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A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography.

Oikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, Thomas KE, Thomas S, Akoumianakis I, Fan LM, Kesavan S, Herdman L, Alashi A, Centeno EH, Lyasheva M, Griffin BP, Flamm SD, Shirodaria C, Sabharwal N, Kelion A, Dweck MR, Van Beek EJR, Deanfield J, Hopewell JC, Neubauer S, Channon KM, Achenbach S, Newby DE, Antoniades C.

Eur Heart J. 2019 Sep 3. pii: ehz592. doi: 10.1093/eurheartj/ehz592. [Epub ahead of print]


Imaging residual inflammatory cardiovascular risk.

Antoniades C, Antonopoulos AS, Deanfield J.

Eur Heart J. 2019 Jul 16. pii: ehz474. doi: 10.1093/eurheartj/ehz474. [Epub ahead of print]


The intestinal microbiota and cardiovascular disease.

Katsimichas T, Antonopoulos AS, Katsimichas A, Ohtani T, Sakata Y, Tousoulis D.

Cardiovasc Res. 2019 Aug 1;115(10):1471-1486. doi: 10.1093/cvr/cvz135.


The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives.

Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis GA, Vogiatzi G, Papaioannou S, Deftereos S, Tousoulis D.

Eur Cardiol. 2019 Apr;14(1):50-59. doi: 10.15420/ecr.2018.33.1. Review.


Study of myocardial redox state in clinical practice: pitfalls and controversies.

Antonopoulos AS, Tousoulis D.

Hellenic J Cardiol. 2019 Apr 29. pii: S1109-9666(19)30117-4. doi: 10.1016/j.hjc.2019.04.006. [Epub ahead of print] No abstract available.


Pre-Dilatation Versus No Pre-Dilatation for Implantation of a Self-Expanding Valve in All Comers Undergoing TAVR: The DIRECT Trial.

Toutouzas K, Benetos G, Voudris V, Drakopoulou M, Stathogiannis K, Latsios G, Synetos A, Antonopoulos A, Kosmas E, Iakovou I, Katsimagklis G, Mastrokostopoulos A, Moraitis S, Zeniou V, Danenberg H, Vavuranakis M, Tousoulis D.

JACC Cardiovasc Interv. 2019 Apr 22;12(8):767-777. doi: 10.1016/j.jcin.2019.02.005. Epub 2019 Mar 27.


Clinical significance of pleural effusions and association with outcome in patients hospitalized with a first episode of acute pericarditis.

Lazaros G, Antonopoulos AS, Imazio M, Solomou E, Lazarou E, Vassilopoulos D, Adler Y, Stefanadis C, Tousoulis D.

Intern Emerg Med. 2019 Aug;14(5):745-751. doi: 10.1007/s11739-019-02041-3. Epub 2019 Mar 13.


Serum IgA1 shows increased levels of α2,6-linked sialic acid in breast cancer.

Lomax-Browne HJ, Robertson C, Antonopoulos A, Leathem AJC, Haslam SM, Dell A, Dwek MV.

Interface Focus. 2019 Apr 6;9(2):20180079. doi: 10.1098/rsfs.2018.0079. Epub 2019 Feb 15.


Cardiovascular effects of electronic cigarettes: A systematic review and meta-analysis.

Skotsimara G, Antonopoulos AS, Oikonomou E, Siasos G, Ioakeimidis N, Tsalamandris S, Charalambous G, Galiatsatos N, Vlachopoulos C, Tousoulis D.

Eur J Prev Cardiol. 2019 Jul;26(11):1219-1228. doi: 10.1177/2047487319832975. Epub 2019 Mar 1.


Effects of Newer Antidiabetic Drugs on Endothelial Function and Arterial Stiffness: A Systematic Review and Meta-Analysis.

Batzias K, Antonopoulos AS, Oikonomou E, Siasos G, Bletsa E, Stampouloglou PK, Mistakidi CV, Noutsou M, Katsiki N, Karopoulos P, Charalambous G, Thanopoulou A, Tentolouris N, Tousoulis D.

J Diabetes Res. 2018 Dec 4;2018:1232583. doi: 10.1155/2018/1232583. eCollection 2018.


Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans.

Giovannone N, Antonopoulos A, Liang J, Geddes Sweeney J, Kudelka MR, King SL, Lee GS, Cummings RD, Dell A, Barthel SR, Widlund HR, Haslam SM, Dimitroff CJ.

Front Immunol. 2018 Dec 14;9:2857. doi: 10.3389/fimmu.2018.02857. eCollection 2018.


Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection.

Patel VH, Karteris E, Chen J, Kyrou I, Mattu HS, Dimitriadis GK, Rodrigo G, Antoniades C, Antonopoulos A, Tan BK, Hillhouse EW, Ng A, Randeva HS.

Clin Sci (Lond). 2018 Dec 13;132(24):2547-2564. doi: 10.1042/CS20180150. Print 2018 Dec 21.


Statins in atrial fibrillation prevention: A closed chapter?

Antonopoulos AS, Tousoulis D.

Hellenic J Cardiol. 2019 Jan - Feb;60(1):48-50. doi: 10.1016/j.hjc.2018.10.006. Epub 2018 Nov 7. No abstract available.


Cardiac Magnetic Resonance Imaging of Epicardial and Intramyocardial Adiposity as an Early Sign of Myocardial Disease.

Antonopoulos AS, Antoniades C.

Circ Cardiovasc Imaging. 2018 Aug;11(8):e008083. doi: 10.1161/CIRCIMAGING.118.008083. No abstract available.


Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion.

Wang SS, Gao X, Solar VD, Yu X, Antonopoulos A, Friedman AE, Matich EK, Atilla-Gokcumen GE, Nasirikenari M, Lau JT, Dell A, Haslam SM, Laine RA, Matta KL, Neelamegham S.

Cell Chem Biol. 2018 Dec 20;25(12):1519-1532.e5. doi: 10.1016/j.chembiol.2018.09.012. Epub 2018 Oct 18.


The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants.

El Jellas K, Johansson BB, Fjeld K, Antonopoulos A, Immervoll H, Choi MH, Hoem D, Lowe ME, Lombardo D, Njølstad PR, Dell A, Mas E, Haslam SM, Molven A.

J Biol Chem. 2018 Dec 14;293(50):19476-19491. doi: 10.1074/jbc.RA118.001934. Epub 2018 Oct 12.


XBP1s activation can globally remodel N-glycan structure distribution patterns.

Wong MY, Chen K, Antonopoulos A, Kasper BT, Dewal MB, Taylor RJ, Whittaker CA, Hein PP, Dell A, Genereux JC, Haslam SM, Mahal LK, Shoulders MD.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10089-E10098. doi: 10.1073/pnas.1805425115. Epub 2018 Oct 10.


B-type natriuretic peptide levels and benign adiposity in obese heart failure patients.

Katsi V, Marketou M, Antonopoulos AS, Vrachatis D, Parthenakis F, Tousoulis D.

Heart Fail Rev. 2019 Mar;24(2):219-226. doi: 10.1007/s10741-018-9739-3. Review.


Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data.

Oikonomou EK, Marwan M, Desai MY, Mancio J, Alashi A, Hutt Centeno E, Thomas S, Herdman L, Kotanidis CP, Thomas KE, Griffin BP, Flamm SD, Antonopoulos AS, Shirodaria C, Sabharwal N, Deanfield J, Neubauer S, Hopewell JC, Channon KM, Achenbach S, Antoniades C.

Lancet. 2018 Sep 15;392(10151):929-939. doi: 10.1016/S0140-6736(18)31114-0. Epub 2018 Aug 28.


Loss of GCNT2/I-branched glycans enhances melanoma growth and survival.

Sweeney JG, Liang J, Antonopoulos A, Giovannone N, Kang S, Mondala TS, Head SR, King SL, Tani Y, Brackett D, Dell A, Murphy GF, Haslam SM, Widlund HR, Dimitroff CJ.

Nat Commun. 2018 Aug 22;9(1):3368. doi: 10.1038/s41467-018-05795-0.


IL-6 is associated to IGF-1Ec upregulation and Ec peptide secretion, from prostate tumors.

Armakolas A, Dimakakos A, Loukogiannaki C, Armakolas N, Antonopoulos A, Florou C, Tsioli P, Papageorgiou E, Alexandrou TP, Stathaki M, Spinos D, Pektasides D, Patsouris E, Koutsilieris M.

Mol Med. 2018 Mar 15;24(1):6. doi: 10.1186/s10020-018-0003-z.


Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans.

Giovannone N, Liang J, Antonopoulos A, Geddes Sweeney J, King SL, Pochebit SM, Bhattacharyya N, Lee GS, Dell A, Widlund HR, Haslam SM, Dimitroff CJ.

Nat Commun. 2018 Aug 17;9(1):3287. doi: 10.1038/s41467-018-05770-9.


The landscape of acute pericarditis in Greece: Experience from a tertiary referral center.

Lazaros G, Solomou E, Antonopoulos AS, Vlachopoulos C, Vasileiou P, Karavidas A, Bei E, Leontsinis G, Lazarou E, Vassilopoulos D, Tsioufis C, Kallikazaros I, Stefanadis C, Tousoulis D.

Hellenic J Cardiol. 2019 Mar - Apr;60(2):139-140. doi: 10.1016/j.hjc.2018.06.011. Epub 2018 Jun 27. No abstract available.


Perivascular Fat Attenuation Index by Computed Tomography as a Metric of Coronary Inflammation.

Antonopoulos AS, Antoniades C.

J Am Coll Cardiol. 2018 Jun 12;71(23):2708-2709. doi: 10.1016/j.jacc.2018.03.511. No abstract available.


Predictors of switching from nonsteroidal anti-inflammatory drugs to corticosteroids in patients with acute pericarditis and impact on clinical outcome.

Lazaros G, Antonopoulos AS, Vlachopoulos C, Oikonomou E, Karavidas A, Chrysochoou C, Lazarou E, Vassilopoulos D, Imazio M, Tousoulis D.

Hellenic J Cardiol. 2018 Apr 20. pii: S1109-9666(18)30095-2. doi: 10.1016/j.hjc.2018.04.001. [Epub ahead of print]


The Role of Epicardial Fat in Pericardial Diseases.

Lazaros G, Antonopoulos A, Antoniades C, Tousoulis D.

Curr Cardiol Rep. 2018 Apr 19;20(6):40. doi: 10.1007/s11886-018-0986-7. Review.


Interrelationship between diabetes mellitus and heart failure: the role of peroxisome proliferator-activated receptors in left ventricle performance.

Oikonomou E, Mourouzis K, Fountoulakis P, Papamikroulis GA, Siasos G, Antonopoulos A, Vogiatzi G, Tsalamadris S, Vavuranakis M, Tousoulis D.

Heart Fail Rev. 2018 May;23(3):389-408. doi: 10.1007/s10741-018-9682-3. Review.


Rational Approaches Targeting the Prevention of Cardiovascular Calcification: The Evolving Field of Osteocardiology.

Lazaros G, Antonopoulos AS, Tousoulis D.

Cardiology. 2018;139(3):184-186. doi: 10.1159/000486171. Epub 2018 Feb 2. No abstract available.


Prognostic significance of arterial stiffness and osteoprotegerin in patients with stable coronary artery disease.

Siasos G, Oikonomou E, Maniatis K, Georgiopoulos G, Kokkou E, Tsigkou V, Zaromitidou M, Antonopoulos A, Vavuranakis M, Stefanadis C, Papavassiliou AG, Tousoulis D.

Eur J Clin Invest. 2018 Mar;48(3). doi: 10.1111/eci.12890. Epub 2018 Jan 29.


18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomographic Imaging Detects Aortic Wall Inflammation in Patients With Repaired Coarctation of Aorta.

Brili S, Oikonomou E, Antonopoulos AS, Pianou N, Georgakopoulos A, Koutagiar I, Kafouris P, Stroumpouli E, Dounis C, Metaxas M, Spyrou G, Anagnostopoulos CD, Tousoulis D.

Circ Cardiovasc Imaging. 2018 Jan;11(1):e007002. doi: 10.1161/CIRCIMAGING.117.007002. No abstract available.


Associations between Adiponectin Gene Variability, Proinflammatory and Angiogenetic Markers: Implications for Microvascular Disease Development in Type 2 Diabetes Mellitus?

Kollia C, Antonopoulos AS, Siasos G, Konsola T, Oikonomou E, Gouliopoulos N, Tsigkou V, Papapanagiotou A, Kassi E, Tentolouris N, Katsiki N, Vavuranakis M, Papavassiliou AG, Tousoulis D.

Curr Vasc Pharmacol. 2019;17(2):204-208. doi: 10.2174/1570161116666180108113825.


Flow-Mediated Dilation of Brachial Artery as a Screening Tool for Anthracycline-Induced Cardiotoxicity.

Anastasiou M, Oikonomou E, Zagouri F, Siasos G, Antonopoulos AS, Psaltopoulou T, Bamias A, Dimopoulos MA, Tousoulis D.

J Am Coll Cardiol. 2017 Dec 19;70(24):3072. doi: 10.1016/j.jacc.2017.09.1140. No abstract available.


The role of sympathectomy in long QT syndrome.

Antonopoulos A, Lawrence D, Patrini D, Scarci M, George R, Hayward M, Mitsos S, Panagiotopoulos N.

J Thorac Dis. 2017 Sep;9(9):3394-3397. doi: 10.21037/jtd.2017.08.45. Review.


Coronary versus carotid artery plaques. Similarities and differences regarding biomarkers morphology and prognosis.

Sigala F, Oikonomou E, Antonopoulos AS, Galyfos G, Tousoulis D.

Curr Opin Pharmacol. 2018 Apr;39:9-18. doi: 10.1016/j.coph.2017.11.010. Epub 2017 Dec 1. Review.


Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia.

Toutouzas K, Skoumas J, Koutagiar I, Benetos G, Pianou N, Georgakopoulos A, Galanakos S, Antonopoulos A, Drakopoulou M, Oikonomou EK, Kafouris P, Athanasiadis E, Metaxas M, Spyrou G, Pallantza Z, Galiatsatos N, Aggeli C, Antoniades C, Keramida G, Peters AM, Anagnostopoulos CD, Tousoulis D.

J Clin Lipidol. 2018 Jan - Feb;12(1):33-43. doi: 10.1016/j.jacl.2017.10.019. Epub 2017 Nov 2.


Anti-inflammatory agents in peripheral arterial disease.

Antonopoulos AS, Papanikolaou E, Vogiatzi G, Oikonomou E, Tousoulis D.

Curr Opin Pharmacol. 2018 Apr;39:1-8. doi: 10.1016/j.coph.2017.11.001. Epub 2017 Nov 21. Review.


Statins and left ventricular function.

Bakakos A, Oikonomou E, Vogiatzi G, Siasos G, Tsalamandris S, Antonopoulos A, Mourouzis C, Fountoulakis P, Vavuranakis M, Tousoulis D.

Curr Pharm Des. 2017 Sep 26. doi: 10.2174/1381612823666170926125754. [Epub ahead of print]


Arterial Thoracic Outlet Syndrome Treated Successfully with Totally Endoscopic First Rib Resection.

Mitsos S, Patrini D, Velo S, Antonopoulos A, Hayward M, George RS, Lawrence D, Panagiotopoulos N.

Case Rep Pulmonol. 2017;2017:9350735. doi: 10.1155/2017/9350735. Epub 2017 Aug 6.


Long-term endothelial dysfunction after trans-radial catheterization: A meta-analytic approach.

Antonopoulos AS, Latsios G, Oikonomou E, Aznaouridis K, Papanikolaou A, Syrseloudis D, Siasos G, Vavuranakis M, Toutouzas K, Tousoulis D.

J Card Surg. 2017 Aug;32(8):464-473. doi: 10.1111/jocs.13181.


Western Dietary Pattern Is Associated With Severe Coronary Artery Disease.

Oikonomou E, Psaltopoulou T, Georgiopoulos G, Siasos G, Kokkou E, Antonopoulos A, Vogiatzi G, Tsalamandris S, Gennimata V, Papanikolaou A, Tousoulis D.

Angiology. 2018 Apr;69(4):339-346. doi: 10.1177/0003319717721603. Epub 2017 Jul 21.


Redox State in Atrial Fibrillation Pathogenesis and Relevant Therapeutic Approaches.

Antonopoulos AS, Goliopoulou A, Oikonomou E, Tsalamandris S, Papamikroulis GA, Lazaros G, Tsiamis E, Latsios G, Brili S, Papaioannou S, Gennimata V, Tousoulis D.

Curr Med Chem. 2019;26(5):765-779. doi: 10.2174/0929867324666170718130408. Review.


Detecting human coronary inflammation by imaging perivascular fat.

Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I, Petrou M, Sayeed R, Krasopoulos G, Psarros C, Ciccone P, Brophy CM, Digby J, Kelion A, Uberoi R, Anthony S, Alexopoulos N, Tousoulis D, Achenbach S, Neubauer S, Channon KM, Antoniades C.

Sci Transl Med. 2017 Jul 12;9(398). pii: eaal2658. doi: 10.1126/scitranslmed.aal2658.


Macrovascular function indices for the prediction of diabetic retinopathy development in patients with type 2 diabetes.

Gouliopoulos N, Antonopoulos AS, Siasos G, Moschos MM, Oikonomou E, Kassi E, Tousoulis D.

Eur J Prev Cardiol. 2017 Sep;24(13):1405-1407. doi: 10.1177/2047487317717823. Epub 2017 Jun 28. No abstract available.


HEK293T cell lines defective for O-linked glycosylation.

Termini JM, Silver ZA, Connor B, Antonopoulos A, Haslam SM, Dell A, Desrosiers RC.

PLoS One. 2017 Jun 27;12(6):e0179949. doi: 10.1371/journal.pone.0179949. eCollection 2017.


Anesthetic ointment only (lidocaine/prilocaine) instead of injectable local lidocaine in trans-radial catheterization: A viable no-needle alternative.

Latsios G, Toutouzas K, Antonopoulos AS, Melidi E, Synetos A, Vogiatzi G, Stasinopoulou A, Tsioufis K, Tsiamis E, Tousoulis D.

J Interv Cardiol. 2017 Aug;30(4):382-386. doi: 10.1111/joic.12399. Epub 2017 Jun 26.


The molecular mechanisms of obesity paradox.

Antonopoulos AS, Tousoulis D.

Cardiovasc Res. 2017 Jul 1;113(9):1074-1086. doi: 10.1093/cvr/cvx106. Review.


Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress.

Margaritis M, Sanna F, Lazaros G, Akoumianakis I, Patel S, Antonopoulos AS, Duke C, Herdman L, Psarros C, Oikonomou EK, Shirodaria C, Petrou M, Sayeed R, Krasopoulos G, Lee R, Tousoulis D, Channon KM, Antoniades C.

Eur Heart J. 2017 Nov 1;38(41):3094-3104. doi: 10.1093/eurheartj/ehx177.


Microangiopathy, Arterial Stiffness, and Risk Stratification in Patients With Type 2 Diabetes.

Antonopoulos AS, Siasos G, Tousoulis D.

JAMA Cardiol. 2017 Jul 1;2(7):820-821. doi: 10.1001/jamacardio.2017.0159. No abstract available.


The role of epicardial adipose tissue in cardiac biology: classic concepts and emerging roles.

Antonopoulos AS, Antoniades C.

J Physiol. 2017 Jun 15;595(12):3907-3917. doi: 10.1113/JP273049. Epub 2017 Mar 13. Review.

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