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New insights into extracellular vesicle biogenesis and function.

Latifkar A, Hur YH, Sanchez JC, Cerione RA, Antonyak MA.

J Cell Sci. 2019 Jul 1;132(13). pii: jcs222406. doi: 10.1242/jcs.222406. Review.


Matrix stiffness regulates microvesicle-induced fibroblast activation.

Schwager SC, Bordeleau F, Zhang J, Antonyak MA, Cerione RA, Reinhart-King CA.

Am J Physiol Cell Physiol. 2019 Jul 1;317(1):C82-C92. doi: 10.1152/ajpcell.00418.2018. Epub 2019 Apr 24.


Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.

Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA.

Dev Cell. 2019 May 6;49(3):393-408.e7. doi: 10.1016/j.devcel.2019.03.011. Epub 2019 Apr 11.


Lipid-filled vesicles modulate macrophages.

Antonyak MA, Lukey MJ, Cerione RA.

Science. 2019 Mar 1;363(6430):931-932. doi: 10.1126/science.aaw6765. No abstract available.


Opening up about Tissue Transglutaminase: When Conformation Matters More than Enzymatic Activity.

Katt WP, Antonyak MA, Cerione RA.

Med One. 2018;3(6). pii: e180011. doi: 10.20900/mo.20180011. Epub 2018 Nov 22.


A small molecule regulator of tissue transglutaminase conformation inhibits the malignant phenotype of cancer cells.

Katt WP, Blobel NJ, Komarova S, Antonyak MA, Nakano I, Cerione RA.

Oncotarget. 2018 Sep 28;9(76):34379-34397. doi: 10.18632/oncotarget.26193. eCollection 2018 Sep 28.


Probing the mechanisms of extracellular vesicle biogenesis and function in cancer.

Latifkar A, Cerione RA, Antonyak MA.

Biochem Soc Trans. 2018 Oct 19;46(5):1137-1146. doi: 10.1042/BST20180523. Epub 2018 Oct 8. Review.


The diamond anniversary of tissue transglutaminase: a protein of many talents.

Katt WP, Antonyak MA, Cerione RA.

Drug Discov Today. 2018 Mar;23(3):575-591. doi: 10.1016/j.drudis.2018.01.037. Epub 2018 Jan 31. Review.


The Arf-GAP and protein scaffold Cat1/Git1 as a multifaceted regulator of cancer progression.

Yoo SM, Cerione RA, Antonyak MA.

Small GTPases. 2017 Oct 5:1-9. doi: 10.1080/21541248.2017.1362496. [Epub ahead of print]


A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis.

Feng Q, Zhang C, Lum D, Druso JE, Blank B, Wilson KF, Welm A, Antonyak MA, Cerione RA.

Nat Commun. 2017 Feb 16;8:14450. doi: 10.1038/ncomms14450.


Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake.

French KC, Antonyak MA, Cerione RA.

Semin Cell Dev Biol. 2017 Jul;67:48-55. doi: 10.1016/j.semcdb.2017.01.002. Epub 2017 Jan 16. Review.


Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation.

Yoo SM, Latifkar A, Cerione RA, Antonyak MA.

J Biol Chem. 2017 Mar 3;292(9):3947-3957. doi: 10.1074/jbc.M116.769190. Epub 2017 Jan 18.


The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance.

Kreger BT, Johansen ER, Cerione RA, Antonyak MA.

Cancers (Basel). 2016 Dec 9;8(12). pii: E111.


Breast cancer-derived extracellular vesicles stimulate myofibroblast differentiation and pro-angiogenic behavior of adipose stem cells.

Song YH, Warncke C, Choi SJ, Choi S, Chiou AE, Ling L, Liu HY, Daniel S, Antonyak MA, Cerione RA, Fischbach C.

Matrix Biol. 2017 Jul;60-61:190-205. doi: 10.1016/j.matbio.2016.11.008. Epub 2016 Nov 29.


The distinct traits of extracellular vesicles generated by transformed cells.

Antonyak MA, Cerione RA.

Small GTPases. 2018 Sep 3;9(5):427-432. doi: 10.1080/21541248.2016.1249044. Epub 2016 Nov 16.


Microvesicle Cargo and Function Changes upon Induction of Cellular Transformation.

Kreger BT, Dougherty AL, Greene KS, Cerione RA, Antonyak MA.

J Biol Chem. 2016 Sep 16;291(38):19774-85. doi: 10.1074/jbc.M116.725705. Epub 2016 Jul 20.


Identifying the functional contribution of the defatty-acylase activity of SIRT6.

Zhang X, Khan S, Jiang H, Antonyak MA, Chen X, Spiegelman NA, Shrimp JH, Cerione RA, Lin H.

Nat Chem Biol. 2016 Aug;12(8):614-20. doi: 10.1038/nchembio.2106. Epub 2016 Jun 20.


Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation.

Desrochers LM, Bordeleau F, Reinhart-King CA, Cerione RA, Antonyak MA.

Nat Commun. 2016 Jun 15;7:11958. doi: 10.1038/ncomms11958.


Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology.

Desrochers LM, Antonyak MA, Cerione RA.

Dev Cell. 2016 May 23;37(4):301-309. doi: 10.1016/j.devcel.2016.04.019. Review.


An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland.

Druso JE, Endo M, Lin MC, Peng X, Antonyak MA, Meller S, Cerione RA.

J Biol Chem. 2016 Apr 22;291(17):8886-95. doi: 10.1074/jbc.M115.694349. Epub 2016 Feb 24.


The Different Conformational States of Tissue Transglutaminase Have Opposing Affects on Cell Viability.

Singh G, Zhang J, Ma Y, Cerione RA, Antonyak MA.

J Biol Chem. 2016 Apr 22;291(17):9119-32. doi: 10.1074/jbc.M115.699108. Epub 2016 Feb 18.


Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility.

Bordeleau F, Chan B, Antonyak MA, Lampi MC, Cerione RA, Reinhart-King CA.

J Biomech. 2016 May 24;49(8):1272-1279. doi: 10.1016/j.jbiomech.2015.10.003. Epub 2015 Oct 9.


Emerging picture of the distinct traits and functions of microvesicles and exosomes.

Antonyak MA, Cerione RA.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3589-90. doi: 10.1073/pnas.1502590112. Epub 2015 Mar 11. No abstract available.


Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition.

Santana SM, Antonyak MA, Cerione RA, Kirby BJ.

Phys Biol. 2014 Nov 26;11(6):065001. doi: 10.1088/1478-3975/11/6/065001.


Microfluidic isolation of cancer-cell-derived microvesicles from hetergeneous extracellular shed vesicle populations.

Santana SM, Antonyak MA, Cerione RA, Kirby BJ.

Biomed Microdevices. 2014 Dec;16(6):869-77. doi: 10.1007/s10544-014-9891-z.


Microvesicles as mediators of intercellular communication in cancer.

Antonyak MA, Cerione RA.

Methods Mol Biol. 2014;1165:147-73. doi: 10.1007/978-1-4939-0856-1_11. Review.


Inhibiting heat shock factor 1 in human cancer cells with a potent RNA aptamer.

Salamanca HH, Antonyak MA, Cerione RA, Shi H, Lis JT.

PLoS One. 2014 May 6;9(5):e96330. doi: 10.1371/journal.pone.0096330. eCollection 2014.


A novel mechanism by which tissue transglutaminase activates signaling events that promote cell survival.

Boroughs LK, Antonyak MA, Cerione RA.

J Biol Chem. 2014 Apr 4;289(14):10115-25. doi: 10.1074/jbc.M113.464693. Epub 2014 Feb 25.


Mutations in the polybasic juxtamembrane sequence of both plasma membrane- and endoplasmic reticulum-localized epidermal growth factor receptors confer ligand-independent cell transformation.

Bryant KL, Antonyak MA, Cerione RA, Baird B, Holowka D.

J Biol Chem. 2013 Nov 29;288(48):34930-42. doi: 10.1074/jbc.M113.513333. Epub 2013 Oct 18.


Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis.

Jin Y, Liu Y, Lin Q, Li J, Druso JE, Antonyak MA, Meininger CJ, Zhang SL, Dostal DE, Guan JL, Cerione RA, Peng X.

Mol Cell Biol. 2013 Nov;33(21):4181-97. doi: 10.1128/MCB.00650-13. Epub 2013 Aug 26.


A mechanism for the upregulation of EGF receptor levels in glioblastomas.

Zhang J, Antonyak MA, Singh G, Cerione RA.

Cell Rep. 2013 Jun 27;3(6):2008-20. doi: 10.1016/j.celrep.2013.05.021. Epub 2013 Jun 13.


Rho GTPases and their roles in cancer metabolism.

Wilson KF, Erickson JW, Antonyak MA, Cerione RA.

Trends Mol Med. 2013 Feb;19(2):74-82. doi: 10.1016/j.molmed.2012.10.011. Epub 2012 Dec 5. Review.


Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice.

Peng X, Lin Q, Liu Y, Jin Y, Druso JE, Antonyak MA, Guan JL, Cerione RA.

Protein Cell. 2013 Mar;4(3):231-42. doi: 10.1007/s13238-012-2098-2. Epub 2012 Nov 12. Erratum in: Protein Cell. 2013 Aug;4(8):641.


R(h)oads to microvesicles.

Antonyak MA, Wilson KF, Cerione RA.

Small GTPases. 2012 Oct-Dec;3(4):219-24. doi: 10.4161/sgtp.20755. Epub 2012 Aug 21.


The adaptor protein and Arf GTPase-activating protein Cat-1/Git-1 is required for cellular transformation.

Yoo SM, Antonyak MA, Cerione RA.

J Biol Chem. 2012 Sep 7;287(37):31462-70. doi: 10.1074/jbc.M112.353615. Epub 2012 Jul 17.


Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation.

Milano SK, Kwon W, Pereira R, Antonyak MA, Cerione RA.

J Biol Chem. 2012 Jul 20;287(30):24955-66. doi: 10.1074/jbc.M111.306514. Epub 2012 Jun 7.


Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.

Basso M, Berlin J, Xia L, Sleiman SF, Ko B, Haskew-Layton R, Kim E, Antonyak MA, Cerione RA, Iismaa SE, Willis D, Cho S, Ratan RR.

J Neurosci. 2012 May 9;32(19):6561-9. doi: 10.1523/JNEUROSCI.3353-11.2012. Erratum in: J Neurosci. 2012 Aug 8;32(32):11157.


RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells.

Li B, Antonyak MA, Zhang J, Cerione RA.

Oncogene. 2012 Nov 8;31(45):4740-9. doi: 10.1038/onc.2011.636. Epub 2012 Jan 23.


A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration.

Boroughs LK, Antonyak MA, Johnson JL, Cerione RA.

J Biol Chem. 2011 Oct 28;286(43):37094-107. doi: 10.1074/jbc.M111.242438. Epub 2011 Sep 6.


Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells.

Antonyak MA, Li B, Boroughs LK, Johnson JL, Druso JE, Bryant KL, Holowka DA, Cerione RA.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4852-7. doi: 10.1073/pnas.1017667108. Epub 2011 Feb 28. Erratum in: Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17569.


Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.

McConoughey SJ, Basso M, Niatsetskaya ZV, Sleiman SF, Smirnova NA, Langley BC, Mahishi L, Cooper AJ, Antonyak MA, Cerione RA, Li B, Starkov A, Chaturvedi RK, Beal MF, Coppola G, Geschwind DH, Ryu H, Xia L, Iismaa SE, Pallos J, Pasternack R, Hils M, Fan J, Raymond LA, Marsh JL, Thompson LM, Ratan RR.

EMBO Mol Med. 2010 Sep;2(9):349-70. doi: 10.1002/emmm.201000084.


EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation.

Li B, Antonyak MA, Druso JE, Cheng L, Nikitin AY, Cerione RA.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1408-13. doi: 10.1073/pnas.0907907107. Epub 2010 Jan 4.


Ras and the FAK paradox.

Antonyak MA, Cerione RA.

Mol Cell. 2009 Jul 31;35(2):141-2. doi: 10.1016/j.molcel.2009.07.005.


Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion.

Antonyak MA, Li B, Regan AD, Feng Q, Dusaban SS, Cerione RA.

J Biol Chem. 2009 Jul 3;284(27):17914-25. doi: 10.1074/jbc.M109.013037. Epub 2009 Apr 29.


Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation.

Endo M, Antonyak MA, Cerione RA.

J Biol Chem. 2009 Feb 20;284(8):5107-18. doi: 10.1074/jbc.M807745200. Epub 2008 Dec 19.


GTP-binding-defective forms of tissue transglutaminase trigger cell death.

Datta S, Antonyak MA, Cerione RA.

Biochemistry. 2007 Dec 25;46(51):14819-29. Epub 2007 Dec 1.


Two isoforms of tissue transglutaminase mediate opposing cellular fates.

Antonyak MA, Jansen JM, Miller AM, Ly TK, Endo M, Cerione RA.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18609-14. Epub 2006 Nov 20.


Effects of tissue transglutaminase on beta -amyloid1-42-induced apoptosis.

Wakshlag JJ, Antonyak MA, Boehm JE, Boehm K, Cerione RA.

Protein J. 2006 Jan;25(1):83-94.


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