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Items: 1 to 50 of 154

1.

Pyrrolomycins Are Potent Natural Protonophores.

Valderrama K, Pradel E, Firsov AM, Drobecq H, Bauderlique-le Roy H, Villemagne B, Antonenko YN, Hartkoorn RC.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e01450-19. doi: 10.1128/AAC.01450-19. Print 2019 Oct.

PMID:
31405863
2.

Zwitterionic Protonophore Derived from 2-(2-Hydroxyaryl)alkenylphosphonium as an Uncoupler of Oxidative Phosphorylation.

Rokitskaya TI, Terekhova NV, Khailova LS, Kotova EA, Plotnikov EY, Zorov DB, Tatarinov DA, Antonenko YN.

Bioconjug Chem. 2019 Sep 18;30(9):2435-2443. doi: 10.1021/acs.bioconjchem.9b00516. Epub 2019 Aug 16.

PMID:
31374173
3.

Interaction of Potent Mitochondrial Uncouplers with Thiol-Containing Antioxidants.

Khailova LS, Firsov AM, Kotova EA, Antonenko YN.

Antioxidants (Basel). 2019 Jun 23;8(6). pii: E194. doi: 10.3390/antiox8060194.

4.

Threshold protective effect of deuterated polyunsaturated fatty acids on peroxidation of lipid bilayers.

Firsov AM, Fomich MA, Bekish AV, Sharko OL, Kotova EA, Saal HJ, Vidovic D, Shmanai VV, Pratt DA, Antonenko YN, Shchepinov MS.

FEBS J. 2019 Jun;286(11):2099-2117. doi: 10.1111/febs.14807. Epub 2019 Mar 22.

PMID:
30851224
5.

Mechanism of action of an old antibiotic revisited: Role of calcium ions in protonophoric activity of usnic acid.

Antonenko YN, Khailova LS, Rokitskaya TI, Nosikova ES, Nazarov PA, Luzina OA, Salakhutdinov NF, Kotova EA.

Biochim Biophys Acta Bioenerg. 2019 Apr 1;1860(4):310-316. doi: 10.1016/j.bbabio.2019.01.005. Epub 2019 Jan 30.

PMID:
30710552
6.

Carborane derivatives of 1,2,3-triazole depolarize mitochondria by transferring protons through the lipid part of membranes.

Rokitskaya TI, Khailova LS, Makarenkov AV, Shunaev AV, Tatarskiy VV, Shtil AA, Ol'shevskaya VA, Antonenko YN.

Biochim Biophys Acta Biomembr. 2019 Mar 1;1861(3):573-583. doi: 10.1016/j.bbamem.2018.12.009. Epub 2018 Dec 15.

PMID:
30562498
7.

Minocycline prevents peroxidative permeabilization of cardiolipin-containing bilayer lipid membranes mediated by cytochrome c.

Firsov AM, Kotova EA, Antonenko YN.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):510-513. doi: 10.1016/j.bbrc.2018.11.078. Epub 2018 Nov 16.

PMID:
30454899
8.

Membrane Elastic Deformations Modulate Gramicidin A Transbilayer Dimerization and Lateral Clustering.

Kondrashov OV, Galimzyanov TR, Pavlov KV, Kotova EA, Antonenko YN, Akimov SA.

Biophys J. 2018 Aug 7;115(3):478-493. doi: 10.1016/j.bpj.2018.07.004. Epub 2018 Jul 11.

9.

Effect of Alkyl Chain Length on Translocation of Rhodamine B n-Alkyl Esters across Lipid Membranes.

Rokitskaya TI, Korshunova GA, Antonenko YN.

Biophys J. 2018 Aug 7;115(3):514-521. doi: 10.1016/j.bpj.2018.07.001. Epub 2018 Jul 9.

10.

Effect of Site-Specific Intermolecular Lysine-Tryptophan Interactions on the Aggregation of Gramicidin-Based Peptides Leading to Pore Formation in Lipid Membranes.

Firsov AM, Pogozheva ID, Kovalchuk SI, Kotova EA, Antonenko YN.

J Membr Biol. 2018 Dec;251(5-6):633-640. doi: 10.1007/s00232-018-0040-0. Epub 2018 Jul 11.

PMID:
29995247
11.

Role of mitochondrial outer membrane in the uncoupling activity of N-terminally glutamate-substituted gramicidin A.

Khailova LS, Rokitskaya TI, Kovalchuk SI, Kotova ЕА, Sorochkina AI, Antonenko YN.

Biochim Biophys Acta Biomembr. 2019 Jan;1861(1):281-287. doi: 10.1016/j.bbamem.2018.06.013. Epub 2018 Jun 22.

PMID:
29940153
12.

Protonophoric action of triclosan causes calcium efflux from mitochondria, plasma membrane depolarization and bursts of miniature end-plate potentials.

Popova LB, Nosikova ES, Kotova EA, Tarasova EO, Nazarov PA, Khailova LS, Balezina OP, Antonenko YN.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1000-1007. doi: 10.1016/j.bbamem.2018.01.008. Epub 2018 Jan 6.

13.

A conjugate of decyltriphenylphosphonium with plastoquinone can carry cyclic adenosine monophosphate, but not cyclic guanosine monophosphate, across artificial and natural membranes.

Firsov AM, Rybalkina IG, Kotova EA, Rokitskaya TI, Tashlitsky VN, Korshunova GA, Rybalkin SD, Antonenko YN.

Biochim Biophys Acta Biomembr. 2018 Feb;1860(2):329-334. doi: 10.1016/j.bbamem.2017.10.013. Epub 2017 Oct 14.

14.

Effect of Cyanide on Mitochondrial Membrane Depolarization Induced by Uncouplers.

Khailova LS, Rokitskaya TI, Kotova EA, Antonenko YN.

Biochemistry (Mosc). 2017 Oct;82(10):1140-1146. doi: 10.1134/S0006297917100066.

PMID:
29037134
15.

Fast flip-flop of halogenated cobalt bis(dicarbollide) anion in a lipid bilayer membrane.

Rokitskaya TI, Kosenko ID, Sivaev IB, Antonenko YN, Bregadze VI.

Phys Chem Chem Phys. 2017 Sep 20;19(36):25122-25128. doi: 10.1039/c7cp04207h.

PMID:
28880326
16.

Blocking of Single α-Hemolysin Pore by Rhodamine Derivatives.

Rokitskaya TI, Nazarov PA, Golovin AV, Antonenko YN.

Biophys J. 2017 Jun 6;112(11):2327-2335. doi: 10.1016/j.bpj.2017.04.041.

17.

Mitochondria-targeted antioxidants as highly effective antibiotics.

Nazarov PA, Osterman IA, Tokarchuk AV, Karakozova MV, Korshunova GA, Lyamzaev KG, Skulachev MV, Kotova EA, Skulachev VP, Antonenko YN.

Sci Rep. 2017 May 3;7(1):1394. doi: 10.1038/s41598-017-00802-8.

18.

Calcein leakage as a robust assay for cytochrome c/H2O2-mediated liposome permeabilization.

Firsov AM, Kotova EA, Antonenko YN.

Anal Biochem. 2018 Jul 1;552:19-23. doi: 10.1016/j.ab.2017.03.014. Epub 2017 Mar 18.

PMID:
28322801
19.

pH-Dependent properties of ion channels formed by N-terminally glutamate substituted gramicidin A in planar lipid bilayers.

Chistyulin DK, Rokitskaya TI, Kovalchuk SI, Sorochkina AI, Firsov AM, Kotova EA, Antonenko YN.

Biochim Biophys Acta Biomembr. 2017 May;1859(5):896-902. doi: 10.1016/j.bbamem.2017.02.004. Epub 2017 Feb 7.

20.

Alkyl-substituted phenylamino derivatives of 7-nitrobenz-2-oxa-1,3-diazole as uncouplers of oxidative phosphorylation and antibacterial agents: involvement of membrane proteins in the uncoupling action.

Antonenko YN, Denisov SS, Khailova LS, Nazarov PA, Rokitskaya T, Tashlitsky VN, Firsov AM, Korshunova GA, Kotova EA.

Biochim Biophys Acta Biomembr. 2017 Mar;1859(3):377-387. doi: 10.1016/j.bbamem.2016.12.014. Epub 2016 Dec 21.

21.

Application of Peak Intensity Analysis to Measurements of Protein Binding to Lipid Vesicles and Erythrocytes Using Fluorescence Correlation Spectroscopy: Dependence on Particle Size.

Antonenko YN, Lapashina AS, Kotova EA, Ramonova AA, Moisenovich MM, Agapov II.

J Membr Biol. 2017 Feb;250(1):77-87. doi: 10.1007/s00232-016-9938-6. Epub 2016 Nov 11.

PMID:
27837242
22.

A long-linker conjugate of fluorescein and triphenylphosphonium as mitochondria-targeted uncoupler and fluorescent neuro- and nephroprotector.

Antonenko YN, Denisov SS, Silachev DN, Khailova LS, Jankauskas SS, Rokitskaya TI, Danilina TI, Kotova EA, Korshunova GA, Plotnikov EY, Zorov DB.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2463-2473. doi: 10.1016/j.bbagen.2016.07.014. Epub 2016 Jul 20.

PMID:
27450891
23.

A mitochondria-targeted antioxidant can inhibit peroxidase activity of cytochrome c by detachment of the protein from liposomes.

Firsov AM, Kotova EA, Orlov VN, Antonenko YN, Skulachev VP.

FEBS Lett. 2016 Sep;590(17):2836-43. doi: 10.1002/1873-3468.12319. Epub 2016 Aug 4.

24.

Weak C-H acids as protonophores can carry hydrogen ions through lipid membranes and mitochondria: a case of o-carborane.

Rokitskaya TI, Khailova LS, Makarenkov AV, Ol'shevskaya VA, Kalinin VN, Antonenko YN.

Phys Chem Chem Phys. 2016 Jun 28;18(24):16476-82. doi: 10.1039/c6cp02581a. Epub 2016 Jun 6.

PMID:
27265316
25.

Ubiquinol and plastoquinol triphenylphosphonium conjugates can carry electrons through phospholipid membranes.

Rokitskaya TI, Murphy MP, Skulachev VP, Antonenko YN.

Bioelectrochemistry. 2016 Oct;111:23-30. doi: 10.1016/j.bioelechem.2016.04.009. Epub 2016 Apr 28.

PMID:
27182824
26.

Fullerenol C60(OH)24 increases ion permeability of lipid membranes in a pH-dependent manner.

Rokitskaya TI, Antonenko YN.

Biochim Biophys Acta. 2016 Jun;1858(6):1165-74. doi: 10.1016/j.bbamem.2016.02.009. Epub 2016 Feb 10.

27.

Single channel activity of OmpF-like porin from Yersinia pseudotuberculosis.

Rokitskaya TI, Kotova EA, Naberezhnykh GA, Khomenko VA, Gorbach VI, Firsov AM, Zelepuga EA, Antonenko YN, Novikova OD.

Biochim Biophys Acta. 2016 Apr;1858(4):883-91. doi: 10.1016/j.bbamem.2016.02.005. Epub 2016 Feb 17.

28.

A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast.

Serpionov GV, Alexandrov AI, Antonenko YN, Ter-Avanesyan MD.

Sci Rep. 2015 Dec 17;5:18407. doi: 10.1038/srep18407.

29.

Uncoupling and Toxic Action of Alkyltriphenylphosphonium Cations on Mitochondria and the Bacterium Bacillus subtilis as a Function of Alkyl Chain Length.

Khailova LS, Nazarov PA, Sumbatyan NV, Korshunova GA, Rokitskaya TI, Dedukhova VI, Antonenko YN, Skulachev VP.

Biochemistry (Mosc). 2015 Dec;80(12):1589-97. doi: 10.1134/S000629791512007X.

30.

Carboranyl-Chlorin e6 as a Potent Antimicrobial Photosensitizer.

Omarova EO, Nazarov PA, Firsov AM, Strakhovskaya MG, Arkhipova AY, Moisenovich MM, Agapov II, Ol'shevskaya VA, Zaitsev AV, Kalinin VN, Kotova EA, Antonenko YN.

PLoS One. 2015 Nov 4;10(11):e0141990. doi: 10.1371/journal.pone.0141990. eCollection 2015.

31.

Photodynamic inactivation of gramicidin channels in bilayer lipid membranes: protective efficacy of singlet oxygen quenchers depends on photosensitizer location.

Rokitskaya TI, Firsov AM, Kotova EA, Antonenko YN.

Biochemistry (Mosc). 2015 Jun;80(6):745-51. doi: 10.1134/S0006297915060097. Review.

32.

Gramicidin A disassembles large conductive clusters of its lysine-substituted derivatives in lipid membranes.

Antonenko YN, Gluhov GS, Firsov AM, Pogozheva ID, Kovalchuk SI, Pechnikova EV, Kotova EA, Sokolova OS.

Phys Chem Chem Phys. 2015 Jul 14;17(26):17461-70. doi: 10.1039/c5cp02047f.

PMID:
26077982
33.

Intramitochondrial accumulation of cationic Atto520-biotin proceeds via voltage-dependent slow permeation through lipid membrane.

Antonenko YN, Nechaeva NL, Baksheeva VE, Rokitskaya TI, Plotnikov EY, Kotova EA, Zorov DB.

Biochim Biophys Acta. 2015 Jun;1848(6):1277-84. doi: 10.1016/j.bbamem.2015.02.028. Epub 2015 Mar 6.

34.

Methodology for use of mitochondria-targeted cations in the field of oxidative stress-related research.

Vyssokikh MY, Antonenko YN, Lyamzaev KG, Rokitskaya TI, Skulachev VP.

Methods Mol Biol. 2015;1265:149-59. doi: 10.1007/978-1-4939-2288-8_12.

PMID:
25634274
35.

Electrogenic and nonelectrogenic ion fluxes across lipid and mitochondrial membranes mediated by monensin and monensin ethyl ester.

Antonenko YN, Rokitskaya TI, Huczyński A.

Biochim Biophys Acta. 2015 Apr;1848(4):995-1004. doi: 10.1016/j.bbamem.2015.01.005. Epub 2015 Jan 17.

36.

Peroxidative permeabilization of liposomes induced by cytochrome c/cardiolipin complex.

Firsov AM, Kotova EA, Korepanova EA, Osipov AN, Antonenko YN.

Biochim Biophys Acta. 2015 Mar;1848(3):767-74. doi: 10.1016/j.bbamem.2014.11.027. Epub 2014 Dec 6.

37.

A mitochondria-targeted protonophoric uncoupler derived from fluorescein.

Denisov SS, Kotova EA, Plotnikov EY, Tikhonov AA, Zorov DB, Korshunova GA, Antonenko YN.

Chem Commun (Camb). 2014 Dec 18;50(97):15366-9. doi: 10.1039/c4cc04996a. Epub 2014 Oct 28.

PMID:
25349923
38.

Neuroprotective effect of glutamate-substituted analog of gramicidin A is mediated by the uncoupling of mitochondria.

Silachev DN, Khailova LS, Babenko VA, Gulyaev MV, Kovalchuk SI, Zorova LD, Plotnikov EY, Antonenko YN, Zorov DB.

Biochim Biophys Acta. 2014 Dec;1840(12):3434-42. doi: 10.1016/j.bbagen.2014.09.002. Epub 2014 Sep 12.

PMID:
25218694
39.

A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector.

Khailova LS, Silachev DN, Rokitskaya TI, Avetisyan AV, Lyamsaev KG, Severina II, Il'yasova TM, Gulyaev MV, Dedukhova VI, Trendeleva TA, Plotnikov EY, Zvyagilskaya RA, Chernyak BV, Zorov DB, Antonenko YN, Skulachev VP.

Biochim Biophys Acta. 2014 Oct;1837(10):1739-47. doi: 10.1016/j.bbabio.2014.07.006. Epub 2014 Jul 16.

40.

Inhibition of oxidative hemolysis in erythrocytes by mitochondria-targeted antioxidants of SkQ series.

Omarova EO, Antonenko YN.

Biochemistry (Mosc). 2014 Feb;79(2):139-45. doi: 10.1134/S0006297914020072.

41.

Tuning the hydrophobicity overcomes unfavorable deprotonation making octylamino-substituted 7-nitrobenz-2-oxa-1,3-diazole (n-octylamino-NBD) a protonophore and uncoupler of oxidative phosphorylation in mitochondria.

Denisov SS, Kotova EA, Khailova LS, Korshunova GA, Antonenko YN.

Bioelectrochemistry. 2014 Aug;98:30-8. doi: 10.1016/j.bioelechem.2014.02.002. Epub 2014 Mar 5.

PMID:
24650997
42.

Unsaturated lipids protect the integral membrane peptide gramicidin A from singlet oxygen.

Rokitskaya TI, Kotova EA, Agapov II, Moisenovich MM, Antonenko YN.

FEBS Lett. 2014 May 2;588(9):1590-5. doi: 10.1016/j.febslet.2014.02.046. Epub 2014 Mar 5.

43.

Photodynamic activity of the boronated chlorin e6 amide in artificial and cellular membranes.

Antonenko YN, Kotova EA, Omarova EO, Rokitskaya TI, Ol'shevskaya VA, Kalinin VN, Nikitina RG, Osipchuk JS, Kaplan MA, Ramonova AA, Moisenovich MM, Agapov II, Kirpichnikov MP.

Biochim Biophys Acta. 2014 Mar;1838(3):793-801. doi: 10.1016/j.bbamem.2013.11.012. Epub 2013 Nov 25.

44.

Dodecyl and octyl esters of fluorescein as protonophores and uncouplers of oxidative phosphorylation in mitochondria at submicromolar concentrations.

Shchepinova MM, Denisov SS, Kotova EA, Khailova LS, Knorre DA, Korshunova GA, Tashlitsky VN, Severin FF, Antonenko YN.

Biochim Biophys Acta. 2014 Jan;1837(1):149-58. doi: 10.1016/j.bbabio.2013.09.011. Epub 2013 Sep 27.

45.

Peptide-induced membrane leakage by lysine derivatives of gramicidin A in liposomes, planar bilayers, and erythrocytes.

Sorochkina AI, Kovalchuk SI, Omarova EO, Sobko AA, Kotova EA, Antonenko YN.

Biochim Biophys Acta. 2013 Nov;1828(11):2428-35. doi: 10.1016/j.bbamem.2013.06.018. Epub 2013 Jun 25.

46.

Penetrating cations enhance uncoupling activity of anionic protonophores in mitochondria.

Antonenko YN, Khailova LS, Knorre DA, Markova OV, Rokitskaya TI, Ilyasova TM, Severina II, Kotova EA, Karavaeva YE, Prikhodko AS, Severin FF, Skulachev VP.

PLoS One. 2013 Apr 23;8(4):e61902. doi: 10.1371/journal.pone.0061902. Print 2013.

47.

Electrogenic proton transport across lipid bilayer membranes mediated by cationic derivatives of rhodamine 19: comparison with anionic protonophores.

Rokitskaya TI, Ilyasova TM, Severina II, Antonenko YN, Skulachev VP.

Eur Biophys J. 2013 Jun;42(6):477-85. doi: 10.1007/s00249-013-0898-9. Epub 2013 Apr 5.

PMID:
23558512
48.

Electrostatically induced recruitment of membrane peptides into clusters requires ligand binding at both interfaces.

Antonenko YN, Horner A, Pohl P.

PLoS One. 2012;7(12):e52839. doi: 10.1371/journal.pone.0052839. Epub 2012 Dec 21.

49.

Substitution of ether linkage for ester bond in phospholipids increases permeability of bilayer lipid membrane for SkQ1-type penetrating cations.

Il'yasova TM, Rokitskaya TI, Severina II, Antonenko YN, Skulachev VP.

Biochemistry (Mosc). 2012 Sep;77(9):1038-43. doi: 10.1134/S0006297912090118.

50.

Mild uncoupling of respiration and phosphorylation as a mechanism providing nephro- and neuroprotective effects of penetrating cations of the SkQ family.

Plotnikov EY, Silachev DN, Jankauskas SS, Rokitskaya TI, Chupyrkina AA, Pevzner IB, Zorova LD, Isaev NK, Antonenko YN, Skulachev VP, Zorov DB.

Biochemistry (Mosc). 2012 Sep;77(9):1029-37. doi: 10.1134/S0006297912090106.

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