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Inflammation and Vascular Ageing: From Telomeres to Novel Emerging Mechanisms.

Chiriacò M, Georgiopoulos G, Duranti E, Antonioli L, Puxeddu I, Nannipieri M, Rosada J, Blandizzi C, Taddei S, Virdis A, Masi S.

High Blood Press Cardiovasc Prev. 2019 Jul 19. doi: 10.1007/s40292-019-00331-7. [Epub ahead of print]


High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse.

Piccarducci R, Pietrobono D, Pellegrini C, Daniele S, Fornai M, Antonioli L, Trincavelli ML, Blandizzi C, Martini C.

Oxid Med Cell Longev. 2019 Jun 9;2019:5030475. doi: 10.1155/2019/5030475. eCollection 2019.


The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases.

Antonioli L, Blandizzi C, Pacher P, Haskó G.

Pharmacol Rev. 2019 Jul;71(3):345-382. doi: 10.1124/pr.117.014878. Review.


Phytochemicals as Novel Therapeutic Strategies for NLRP3 Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases.

Pellegrini C, Fornai M, Antonioli L, Blandizzi C, Calderone V.

Int J Mol Sci. 2019 Jun 13;20(12). pii: E2876. doi: 10.3390/ijms20122876. Review.


P2X4 receptors, immunity, and sepsis.

Antonioli L, Blandizzi C, Fornai M, Pacher P, Lee HT, Haskó G.

Curr Opin Pharmacol. 2019 Mar 25;47:65-74. doi: 10.1016/j.coph.2019.02.011. [Epub ahead of print] Review.


Higher Body Mass Index and Black Race Increase Risk of Rhabdomyolysis and Acute Kidney Injury After Trauma.

Hakakian D, Kong K, DiFazio LT, Adams JM, Antonioli L, Rolandelli RH, Nemeth ZH.

J Invest Surg. 2019 Mar 19:1-2. doi: 10.1080/08941939.2018.1502378. [Epub ahead of print] No abstract available.


Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy.

Rota L, Pellegrini C, Benvenuti L, Antonioli L, Fornai M, Blandizzi C, Cattaneo A, Colla E.

Transl Neurodegener. 2019 Feb 6;8:5. doi: 10.1186/s40035-019-0146-z. eCollection 2019.


Rethinking Communication in the Immune System: The Quorum Sensing Concept.

Antonioli L, Blandizzi C, Pacher P, Guilliams M, Haskó G.

Trends Immunol. 2019 Feb;40(2):88-97. doi: 10.1016/ Epub 2019 Jan 2. Review.


A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation.

Pellegrini C, Fornai M, Colucci R, Benvenuti L, D’Antongiovanni V, Natale G, Fulceri F, Giorgis M, Marini E, Gastaldi S, Bertinaria M, Blandizzi C, Antonioli L.

Front Pharmacol. 2018 Dec 3;9:1405. doi: 10.3389/fphar.2018.01405. eCollection 2018.


Pathophysiology of NSAID-Associated Intestinal Lesions in the Rat: Luminal Bacteria and Mucosal Inflammation as Targets for Prevention.

Colucci R, Pellegrini C, Fornai M, Tirotta E, Antonioli L, Renzulli C, Ghelardi E, Piccoli E, Gentile D, Benvenuti L, Natale G, Fulceri F, Palazón-Riquelme P, López-Castejón G, Blandizzi C, Scarpignato C.

Front Pharmacol. 2018 Nov 29;9:1340. doi: 10.3389/fphar.2018.01340. eCollection 2018.


Risankizumab for the treatment of moderate to severe psoriasis.

Chiricozzi A, Antonioli L, Panduri S, Fornai M, Romanelli M, Blandizzi C.

Expert Opin Biol Ther. 2019 Jan;19(1):1-8. doi: 10.1080/14712598.2019.1551354. Epub 2018 Nov 27.


"Cecal Resection with Bipolar Sealing in a Rat Model": A Promising Approach for Future Human Studies.

Sanchez Trejo HA, Hakakian D, Rolandelli RH, Nouri AM, Antonioli L, Nemeth ZH.

J Invest Surg. 2018 Oct 19:1-2. doi: 10.1080/08941939.2018.1483450. [Epub ahead of print] No abstract available.


Luteolin Prevents Cardiometabolic Alterations and Vascular Dysfunction in Mice With HFD-Induced Obesity.

Gentile D, Fornai M, Pellegrini C, Colucci R, Benvenuti L, Duranti E, Masi S, Carpi S, Nieri P, Nericcio A, Garelli F, Virdis A, Pistelli L, Blandizzi C, Antonioli L.

Front Pharmacol. 2018 Sep 25;9:1094. doi: 10.3389/fphar.2018.01094. eCollection 2018.


The ecto-enzymes CD73 and adenosine deaminase modulate 5'-AMP-derived adenosine in myofibroblasts of the rat small intestine.

Bin A, Caputi V, Bistoletti M, Montopoli M, Colucci R, Antonioli L, De Martin S, Castagliuolo I, Orso G, Giaroni C, Debetto P, Giron MC.

Purinergic Signal. 2018 Dec;14(4):409-421. doi: 10.1007/s11302-018-9623-6. Epub 2018 Sep 29.


Interplay between colonic inflammation and tachykininergic pathways in the onset of colonic dysmotility in a mouse model of diet-induced obesity.

Antonioli L, Caputi V, Fornai M, Pellegrini C, Gentile D, Giron MC, Orso G, Bernardini N, Segnani C, Ippolito C, Csóka B, Haskó G, Németh ZH, Scarpignato C, Blandizzi C, Colucci R.

Int J Obes (Lond). 2019 Feb;43(2):331-343. doi: 10.1038/s41366-018-0166-2. Epub 2018 Aug 6.


Neuronal regulation of intestinal immune functions in health and disease.

Fornai M, van den Wijngaard RM, Antonioli L, Pellegrini C, Blandizzi C, de Jonge WJ.

Neurogastroenterol Motil. 2018 Dec;30(12):e13406. doi: 10.1111/nmo.13406. Epub 2018 Jul 29. Review.


Quorum sensing in the immune system.

Antonioli L, Blandizzi C, Pacher P, Guilliams M, Haskó G.

Nat Rev Immunol. 2018 Sep;18(9):537-538. doi: 10.1038/s41577-018-0040-4. No abstract available.


What's New in Emergencies, Trauma, and Shock? Using Abdominal Computed Tomography in Geriatric Patients on Warfarin.

Bogdanovski DA, Hakakian D, DiFazio LT, Antonioli L, Nemeth ZH.

J Emerg Trauma Shock. 2018 Apr-Jun;11(2):71-72. doi: 10.4103/JETS.JETS_85_17. No abstract available.


Dietary flavonoids as a potential intervention to improve redox balance in obesity and related co-morbidities: a review.

Gentile D, Fornai M, Pellegrini C, Colucci R, Blandizzi C, Antonioli L.

Nutr Res Rev. 2018 Dec;31(2):239-247. doi: 10.1017/S0954422418000082. Epub 2018 Jun 6. Review.


Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

Pellegrini C, Antonioli L, Colucci R, Blandizzi C, Fornai M.

Acta Neuropathol. 2018 Sep;136(3):345-361. doi: 10.1007/s00401-018-1856-5. Epub 2018 May 24. Review.


Adenosine signaling and the immune system: When a lot could be too much.

Antonioli L, Fornai M, Blandizzi C, Pacher P, Haskó G.

Immunol Lett. 2019 Jan;205:9-15. doi: 10.1016/j.imlet.2018.04.006. Epub 2018 Apr 24. Review.


The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity.

Gentile D, Fornai M, Colucci R, Pellegrini C, Tirotta E, Benvenuti L, Segnani C, Ippolito C, Duranti E, Virdis A, Carpi S, Nieri P, Németh ZH, Pistelli L, Bernardini N, Blandizzi C, Antonioli L.

PLoS One. 2018 Apr 11;13(4):e0195502. doi: 10.1371/journal.pone.0195502. eCollection 2018.


Purinergic Ligands as Potential Therapeutic Tools for the Treatment of Inflammation-Related Intestinal Diseases.

Dal Ben D, Antonioli L, Lambertucci C, Fornai M, Blandizzi C, Volpini R.

Front Pharmacol. 2018 Mar 14;9:212. doi: 10.3389/fphar.2018.00212. eCollection 2018. Review.


Transanal Minimally Invasive Surgery: A Promising Alternative for Certain Advanced Rectal Cancer Patients.

Sanchez-Trejo HA, Hakakian D, Curran T, Antonioli L, Csoka B, Nemeth ZH.

J Invest Surg. 2019 Jun;32(4):377-378. doi: 10.1080/08941939.2018.1431340. Epub 2018 Feb 26. No abstract available.


Adenosine metabolism, immunity and joint health.

Haskó G, Antonioli L, Cronstein BN.

Biochem Pharmacol. 2018 May;151:307-313. doi: 10.1016/j.bcp.2018.02.002. Epub 2018 Feb 7. Review.


Anti-inflammatory effect of a novel locally acting A2A receptor agonist in a rat model of oxazolone-induced colitis.

Antonioli L, El-Tayeb A, Pellegrini C, Fornai M, Awwad O, Giustarini G, Natale G, Ryskalin L, Németh ZH, Müller CE, Blandizzi C, Colucci R.

Purinergic Signal. 2018 Mar;14(1):27-36. doi: 10.1007/s11302-017-9591-2. Epub 2017 Nov 8.


Colonic motor dysfunctions in a mouse model of high-fat diet-induced obesity: an involvement of A2B adenosine receptors.

Antonioli L, Pellegrini C, Fornai M, Tirotta E, Gentile D, Benvenuti L, Giron MC, Caputi V, Marsilio I, Orso G, Bernardini N, Segnani C, Ippolito C, Csóka B, Németh ZH, Haskó G, Scarpignato C, Blandizzi C, Colucci R.

Purinergic Signal. 2017 Dec;13(4):497-510. doi: 10.1007/s11302-017-9577-0. Epub 2017 Aug 14.


Hypoxia-inducible-factor-1 in trauma and critical care.

Bogdanovski DA, DiFazio LT, Bogdanovski AK, Csóka B, Jordan GB, Paul ER, Antonioli L, Pilip SA, Nemeth ZH.

J Crit Care. 2017 Dec;42:207-212. doi: 10.1016/j.jcrc.2017.07.029. Epub 2017 Jul 12. Review.


A2A adenosine receptors control pancreatic dysfunction in high-fat-diet-induced obesity.

Csóka B, Törő G, Vindeirinho J, Varga ZV, Koscsó B, Németh ZH, Kókai E, Antonioli L, Suleiman M, Marchetti P, Cseri K, Deák Á, Virág L, Pacher P, Bai P, Haskó G.

FASEB J. 2017 Nov;31(11):4985-4997. doi: 10.1096/fj.201700398R. Epub 2017 Aug 1.


Switching off CD73: a way to boost the activity of conventional and targeted antineoplastic therapies.

Antonioli L, Novitskiy SV, Sachsenmeier KF, Fornai M, Blandizzi C, Haskó G.

Drug Discov Today. 2017 Nov;22(11):1686-1696. doi: 10.1016/j.drudis.2017.06.005. Epub 2017 Jul 1. Review.


Crohn's Disease and Ulcerative Colitis Show Unique Cytokine Profiles.

Nemeth ZH, Bogdanovski DA, Barratt-Stopper P, Paglinco SR, Antonioli L, Rolandelli RH.

Cureus. 2017 Apr 19;9(4):e1177. doi: 10.7759/cureus.1177.


Effects of L-DOPA/benserazide co-treatment on colonic excitatory cholinergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration.

Pellegrini C, Antonioli L, Colucci R, Tirotta E, Gentile D, Ippolito C, Segnani C, Levandis G, Cerri S, Blandini F, Barocelli E, Ballabeni V, Bernardini N, Blandizzi C, Fornai M.

Neuropharmacology. 2017 Sep 1;123:22-33. doi: 10.1016/j.neuropharm.2017.05.016. Epub 2017 May 17.


The Impact of Gender on Complications and Outcomes of Pelvic Fracture.

Adams JM, Bogdanovski DA, Difazio LT, Bilaniuk JW, Siegel BK, Antonioli L, Pilip SA, Nemeth ZH.

Am Surg. 2017 Apr 1;83(4):e106-109. No abstract available.


Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.

Cocco M, Pellegrini C, Martínez-Banaclocha H, Giorgis M, Marini E, Costale A, Miglio G, Fornai M, Antonioli L, López-Castejón G, Tapia-Abellán A, Angosto D, Hafner-Bratkovič I, Regazzoni L, Blandizzi C, Pelegrín P, Bertinaria M.

J Med Chem. 2017 May 11;60(9):3656-3671. doi: 10.1021/acs.jmedchem.6b01624. Epub 2017 Apr 24.


Roles and Modalities of Ectonucleotidases in Remodeling the Multiple Myeloma Niche.

Chillemi A, Quarona V, Antonioli L, Ferrari D, Horenstein AL, Malavasi F.

Front Immunol. 2017 Mar 20;8:305. doi: 10.3389/fimmu.2017.00305. eCollection 2017.


Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation.

Pellegrini C, Antonioli L, Lopez-Castejon G, Blandizzi C, Fornai M.

Front Immunol. 2017 Jan 25;8:36. doi: 10.3389/fimmu.2017.00036. eCollection 2017. Review.


A Purinergic Trail for Metastases.

Ferrari D, Malavasi F, Antonioli L.

Trends Pharmacol Sci. 2017 Mar;38(3):277-290. doi: 10.1016/ Epub 2016 Dec 16. Review.


Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment.

Antonioli L, Blandizzi C, Malavasi F, Ferrari D, Haskó G.

Oncoimmunology. 2016 Jul 29;5(9):e1216292. eCollection 2016.


Intestinal dysfunction in Parkinson's disease: Lessons learned from translational studies and experimental models.

Pellegrini C, Colucci R, Antonioli L, Barocelli E, Ballabeni V, Bernardini N, Blandizzi C, de Jonge WJ, Fornai M.

Neurogastroenterol Motil. 2016 Dec;28(12):1781-1791. doi: 10.1111/nmo.12933. Epub 2016 Sep 9. Review.


Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration.

Pellegrini C, Fornai M, Colucci R, Tirotta E, Blandini F, Levandis G, Cerri S, Segnani C, Ippolito C, Bernardini N, Cseri K, Blandizzi C, Haskó G, Antonioli L.

J Neuroinflammation. 2016 Jun 13;13(1):146. doi: 10.1186/s12974-016-0608-5.


Neonatal Adaptation Issues After Maternal Exposure to Prescription Drugs: Withdrawal Syndromes and Residual Pharmacological Effects.

Convertino I, Sansone AC, Marino A, Galiulo MT, Mantarro S, Antonioli L, Fornai M, Blandizzi C, Tuccori M.

Drug Saf. 2016 Oct;39(10):903-24. doi: 10.1007/s40264-016-0435-8. Review.


Myeloid cells in the tumor microenvironment: Role of adenosine.

Morello S, Pinto A, Blandizzi C, Antonioli L.

Oncoimmunology. 2015 Dec 3;5(3):e1108515. eCollection 2016 Mar. Review.


Anti-CD73 in cancer immunotherapy: awakening new opportunities.

Antonioli L, Yegutkin GG, Pacher P, Blandizzi C, Haskó G.

Trends Cancer. 2016 Feb 1;2(2):95-109.


Small bowel protection against NSAID-injury in rats: Effect of rifaximin, a poorly absorbed, GI targeted, antibiotic.

Fornai M, Antonioli L, Pellegrini C, Colucci R, Sacco D, Tirotta E, Natale G, Bartalucci A, Flaibani M, Renzulli C, Ghelardi E, Blandizzi C, Scarpignato C.

Pharmacol Res. 2016 Feb;104:186-96. doi: 10.1016/j.phrs.2015.12.031. Epub 2015 Dec 30.


Histochemical Detection of Collagen Fibers by Sirius Red/Fast Green Is More Sensitive than van Gieson or Sirius Red Alone in Normal and Inflamed Rat Colon.

Segnani C, Ippolito C, Antonioli L, Pellegrini C, Blandizzi C, Dolfi A, Bernardini N.

PLoS One. 2015 Dec 16;10(12):e0144630. doi: 10.1371/journal.pone.0144630. eCollection 2015.


The metabolic exercise test data combined with Cardiac And Kidney Indexes (MECKI) score and prognosis in heart failure. A validation study.

Corrà U, Agostoni P, Giordano A, Cattadori G, Battaia E, La Gioia R, Scardovi AB, Emdin M, Metra M, Sinagra G, Limongelli G, Raimondo R, Re F, Guazzi M, Belardinelli R, Parati G, Magrì D, Fiorentini C, Cicoira M, Salvioni E, Giovannardi M, Veglia F, Mezzani A, Scrutinio D, Di Lenarda A, Ricci R, Apostolo A, Iorio AM, Paolillo S, Palermo P, Contini M, Vassanelli C, Passino C, Giannuzzi P, Piepoli MF; MECKI Score Research Group; Other Members of the MECKI Score research Group, Antonioli L, Segurini C, Bertella E, Farina S, Bovis F, Pietrucci F, Malfatto G, Roselli T, Buono A, Calabrò R, De Maria R, Santoro D, Campanale S, Caputo D, Bertipaglia D, Berton E.

Int J Cardiol. 2016 Jan 15;203:1067-72. doi: 10.1016/j.ijcard.2015.11.075. Epub 2015 Nov 10.


Enteric Dysfunctions in Experimental Parkinson's Disease: Alterations of Excitatory Cholinergic Neurotransmission Regulating Colonic Motility in Rats.

Fornai M, Pellegrini C, Antonioli L, Segnani C, Ippolito C, Barocelli E, Ballabeni V, Vegezzi G, Al Harraq Z, Blandini F, Levandis G, Cerri S, Blandizzi C, Bernardini N, Colucci R.

J Pharmacol Exp Ther. 2016 Feb;356(2):434-44. doi: 10.1124/jpet.115.228510. Epub 2015 Nov 18.


Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidence.

Pellegrini C, Antonioli L, Colucci R, Ballabeni V, Barocelli E, Bernardini N, Blandizzi C, Fornai M.

Parkinsonism Relat Disord. 2015 Dec;21(12):1407-14. doi: 10.1016/j.parkreldis.2015.10.011. Epub 2015 Oct 21. Review.


The AMPK enzyme-complex: from the regulation of cellular energy homeostasis to a possible new molecular target in the management of chronic inflammatory disorders.

Antonioli L, Colucci R, Pellegrini C, Giustarini G, Sacco D, Tirotta E, Caputi V, Marsilio I, Giron MC, Németh ZH, Blandizzi C, Fornai M.

Expert Opin Ther Targets. 2016;20(2):179-91. doi: 10.1517/14728222.2016.1086752. Epub 2015 Sep 28. Review.


Comment on "High expression of CD39/ENTPD1 in malignant epithelial cells of human rectal adenocarcinoma".

Antonioli L, di Paolo A, Fornai M, Danesi R, Blandizzi C.

Tumour Biol. 2015 Sep;36(10):7397-8. doi: 10.1007/s13277-015-4030-x. Epub 2015 Sep 17. No abstract available.


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