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Items: 45


LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.

Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V.

Cell Metab. 2019 Apr 2;29(4):871-885.e5. doi: 10.1016/j.cmet.2019.02.014. Epub 2019 Mar 7.


Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice.

Antoch MP, Wrobel M, Kuropatwinski KK, Gitlin I, Leonova KI, Toshkov I, Gleiberman AS, Hutson AD, Chernova OB, Gudkov AV.

Aging (Albany NY). 2017 Mar 19;9(3):615-626. doi: 10.18632/aging.101206.


Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody.

Frescas D, Roux CM, Aygun-Sunar S, Gleiberman AS, Krasnov P, Kurnasov OV, Strom E, Virtuoso LP, Wrobel M, Osterman AL, Antoch MP, Mett V, Chernova OB, Gudkov AV.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1668-E1677. doi: 10.1073/pnas.1614661114. Epub 2017 Feb 13.


Metabolic clock generates nutrient anticipation rhythms in mTOR signaling.

Khapre RV, Patel SA, Kondratova AA, Chaudhary A, Velingkaar N, Antoch MP, Kondratov RV.

Aging (Albany NY). 2014 Aug;6(8):675-89.


Daily rhythms are retained both in spontaneously developed sarcomas and in xenografts grown in immunocompromised SCID mice.

Comas M, Kuropatwinski KK, Wrobel M, Toshkov I, Antoch MP.

Chronobiol Int. 2014 Oct;31(8):901-10. doi: 10.3109/07420528.2014.925469. Epub 2014 Jun 16.


Tissue-specific changes in molecular clocks during the transition from pregnancy to lactation in mice.

Casey TM, Crodian J, Erickson E, Kuropatwinski KK, Gleiberman AS, Antoch MP.

Biol Reprod. 2014 Jun;90(6):127. doi: 10.1095/biolreprod.113.116137. Epub 2014 Apr 23.


BMAL1-dependent regulation of the mTOR signaling pathway delays aging.

Khapre RV, Kondratova AA, Patel S, Dubrovsky Y, Wrobel M, Antoch MP, Kondratov RV.

Aging (Albany NY). 2014 Jan;6(1):48-57.


Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis.

Antoch MP, Toshkov I, Kuropatwinski KK, Jackson M.

Cell Cycle. 2013 Dec 1;12(23):3673-80. doi: 10.4161/cc.26614. Epub 2013 Oct 2.


Pharmacological modulators of the circadian clock as potential therapeutic drugs: focus on genotoxic/anticancer therapy.

Antoch MP, Kondratov RV.

Handb Exp Pharmacol. 2013;(217):289-309. doi: 10.1007/978-3-642-25950-0_12. Review.


Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice.

Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV, Blagosklonny MV, Gudkov AV.

Aging (Albany NY). 2012 Oct;4(10):709-14.


New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis.

Comas M, Toshkov I, Kuropatwinski KK, Chernova OB, Polinsky A, Blagosklonny MV, Gudkov AV, Antoch MP.

Aging (Albany NY). 2012 Oct;4(10):715-22.


Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription.

Spengler ML, Kuropatwinski KK, Comas M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2457-65. doi: 10.1073/pnas.1206274109. Epub 2012 Aug 15.


Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1.

Hu Y, Spengler ML, Kuropatwinski KK, Comas-Soberats M, Jackson M, Chernov MV, Gleiberman AS, Fedtsova N, Rustum YM, Gudkov AV, Antoch MP.

Oncotarget. 2011 Dec;2(12):1279-90.


Circadian clock proteins control adaptation to novel environment and memory formation.

Kondratova AA, Dubrovsky YV, Antoch MP, Kondratov RV.

Aging (Albany NY). 2010 May;2(5):285-97.


A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice.

Leonova KI, Shneyder J, Antoch MP, Toshkov IA, Novototskaya LR, Komarov PG, Komarova EA, Gudkov AV.

Cell Cycle. 2010 Apr 1;9(7):1434-43. Epub 2010 Apr 1.


Rapamycin extends maximal lifespan in cancer-prone mice.

Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Antoch MP, Blagosklonny MV.

Am J Pathol. 2010 May;176(5):2092-7. doi: 10.2353/ajpath.2010.091050. Epub 2010 Apr 2.


Pharmacological modulators of the circadian clock as potential therapeutic drugs.

Antoch MP, Chernov MV.

Mutat Res. 2009 Nov-Dec;680(1-2):109-15. Review.


Pharmacological modulators of the circadian clock as potential therapeutic drugs.

Antoch MP, Chernov MV.

Mutat Res. 2009 Sep;679(1-2):17-23. Epub 2009 Aug 14.


Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1.

Kondratov RV, Vykhovanets O, Kondratova AA, Antoch MP.

Aging (Albany NY). 2009 Dec 30;1(12):979-87.


Circadian proteins and genotoxic stress response.

Antoch MP, Kondratov RV.

Circ Res. 2010 Jan 8;106(1):68-78. doi: 10.1161/CIRCRESAHA.109.207076. Review.


A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation.

Spengler ML, Kuropatwinski KK, Schumer M, Antoch MP.

Cell Cycle. 2009 Dec 15;8(24):4138-46. Epub 2009 Dec 8.


The clock proteins, aging, and tumorigenesis.

Kondratov RV, Antoch MP.

Cold Spring Harb Symp Quant Biol. 2007;72:477-82. doi: 10.1101/sqb.2007.72.050. Review.


Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis.

Antoch MP, Gorbacheva VY, Vykhovanets O, Toshkov IA, Kondratov RV, Kondratova AA, Lee C, Nikitin AY.

Cell Cycle. 2008 May 1;7(9):1197-204. Epub 2008 Mar 10.


Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock.

Lemos DR, Goodspeed L, Tonelli L, Antoch MP, Ojeda SR, Urbanski HF.

Endocrinology. 2007 Dec;148(12):5811-21. Epub 2007 Sep 6.


Circadian proteins in the regulation of cell cycle and genotoxic stress responses.

Kondratov RV, Antoch MP.

Trends Cell Biol. 2007 Jul;17(7):311-7. Epub 2007 Jul 20. Review.


Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation.

Miller BH, McDearmon EL, Panda S, Hayes KR, Zhang J, Andrews JL, Antoch MP, Walker JR, Esser KA, Hogenesch JB, Takahashi JS.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3342-7. Epub 2007 Feb 20.


The role of mammalian circadian proteins in normal physiology and genotoxic stress responses.

Kondratov RV, Gorbacheva VY, Antoch MP.

Curr Top Dev Biol. 2007;78:173-216. Review.


Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock.

Kondratov RV, Kondratova AA, Gorbacheva VY, Vykhovanets OV, Antoch MP.

Genes Dev. 2006 Jul 15;20(14):1868-73.


The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.

Vitaterna MH, Ko CH, Chang AM, Buhr ED, Fruechte EM, Schook A, Antoch MP, Turek FW, Takahashi JS.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9327-32. Epub 2006 Jun 5.


Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES.

Kondratov RV, Kondratova AA, Lee C, Gorbacheva VY, Chernov MV, Antoch MP.

Cell Cycle. 2006 Apr;5(8):890-5. Epub 2006 Apr 17.


Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation.

Kondratov RV, Shamanna RK, Kondratova AA, Gorbacheva VY, Antoch MP.

FASEB J. 2006 Mar;20(3):530-2. Epub 2006 Jan 25.


Circadian clock genes as modulators of sensitivity to genotoxic stress.

Antoch MP, Kondratov RV, Takahashi JS.

Cell Cycle. 2005 Jul;4(7):901-7. Epub 2005 Jul 26. Review.


Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex.

Gorbacheva VY, Kondratov RV, Zhang R, Cherukuri S, Gudkov AV, Takahashi JS, Antoch MP.

Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3407-12. Epub 2005 Feb 2.


The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker.

Triqueneaux G, Thenot S, Kakizawa T, Antoch MP, Safi R, Takahashi JS, Delaunay F, Laudet V.

J Mol Endocrinol. 2004 Dec;33(3):585-608.


Coordinated transcription of key pathways in the mouse by the circadian clock.

Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB.

Cell. 2002 May 3;109(3):307-20.


The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5.

Wilsbacher LD, Sangoram AM, Antoch MP, Takahashi JS.

Genome Res. 2000 Dec;10(12):1928-40.


The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.

Applebury ML, Antoch MP, Baxter LC, Chun LL, Falk JD, Farhangfar F, Kage K, Krzystolik MG, Lyass LA, Robbins JT.

Neuron. 2000 Sep;27(3):513-23.


Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

Lowrey PL, Shimomura K, Antoch MP, Yamazaki S, Zemenides PD, Ralph MR, Menaker M, Takahashi JS.

Science. 2000 Apr 21;288(5465):483-92.


Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription.

Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A, Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ, Takahashi JS.

Neuron. 1998 Nov;21(5):1101-13.


Functional identification of the mouse circadian Clock gene by transgenic BAC rescue.

Antoch MP, Song EJ, Chang AM, Vitaterna MH, Zhao Y, Wilsbacher LD, Sangoram AM, King DP, Pinto LH, Takahashi JS.

Cell. 1997 May 16;89(4):655-67.


Positional cloning of the mouse circadian clock gene.

King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL, Turek FW, Takahashi JS.

Cell. 1997 May 16;89(4):641-53.


Transducin GTPase provides for rapid quenching of the cGMP cascade in rod outer segments.

Arshavsky VYu, Antoch MP, Lukjanov KA, Philippov PP.

FEBS Lett. 1989 Jul 3;250(2):353-6.


On the role of transducin GTPase in the quenching of a phosphodiesterase cascade of vision.

Arshavsky VYu, Antoch MP, Philippov PP.

FEBS Lett. 1987 Nov 16;224(1):19-22.


[Structural organization characteristics of histones H1 and H5].

Antoch MP, Odintsova TI, Ermokhina TM, Krasheninnikov IA, Tiktopulo EI.

Dokl Akad Nauk SSSR. 1981;256(3):739-42. Russian. No abstract available.


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