatures.

Horrell S, Kekilli D, Sen K, Owen RL, Dworkowski FSN, Antonyuk SV, Keal TW, Yong CW, Eady RR, Hasnain SS, Strange RW, Hough MA.

IUCrJ. 2018 Mar 16;5(Pt 3):283-292. doi: 10.1107/S205225251800386X. eCollection 2018 May 1.


The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.

Capper MJ, Wright GSA, Barbieri L, Luchinat E, Mercatelli E, McAlary L, Yerbury JJ, O'Neill PM, Antonyuk SV, Banci L, Hasnain SS.

Nat Commun. 2018 Apr 27;9(1):1693. doi: 10.1038/s41467-018-04114-x.


Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system.

Wright GSA, Saeki A, Hikima T, Nishizono Y, Hisano T, Kamaya M, Nukina K, Nishitani H, Nakamura H, Yamamoto M, Antonyuk SV, Hasnain SS, Shiro Y, Sawai H.

Sci Signal. 2018 Apr 10;11(525). pii: eaaq0825. doi: 10.1126/scisignal.aaq0825.


An unprecedented dioxygen species revealed by serial femtosecond rotation crystallography in copper nitrite reductase.

Halsted TP, Yamashita K, Hirata K, Ago H, Ueno G, Tosha T, Eady RR, Antonyuk SV, Yamamoto M, Hasnain SS.

IUCrJ. 2018 Jan 1;5(Pt 1):22-31. doi: 10.1107/S2052252517016128. eCollection 2018 Jan 1.


Structural Study of the C-Terminal Domain of Nonstructural Protein 1 from Japanese Encephalitis Virus.

Poonsiri T, Wright GSA, Diamond MS, Turtle L, Solomon T, Antonyuk SV.

J Virol. 2018 Mar 14;92(7). pii: e01868-17. doi: 10.1128/JVI.01868-17. Print 2018 Apr 1.


Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.

Helassa N, Antonyuk SV, Lian LY, Haynes LP, Burgoyne RD.

Hum Mol Genet. 2017 Jul 1;26(13):2426-2435. doi: 10.1093/hmg/ddx133.


Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.

Dickens D, Chiduza GN, Wright GS, Pirmohamed M, Antonyuk SV, Hasnain SS.

Sci Rep. 2017 Mar 8;7:43580. doi: 10.1038/srep43580.


Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal.

Horrell S, Antonyuk SV, Eady RR, Hasnain SS, Hough MA, Strange RW.

IUCrJ. 2016 Jun 15;3(Pt 4):271-81. doi: 10.1107/S205225251600823X. eCollection 2016 Jul 1.


New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.

McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, Wang K, Kim TK, He Y, Santos T, Woods S, Lee P, Donkin D, Kim E, Fraczek L, Lykins J, Esaa F, Alibana-Clouser F, Dovgin S, Weiss L, Brasseur G, Wirth D, Kent M, Hood L, Meunieur B, Roberts CW, Hasnain SS, Antonyuk SV, Fishwick C, McLeod R.

Sci Rep. 2016 Jul 14;6:29179. doi: 10.1038/srep29179.


A faulty interaction between SOD1 and hCCS in neurodegenerative disease.

Wright GS, Antonyuk SV, Hasnain SS.

Sci Rep. 2016 Jun 10;6:27691. doi: 10.1038/srep27691.


Fresh insight to functioning of selected enzymes of the nitrogen cycle.

Eady RR, Antonyuk SV, Hasnain SS.

Curr Opin Chem Biol. 2016 Apr;31:103-12. doi: 10.1016/j.cbpa.2016.02.009. Epub 2016 Mar 17. Review.


Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes.

Murray B, Antonyuk SV, Marina A, Lu SC, Mato JM, Hasnain SS, Rojas AL.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2104-9. doi: 10.1073/pnas.1510959113. Epub 2016 Feb 8.


Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential.

Blakeley MP, Hasnain SS, Antonyuk SV.

IUCrJ. 2015 Jun 30;2(Pt 4):464-74. doi: 10.1107/S2052252515011239. eCollection 2015 Jul 1. Review.


Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1.

Capper MJ, O'Neill PM, Fisher N, Strange RW, Moss D, Ward SA, Berry NG, Lawrenson AS, Hasnain SS, Biagini GA, Antonyuk SV.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):755-60. doi: 10.1073/pnas.1416611112. Epub 2015 Jan 6.


Structure and function study of the complex that synthesizes S-adenosylmethionine.

Murray B, Antonyuk SV, Marina A, Van Liempd SM, Lu SC, Mato JM, Hasnain SS, Rojas AL.

IUCrJ. 2014 Jun 12;1(Pt 4):240-9. doi: 10.1107/S2052252514012585. eCollection 2014 Jul 1.


The structure of a purple acid phosphatase involved in plant growth and pathogen defence exhibits a novel immunoglobulin-like fold.

Antonyuk SV, Olczak M, Olczak T, Ciuraszkiewicz J, Strange RW.

IUCrJ. 2014 Feb 28;1(Pt 2):101-9. doi: 10.1107/S205225251400400X. eCollection 2014 Mar 1.


Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase.

Leferink NG, Antonyuk SV, Houwman JA, Scrutton NS, Eady RR, Hasnain SS.

Nat Commun. 2014 Jul 15;5:4395. doi: 10.1038/ncomms5395.


Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life.

Austin JA, Wright GS, Watanabe S, Grossmann JG, Antonyuk SV, Yamanaka K, Hasnain SS.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4309-14. doi: 10.1073/pnas.1317317111. Epub 2014 Mar 3.


Ligand binding and aggregation of pathogenic SOD1.

Wright GS, Antonyuk SV, Kershaw NM, Strange RW, Samar Hasnain S.

Nat Commun. 2013;4:1758. doi: 10.1038/ncomms2750.


Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426.

Padmanabhan B, Nakamura Y, Antonyuk SV, Strange RW, Hasnain SS, Yokoyama S, Bessho Y.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):342-5. doi: 10.1107/S1744309113003369. Epub 2013 Mar 28.


Structures of protein-protein complexes involved in electron transfer.

Antonyuk SV, Han C, Eady RR, Hasnain SS.

Nature. 2013 Apr 4;496(7443):123-6. doi: 10.1038/nature11996. Epub 2013 Mar 27.


X-ray crystallography and computational docking for the detection and development of protein-ligand interactions.

Kershaw NM, Wright GS, Sharma R, Antonyuk SV, Strange RW, Berry NG, O'Neill PM, Hasnain SS.

Curr Med Chem. 2013;20(4):569-75.


Structural evidence for a copper-bound carbonate intermediate in the peroxidase and dismutase activities of superoxide dismutase.

Strange RW, Hough MA, Antonyuk SV, Hasnain SS.

PLoS One. 2012;7(9):e44811. doi: 10.1371/journal.pone.0044811. Epub 2012 Sep 11.


Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins.

Antonyuk SV, Rustage N, Petersen CA, Arnst JL, Heyes DJ, Sharma R, Berry NG, Scrutton NS, Eady RR, Andrew CR, Hasnain SS.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15780-5. doi: 10.1073/pnas.1109051108. Epub 2011 Sep 7.


Proton-coupled electron transfer in the catalytic cycle of Alcaligenes xylosoxidans copper-dependent nitrite reductase.

Leferink NG, Han C, Antonyuk SV, Heyes DJ, Rigby SE, Hough MA, Eady RR, Scrutton NS, Hasnain SS.

Biochemistry. 2011 May 17;50(19):4121-31. doi: 10.1021/bi200246f. Epub 2011 Apr 19.


Monitoring and validating active site redox states in protein crystals.

Antonyuk SV, Hough MA.

Biochim Biophys Acta. 2011 Jun;1814(6):778-84. doi: 10.1016/j.bbapap.2010.12.017. Epub 2011 Jan 6.


Distal-to-proximal NO conversion in hemoproteins: the role of the proximal pocket.

Hough MA, Antonyuk SV, Barbieri S, Rustage N, McKay AL, Servid AE, Eady RR, Andrew CR, Hasnain SS.

J Mol Biol. 2011 Jan 14;405(2):395-409. doi: 10.1016/j.jmb.2010.10.035. Epub 2010 Nov 10.


Structure of putative 4-amino-4-deoxychorismate lyase from Thermus thermophilus HB8.

Padmanabhan B, Bessho Y, Ebihara A, Antonyuk SV, Ellis MJ, Strange RW, Kuramitsu S, Watanabe N, Hasnain SS, Yokoyama S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1234-9. doi: 10.1107/S1744309109050052. Epub 2009 Nov 27.


Structure of glyceraldehyde-3-phosphate dehydrogenase from the archaeal hyperthermophile Methanocaldococcus jannaschii.

Malay AD, Bessho Y, Ellis MJ, Antonyuk SV, Strange RW, Hasnain SS, Shinkai A, Padmanabhan B, Yokoyama S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1227-33. doi: 10.1107/S1744309109047046. Epub 2009 Nov 27.


Structure of dihydrodipicolinate synthase from Methanocaldococcus jannaschii.

Padmanabhan B, Strange RW, Antonyuk SV, Ellis MJ, Hasnain SS, Iino H, Agari Y, Bessho Y, Yokoyama S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1222-6. doi: 10.1107/S174430910904651X. Epub 2009 Nov 27.


Structure of a putative beta-phosphoglucomutase (TM1254) from Thermotoga maritima.

Strange RW, Antonyuk SV, Ellis MJ, Bessho Y, Kuramitsu S, Shinkai A, Yokoyama S, Hasnain SS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1218-21. doi: 10.1107/S1744309109046302. Epub 2009 Nov 27.


The structure of an archaeal ribose-5-phosphate isomerase from Methanocaldococcus jannaschii (MJ1603).

Strange RW, Antonyuk SV, Ellis MJ, Bessho Y, Kuramitsu S, Yokoyama S, Hasnain SS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1214-7. doi: 10.1107/S1744309109044923. Epub 2009 Nov 27.


Structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD(+) and lactic acid (or pyruvate).

Antonyuk SV, Strange RW, Ellis MJ, Bessho Y, Kuramitsu S, Inoue Y, Yokoyama S, Hasnain SS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1209-13. doi: 10.1107/S1744309109044935. Epub 2009 Nov 27.


Structure of SurE protein from Aquifex aeolicus VF5 at 1.5 A resolution.

Antonyuk SV, Ellis MJ, Strange RW, Bessho Y, Kuramitsu S, Shinkai A, Yokoyama S, Hasnain SS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1204-8. doi: 10.1107/S1744309109043814. Epub 2009 Nov 27.


Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) from Sulfolobus tokodaii.

Antonyuk SV, Strange RW, Ellis MJ, Bessho Y, Kuramitsu S, Shinkai A, Yokoyama S, Hasnain SS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1200-3. doi: 10.1107/S1744309109043772. Epub 2009 Nov 27.


Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A.

Galaleldeen A, Strange RW, Whitson LJ, Antonyuk SV, Narayana N, Taylor AB, Schuermann JP, Holloway SP, Hasnain SS, Hart PJ.

Arch Biochem Biophys. 2009 Dec;492(1-2):40-7. doi: 10.1016/ Epub 2009 Oct 1.


The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding.

Antonyuk SV, Strange RW, Marklund SL, Hasnain SS.

J Mol Biol. 2009 May 1;388(2):310-26. doi: 10.1016/j.jmb.2009.03.026. Epub 2009 Mar 14.


Crystal structure of human prion protein bound to a therapeutic antibody.

Antonyuk SV, Trevitt CR, Strange RW, Jackson GS, Sangar D, Batchelor M, Cooper S, Fraser C, Jones S, Georgiou T, Khalili-Shirazi A, Clarke AR, Hasnain SS, Collinge J.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2554-8. doi: 10.1073/pnas.0809170106. Epub 2009 Feb 9.


Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis.

Cao X, Antonyuk SV, Seetharaman SV, Whitson LJ, Taylor AB, Holloway SP, Strange RW, Doucette PA, Valentine JS, Tiwari A, Hayward LJ, Padua S, Cohlberg JA, Hasnain SS, Hart PJ.

J Biol Chem. 2008 Jun 6;283(23):16169-77. doi: 10.1074/jbc.M801522200. Epub 2008 Mar 31.


Crystallography with online optical and X-ray absorption spectroscopies demonstrates an ordered mechanism in copper nitrite reductase.

Hough MA, Antonyuk SV, Strange RW, Eady RR, Hasnain SS.

J Mol Biol. 2008 Apr 25;378(2):353-61. doi: 10.1016/j.jmb.2008.01.097. Epub 2008 Feb 12.


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