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Items: 32


Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis.

Brenig R, Pop OT, Triantafyllou E, Geng A, Singanayagam A, Perez-Shibayama C, Besse L, Cupovic J, Künzler P, Boldanova T, Brand S, Semela D, Duong FH, Weston CJ, Ludewig B, Heim MH, Wendon J, Antoniades CG, Bernsmeier C.

Life Sci Alliance. 2019 Dec 10;3(1). pii: e201900465. doi: 10.26508/lsa.201900465. Print 2020 Jan.


CD8+T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction.

Lebossé F, Gudd C, Tunc E, Singanayagam A, Nathwani R, Triantafyllou E, Pop O, Kumar N, Mukherjee S, Hou TZ, Quaglia A, Zoulim F, Wendon J, Dhar A, Thursz M, Antoniades CG, Khamri W.

EBioMedicine. 2019 Nov;49:258-268. doi: 10.1016/j.ebiom.2019.10.011. Epub 2019 Oct 31.


The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure.

Triantafyllou E, Woollard KJ, McPhail MJW, Antoniades CG, Possamai LA.

Front Immunol. 2018 Dec 14;9:2948. doi: 10.3389/fimmu.2018.02948. eCollection 2018. Review.


CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure.

Bernsmeier C, Triantafyllou E, Brenig R, Lebosse FJ, Singanayagam A, Patel VC, Pop OT, Khamri W, Nathwani R, Tidswell R, Weston CJ, Adams DH, Thursz MR, Wendon JA, Antoniades CG.

Gut. 2018 Jun;67(6):1155-1167. doi: 10.1136/gutjnl-2017-314184. Epub 2017 Jun 7.


MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure.

Triantafyllou E, Pop OT, Possamai LA, Wilhelm A, Liaskou E, Singanayagam A, Bernsmeier C, Khamri W, Petts G, Dargue R, Davies SP, Tickle J, Yuksel M, Patel VC, Abeles RD, Stamataki Z, Curbishley SM, Ma Y, Wilson ID, Coen M, Woollard KJ, Quaglia A, Wendon J, Thursz MR, Adams DH, Weston CJ, Antoniades CG.

Gut. 2018 Feb;67(2):333-347. doi: 10.1136/gutjnl-2016-313615. Epub 2017 Apr 27.


Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure.

Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, Possamai LA, Lebosse F, Auzinger G, Bernal W, Willars C, Weston CJ, Lombardi G, Wendon J, Thursz M, Antoniades CG.

Gastroenterology. 2017 Jul;153(1):263-276.e8. doi: 10.1053/j.gastro.2017.03.023. Epub 2017 Mar 28.


TAM receptor tyrosine kinase function and the immunopathology of liver disease.

Mukherjee SK, Wilhelm A, Antoniades CG.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G899-905. doi: 10.1152/ajpgi.00382.2015. Epub 2016 Feb 11. Review.


Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase.

Vergis N, Khamri W, Beale K, Sadiq F, Aletrari MO, Moore C, Atkinson SR, Bernsmeier C, Possamai LA, Petts G, Ryan JM, Abeles RD, James S, Foxton M, Hogan B, Foster GR, O'Brien AJ, Ma Y, Shawcross DL, Wendon JA, Antoniades CG, Thursz MR.

Gut. 2017 Mar;66(3):519-529. doi: 10.1136/gutjnl-2015-310378. Epub 2016 Feb 9.


Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis.

McPhail MJW, Shawcross DL, Lewis MR, Coltart I, Want EJ, Antoniades CG, Veselkov K, Triantafyllou E, Patel V, Pop O, Gomez-Romero M, Kyriakides M, Zia R, Abeles RD, Crossey MME, Jassem W, O'Grady J, Heaton N, Auzinger G, Bernal W, Quaglia A, Coen M, Nicholson JK, Wendon JA, Holmes E, Taylor-Robinson SD.

J Hepatol. 2016 May;64(5):1058-1067. doi: 10.1016/j.jhep.2016.01.003. Epub 2016 Jan 18.


High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial.

Larsen FS, Schmidt LE, Bernsmeier C, Rasmussen A, Isoniemi H, Patel VC, Triantafyllou E, Bernal W, Auzinger G, Shawcross D, Eefsen M, Bjerring PN, Clemmesen JO, Hockerstedt K, Frederiksen HJ, Hansen BA, Antoniades CG, Wendon J.

J Hepatol. 2016 Jan;64(1):69-78. doi: 10.1016/j.jhep.2015.08.018. Epub 2015 Aug 29.


Acute alcoholic hepatitis and cellular Th1 immune responses to alcohol dehydrogenase.

Blackmore LJ, Ryan JM, Huang X, Hussain M, Triantafyllou E, Vergis N, Vijay GM, Antoniades CG, Thursz MR, Jassem W, Vergani D, Shawcross DL, Ma Y.

Lancet. 2015 Feb 26;385 Suppl 1:S22. doi: 10.1016/S0140-6736(15)60337-3.


Immunotherapy in the treatment and prevention of infection in acute-on-chronic liver failure.

Bernsmeier C, Singanayagam A, Patel VC, Wendon J, Antoniades CG.

Immunotherapy. 2015;7(6):641-54. doi: 10.2217/imt.15.27. Epub 2015 Jun 12. Review.


Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK.

Bernsmeier C, Pop OT, Singanayagam A, Triantafyllou E, Patel VC, Weston CJ, Curbishley S, Sadiq F, Vergis N, Khamri W, Bernal W, Auzinger G, Heneghan M, Ma Y, Jassem W, Heaton ND, Adams DH, Quaglia A, Thursz MR, Wendon J, Antoniades CG.

Gastroenterology. 2015 Mar;148(3):603-615.e14. doi: 10.1053/j.gastro.2014.11.045. Epub 2014 Dec 3.


Could targeting secretory leukocyte protease inhibitor be an effective therapeutic option to prevent infections in acute liver failure?

Possamai LA, Khamri W, Triantafyllou E, Wendon JA, Thursz MR, Antoniades CG.

Immunotherapy. 2014;6(6):667-9. doi: 10.2217/imt.14.49. No abstract available.


What's new in acute liver failure?

Bernsmeier C, Antoniades CG, Wendon J.

Intensive Care Med. 2014 Oct;40(10):1545-8. doi: 10.1007/s00134-014-3350-4. Epub 2014 Jul 1. No abstract available.


Understanding infection susceptibility in patients with acute-on-chronic liver failure.

Selvapatt N, Singanayagam A, Wendon J, Antoniades CG.

Intensive Care Med. 2014 Sep;40(9):1363-6. doi: 10.1007/s00134-014-3349-x. Epub 2014 Jun 6. Review. No abstract available.


Modulation of monocyte/macrophage function: a therapeutic strategy in the treatment of acute liver failure.

Possamai LA, Thursz MR, Wendon JA, Antoniades CG.

J Hepatol. 2014 Aug;61(2):439-45. doi: 10.1016/j.jhep.2014.03.031. Epub 2014 Apr 2. Review.


Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure.

Antoniades CG, Khamri W, Abeles RD, Taams LS, Triantafyllou E, Possamai LA, Bernsmeier C, Mitry RR, O'Brien A, Gilroy D, Goldin R, Heneghan M, Heaton N, Jassem W, Bernal W, Vergani D, Ma Y, Quaglia A, Wendon J, Thursz M.

Hepatology. 2014 Apr;59(4):1564-76. doi: 10.1002/hep.26933. Epub 2014 Feb 28.


Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*.

Possamai LA, McPhail MJ, Quaglia A, Zingarelli V, Abeles RD, Tidswell R, Puthucheary Z, Rawal J, Karvellas CJ, Leslie EM, Hughes RD, Ma Y, Jassem W, Shawcross DL, Bernal W, Dharwan A, Heaton ND, Thursz M, Wendon JA, Mitry RR, Antoniades CG.

Crit Care Med. 2013 Nov;41(11):2543-50. doi: 10.1097/CCM.0b013e31829791a2.


Reply: To PMID 22334567.

Antoniades CG, Wendon J.

Hepatology. 2013 Sep;58(3):1187-8. doi: 10.1002/hep.26281. Epub 2013 Jul 29. No abstract available.


CD14, CD16 and HLA-DR reliably identifies human monocytes and their subsets in the context of pathologically reduced HLA-DR expression by CD14(hi) /CD16(neg) monocytes: Expansion of CD14(hi) /CD16(pos) and contraction of CD14(lo) /CD16(pos) monocytes in acute liver failure.

Abeles RD, McPhail MJ, Sowter D, Antoniades CG, Vergis N, Vijay GK, Xystrakis E, Khamri W, Shawcross DL, Ma Y, Wendon JA, Vergani D.

Cytometry A. 2012 Oct;81(10):823-34. doi: 10.1002/cyto.a.22104. Epub 2012 Jul 26.


Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans.

Antoniades CG, Quaglia A, Taams LS, Mitry RR, Hussain M, Abeles R, Possamai LA, Bruce M, McPhail M, Starling C, Wagner B, Barnardo A, Pomplun S, Auzinger G, Bernal W, Heaton N, Vergani D, Thursz MR, Wendon J.

Hepatology. 2012 Aug;56(2):735-46. doi: 10.1002/hep.25657. Epub 2012 Jul 6.


Severity of the compensatory anti-inflammatory response determined by monocyte HLA-DR expression may assist outcome prediction in cirrhosis.

Berry PA, Antoniades CG, Carey I, McPhail MJ, Hussain MJ, Davies ET, Wendon JA, Vergani D.

Intensive Care Med. 2011 Mar;37(3):453-60. doi: 10.1007/s00134-010-2099-7. Epub 2010 Dec 16.


Admission levels and early changes in serum interleukin-10 are predictive of poor outcome in acute liver failure and decompensated cirrhosis.

Berry PA, Antoniades CG, Hussain MJ, McPhail MJ, Bernal W, Vergani D, Wendon JA.

Liver Int. 2010 May;30(5):733-40. doi: 10.1111/j.1478-3231.2010.02219.x.


Role of monocytes and macrophages in experimental and human acute liver failure.

Possamai LA, Antoniades CG, Anstee QM, Quaglia A, Vergani D, Thursz M, Wendon J.

World J Gastroenterol. 2010 Apr 21;16(15):1811-9.


Importance of the compensatory anti-inflammatory response following severe sepsis on cirrhosis.

Berry PA, Antoniades CG, Wendon J.

Hepatology. 2010 Apr;51(4):1469-70; author reply 1470. doi: 10.1002/hep.23552. No abstract available.


The importance of immune dysfunction in determining outcome in acute liver failure.

Antoniades CG, Berry PA, Wendon JA, Vergani D.

J Hepatol. 2008 Nov;49(5):845-61. doi: 10.1016/j.jhep.2008.08.009. Epub 2008 Aug 21. Review.


Current and future management of chronic hepatitis C infection.

Cross TJ, Antoniades CG, Harrison PM.

Postgrad Med J. 2008 Apr;84(990):172-6. doi: 10.1136/pgmj.2008.068205. Review.


Liver transplantation in patients over 60 and 65 years: an evaluation of long-term outcomes and survival.

Cross TJ, Antoniades CG, Muiesan P, Al-Chalabi T, Aluvihare V, Agarwal K, Portmann BC, Rela M, Heaton ND, O'Grady JG, Heneghan MA.

Liver Transpl. 2007 Oct;13(10):1382-8.


Actin-free Gc globulin: a rapidly assessed biomarker of organ dysfunction in acute liver failure and cirrhosis.

Antoniades CG, Berry PA, Bruce M, Cross TJ, Portal AJ, Hussain MJ, Bernal W, Wendon JA, Vergani D.

Liver Transpl. 2007 Sep;13(9):1254-61.


Reduced monocyte HLA-DR expression: a novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure.

Antoniades CG, Berry PA, Davies ET, Hussain M, Bernal W, Vergani D, Wendon J.

Hepatology. 2006 Jul;44(1):34-43.


Paralysed monocytes in acute on chronic liver disease.

Antoniades CG, Wendon J, Vergani D.

J Hepatol. 2005 Feb;42(2):163-5. No abstract available.


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