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Correction to: PRSS21/testisin inhibits ovarian tumor metastasis and antagonizes proangiogenic angiopoietins ANG2 and ANGPTL4.

Conway GD, Buzza MS, Martin EW, Duru N, Johnson TA, Peroutka RJ, Pawar NR, Antalis TM.

J Mol Med (Berl). 2019 Sep;97(9):1375. doi: 10.1007/s00109-019-01820-x.


Fibrinolysis and Inflammation in Venous Thrombus Resolution.

Mukhopadhyay S, Johnson TA, Duru N, Buzza MS, Pawar NR, Sarkar R, Antalis TM.

Front Immunol. 2019 Jun 14;10:1348. doi: 10.3389/fimmu.2019.01348. eCollection 2019. Review.


PRSS21/testisin inhibits ovarian tumor metastasis and antagonizes proangiogenic angiopoietins ANG2 and ANGPTL4.

Conway GD, Buzza MS, Martin EW, Duru N, Johnson TA, Peroutka RJ, Pawar NR, Antalis TM.

J Mol Med (Berl). 2019 May;97(5):691-709. doi: 10.1007/s00109-019-01763-3. Epub 2019 Mar 25. Erratum in: J Mol Med (Berl). 2019 Sep;97(9):1375.


Membrane-Anchored Serine Proteases and Protease-Activated Receptor-2-Mediated Signaling: Co-Conspirators in Cancer Progression.

Pawar NR, Buzza MS, Antalis TM.

Cancer Res. 2019 Jan 15;79(2):301-310. doi: 10.1158/0008-5472.CAN-18-1745. Epub 2019 Jan 4. Review.


Serpins in Venous Thrombosis and Venous Thrombus Resolution.

Mukhopadhyay S, Johnson TA, Sarkar R, Antalis TM.

Methods Mol Biol. 2018;1826:197-211. doi: 10.1007/978-1-4939-8645-3_13.


Improving Cancer Detection and Treatment with Liquid Biopsies and ptDNA.

Kessler MD, Pawar NR, Martin SS, Antalis TM, O'Connor TD.

Trends Cancer. 2018 Sep;4(9):643-654. doi: 10.1016/j.trecan.2018.07.004. Epub 2018 Aug 1. Review.


Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.

Buzza MS, Johnson TA, Conway GD, Martin EW, Mukhopadhyay S, Shea-Donohue T, Antalis TM.

J Biol Chem. 2017 Jun 30;292(26):10801-10812. doi: 10.1074/jbc.M116.771469. Epub 2017 May 10.


Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice.

Mukhopadhyay S, Antalis TM, Nguyen KP, Hoofnagle MH, Sarkar R.

Blood. 2017 Jun 15;129(24):3245-3255. doi: 10.1182/blood-2016-07-727180. Epub 2017 Mar 20.


Coagulation signaling to epithelia.

Antalis TM.

Blood. 2016 Jun 23;127(25):3114-6. doi: 10.1182/blood-2016-05-715052. No abstract available.


Membrane-anchored proteases in endothelial cell biology.

Antalis TM, Conway GD, Peroutka RJ, Buzza MS.

Curr Opin Hematol. 2016 May;23(3):243-52. doi: 10.1097/MOH.0000000000000238. Review.


Essential Components of Cancer Education.

Welch DR, Antalis TM, Burnstein K, Vona-Davis L, Jensen RA, Nakshatri H, Riegel AT, Spitz DR, Watson DK, Weiner GJ; Cancer Biology Training Consortium.

Cancer Res. 2015 Dec 15;75(24):5202-5. doi: 10.1158/0008-5472.CAN-15-2077. Epub 2015 Dec 1. Review.


Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis.

Manton KJ, Douglas ML, Netzel-Arnett S, Fitzpatrick DR, Nicol DL, Boyd AW, Clements JA, Antalis TM.

Br J Cancer. 2015 Dec 1;113(11):1640. doi: 10.1038/bjc.2015.384. No abstract available.


Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden.

Martin EW, Buzza MS, Driesbaugh KH, Liu S, Fortenberry YM, Leppla SH, Antalis TM.

Oncotarget. 2015 Oct 20;6(32):33534-53. doi: 10.18632/oncotarget.5214.


Proteolytic activation of the protease-activated receptor (PAR)-2 by the glycosylphosphatidylinositol-anchored serine protease testisin.

Driesbaugh KH, Buzza MS, Martin EW, Conway GD, Kao JP, Antalis TM.

J Biol Chem. 2015 Feb 6;290(6):3529-41. doi: 10.1074/jbc.M114.628560. Epub 2014 Dec 17.


Enhanced venous thrombus resolution in plasminogen activator inhibitor type-2 deficient mice.

Siefert SA, Chabasse C, Mukhopadhyay S, Hoofnagle MH, Strickland DK, Sarkar R, Antalis TM.

J Thromb Haemost. 2014 Oct;12(10):1706-16. doi: 10.1111/jth.12657. Epub 2014 Sep 30.


SerpinB2 mediated regulation of macrophage function during enteric infection.

Shea-Donohue T, Zhao A, Antalis TM.

Gut Microbes. 2014 Mar-Apr;5(2):254-8. doi: 10.4161/gmic.28093. Epub 2014 Feb 5.



Alaish SM, Timmons J, Smith A, Buzza MS, Murphy E, Zhao A, Sun Y, Turner DJ, Shea-Donahue T, Antalis TM, Cross A, Dorsey SG.

Physiol Rep. 2013 Sep;1(4). doi: 10.1002/phy2.73.


SerpinB2 is critical to Th2 immunity against enteric nematode infection.

Zhao A, Yang Z, Sun R, Grinchuk V, Netzel-Arnett S, Anglin IE, Driesbaugh KH, Notari L, Bohl JA, Madden KB, Urban JF Jr, Antalis TM, Shea-Donohue T.

J Immunol. 2013 Jun 1;190(11):5779-87. doi: 10.4049/jimmunol.1200293. Epub 2013 Apr 29.


The transcription factor C/EBP-β mediates constitutive and LPS-inducible transcription of murine SerpinB2.

Udofa EA, Stringer BW, Gade P, Mahony D, Buzza MS, Kalvakolanu DV, Antalis TM.

PLoS One. 2013;8(3):e57855. doi: 10.1371/journal.pone.0057855. Epub 2013 Mar 5.


Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.

Buzza MS, Martin EW, Driesbaugh KH, Désilets A, Leduc R, Antalis TM.

J Biol Chem. 2013 Apr 12;288(15):10328-37. doi: 10.1074/jbc.M112.443432. Epub 2013 Feb 26.


Regulation of the human plasminogen activator inhibitor type 2 gene: cooperation of an upstream silencer and transactivator.

Stringer B, Udofa EA, Antalis TM.

J Biol Chem. 2012 Mar 23;287(13):10579-89. doi: 10.1074/jbc.M111.318758. Epub 2012 Feb 9.


Matriptase protects against experimental colitis and promotes intestinal barrier recovery.

Netzel-Arnett S, Buzza MS, Shea-Donohue T, Désilets A, Leduc R, Fasano A, Bugge TH, Antalis TM.

Inflamm Bowel Dis. 2012 Jul;18(7):1303-14. doi: 10.1002/ibd.21930. Epub 2011 Nov 13.


Serpin-Enzyme Receptors LDL Receptor-Related Protein 1.

Strickland DK, Muratoglu SC, Antalis TM.

Methods Enzymol. 2011;499:17-31. doi: 10.1016/B978-0-12-386471-0.00002-X.


Membrane-anchored serine proteases in health and disease.

Antalis TM, Bugge TH, Wu Q.

Prog Mol Biol Transl Sci. 2011;99:1-50. doi: 10.1016/B978-0-12-385504-6.00001-4. Review.


The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.

Antalis TM, Buzza MS, Hodge KM, Hooper JD, Netzel-Arnett S.

Biochem J. 2010 Jun 15;428(3):325-46. doi: 10.1042/BJ20100046. Review.


The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b.

Cao C, Gao Y, Li Y, Antalis TM, Castellino FJ, Zhang L.

J Clin Invest. 2010 Jun;120(6):1971-80. doi: 10.1172/JCI40380. Epub 2010 May 10.


TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells.

Chen YW, Lee MS, Lucht A, Chou FP, Huang W, Havighurst TC, Kim K, Wang JK, Antalis TM, Johnson MD, Lin CY.

Am J Pathol. 2010 Jun;176(6):2986-96. doi: 10.2353/ajpath.2010.090665. Epub 2010 Apr 9.


Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine.

Buzza MS, Netzel-Arnett S, Shea-Donohue T, Zhao A, Lin CY, List K, Szabo R, Fasano A, Bugge TH, Antalis TM.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4200-5. doi: 10.1073/pnas.0903923107. Epub 2010 Feb 8.


Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo.

Nhu QM, Shirey K, Teijaro JR, Farber DL, Netzel-Arnett S, Antalis TM, Fasano A, Vogel SN.

Mucosal Immunol. 2010 Jan;3(1):29-39. doi: 10.1038/mi.2009.120. Epub 2009 Oct 28.


Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2.

Tripathi A, Lammers KM, Goldblum S, Shea-Donohue T, Netzel-Arnett S, Buzza MS, Antalis TM, Vogel SN, Zhao A, Yang S, Arrietta MC, Meddings JB, Fasano A.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16799-804. doi: 10.1073/pnas.0906773106. Epub 2009 Sep 15.


The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability.

Netzel-Arnett S, Bugge TH, Hess RA, Carnes K, Stringer BW, Scarman AL, Hooper JD, Tonks ID, Kay GF, Antalis TM.

Biol Reprod. 2009 Nov;81(5):921-32. doi: 10.1095/biolreprod.109.076273. Epub 2009 Jul 1.


Type II transmembrane serine proteases.

Bugge TH, Antalis TM, Wu Q.

J Biol Chem. 2009 Aug 28;284(35):23177-81. doi: 10.1074/jbc.R109.021006. Epub 2009 Jun 1. Review.


Methods in molecular biology. Proteases and cancer. Methods and protocols. Preface.

Antalis TM, Bugge TH.

Methods Mol Biol. 2009;539:v-vii. No abstract available.


SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival.

Tonnetti L, Netzel-Arnett S, Darnell GA, Hayes T, Buzza MS, Anglin IE, Suhrbier A, Antalis TM.

Cancer Res. 2008 Jul 15;68(14):5648-57. doi: 10.1158/0008-5472.CAN-07-5850.


Human papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein.

Darnell GA, Schroder WA, Antalis TM, Lambley E, Major L, Gardner J, Birrell G, Cid-Arregui A, Suhrbier A.

J Biol Chem. 2007 Dec 28;282(52):37492-500. Epub 2007 Oct 31.


Mechanisms of disease: protease functions in intestinal mucosal pathobiology.

Antalis TM, Shea-Donohue T, Vogel SN, Sears C, Fasano A.

Nat Clin Pract Gastroenterol Hepatol. 2007 Jul;4(7):393-402. Review.


Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation.

Netzel-Arnett S, Currie BM, Szabo R, Lin CY, Chen LM, Chai KX, Antalis TM, Bugge TH, List K.

J Biol Chem. 2006 Nov 3;281(44):32941-5. Epub 2006 Sep 15.


SerpinB2 is an inducible host factor involved in enhancing HIV-1 transcription and replication.

Darnell GA, Schroder WA, Gardner J, Harrich D, Yu H, Medcalf RL, Warrilow D, Antalis TM, Sonza S, Suhrbier A.

J Biol Chem. 2006 Oct 20;281(42):31348-58. Epub 2006 Aug 21.


Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity.

Szabo R, Netzel-Arnett S, Hobson JP, Antalis TM, Bugge TH.

Biochem J. 2005 Aug 15;390(Pt 1):231-42.


Amalfi to Washington D. C.--twenty years of plasminogen activator research.

Antalis TM, Bugge TH, Lawrence DA, Netzel-Arnett S, Schwartz BS, Strickland DK.

Thromb Haemost. 2005 Apr;93(4):625-6. No abstract available.


Silencing of integrated human papillomavirus type 18 oncogene transcription in cells expressing SerpinB2.

Darnell GA, Antalis TM, Rose BR, Suhrbier A.

J Virol. 2005 Apr;79(7):4246-56.


Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis.

Manton KJ, Douglas ML, Netzel-Arnett S, Fitzpatrick DR, Nicol DL, Boyd AW, Clements JA, Antalis TM.

Br J Cancer. 2005 Feb 28;92(4):760-9. Erratum in: Br J Cancer. 2015 Dec 1;113(11):1640.


Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes.

Hobson JP, Netzel-Arnett S, Szabo R, Réhault SM, Church FC, Strickland DK, Lawrence DA, Antalis TM, Bugge TH.

J Biol Chem. 2004 Nov 5;279(45):46981-94. Epub 2004 Aug 24.


Serpin mutagenesis.

Antalis TM, Lawrence DA.

Methods. 2004 Feb;32(2):130-40.


Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif.

Darnell GA, Antalis TM, Johnstone RW, Stringer BW, Ogbourne SM, Harrich D, Suhrbier A.

Mol Cell Biol. 2003 Sep;23(18):6520-32.


Type II transmembrane serine proteases.

Szabo R, Wu Q, Dickson RB, Netzel-Arnett S, Antalis TM, Bugge TH.

Thromb Haemost. 2003 Aug;90(2):185-93. Review.


Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer.

Netzel-Arnett S, Hooper JD, Szabo R, Madison EL, Quigley JP, Bugge TH, Antalis TM.

Cancer Metastasis Rev. 2003 Jun-Sep;22(2-3):237-58. Review.


Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis.

Aimes RT, Zijlstra A, Hooper JD, Ogbourne SM, Sit ML, Fuchs S, Gotley DC, Quigley JP, Antalis TM.

Thromb Haemost. 2003 Mar;89(3):561-72.


Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3.

Barbour AP, Reeder JA, Walsh MD, Fawcett J, Antalis TM, Gotley DC.

Cancer Res. 2003 Feb 15;63(4):887-92.


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