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Items: 1 to 50 of 58

1.

Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid Leukemia.

Puente-Moncada N, Costales P, Antolín I, Núñez LE, Oro P, Hermosilla MA, Pérez-Escuredo J, Ríos-Lombardía N, Sanchez-Sanchez AM, Luño E, Rodríguez C, Martín V, Morís F.

Mol Cancer Ther. 2018 Mar;17(3):614-624. doi: 10.1158/1535-7163.MCT-17-0530. Epub 2018 Jan 16.

2.

Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin.

Letra-Vilela R, Sánchez-Sánchez AM, Rocha AM, Martin V, Branco-Santos J, Puente-Moncada N, Santa-Marta M, Outeiro TF, Antolín I, Rodriguez C, Herrera F.

Mol Cell Endocrinol. 2016 Oct 15;434:238-49. doi: 10.1016/j.mce.2016.07.012. Epub 2016 Jul 9.

PMID:
27402602
3.

Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells.

Sanchez-Sanchez AM, Antolin I, Puente-Moncada N, Suarez S, Gomez-Lobo M, Rodriguez C, Martin V.

PLoS One. 2015 Aug 7;10(8):e0135420. doi: 10.1371/journal.pone.0135420. eCollection 2015.

4.

Involvement of autophagy in melatonin-induced cytotoxicity in glioma-initiating cells.

Martín V, Sanchez-Sanchez AM, Puente-Moncada N, Gomez-Lobo M, Alvarez-Vega MA, Antolín I, Rodriguez C.

J Pineal Res. 2014 Oct;57(3):308-16. doi: 10.1111/jpi.12170. Epub 2014 Sep 9.

PMID:
25163989
5.

Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells.

Martín V, Sanchez-Sanchez AM, Herrera F, Gomez-Manzano C, Fueyo J, Alvarez-Vega MA, Antolín I, Rodriguez C.

Br J Cancer. 2013 May 28;108(10):2005-12. doi: 10.1038/bjc.2013.188. Epub 2013 Apr 30.

6.

Mechanisms involved in the pro-apoptotic effect of melatonin in cancer cells.

Rodriguez C, Martín V, Herrera F, García-Santos G, Rodriguez-Blanco J, Casado-Zapico S, Sánchez-Sánchez AM, Suárez S, Puente-Moncada N, Anítua MJ, Antolín I.

Int J Mol Sci. 2013 Mar 25;14(4):6597-613. doi: 10.3390/ijms14046597. Review.

7.

Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells.

Rodríguez-Blanco J, Martín V, García-Santos G, Herrera F, Casado-Zapico S, Antolín I, Rodriguez C.

J Neurosci Res. 2012 Sep;90(9):1850-60. doi: 10.1002/jnr.23066. Epub 2012 Apr 19.

PMID:
22513717
8.

Fas/Fas ligand regulation mediates cell death in human Ewing's sarcoma cells treated with melatonin.

García-Santos G, Martin V, Rodríguez-Blanco J, Herrera F, Casado-Zapico S, Sánchez-Sánchez AM, Antolín I, Rodríguez C.

Br J Cancer. 2012 Mar 27;106(7):1288-96. doi: 10.1038/bjc.2012.66. Epub 2012 Mar 1.

9.

Intracellular redox state as determinant for melatonin antiproliferative vs cytotoxic effects in cancer cells.

Sánchez-Sánchez AM, Martín V, García-Santos G, Rodríguez-Blanco J, Casado-Zapico S, Suarez-Garnacho S, Antolín I, Rodriguez C.

Free Radic Res. 2011 Nov;45(11-12):1333-41. doi: 10.3109/10715762.2011.623700. Epub 2011 Oct 14.

PMID:
21923620
10.

Regulation of the expression of death receptors and their ligands by melatonin in haematological cancer cell lines and in leukaemia cells from patients.

Casado-Zapico S, Martín V, García-Santos G, Rodríguez-Blanco J, Sánchez-Sánchez AM, Luño E, Suárez C, García-Pedrero JM, Menendez ST, Antolín I, Rodriguez C.

J Pineal Res. 2011 Apr;50(3):345-55. doi: 10.1111/j.1600-079X.2010.00850.x. Epub 2011 Feb 24.

PMID:
21392090
11.

Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway.

Casado-Zapico S, Rodriguez-Blanco J, García-Santos G, Martín V, Sánchez-Sánchez AM, Antolín I, Rodriguez C.

J Pineal Res. 2010 Jan;48(1):72-80. doi: 10.1111/j.1600-079X.2009.00727.x.

PMID:
20025643
12.

Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death.

Martín V, García-Santos G, Rodriguez-Blanco J, Casado-Zapico S, Sanchez-Sanchez A, Antolín I, Medina M, Rodriguez C.

Cancer Lett. 2010 Jan 28;287(2):216-23. doi: 10.1016/j.canlet.2009.06.016. Epub 2009 Jul 25.

PMID:
19632770
13.

Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine.

Rodriguez-Blanco J, Martín V, Herrera F, García-Santos G, Antolín I, Rodriguez C.

J Neurochem. 2008 Oct;107(1):127-40. doi: 10.1111/j.1471-4159.2008.05588.x. Epub 2008 Jul 28.

14.

Involvement of protein kinase C in melatonin's oncostatic effect in C6 glioma cells.

Martín V, Herrera F, García-Santos G, Antolín I, Rodriguez-Blanco J, Medina M, Rodriguez C.

J Pineal Res. 2007 Oct;43(3):239-44.

PMID:
17803520
15.

Signaling pathways involved in antioxidant control of glioma cell proliferation.

Martín V, Herrera F, García-Santos G, Antolín I, Rodriguez-Blanco J, Rodriguez C.

Free Radic Biol Med. 2007 Jun 1;42(11):1715-22. Epub 2007 Mar 12.

PMID:
17462539
16.

Antioxidants do not prevent acrylonitrile-induced toxicity.

Carrera MP, Antolín I, Martín V, Sainz RM, Mayo JC, Herrera F, García-Santos G, Rodríguez C.

Toxicol Lett. 2007 Mar 30;169(3):236-44. Epub 2007 Feb 6.

PMID:
17337135
17.

Melatonin prevents glutamate-induced oxytosis in the HT22 mouse hippocampal cell line through an antioxidant effect specifically targeting mitochondria.

Herrera F, Martin V, García-Santos G, Rodriguez-Blanco J, Antolín I, Rodriguez C.

J Neurochem. 2007 Feb;100(3):736-46.

18.

Tryptamine induces cell death with ultrastructural features of autophagy in neurons and glia: Possible relevance for neurodegenerative disorders.

Herrera F, Martin V, Carrera P, García-Santos G, Rodriguez-Blanco J, Rodriguez C, Antolín I.

Anat Rec A Discov Mol Cell Evol Biol. 2006 Sep;288(9):1026-30.

19.

Melatonin induces apoptosis in human neuroblastoma cancer cells.

García-Santos G, Antolín I, Herrera F, Martín V, Rodriguez-Blanco J, del Pilar Carrera M, Rodriguez C.

J Pineal Res. 2006 Sep;41(2):130-5.

PMID:
16879318
20.

Intracellular signaling pathways involved in the cell growth inhibition of glioma cells by melatonin.

Martín V, Herrera F, Carrera-Gonzalez P, García-Santos G, Antolín I, Rodriguez-Blanco J, Rodriguez C.

Cancer Res. 2006 Jan 15;66(2):1081-8.

21.

Melatonin and Parkinson's disease.

Mayo JC, Sainz RM, Tan DX, Antolín I, Rodríguez C, Reiter RJ.

Endocrine. 2005 Jul;27(2):169-78. Review.

PMID:
16217130
22.

Standard curve for housekeeping and target genes: specific criteria for selection of loading control in Northern blot analysis.

Herrera F, Martín V, Antolín I, García-Santos G, Rodríguez-Blanco J, Rodríguez C.

J Biotechnol. 2005 Jun 29;117(4):337-41. Epub 2005 Apr 25.

PMID:
15925716
23.

Intracellular redox state regulation by parthenolide.

Herrera F, Martin V, Rodriguez-Blanco J, García-Santos G, Antolín I, Rodriguez C.

Biochem Biophys Res Commun. 2005 Jul 1;332(2):321-5.

PMID:
15910740
24.

Antioxidant activity and neuroprotective effects of zolpidem and several synthesis intermediates.

García-Santos G, Herrera F, Martín V, Rodriguez-Blanco J, Antolín I, Fernández-Marí F, Rodriguez C.

Free Radic Res. 2004 Dec;38(12):1289-99.

PMID:
15763953
25.

Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells.

Herrera F, Mayo JC, Martín V, Sainz RM, Antolin I, Rodriguez C.

Cancer Lett. 2004 Jul 28;211(1):47-55.

PMID:
15194216
26.

Regulation of antioxidant enzymes: a significant role for melatonin.

Rodriguez C, Mayo JC, Sainz RM, Antolín I, Herrera F, Martín V, Reiter RJ.

J Pineal Res. 2004 Jan;36(1):1-9. Review.

PMID:
14675124
27.

Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction.

Ressmeyer AR, Mayo JC, Zelosko V, Sáinz RM, Tan DX, Poeggeler B, Antolín I, Zsizsik BK, Reiter RJ, Hardeland R.

Redox Rep. 2003;8(4):205-13.

PMID:
14599344
28.

Molecular characterization of ciprofloxacin resistance of gonococcal strains in Spain.

Alcalá B, Arreaza L, Salcedo C, Antolín I, Borrell N, Cacho J, De Las Cuevas C, Otero L, Sauca G, Vázquez F, Villar H, Vázquez JA.

Sex Transm Dis. 2003 May;30(5):395-8.

PMID:
12916129
29.

Daily rhythm of gene expression in rat superoxide dismutases.

Martín V, Sainz RM, Mayo JC, Antolín I, Herrera F, Rodríguez C.

Endocr Res. 2003 Feb;29(1):83-95.

PMID:
12665321
30.

Several antioxidant pathways are involved in astrocyte protection by melatonin.

Martín V, Sainz RM, Antolín I, Mayo JC, Herrera F, Rodríguez C.

J Pineal Res. 2002 Nov;33(4):204-12.

PMID:
12390502
31.

Protective effect of melatonin in a chronic experimental model of Parkinson's disease.

Antolín I, Mayo JC, Sainz RM, del Brío Mde L, Herrera F, Martín V, Rodríguez C.

Brain Res. 2002 Jul 12;943(2):163-73.

PMID:
12101038
32.

Effects of acetoacetate and D-beta-hydroxybutyrate on bovine in vitro embryo development in serum-free medium.

Gómez E, Duque P, Díaz E, Facal N, Antolín I, Hidalgo C, Díez C.

Theriogenology. 2002 Mar 15;57(5):1551-62.

PMID:
12054213
33.

Glutamate induces oxidative stress not mediated by glutamate receptors or cystine transporters: protective effect of melatonin and other antioxidants.

Herrera F, Sainz RM, Mayo JC, Martín V, Antolín I, Rodriguez C.

J Pineal Res. 2001 Nov;31(4):356-62.

PMID:
11703566
34.
35.

Melatonin regulates glucocorticoid receptor: an answer to its antiapoptotic action in thymus.

Sainz RM, Mayo JC, Reiter RJ, Antolin I, Esteban MM, Rodriguez C.

FASEB J. 1999 Sep;13(12):1547-56.

PMID:
10463946
36.

Ultrastructural confirmation of neuronal protection by melatonin against the neurotoxin 6-hydroxydopamine cell damage.

Mayo JC, Sainz RM, Antolín I, Rodriguez C.

Brain Res. 1999 Feb 13;818(2):221-7.

PMID:
10082807
37.

Melatonin decreases mRNA for histone H4 in thymus of young rats.

Sáinz RM, Mayo JC, Kotler M, Uría H, Antolín I, Rodríguez C.

Life Sci. 1998;63(13):1109-17.

PMID:
9763206
38.

Inhibition of cell proliferation: a mechanism likely to mediate the prevention of neuronal cell death by melatonin.

Mayo JC, Sainz RM, Uría H, Antolín I, Estéban MM, Rodríguez.

J Pineal Res. 1998 Aug;25(1):12-8.

PMID:
9694399
39.

Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: implications for Parkinson's disease.

Mayo JC, Sainz RM, Uria H, Antolin I, Esteban MM, Rodriguez C.

J Pineal Res. 1998 Apr;24(3):179-92.

PMID:
9551855
40.

Melatonin increases gene expression for antioxidant enzymes in rat brain cortex.

Kotler M, Rodríguez C, Sáinz RM, Antolín I, Menéndez-Peláez A.

J Pineal Res. 1998 Mar;24(2):83-9.

PMID:
9510432
42.

Androgen-dependent mast cell degranulation in the Harderian gland of female Syrian hamsters: in vivo and organ culture evidence.

Mayo JC, Sáinz RM, Antolín I, Uría H, Menéndez-Peláez A, Rodríguez C.

Anat Embryol (Berl). 1997 Aug;196(2):133-40.

PMID:
9278158
43.

Isolation and identification of sex-specific cDNA clones from the Syrian hamster harderian gland.

Domínguez P, Antolín I, Prieto F, Menéndez-Peláez A.

Microsc Res Tech. 1996 Jun 1;34(2):111-7.

PMID:
8722704
44.

Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes.

Antolín I, Rodríguez C, Saínz RM, Mayo JC, Uría H, Kotler ML, Rodríguez-Colunga MJ, Tolivia D, Menéndez-Peláez A.

FASEB J. 1996 Jun;10(8):882-90.

PMID:
8666165
45.

Regulation of the aminolevulinate synthase gene in the Syrian hamster Harderian gland: changes during development and circadian rhythm and role of some hormones.

Rodriguez C, Kotler M, Antolin I, Sainz RM, Menendez-Pelaez A.

Microsc Res Tech. 1996 May 1;34(1):65-70. Review.

PMID:
8859889
46.

Invasive processes in the normal Harderian gland of Syrian hamster.

Tolivia D, Uria H, Mayo JC, Antolin I, Rodriguez-Colunga MJ, Menendez-Pelaez A.

Microsc Res Tech. 1996 May 1;34(1):55-64.

PMID:
8859888
47.

Castration increases cell damage induced by porphyrins in the Harderian gland of male Syrian hamster. Necrosis and not apoptosis mediates the subsequent cell death.

Antolín I, Rodríguez C, Uría H, Sáinz RM, Mayo JC, Kotler ML, Rodríguez-Colunga MJ, Tolivia D, Menéndez-Peláez A.

J Struct Biol. 1996 May-Jun;116(3):377-89.

PMID:
8812996
48.

The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes.

Sainz RM, Mayo JC, Uría H, Kotler M, Antolín I, Rodriguez C, Menendez-Pelaez A.

J Pineal Res. 1995 Nov;19(4):178-88.

PMID:
8789249
49.

Androgen regulation of gene expression in the Syrian hamster Harderian gland.

Domínguez P, Antolín I, Boga JA, Uría H, Menéndez-Peláez A.

Mol Cell Endocrinol. 1994 Dec;106(1-2):81-9.

PMID:
7895917

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