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Items: 39


Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.

Jones S, King PJ, Antonescu CN, Sugiyama MG, Bhamra A, Surinova S, Angelopoulos N, Kragh M, Pedersen MW, Hartley JA, Futter CE, Hochhauser D.

Sci Rep. 2020 Jan 20;10(1):663. doi: 10.1038/s41598-019-57153-9.


Targeted enhancement of flotillin-dependent endocytosis augments cellular uptake and impact of cytotoxic drugs.

Fekri F, Abousawan J, Bautista S, Orofiamma L, Dayam RM, Antonescu CN, Karshafian R.

Sci Rep. 2019 Nov 28;9(1):17768. doi: 10.1038/s41598-019-54062-9.


The intricate relationship between metabolism and endocytic membrane traffic.

Antonescu CN.

Traffic. 2019 Dec;20(12):887-888. doi: 10.1111/tra.12695. No abstract available.


Editorial: Signaling Control by Compartmentalization Along the Endocytic Route.

Antonescu CN, Liu AP.

Front Cell Dev Biol. 2019 Oct 17;7:237. doi: 10.3389/fcell.2019.00237. eCollection 2019. No abstract available.


GGA3-mediated recycling of the RET receptor tyrosine kinase contributes to cell migration and invasion.

Crupi MJF, Maritan SM, Reyes-Alvarez E, Lian EY, Hyndman BD, Rekab AN, Moodley S, Antonescu CN, Mulligan LM.

Oncogene. 2019 Oct 23. doi: 10.1038/s41388-019-1068-z. [Epub ahead of print]


Energetic adaptations: Metabolic control of endocytic membrane traffic.

Rahmani S, Defferrari MS, Wakarchuk WW, Antonescu CN.

Traffic. 2019 Dec;20(12):912-931. doi: 10.1111/tra.12705. Epub 2019 Nov 15. Review.


Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling.

Sugiyama MG, Fairn GD, Antonescu CN.

Front Cell Dev Biol. 2019 May 3;7:70. doi: 10.3389/fcell.2019.00070. eCollection 2019. Review.


mTOR complex 1 controls the nuclear localization and function of glycogen synthase kinase 3β.

Bautista SJ, Boras I, Vissa A, Mecica N, Yip CM, Kim PK, Antonescu CN.

J Biol Chem. 2018 Sep 21;293(38):14723-14739. doi: 10.1074/jbc.RA118.002800. Epub 2018 Jul 30.


Selective regulation of clathrin-mediated epidermal growth factor receptor signaling and endocytosis by phospholipase C and calcium.

Delos Santos RC, Bautista S, Lucarelli S, Bone LN, Dayam RM, Abousawan J, Botelho RJ, Antonescu CN.

Mol Biol Cell. 2017 Oct 15;28(21):2802-2818. doi: 10.1091/mbc.E16-12-0871. Epub 2017 Aug 16.


Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization.

Hyndman BD, Crupi MJF, Peng S, Bone LN, Rekab AN, Lian EY, Wagner SM, Antonescu CN, Mulligan LM.

J Cell Sci. 2017 Oct 1;130(19):3282-3296. doi: 10.1242/jcs.203885. Epub 2017 Aug 9.


Measurement of Epidermal Growth Factor Receptor-Derived Signals Within Plasma Membrane Clathrin Structures.

Lucarelli S, Delos Santos RC, Antonescu CN.

Methods Mol Biol. 2017;1652:191-225. doi: 10.1007/978-1-4939-7219-7_15.


The ENU-3 protein family members function in the Wnt pathway parallel to UNC-6/Netrin to promote motor neuron axon outgrowth in C. elegans.

Florica RO, Hipolito V, Bautista S, Anvari H, Rapp C, El-Rass S, Asgharian A, Antonescu CN, Killeen MT.

Dev Biol. 2017 Oct 1;430(1):249-261. doi: 10.1016/j.ydbio.2017.06.036. Epub 2017 Jul 8.


The big and intricate dreams of little organelles: Embracing complexity in the study of membrane traffic.

Liu AP, Botelho RJ, Antonescu CN.

Traffic. 2017 Sep;18(9):567-579. doi: 10.1111/tra.12497. Epub 2017 Jul 4. Review.


Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer.

Ata R, Antonescu CN.

Int J Mol Sci. 2017 Jan 18;18(1). pii: E189. doi: 10.3390/ijms18010189. Review.


The acyltransferase LYCAT controls specific phosphoinositides and related membrane traffic.

Bone LN, Dayam RM, Lee M, Kono N, Fairn GD, Arai H, Botelho RJ, Antonescu CN.

Mol Biol Cell. 2017 Jan 1;28(1):161-172. doi: 10.1091/mbc.E16-09-0668. Epub 2016 Nov 9.


Similar requirement for clathrin in EGF- and HGF- stimulated Akt phosphorylation.

Lucarelli S, Pandey R, Judge G, Antonescu CN.

Commun Integr Biol. 2016 Apr 21;9(3):e1175696. doi: 10.1080/19420889.2016.1175696. eCollection 2016 May-Jun.


Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms.

Fekri F, Delos Santos RC, Karshafian R, Antonescu CN.

PLoS One. 2016 Jun 8;11(6):e0156754. doi: 10.1371/journal.pone.0156754. eCollection 2016.


mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells.

Saric A, Hipolito VE, Kay JG, Canton J, Antonescu CN, Botelho RJ.

Mol Biol Cell. 2016 Jan 15;27(2):321-33. doi: 10.1091/mbc.E15-05-0272. Epub 2015 Nov 18.


Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2.

Crupi MJ, Yoganathan P, Bone LN, Lian E, Fetz A, Antonescu CN, Mulligan LM.

Traffic. 2015 Nov;16(11):1155-73. doi: 10.1111/tra.12315. Epub 2015 Sep 21.


Epidermal growth factor-stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis.

Garay C, Judge G, Lucarelli S, Bautista S, Pandey R, Singh T, Antonescu CN.

Mol Biol Cell. 2015 Oct 1;26(19):3504-19. doi: 10.1091/mbc.E14-09-1412. Epub 2015 Aug 5.


Charming neighborhoods on the cell surface: plasma membrane microdomains regulate receptor tyrosine kinase signaling.

Delos Santos RC, Garay C, Antonescu CN.

Cell Signal. 2015 Oct;27(10):1963-76. doi: 10.1016/j.cellsig.2015.07.004. Epub 2015 Jul 9. Review.


AMP-Activated Protein Kinase Regulates the Cell Surface Proteome and Integrin Membrane Traffic.

Ross E, Ata R, Thavarajah T, Medvedev S, Bowden P, Marshall JG, Antonescu CN.

PLoS One. 2015 May 26;10(5):e0128013. doi: 10.1371/journal.pone.0128013. eCollection 2015.


Reciprocal regulation of endocytosis and metabolism.

Antonescu CN, McGraw TE, Klip A.

Cold Spring Harb Perspect Biol. 2014 Jul 1;6(7):a016964. doi: 10.1101/cshperspect.a016964. Review.


Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint.

Aguet F, Antonescu CN, Mettlen M, Schmid SL, Danuser G.

Dev Cell. 2013 Aug 12;26(3):279-91. doi: 10.1016/j.devcel.2013.06.019. Epub 2013 Jul 25.


Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles.

Boguslavsky S, Chiu T, Foley KP, Osorio-Fuentealba C, Antonescu CN, Bayer KU, Bilan PJ, Klip A.

Mol Biol Cell. 2012 Oct;23(20):4065-78. doi: 10.1091/mbc.E12-04-0263. Epub 2012 Aug 23.


Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size.

Antonescu CN, Aguet F, Danuser G, Schmid SL.

Mol Biol Cell. 2011 Jul 15;22(14):2588-600. doi: 10.1091/mbc.E11-04-0362. Epub 2011 May 25.


Direct involvement of tumor necrosis factor-α in the regulation of glucose uptake in rainbow trout muscle cells.

Vraskou Y, Roher N, Díaz M, Antonescu CN, MacKenzie SA, Planas JV.

Am J Physiol Regul Integr Comp Physiol. 2011 Mar;300(3):R716-23. doi: 10.1152/ajpregu.00514.2010. Epub 2010 Dec 29.


Phosphatidic acid plays a regulatory role in clathrin-mediated endocytosis.

Antonescu CN, Danuser G, Schmid SL.

Mol Biol Cell. 2010 Aug 15;21(16):2944-52. doi: 10.1091/mbc.E10-05-0421. Epub 2010 Jun 23.


Documenting GLUT4 exocytosis and endocytosis in muscle cell monolayers.

Ishikura S, Antonescu CN, Klip A.

Curr Protoc Cell Biol. 2010 Mar;Chapter 15:Unit 15.15. doi: 10.1002/0471143030.cb1515s46.


Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits.

Mettlen M, Stoeber M, Loerke D, Antonescu CN, Danuser G, Schmid SL.

Mol Biol Cell. 2009 Jul;20(14):3251-60. doi: 10.1091/mbc.E09-03-0256. Epub 2009 May 20.


Ready, set, internalize: mechanisms and regulation of GLUT4 endocytosis.

Antonescu CN, Foti M, Sauvonnet N, Klip A.

Biosci Rep. 2009 Feb;29(1):1-11. doi: 10.1042/BSR20080105. Review.


A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle.

Schertzer JD, Antonescu CN, Bilan PJ, Jain S, Huang X, Liu Z, Bonen A, Klip A.

Endocrinology. 2009 Apr;150(4):1935-40. doi: 10.1210/en.2008-1372. Epub 2008 Dec 12.


Dissecting GLUT4 traffic components in L6 myocytes by fluorescence-based, single-cell assays.

Antonescu CN, Randhawa VK, Klip A.

Methods Mol Biol. 2008;457:367-78.


Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells.

Samokhvalov V, Bilan PJ, Schertzer JD, Antonescu CN, Klip A.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E37-46. doi: 10.1152/ajpendo.90667.2008. Epub 2008 Oct 7.


Insulin action on glucose transporters through molecular switches, tracks and tethers.

Zaid H, Antonescu CN, Randhawa VK, Klip A.

Biochem J. 2008 Jul 15;413(2):201-15. doi: 10.1042/BJ20080723. Review.


Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling.

Antonescu CN, Díaz M, Femia G, Planas JV, Klip A.

Traffic. 2008 Jul;9(7):1173-90. doi: 10.1111/j.1600-0854.2008.00755.x. Epub 2008 Apr 24.


Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity.

Antonescu CN, Huang C, Niu W, Liu Z, Eyers PA, Heidenreich KA, Bilan PJ, Klip A.

Endocrinology. 2005 Sep;146(9):3773-81. Epub 2005 Jun 9.


Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice.

Konrad D, Bilan PJ, Nawaz Z, Sweeney G, Niu W, Liu Z, Antonescu CN, Rudich A, Klip A.

Diabetes. 2002 Sep;51(9):2719-26.

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