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Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.

Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy DJ, Guo JY, Jin J, Crawford HC, Zhang L, White E, Lin RZ, Su X, Tuveson DA, Zong WX.

Cell Rep. 2019 Oct 29;29(5):1287-1298.e6. doi: 10.1016/j.celrep.2019.09.056.


BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin.

Park J, Zhu Q, Mirek E, Na L, Raduwan H, Anthony TG, Belden WJ.

PLoS One. 2019 Oct 21;14(10):e0223803. doi: 10.1371/journal.pone.0223803. eCollection 2019.


Age modulates liver responses to asparaginase-induced amino acid stress in mice.

Nikonorova IA, Zhu Q, Signore CC, Mirek ET, Jonsson WO, Kong B, Guo GL, Belden WJ, Anthony TG.

J Biol Chem. 2019 Sep 20;294(38):13864-13875. doi: 10.1074/jbc.RA119.009864. Epub 2019 Aug 14.


Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights.

Jonsson WO, Margolies NS, Anthony TG.

Nutrients. 2019 Jun 15;11(6). pii: E1349. doi: 10.3390/nu11061349. Review.


Effects of ascorbic acid supplementation on oxidative stress markers in healthy women following a single bout of exercise.

Yimcharoen M, Kittikunnathum S, Suknikorn C, Nak-On W, Yeethong P, Anthony TG, Bunpo P.

J Int Soc Sports Nutr. 2019 Jan 21;16(1):2. doi: 10.1186/s12970-019-0269-8.


Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids.

Neinast MD, Jang C, Hui S, Murashige DS, Chu Q, Morscher RJ, Li X, Zhan L, White E, Anthony TG, Rabinowitz JD, Arany Z.

Cell Metab. 2019 Feb 5;29(2):417-429.e4. doi: 10.1016/j.cmet.2018.10.013. Epub 2018 Nov 15.


Effects of ovariectomy and exercise training intensity on energy substrate and hepatic lipid metabolism, and spontaneous physical activity in mice.

Tuazon MA, Campbell SC, Klein DJ, Shapses SA, Anacker KR, Anthony TG, Uzumcu M, Henderson GC.

Metabolism. 2018 Jun;83:234-244. doi: 10.1016/j.metabol.2018.02.011. Epub 2018 Mar 6.


Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.

Nikonorova IA, Mirek ET, Signore CC, Goudie MP, Wek RC, Anthony TG.

J Biol Chem. 2018 Apr 6;293(14):5005-5015. doi: 10.1074/jbc.RA117.001625. Epub 2018 Feb 15.


Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.

Al-Baghdadi RJT, Nikonorova IA, Mirek ET, Wang Y, Park J, Belden WJ, Wek RC, Anthony TG.

Sci Rep. 2017 Apr 28;7(1):1272. doi: 10.1038/s41598-017-01041-7.


Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice.

Pettit AP, Jonsson WO, Bargoud AR, Mirek ET, Peelor FF 3rd, Wang Y, Gettys TW, Kimball SR, Miller BF, Hamilton KL, Wek RC, Anthony TG.

J Nutr. 2017 Jun;147(6):1031-1040. doi: 10.3945/jn.116.246710. Epub 2017 Apr 26. Erratum in: J Nutr. 2017 Sep;147(9):1826.


Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.

Nikonorova IA, Al-Baghdadi RJT, Mirek ET, Wang Y, Goudie MP, Wetstein BB, Dixon JL, Hine C, Mitchell JR, Adams CM, Wek RC, Anthony TG.

J Biol Chem. 2017 Apr 21;292(16):6786-6798. doi: 10.1074/jbc.M116.768408. Epub 2017 Feb 27.


Measuring the Ability of Mice to Sense Dietary Essential Amino Acid Deficiency: The Importance of Amino Acid Status and Timing.

Gietzen DW, Anthony TG, Fafournoux P, Maurin AC, Koehnle TJ, Hao S.

Cell Rep. 2016 Aug 23;16(8):2049-2050. doi: 10.1016/j.celrep.2016.08.021. No abstract available.


Mechanisms of protein balance in skeletal muscle.

Anthony TG.

Domest Anim Endocrinol. 2016 Jul;56 Suppl:S23-32. doi: 10.1016/j.domaniend.2016.02.012. Review.


General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.

Phillipson-Weiner L, Mirek ET, Wang Y, McAuliffe WG, Wek RC, Anthony TG.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1061-70. doi: 10.1152/ajpgi.00052.2016. Epub 2016 Mar 11.


Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.

Fusakio ME, Willy JA, Wang Y, Mirek ET, Al Baghdadi RJ, Adams CM, Anthony TG, Wek RC.

Mol Biol Cell. 2016 May 1;27(9):1536-51. doi: 10.1091/mbc.E16-01-0039. Epub 2016 Mar 9.


Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction.

Wanders D, Stone KP, Forney LA, Cortez CC, Dille KN, Simon J, Xu M, Hotard EC, Nikonorova IA, Pettit AP, Anthony TG, Gettys TW.

Diabetes. 2016 Jun;65(6):1499-510. doi: 10.2337/db15-1324. Epub 2016 Mar 2.


Ascorbic acid supplementation does not alter oxidative stress markers in healthy volunteers engaged in a supervised exercise program.

Bunpo P, Anthony TG.

Appl Physiol Nutr Metab. 2016 Feb;41(2):175-80. doi: 10.1139/apnm-2015-0285. Epub 2015 Oct 26.


Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats.

Anthony TG, Mirek ET, Bargoud AR, Phillipson-Weiner L, DeOliveira CM, Wetstein B, Graf BL, Kuhn PE, Raskin I.

Appl Physiol Nutr Metab. 2015 Dec;40(12):1324-8. doi: 10.1139/apnm-2015-0301. Epub 2015 Sep 17.


Homeostatic responses to amino acid insufficiency.

Anthony TG.

Anim Nutr. 2015 Sep;1(3):135-137. doi: 10.1016/j.aninu.2015.10.001. Epub 2015 Oct 24. Review.


The role of leucine and its metabolites in protein and energy metabolism.

Duan Y, Li F, Li Y, Tang Y, Kong X, Feng Z, Anthony TG, Watford M, Hou Y, Wu G, Yin Y.

Amino Acids. 2016 Jan;48(1):41-51. doi: 10.1007/s00726-015-2067-1. Epub 2015 Aug 9. Review.


Defining meal requirements for protein to optimize metabolic roles of amino acids.

Layman DK, Anthony TG, Rasmussen BB, Adams SH, Lynch CJ, Brinkworth GD, Davis TA.

Am J Clin Nutr. 2015 Jun;101(6):1330S-1338S. doi: 10.3945/ajcn.114.084053. Epub 2015 Apr 29.


GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.

Wilson GJ, Lennox BA, She P, Mirek ET, Al Baghdadi RJ, Fusakio ME, Dixon JL, Henderson GC, Wek RC, Anthony TG.

Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E283-93. doi: 10.1152/ajpendo.00361.2014. Epub 2014 Dec 9.


Intensity-dependent and sex-specific alterations in hepatic triglyceride metabolism in mice following acute exercise.

Tuazon MA, McConnell TR, Wilson GJ, Anthony TG, Henderson GC.

J Appl Physiol (1985). 2015 Jan 1;118(1):61-70. doi: 10.1152/japplphysiol.00440.2014. Epub 2014 Sep 25.


Selective mRNA translation during eIF2 phosphorylation induces expression of IBTK╬▒.

Baird TD, Palam LR, Fusakio ME, Willy JA, Davis CM, McClintick JN, Anthony TG, Wek RC.

Mol Biol Cell. 2014 May;25(10):1686-97. doi: 10.1091/mbc.E14-02-0704. Epub 2014 Mar 19.


General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice.

She P, Bunpo P, Cundiff JK, Wek RC, Harris RA, Anthony TG.

J Biol Chem. 2013 Oct 25;288(43):31250-60. doi: 10.1074/jbc.M113.498469. Epub 2013 Sep 9.


The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.

Wilson GJ, Bunpo P, Cundiff JK, Wek RC, Anthony TG.

Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1124-33. doi: 10.1152/ajpendo.00080.2013. Epub 2013 Sep 3.


Remodeling of lipid metabolism by dietary restriction of essential amino acids.

Anthony TG, Morrison CD, Gettys TW.

Diabetes. 2013 Aug;62(8):2635-44. doi: 10.2337/db12-1613. Review. No abstract available.


Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity.

Lackey DE, Lynch CJ, Olson KC, Mostaedi R, Ali M, Smith WH, Karpe F, Humphreys S, Bedinger DH, Dunn TN, Thomas AP, Oort PJ, Kieffer DA, Amin R, Bettaieb A, Haj FG, Permana P, Anthony TG, Adams SH.

Am J Physiol Endocrinol Metab. 2013 Jun 1;304(11):E1175-87. doi: 10.1152/ajpendo.00630.2012. Epub 2013 Mar 19.


Detection of amino acid deprivation in the central nervous system.

Anthony TG, Gietzen DW.

Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):96-101. doi: 10.1097/MCO.0b013e32835b618b. Review.


TXNIP switches tracks toward a terminal UPR.

Anthony TG, Wek RC.

Cell Metab. 2012 Aug 8;16(2):135-7. doi: 10.1016/j.cmet.2012.07.012.


Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats.

Wilson GJ, Layman DK, Moulton CJ, Norton LE, Anthony TG, Proud CG, Rupassara SI, Garlick PJ.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1236-42. doi: 10.1152/ajpendo.00242.2011. Epub 2011 Sep 13.


The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

Teske BF, Wek SA, Bunpo P, Cundiff JK, McClintick JN, Anthony TG, Wek RC.

Mol Biol Cell. 2011 Nov;22(22):4390-405. doi: 10.1091/mbc.E11-06-0510. Epub 2011 Sep 14.


The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase.

Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG.

J Nutr. 2010 Nov;140(11):2020-7. doi: 10.3945/jn.110.129197. Epub 2010 Sep 22.


Obesity: stressing about unfolded proteins.

Wek RC, Anthony TG.

Nat Med. 2010 Apr;16(4):374-6. doi: 10.1038/nm0410-374. No abstract available. Erratum in: Nat Med. 2010 May;16(5):607.


GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG.

J Biol Chem. 2009 Nov 20;284(47):32742-9. doi: 10.1074/jbc.M109.047910. Epub 2009 Sep 25.


Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention.

Wek RC, Anthony TG.

Cell Metab. 2009 Jul;10(1):1-2. doi: 10.1016/j.cmet.2009.06.005.


The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats.

Norton LE, Layman DK, Bunpo P, Anthony TG, Brana DV, Garlick PJ.

J Nutr. 2009 Jun;139(6):1103-9. doi: 10.3945/jn.108.103853. Epub 2009 Apr 29.


AMPing down leucine action in skeletal muscle.

Anthony TG, Anthony JC.

J Nutr. 2008 Dec;138(12):2307-8. doi: 10.3945/jn.108.098392. No abstract available.


Alanyl-glutamine consumption modifies the suppressive effect of L-asparaginase on lymphocyte populations in mice.

Bunpo P, Murray B, Cundiff J, Brizius E, Aldrich CJ, Anthony TG.

J Nutr. 2008 Feb;138(2):338-43.


Evidence of non-neutral polymorphism in Plasmodium falciparum gamete surface protein genes Pfs47 and Pfs48/45.

Anthony TG, Polley SD, Vogler AP, Conway DJ.

Mol Biochem Parasitol. 2007 Dec;156(2):117-23. Epub 2007 Jul 20.


Mechanisms of food intake repression in indispensable amino acid deficiency.

Gietzen DW, Hao S, Anthony TG.

Annu Rev Nutr. 2007;27:63-78. Review.


EXtENDINg beta cell survival by UPRegulating ATF4 translation.

Wek RC, Anthony TG.

Cell Metab. 2006 Nov;4(5):333-4. Review.


Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.

Reinert RB, Oberle LM, Wek SA, Bunpo P, Wang XP, Mileva I, Goodwin LO, Aldrich CJ, Durden DL, McNurlan MA, Wek RC, Anthony TG.

J Biol Chem. 2006 Oct 20;281(42):31222-33. Epub 2006 Aug 24.


Decompression schedule optimization with an isoprobabilistic risk of decompression sickness.

Horn BJ, Wake GC, Anthony TG.

Aviat Space Environ Med. 2006 Jan;77(1):13-9.


Coping with stress: eIF2 kinases and translational control.

Wek RC, Jiang HY, Anthony TG.

Biochem Soc Trans. 2006 Feb;34(Pt 1):7-11. Review.


Fragmented population structure of plasmodium falciparum in a region of declining endemicity.

Anthony TG, Conway DJ, Cox-Singh J, Matusop A, Ratnam S, Shamsul S, Singh B.

J Infect Dis. 2005 May 1;191(9):1558-64. Epub 2005 Mar 25.


Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, Cavener DR, McGrath BC, Rudell JB, Koehnle TJ, Gietzen DW.

Science. 2005 Mar 18;307(5716):1776-8.


Leucine reduces the duration of insulin-induced PI 3-kinase activity in rat skeletal muscle.

Baum JI, O'Connor JC, Seyler JE, Anthony TG, Freund GG, Layman DK.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E86-91. Epub 2004 Aug 31.

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