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Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective.

Athersuch TJ, Antoine DJ, Boobis AR, Coen M, Daly AK, Possamai L, Nicholson JK, Wilson ID.

Toxicol Res (Camb). 2018 Mar 6;7(3):347-357. doi: 10.1039/c7tx00340d. eCollection 2018 May 8. Review.


High mobility group box-1 drives fibrosis progression signaling via the receptor for advanced glycation end-products in mice.

Ge X, Arriazu E, Magdaleno F, Antoine DJ, Dela Cruz R, Theise N, Nieto N.

Hepatology. 2018 May 18. doi: 10.1002/hep.30093. [Epub ahead of print]


TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.

Francis B, Clarke JI, Walker LE, Brillant N, Jorgensen AL, Park BK, Pirmohamed M, Antoine DJ.

J Hepatol. 2018 May 3. pii: S0168-8278(18)32042-7. doi: 10.1016/j.jhep.2018.04.024. [Epub ahead of print]


Evaluation of plasma microRNA-122, high-mobility group box 1 and keratin-18 concentrations to stratify acute gallstone disease: a pilot observational cohort study in an emergency general surgery unit.

Th'ng F, Vliegenthart B, Lea JD, Antoine DJ, Dear JW, Mole DJ; Edinburgh Emergency Surgery Study Group, Royal Infirmary of Edinburgh, NHS Lothian.

BMJ Open. 2018 Apr 27;8(4):e020061. doi: 10.1136/bmjopen-2017-020061.


Systems Toxicology Approach to Identifying Paracetamol Overdose.

Mason CL, Leedale J, Tasoulis S, Jarman I, Antoine DJ, Webb SD.

CPT Pharmacometrics Syst Pharmacol. 2018 Jun;7(6):394-403. doi: 10.1002/psp4.12298. Epub 2018 Apr 18.


Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin.

McWilliam SJ, Antoine DJ, Jorgensen AL, Smyth RL, Pirmohamed M.

Sci Rep. 2018 Mar 23;8(1):5094. doi: 10.1038/s41598-018-23466-4.


HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.

Khambu B, Huda N, Chen X, Antoine DJ, Li Y, Dai G, Köhler UA, Zong WX, Waguri S, Werner S, Oury TD, Dong Z, Yin XM.

J Clin Invest. 2018 Jun 1;128(6):2419-2435. doi: 10.1172/JCI91814. Epub 2018 May 7.


HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis.

Hernandez C, Huebener P, Pradere JP, Antoine DJ, Friedman RA, Schwabe RF.

J Clin Invest. 2018 Jun 1;128(6):2436-2451. doi: 10.1172/JCI91786. Epub 2018 May 7.


Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.

Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaao1313. doi: 10.1126/scitranslmed.aao1313.


Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.

Dear JW, Clarke JI, Francis B, Allen L, Wraight J, Shen J, Dargan PI, Wood D, Cooper J, Thomas SHL, Jorgensen AL, Pirmohamed M, Park BK, Antoine DJ.

Lancet Gastroenterol Hepatol. 2018 Feb;3(2):104-113. doi: 10.1016/S2468-1253(17)30266-2. Epub 2017 Nov 14.


Repurposing Statins for Renal Protection: Is It a Class Effect?

McWilliam SJ, Antoine DJ, Pirmohamed M.

Clin Transl Sci. 2018 Mar;11(2):100-102. doi: 10.1111/cts.12521. Epub 2017 Nov 15. No abstract available.


Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature.

Caparrotta TM, Antoine DJ, Dear JW.

Eur J Clin Pharmacol. 2018 Feb;74(2):147-160. doi: 10.1007/s00228-017-2356-6. Epub 2017 Oct 24. Review.


High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy.

Ravizza T, Terrone G, Salamone A, Frigerio F, Balosso S, Antoine DJ, Vezzani A.

Brain Behav Immun. 2018 Aug;72:14-21. doi: 10.1016/j.bbi.2017.10.008. Epub 2017 Oct 13.


Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo.

Brillant N, Elmasry M, Burton NC, Rodriguez JM, Sharkey JW, Fenwick S, Poptani H, Kitteringham NR, Goldring CE, Kipar A, Park BK, Antoine DJ.

Toxicol Appl Pharmacol. 2017 Oct 1;332:64-74. doi: 10.1016/j.taap.2017.07.019. Epub 2017 Jul 26.


A Short-Term Biological Indicator for Long-Term Kidney Damage after Radionuclide Therapy in Mice.

Pellegrini G, Siwowska K, Haller S, Antoine DJ, Schibli R, Kipar A, Müller C.

Pharmaceuticals (Basel). 2017 Jun 21;10(2). pii: E57. doi: 10.3390/ph10020057.


Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.

Pauletti A, Terrone G, Shekh-Ahmad T, Salamone A, Ravizza T, Rizzi M, Pastore A, Pascente R, Liang LP, Villa BR, Balosso S, Abramov AY, van Vliet EA, Del Giudice E, Aronica E, Antoine DJ, Patel M, Walker MC, Vezzani A.

Brain. 2017 Jul 1;140(7):1885-1899. doi: 10.1093/brain/awx117.


Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.

Walker LE, Frigerio F, Ravizza T, Ricci E, Tse K, Jenkins RE, Sills GJ, Jorgensen A, Porcu L, Thippeswamy T, Alapirtti T, Peltola J, Brodie MJ, Park BK, Marson AG, Antoine DJ, Vezzani A, Pirmohamed M.

J Clin Invest. 2017 Jun 1;127(6):2118-2132. doi: 10.1172/JCI92001. Epub 2017 May 15.


The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation.

Yang H, Wang H, Wang Y, Addorisio M, Li J, Postiglione MJ, Chavan SS, Al-Abed Y, Antoine DJ, Andersson U, Tracey KJ.

J Intern Med. 2017 Jul;282(1):76-93. doi: 10.1111/joim.12619. Epub 2017 May 31.


Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells.

Ogese MO, Faulkner L, Jenkins RE, French NS, Copple IM, Antoine DJ, Elmasry M, Malik H, Goldring CE, Park BK, Betts CJ, Naisbitt DJ.

Toxicol Sci. 2017 Jul 1;158(1):76-89. doi: 10.1093/toxsci/kfx069.


Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials.

Longo DM, Generaux GT, Howell BA, Siler SQ, Antoine DJ, Button D, Caggiano A, Eisen A, Iaci J, Stanulis R, Parry T, Mosedale M, Watkins PB.

Clin Pharmacol Ther. 2017 Dec;102(6):961-969. doi: 10.1002/cpt.711. Epub 2017 May 27.


Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies.

Clarke JI, Forootan SS, Lea JD, Howell LS, Rodriguez JM, Kipar A, Goldring CE, Park BK, Copple IM, Antoine DJ.

Toxicol Res (Camb). 2017 Apr 11;6(4):406-411. doi: 10.1039/c6tx00442c. eCollection 2017 Jul 1.


Optimising the use of medicines to reduce acute kidney injury in children and babies.

Oni L, Hawcutt DB, Turner MA, Beresford MW, McWilliam S, Barton C, Park BK, Murray P, Wilm B, Copple I, Floyd R, Peak M, Sharma A, Antoine DJ.

Pharmacol Ther. 2017 Jun;174:55-62. doi: 10.1016/j.pharmthera.2017.02.018. Epub 2017 Feb 12. Review.


Transformative biomarkers for drug-induced liver injury: are we there yet?

Antoine DJ, Dear JW.

Biomark Med. 2017 Feb;11(2):103-106. doi: 10.2217/bmm-2016-0338. Epub 2017 Jan 18. No abstract available.


A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat.

Thulin P, Hornby RJ, Auli M, Nordahl G, Antoine DJ, Starkey Lewis P, Goldring CE, Park BK, Prats N, Glinghammar B, Schuppe-Koistinen I.

Biomarkers. 2017 Jul;22(5):461-469. doi: 10.1080/1354750X.2016.1269131. Epub 2016 Dec 15.


Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury.

Usui T, Whitaker P, Meng X, Watson J, Antoine DJ, French NS, Park BK, Naisbitt DJ.

Chem Res Toxicol. 2016 Nov 21;29(11):1793-1795. Epub 2016 Nov 9.


A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease.

Walker LE, Griffiths MJ, McGill F, Lewthwaite P, Sills GJ, Jorgensen A, Antoine DJ, Solomon T, Marson AG, Pirmohamed M.

Biomarkers. 2017 Nov;22(7):635-642. doi: 10.1080/1354750X.2016.1265003. Epub 2016 Dec 8.


Aminoglycoside-induced nephrotoxicity in children.

McWilliam SJ, Antoine DJ, Smyth RL, Pirmohamed M.

Pediatr Nephrol. 2017 Nov;32(11):2015-2025. doi: 10.1007/s00467-016-3533-z. Epub 2016 Nov 15. Review.


Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.

Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, Hanley NA, Hay DC, Ingelman-Sundberg M, Juhila S, Kitteringham N, Silva-Lima B, Norris A, Pridgeon C, Ross JA, Young RS, Tagle D, Tornesi B, van de Water B, Weaver RJ, Zhang F, Park BK.

Hepatology. 2017 Feb;65(2):710-721. doi: 10.1002/hep.28886. Epub 2016 Nov 30. Review.


Redox-dependent regulation of hepatocyte absent in melanoma 2 inflammasome activation in sterile liver injury in mice.

Sun Q, Loughran P, Shapiro R, Shrivastava IH, Antoine DJ, Li T, Yan Z, Fan J, Billiar TR, Scott MJ.

Hepatology. 2017 Jan;65(1):253-268. doi: 10.1002/hep.28893. Epub 2016 Nov 29.


Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.

Vliegenthart A, Kimmitt RA, Seymour JH, Homer NZ, Clarke JI, Eddleston M, Gray A, Wood DM, Dargan PI, Cooper JG, Antoine DJ, Webb DJ, Lewis SC, Bateman DN, Dear JW.

Clin Pharmacol Ther. 2017 Apr;101(4):531-540. doi: 10.1002/cpt.541. Epub 2016 Nov 30.


A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.

Lundbäck P, Lea JD, Sowinska A, Ottosson L, Fürst CM, Steen J, Aulin C, Clarke JI, Kipar A, Klevenvall L, Yang H, Palmblad K, Park BK, Tracey KJ, Blom AM, Andersson U, Antoine DJ, Erlandsson Harris H.

Hepatology. 2016 Nov;64(5):1699-1710. doi: 10.1002/hep.28736. Epub 2016 Sep 1.


Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.

Qin S, Zhou Y, Gray L, Kusebauch U, McEvoy L, Antoine DJ, Hampson L, Park KB, Campbell D, Caballero J, Glusman G, Yan X, Kim TK, Yuan Y, Wang K, Rowen L, Moritz RL, Omenn GS, Pirmohamed M, Hood L.

J Proteome Res. 2016 Oct 7;15(10):3724-3740. Epub 2016 Sep 19.


Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice.

Stark K, Philippi V, Stockhausen S, Busse J, Antonelli A, Miller M, Schubert I, Hoseinpour P, Chandraratne S, von Brühl ML, Gaertner F, Lorenz M, Agresti A, Coletti R, Antoine DJ, Heermann R, Jung K, Reese S, Laitinen I, Schwaiger M, Walch A, Sperandio M, Nawroth PP, Reinhardt C, Jäckel S, Bianchi ME, Massberg S.

Blood. 2016 Nov 17;128(20):2435-2449. Epub 2016 Aug 29.


Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis.

Weemhoff JL, Woolbright BL, Jenkins RE, McGill MR, Sharpe MR, Olson JC, Antoine DJ, Curry SC, Jaeschke H.

Liver Int. 2017 Mar;37(3):377-384. doi: 10.1111/liv.13202. Epub 2016 Aug 6.


Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype.

Reed KR, Song F, Young MA, Hassan N, Antoine DJ, Gemici NB, Clarke AR, Jenkins JR.

Oncotarget. 2016 Aug 9;7(32):51665-51673. doi: 10.18632/oncotarget.10076.


Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.

Yang H, Wang H, Levine YA, Gunasekaran MK, Wang Y, Addorisio M, Zhu S, Li W, Li J, de Kleijn DP, Olofsson PS, Warren HS, He M, Al-Abed Y, Roth J, Antoine DJ, Chavan SS, Andersson U, Tracey KJ.

JCI Insight. 2016;1(7). pii: e85375. Epub 2016 May 19.


Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423.

Pavkovic M, Robinson-Cohen C, Chua AS, Nicoara O, Cárdenas-González M, Bijol V, Ramachandran K, Hampson L, Pirmohamed M, Antoine DJ, Frendl G, Himmelfarb J, Waikar SS, Vaidya VS.

Toxicol Sci. 2016 Jul;152(1):205-13. doi: 10.1093/toxsci/kfw077. Epub 2016 Apr 27.


Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon?

Clarke JI, Dear JW, Antoine DJ.

Expert Opin Drug Saf. 2016 May;15(5):625-34. doi: 10.1517/14740338.2016.1160057. Epub 2016 Mar 17. Review.


How to treat paracetamol overdose and when to do it.

Antoine DJ, Dear JW.

Expert Rev Clin Pharmacol. 2016;9(5):633-5. doi: 10.1586/17512433.2016.1154786. Epub 2016 Mar 2. No abstract available.


Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury.

Arriazu E, Ge X, Leung TM, Magdaleno F, Lopategi A, Lu Y, Kitamura N, Urtasun R, Theise N, Antoine DJ, Nieto N.

Gut. 2017 Jun;66(6):1123-1137. doi: 10.1136/gutjnl-2015-310752. Epub 2016 Jan 27.


HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients.

Napolitano A, Antoine DJ, Pellegrini L, Baumann F, Pagano I, Pastorino S, Goparaju CM, Prokrym K, Canino C, Pass HI, Carbone M, Yang H.

Clin Cancer Res. 2016 Jun 15;22(12):3087-96. doi: 10.1158/1078-0432.CCR-15-1130. Epub 2016 Jan 5.


Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury.

Vliegenthart AD, Shaffer JM, Clarke JI, Peeters LE, Caporali A, Bateman DN, Wood DM, Dargan PI, Craig DG, Moore JK, Thompson AI, Henderson NC, Webb DJ, Sharkey J, Antoine DJ, Park BK, Bailey MA, Lader E, Simpson KJ, Dear JW.

Sci Rep. 2015 Oct 22;5:15501. doi: 10.1038/srep15501.


Redox-Dependent HMGB1 Isoforms as Pivotal Co-Ordinators of Drug-Induced Liver Injury: Mechanistic Biomarkers and Therapeutic Targets.

Lea JD, Clarke JI, McGuire N, Antoine DJ.

Antioxid Redox Signal. 2016 Apr 20;24(12):652-65. doi: 10.1089/ars.2015.6406. Epub 2015 Dec 15. Review.


Paracetamol (acetaminophen) poisoning.

Park BK, Dear JW, Antoine DJ.

BMJ Clin Evid. 2015 Oct 19;2015. pii: 2101. Review.


CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure.

Stutchfield BM, Antoine DJ, Mackinnon AC, Gow DJ, Bain CC, Hawley CA, Hughes MJ, Francis B, Wojtacha D, Man TY, Dear JW, Devey LR, Mowat AM, Pollard JW, Park BK, Jenkins SJ, Simpson KJ, Hume DA, Wigmore SJ, Forbes SJ.

Gastroenterology. 2015 Dec;149(7):1896-1909.e14. doi: 10.1053/j.gastro.2015.08.053. Epub 2015 Sep 5.


Where are we now with paracetamol?

Dear JW, Antoine DJ, Park BK.

BMJ. 2015 Jul 10;351:h3705. doi: 10.1136/bmj.h3705. No abstract available.


Target biomarker profile for the clinical management of paracetamol overdose.

Vliegenthart AD, Antoine DJ, Dear JW.

Br J Clin Pharmacol. 2015 Sep;80(3):351-62. doi: 10.1111/bcp.12699. Epub 2015 Jul 29. Review.


Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study.

Lee KC, Baker LA, Stanzani G, Alibhai H, Chang YM, Jimenez Palacios C, Leckie PJ, Giordano P, Priestnall SL, Antoine DJ, Jenkins RE, Goldring CE, Park BK, Andreola F, Agarwal B, Mookerjee RP, Davies NA, Jalan R.

J Hepatol. 2015 Sep;63(3):634-42. doi: 10.1016/j.jhep.2015.04.020. Epub 2015 May 1.


Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury.

Antoine DJ, Sabbisetti VS, Francis B, Jorgensen AL, Craig DG, Simpson KJ, Bonventre JV, Park BK, Dear JW.

Hepatology. 2015 Aug;62(2):591-9. doi: 10.1002/hep.27857. Epub 2015 May 29.

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