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Items: 1 to 50 of 51

1.

Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE).

Skipper KA, Hollensen AK, Antoniou MN, Mikkelsen JG.

BMC Biotechnol. 2019 Nov 9;19(1):75. doi: 10.1186/s12896-019-0570-2.

2.

In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques.

Shangaris P, Loukogeorgakis SP, Subramaniam S, Flouri C, Jackson LH, Wang W, Blundell MP, Liu S, Eaton S, Bakhamis N, Ramachandra DL, Maghsoudlou P, Urbani L, Waddington SN, Eddaoudi A, Archer J, Antoniou MN, Stuckey DJ, Schmidt M, Thrasher AJ, Ryan TM, Coppi P, David AL.

Sci Rep. 2019 Aug 12;9(1):11592. doi: 10.1038/s41598-019-48078-4.

3.

Glyphosate does not substitute for glycine in proteins of actively dividing mammalian cells.

Antoniou MN, Nicolas A, Mesnage R, Biserni M, Rao FV, Martin CV.

BMC Res Notes. 2019 Aug 8;12(1):494. doi: 10.1186/s13104-019-4534-3.

4.

Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study.

Mesnage R, Le Roy CI, Biserni M, Salles B, Antoniou MN.

Food Chem Toxicol. 2019 Sep;131:110547. doi: 10.1016/j.fct.2019.05.055. Epub 2019 Jun 3.

5.

Safety and early efficacy outcomes for lentiviral fibroblast gene therapy in recessive dystrophic epidermolysis bullosa.

Lwin SM, Syed F, Di WL, Kadiyirire T, Liu L, Guy A, Petrova A, Abdul-Wahab A, Reid F, Phillips R, Elstad M, Georgiadis C, Aristodemou S, Lovell PA, McMillan JR, Mee J, Miskinyte S, Titeux M, Ozoemena L, Pramanik R, Serrano S, Rowles R, Maurin C, Orrin E, Martinez-Queipo M, Rashidghamat E, Tziotzios C, Onoufriadis A, Chen M, Chan L, Farzaneh F, Del Rio M, Tolar J, Bauer JW, Larcher F, Antoniou MN, Hovnanian A, Thrasher AJ, Mellerio JE, Qasim W, McGrath JA.

JCI Insight. 2019 Jun 6;4(11). pii: 126243. doi: 10.1172/jci.insight.126243. eCollection 2019 Jun 6.

6.

Quizalofop-p-Ethyl Induces Adipogenesis in 3T3-L1 Adipocytes.

Biserni M, Mesnage R, Ferro R, Wozniak E, Xenakis T, Mein CA, Antoniou MN.

Toxicol Sci. 2019 Aug 1;170(2):452-461. doi: 10.1093/toxsci/kfz097.

7.

Effects of single and combined toxic exposures on the gut microbiome: Current knowledge and future directions.

Tsiaoussis J, Antoniou MN, Koliarakis I, Mesnage R, Vardavas CI, Izotov BN, Psaroulaki A, Tsatsakis A.

Toxicol Lett. 2019 Sep 15;312:72-97. doi: 10.1016/j.toxlet.2019.04.014. Epub 2019 Apr 27. Review.

PMID:
31034867
8.

Correction of IVS I-110(G>A) β-thalassemia by CRISPR/Cas-and TALEN-mediated disruption of aberrant regulatory elements in human hematopoietic stem and progenitor cells.

Patsali P, Turchiano G, Papasavva P, Romito M, Loucari CC, Stephanou C, Christou S, Sitarou M, Mussolino C, Cornu TI, Antoniou MN, Lederer CW, Cathomen T, Kleanthous M.

Haematologica. 2019 Nov;104(11):e497-e501. doi: 10.3324/haematol.2018.215178. Epub 2019 Apr 19. No abstract available.

9.

Insight into the confusion over surfactant co-formulants in glyphosate-based herbicides.

Mesnage R, Benbrook C, Antoniou MN.

Food Chem Toxicol. 2019 Jun;128:137-145. doi: 10.1016/j.fct.2019.03.053. Epub 2019 Apr 3. Review.

10.

Author Correction: An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process.

Mesnage R, Agapito-Tenfen SZ, Vilperte V, Renney G, Ward M, Séralini GE, Nodari RO, Antoniou MN.

Sci Rep. 2019 Mar 15;9(1):4727. doi: 10.1038/s41598-019-39021-8.

11.

Addressing concerns over the fate of DNA derived from genetically modified food in the human body: A review.

Nawaz MA, Mesnage R, Tsatsakis AM, Golokhvast KS, Yang SH, Antoniou MN, Chung G.

Food Chem Toxicol. 2019 Feb;124:423-430. doi: 10.1016/j.fct.2018.12.030. Epub 2018 Dec 21. Review.

PMID:
30580028
12.

An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas.

Sevim Ç, Çomaklı S, Taghizadehghalehjoughi A, Özkaraca M, Mesnage R, Kovatsi L, Burykina TI, Kalogeraki A, Antoniou MN, Tsatsakis A.

Toxicol Rep. 2018 Nov 19;6:42-50. doi: 10.1016/j.toxrep.2018.11.008. eCollection 2019.

13.

Reply to 'Comments on two recent publications on GM maize and Roundup'.

Antoniou MN, Mesnage R, Agapito-Tenfen S, Séralini GE.

Sci Rep. 2018 Sep 3;8(1):13339. doi: 10.1038/s41598-018-30751-9.

14.

An Optimized Lentiviral Vector Efficiently Corrects the Human Sickle Cell Disease Phenotype.

Weber L, Poletti V, Magrin E, Antoniani C, Martin S, Bayard C, Sadek H, Felix T, Meneghini V, Antoniou MN, El-Nemer W, Mavilio F, Cavazzana M, Andre-Schmutz I, Miccio A.

Mol Ther Methods Clin Dev. 2018 Aug 4;10:268-280. doi: 10.1016/j.omtm.2018.07.012. eCollection 2018 Sep 21.

15.

Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line.

Mesnage R, Biserni M, Wozniak E, Xenakis T, Mein CA, Antoniou MN.

Toxicol Rep. 2018 Aug 11;5:819-826. doi: 10.1016/j.toxrep.2018.08.005. eCollection 2018.

16.

Author Correction: Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide.

Mesnage R, Renney G, Séralini GE, Ward M, Antoniou MN.

Sci Rep. 2018 Aug 17;8(1):12572. doi: 10.1038/s41598-018-30760-8.

17.

Evaluation of neonicotinoid insecticides for oestrogenic, thyroidogenic and adipogenic activity reveals imidacloprid causes lipid accumulation.

Mesnage R, Biserni M, Genkova D, Wesolowski L, Antoniou MN.

J Appl Toxicol. 2018 Dec;38(12):1483-1491. doi: 10.1002/jat.3651. Epub 2018 Jun 27.

18.

Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126.

Mesnage R, Biserni M, Balu S, Frainay C, Poupin N, Jourdan F, Wozniak E, Xenakis T, Mein CA, Antoniou MN.

Arch Toxicol. 2018 Aug;92(8):2533-2547. doi: 10.1007/s00204-018-2235-7. Epub 2018 Jun 14.

19.

Short-hairpin RNA against aberrant HBBIVSI-110(G>A) mRNA restores β-globin levels in a novel cell model and acts as mono- and combination therapy for β-thalassemia in primary hematopoietic stem cells.

Patsali P, Papasavva P, Stephanou C, Christou S, Sitarou M, Antoniou MN, Lederer CW, Kleanthous M.

Haematologica. 2018 Sep;103(9):e419-e423. doi: 10.3324/haematol.2018.189357. Epub 2018 Apr 26. No abstract available.

20.

A comparison of intrauterine hemopoietic cell transplantation and lentiviral gene transfer for the correction of severe β-thalassemia in a HbbTh3/+ murine model.

Dighe NM, Tan KW, Tan LG, Shaw SSW, Buckley SMK, Sandikin D, Johana N, Tan YW, Biswas A, Choolani M, Waddington SN, Antoniou MN, Chan JKY, Mattar CNZ.

Exp Hematol. 2018 Jun;62:45-55. doi: 10.1016/j.exphem.2018.03.006. Epub 2018 Mar 29.

21.

Ignoring Adjuvant Toxicity Falsifies the Safety Profile of Commercial Pesticides.

Mesnage R, Antoniou MN.

Front Public Health. 2018 Jan 22;5:361. doi: 10.3389/fpubh.2017.00361. eCollection 2017. Review.

22.

Facts and Fallacies in the Debate on Glyphosate Toxicity.

Mesnage R, Antoniou MN.

Front Public Health. 2017 Nov 24;5:316. doi: 10.3389/fpubh.2017.00316. eCollection 2017.

23.

No Overgeneralization in Mesnage et al. Regarding Bisphenol A Alternatives: Response.

Antoniou MN, Mesnage R.

Toxicol Sci. 2017 Nov 1;160(1):3. doi: 10.1093/toxsci/kfx168. No abstract available.

PMID:
28973582
24.

Evaluation of estrogen receptor alpha activation by glyphosate-based herbicide constituents.

Mesnage R, Phedonos A, Biserni M, Arno M, Balu S, Corton JC, Ugarte R, Antoniou MN.

Food Chem Toxicol. 2017 Oct;108(Pt A):30-42. doi: 10.1016/j.fct.2017.07.025. Epub 2017 Jul 12.

25.

Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells.

Mesnage R, Phedonos A, Arno M, Balu S, Corton JC, Antoniou MN.

Toxicol Sci. 2017 Aug 1;158(2):431-443. doi: 10.1093/toxsci/kfx101.

26.

Ubiquitous Chromatin-opening Elements (UCOEs): Applications in biomanufacturing and gene therapy.

Neville JJ, Orlando J, Mann K, McCloskey B, Antoniou MN.

Biotechnol Adv. 2017 Sep;35(5):557-564. doi: 10.1016/j.biotechadv.2017.05.004. Epub 2017 May 17. Review.

27.

Cornell Alliance for Science Evaluation of Consensus on Genetically Modified Food Safety: Weaknesses in Study Design.

Antoniou MN, Robinson CJ.

Front Public Health. 2017 Apr 12;5:79. doi: 10.3389/fpubh.2017.00079. eCollection 2017.

28.

Erratum to: Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure.

Mesnage R, Arno M, Costanzo M, Malatesta M, Séralini GE, Antoniou MN.

Environ Health. 2017 Mar 23;16(1):28. doi: 10.1186/s12940-017-0236-2. No abstract available.

29.

Is it time to reassess current safety standards for glyphosate-based herbicides?

Vandenberg LN, Blumberg B, Antoniou MN, Benbrook CM, Carroll L, Colborn T, Everett LG, Hansen M, Landrigan PJ, Lanphear BP, Mesnage R, Vom Saal FS, Welshons WV, Myers JP.

J Epidemiol Community Health. 2017 Jun;71(6):613-618. doi: 10.1136/jech-2016-208463. Epub 2017 Mar 20. Review.

30.

Transcriptome and metabolome analysis of liver and kidneys of rats chronically fed NK603 Roundup-tolerant genetically modified maize.

Mesnage R, Arno M, Séralini GE, Antoniou MN.

Environ Sci Eur. 2017;29(1):6. doi: 10.1186/s12302-017-0105-1. Epub 2017 Feb 7.

31.

Suitability of small diagnostic peripheral-blood samples for cell-therapy studies.

Stephanou C, Papasavva P, Zachariou M, Patsali P, Epitropou M, Ladas P, Al-Abdulla R, Christou S, Antoniou MN, Lederer CW, Kleanthous M.

Cytotherapy. 2017 Feb;19(2):311-326. doi: 10.1016/j.jcyt.2016.11.007.

PMID:
28088294
32.

Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide.

Mesnage R, Renney G, Séralini GE, Ward M, Antoniou MN.

Sci Rep. 2017 Jan 9;7:39328. doi: 10.1038/srep39328. Erratum in: Sci Rep. 2018 Aug 17;8(1):12572.

33.

An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process.

Mesnage R, Agapito-Tenfen SZ, Vilperte V, Renney G, Ward M, Séralini GE, Nodari RO, Antoniou MN.

Sci Rep. 2016 Dec 19;6:37855. doi: 10.1038/srep37855. Erratum in: Sci Rep. 2019 Mar 15;9(1):4727.

34.

Haemophilia B curative FIX production from a low dose UCOE-based lentiviral vector following hepatic pre-natal delivery.

Kao VY, Ferreira S, Waddington SN, Antoniou MN.

Curr Gene Ther. 2016 Nov 2. [Epub ahead of print]

PMID:
27809754
35.

Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.

Klein P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G, Butler-Browne G, Bastide B, Mouly V, Trollet C.

Nucleic Acids Res. 2016 Dec 15;44(22):10929-10945. Epub 2016 Aug 9.

36.

Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement.

Myers JP, Antoniou MN, Blumberg B, Carroll L, Colborn T, Everett LG, Hansen M, Landrigan PJ, Lanphear BP, Mesnage R, Vandenberg LN, Vom Saal FS, Welshons WV, Benbrook CM.

Environ Health. 2016 Feb 17;15:19. doi: 10.1186/s12940-016-0117-0.

37.

Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure.

Mesnage R, Arno M, Costanzo M, Malatesta M, Séralini GE, Antoniou MN.

Environ Health. 2015 Aug 25;14:70. doi: 10.1186/s12940-015-0056-1. Erratum in: Environ Health. 2017 Mar 23;16(1):28.

38.

Chromatin function modifying elements in an industrial antibody production platform--comparison of UCOE, MAR, STAR and cHS4 elements.

Saunders F, Sweeney B, Antoniou MN, Stephens P, Cain K.

PLoS One. 2015 Apr 7;10(4):e0120096. doi: 10.1371/journal.pone.0120096. eCollection 2015.

39.

Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector.

Dighe N, Khoury M, Mattar C, Chong M, Choolani M, Chen J, Antoniou MN, Chan JK.

PLoS One. 2014 Aug 12;9(8):e104805. doi: 10.1371/journal.pone.0104805. eCollection 2014.

40.

Gene expression profile and toxic effects in human bronchial epithelial cells exposed to zearalenone.

So MY, Tian Z, Phoon YS, Sha S, Antoniou MN, Zhang J, Wu RS, Tan-Un KC.

PLoS One. 2014 May 2;9(5):e96404. doi: 10.1371/journal.pone.0096404. eCollection 2014.

41.

Genomic cis-acting Sequences Improve Expression and Establishment of a Nonviral Vector.

Hagedorn C, Antoniou MN, Lipps HJ.

Mol Ther Nucleic Acids. 2013 Sep 3;2:e118. doi: 10.1038/mtna.2013.47.

42.

Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy.

Raz V, Sterrenburg E, Routledge S, Venema A, van der Sluijs BM, Trollet C, Dickson G, van Engelen BG, van der Maarel SM, Antoniou MN.

BMC Neurol. 2013 Jul 1;13:70. doi: 10.1186/1471-2377-13-70.

43.

Optimizing retroviral gene expression for effective therapies.

Antoniou MN, Skipper KA, Anakok O.

Hum Gene Ther. 2013 Apr;24(4):363-74. doi: 10.1089/hum.2013.062. Review.

PMID:
23517535
44.

A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny.

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T.

Stem Cells. 2013 Mar;31(3):488-99. doi: 10.1002/stem.1316.

45.

Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing.

Knight S, Zhang F, Mueller-Kuller U, Bokhoven M, Gupta A, Broughton T, Sha S, Antoniou MN, Brendel C, Grez M, Thrasher AJ, Collins M, Takeuchi Y.

J Virol. 2012 Sep;86(17):9088-95. doi: 10.1128/JVI.00485-12. Epub 2012 Jun 13.

46.

Simple scale-up of recombinant antibody production using an UCOE containing vector.

Boscolo S, Mion F, Licciulli M, Macor P, De Maso L, Brce M, Antoniou MN, Marzari R, Santoro C, Sblattero D.

N Biotechnol. 2012 May 15;29(4):477-84. doi: 10.1016/j.nbt.2011.12.005. Epub 2011 Dec 28.

PMID:
22226921
47.

Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter.

Brendel C, Müller-Kuller U, Schultze-Strasser S, Stein S, Chen-Wichmann L, Krattenmacher A, Kunkel H, Dillmann A, Antoniou MN, Grez M.

Gene Ther. 2012 Oct;19(10):1018-29. doi: 10.1038/gt.2011.167. Epub 2011 Nov 10.

PMID:
22071971
48.

A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors.

Zhang F, Frost AR, Blundell MP, Bales O, Antoniou MN, Thrasher AJ.

Mol Ther. 2010 Sep;18(9):1640-9. doi: 10.1038/mt.2010.132. Epub 2010 Jun 29.

49.

Desmin-regulated lentiviral vectors for skeletal muscle gene transfer.

Talbot GE, Waddington SN, Bales O, Tchen RC, Antoniou MN.

Mol Ther. 2010 Mar;18(3):601-8. doi: 10.1038/mt.2009.267. Epub 2009 Nov 24.

50.

Physiological levels of HBB transgene expression from S/MAR element-based replicating episomal vectors.

Sgourou A, Routledge S, Spathas D, Athanassiadou A, Antoniou MN.

J Biotechnol. 2009 Aug 20;143(2):85-94. doi: 10.1016/j.jbiotec.2009.06.018. Epub 2009 Jun 25.

PMID:
19559736

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